Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2024 Volume 28 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2024 Volume 28 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Diagnostic performance of 18F‑FDG PET/CT vs. 18F‑NaF PET/CT in breast cancer with bone metastases: An indirect comparative meta‑analysis

  • Authors:
    • Hongyu Hu
    • Xianwen Hu
    • Zhigang Liang
    • Wenbi Yang
    • Song Li
    • Dandan Li
    • Jiong Cai
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China, Department of Gynecology, Zunyi Hospital of Traditional Chinese Medicine, Zunyi, Guizhou 563000, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 546
    |
    Published online on: September 12, 2024
       https://doi.org/10.3892/ol.2024.14679
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Breast cancer remains the leading cause of cancer‑related death in women, with 5‑year survival rates of as high as 90% for patients with early‑stage breast cancer without metastasis, falling to 10% once bone metastases (BM) occur. Currently, there is no cure for breast cancer with BM. However, appropriate treatment can extend survival and improve patients' quality of life. Therefore, it is important to accurately evaluate the presence of BM in patients with breast cancer. The present meta‑analysis evaluated the diagnostic performance of 18F‑FDG and 18F‑NaF as PET/CT tracers for breast cancer‑associated BM. The present study aimed to compare the diagnostic performance of fluorine‑18 fluorodeoxyglucose (18F‑FDG) positron emission tomography/computed tomographs (PET/CT) and 18F‑sodium fluoride (18F‑NaF) PET/CT in patients with breast cancer and BM. The PubMed and Embase databases were searched for English literature on the diagnostic performance of 18F‑FDG PET/CT and 18F‑NaF PET/CT for breast cancer BM, and two authors independently extracted data. All included studies presented data that could be used to construct a 2x2 contingency table. The methodological quality of the selected studies was assessed using QUADAS‑2, and forest plots were generated based on the sensitivity and specificity of 18F‑FDG PET/CT and 18F‑NaF PET/CT in the diagnosis of BM associated with breast cancer. A total of 14 articles were identified, including eight on the analysis of 18F‑FDG PET/CT, five on 18F‑NaF PET/CT and one on both. The studies on 18F‑FDG PET/CT and 18F‑NaF PET/CT included 530 and 270 patients, respectively. The pooled sensitivities were 0.88 [95% confidence interval (95% CI), 0.76‑0.94] for 18F‑FDG PET/CT and 0.98 (95% CI, 0.92‑1.00) for 18F‑NaF PET/CT, and the pooled specificities were 0.99 (95% CI, 0.97‑1.00) and 0.91 (95% CI: 0.76‑0.97), respectively. The area under the summary receiver operating characteristic curve for both 18F‑FDG PET/CT and 18F‑NaF PET/CT was 0.99 (95% CI, 0.98‑1.00). Lesion‑based analysis using 18F‑FDG PET/CT was performed for 909 lesions, with a sensitivity of 0.84 (95% CI, 0.67‑1.00) and specificity of 1.00 (95% CI, 0.98‑1.00). Compared with 18F‑FDG PET/CT, 18F‑NaF PET/CT showed higher sensitivity (98 vs. 88%) but lower specificity (91 vs. 99%), although the difference between methods was not statistically significant. In conclusion, the results of the present study indicated that 18F‑NaF PET/CT and 18F‑FDG PET/CT are both accurate methods for the detection of BM in patients with breast cancer, and have comparable diagnostic accuracy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I and Jemal A: Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 74:229–263. 2024. View Article : Google Scholar : PubMed/NCBI

2 

Cook GJ, Houston S, Rubens R, Maisey MN and Fogelman I: Detection of bone metastases in breast cancer by 18FDG PET: differing metabolic activity in osteoblastic and osteolytic lesions. J Clin Oncol. 16:3375–3379. 1998. View Article : Google Scholar : PubMed/NCBI

3 

Zengel B, Kilic M, Tasli F, Simsek C, Karatas M, Ozdemir O, Cavdar D, Durusoy R, Bas KK and Uslu A: Breast cancer patients with isolated bone metastases and oligometastatic bone disease show different survival outcomes. Sci Rep. 11:201752021. View Article : Google Scholar : PubMed/NCBI

4 

Pantel K and Hayes DF: Disseminated breast tumour cells: Biological and clinical meaning. Nat Rev Clin Oncol. 15:129–131. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Makhoul I, Montgomery CO, Gaddy D and Suva LJ: The best of both worlds-managing the cancer, saving the bone. Nat Rev Endocrinol. 12:29–42. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Brook N, Brook E, Dharmarajan A, Dass CR and Chan A: Breast cancer bone metastases: Pathogenesis and therapeutic targets. Int J Biochem Cell Biol. 96:63–78. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Weigelt B, Peterse JL and van't Veer LJ: Breast cancer metastasis: Markers and models. Nat Rev Cancer. 5:591–602. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Liu T, Cheng T, Xu W, Yan WL, Liu J and Yang HL: A meta-analysis of 18FDG-PET, MRI and bone scintigraphy for diagnosis of bone metastases in patients with breast cancer. Skeletal Radiol. 40:523–531. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Cook GJ, Azad GK and Goh V: Imaging bone metastases in breast cancer: Staging and response assessment. J Nucl Med. 57 (Suppl 1):27S–33S. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Hansen JA, Naghavi-Behzad M, Gerke O, Baun C, Falch K, Duvnjak S, Alavi A, Høilund-Carlsen PF and Hildebrandt MG: Diagnosis of bone metastases in breast cancer: Lesion-based sensitivity of dual-time-point FDG-PET/CT compared to low-dose CT and bone scintigraphy. PLoS One. 16:e02600662021. View Article : Google Scholar : PubMed/NCBI

11 

Garami Z, Hascsi Z, Varga J, Dinya T, Tanyi M, Garai I, Damjanovich L and Galuska L: The value of 18-FDG PET/CT in early-stage breast cancer compared to traditional diagnostic modalities with an emphasis on changes in disease stage designation and treatment plan. Eur J Surg Oncol. 38:31–37. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Bastawrous S, Bhargava P, Behnia F, Djang DS and Haseley DR: Newer PET application with an old tracer: Role of 18F-NaF skeletal PET/CT in oncologic practice. Radiographics. 34:1295–1316. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Xiong Z, Deng G, Huang X, Li X, Xie X, Wang J, Shuang Z and Wang X: Bone metastasis pattern in initial metastatic breast cancer: A population-based study. Cancer Manag Res. 10:287–295. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Tsuzuki S, Park SH, Eber MR, Peters CM and Shiozawa Y: Skeletal complications in cancer patients with bone metastases. Int J Urol. 23:825–832. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Damle NA, Bal C, Bandopadhyaya GP, Kumar L, Kumar P, Malhotra A and Lata S: The role of 18F-fluoride PET-CT in the detection of bone metastases in patients with breast, lung and prostate carcinoma: A comparison with FDG PET/CT and 99mTc-MDP bone scan. Jpn J Radiol. 31:262–269. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Al-Muqbel KM, Yaghan RJ, Al-Omari MH, Rousan LA, Dagher NM and Al Bashir S: Clinical relevance of 18F-FDG-negative osteoblastic metastatic bone lesions noted on PET/CT in breast cancer patients. Nucl Med Commun. 37:593–601. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Gaeta CM, Vercher-Conejero JL, Sher AC, Kohan A, Rubbert C and Avril N: Recurrent and metastatic breast cancer PET, PET/CT, PET/MRI: FDG and new biomarkers. Q J Nucl Med Mol Imaging. 57:352–366. 2013.PubMed/NCBI

18 

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J and Moher D: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: Explanation and elaboration. BMJ. 339:b27002009. View Article : Google Scholar : PubMed/NCBI

19 

Whiting PF, Rutjes AW, Westwood ME, Mallett S, Deeks JJ, Reitsma JB, Leeflang MM, Sterne JA and Bossuyt PM: QUADAS-2: A revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. 155:529–536. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Deeks JJ: Systematic reviews in health care: Systematic reviews of evaluations of diagnostic and screening tests. BMJ. 323:157–162. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Deeks JJ, Macaskill P and Irwig L: The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed. J Clin Epidemiol. 58:882–893. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Hahn S, Heusner T, Kümmel S, Köninger A, Nagarajah J, Müller S, Boy C, Forsting M, Bockisch A, Antoch G and Stahl A: Comparison of FDG-PET/CT and bone scintigraphy for detection of bone metastases in breast cancer. Acta Radiol. 52:1009–1014. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Broos W, van der Zant FM, Wondergem M and Knol R: Accuracy of 18F-NaF PET/CT in bone metastasis detection and its effect on patient management in patients with breast carcinoma. Nucl Med Commun. 39:325–333. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Rager O, Lee-Felker SA, Tabouret-Viaud C, Felker ER, Poncet A, Amzalag G, Garibotto V, Zaidi H and Walter MA: Accuracy of whole-body HDP SPECT/CT, FDG PET/CT, and their combination for detecting bone metastases in breast cancer: An intra-personal comparison. Am J Nucl Med Mol Imaging. 8:159–168. 2018.PubMed/NCBI

25 

Al-Muqbel KM: Bone marrow metastasis is an early stage of bone metastasis in breast cancer detected clinically by F18-FDG-PET/CT imaging. Biomed Res Int. 2017:98526322017. View Article : Google Scholar : PubMed/NCBI

26 

Caglar M, Kupik O, Karabulut E and Høilund-Carlsen PF: Detection of bone metastases in breast cancer patients in the PET/CT era: Do we still need the bone scan. Rev Esp Med Nucl Imagen Mol. 35:3–11. 2016.PubMed/NCBI

27 

Piccardo A, Altrinetti V, Bacigalupo L, Puntoni M, Biscaldi E, Gozza A, Cabria M, Iacozzi M, Pasa A, Morbelli S, et al: Detection of metastatic bone lesions in breast cancer patients: fused (18)F-Fluoride-PET/MDCT has higher accuracy than MDCT. Preliminary experience. Eur J Radiol. 81:2632–2638. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Heusner TA, Kuemmel S, Koeninger A, Hamami ME, Hahn S, Quinsten A, Bockisch A, Forsting M, Lauenstein T, Antoch G and Stahl A: Diagnostic value of diffusion-weighted magnetic resonance imaging (DWI) compared to FDG PET/CT for whole-body breast cancer staging. Eur J Nucl Med Mol Imaging. 37:1077–1086. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Passah A, Tripathi M, Ballal S, Yadav MP, Kumar R, Roesch F, Meckel M, Sarathi Chakraborty P and Bal C: Evaluation of bone-seeking novel radiotracer 68Ga-NO2AP-Bisphosphonate for the detection of skeletal metastases in carcinoma breast. Eur J Nucl Med Mol Imaging. 44:41–49. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Koizumi M, Motegi K and Umeda T: A novel biomarker, active whole skeletal total lesion glycolysis (WS-TLG), as a quantitative method to measure bone metastatic activity in breast cancer patients. Ann Nucl Med. 33:502–511. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Abikhzer G, Srour S, Fried G, Drumea K, Kozlener E, Frenkel A, Israel O, Fogelman I and Kagna O: Prospective comparison of whole-body bone SPECT and sodium 18F-fluoride PET in the detection of bone metastases from breast cancer. Nucl Med Commun. 37:1160–1168. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Teke F, Teke M, Inal A, Kaplan MA, Kucukoner M, Aksu R, Urakci Z, Tasdemir B and Isikdogan A: Significance of hormone receptor status in comparison of 18F-FDG-PET/CT and 99mTc-MDP bone scintigraphy for evaluating bone metastases in patients with breast cancer: Single center experience. Asian Pac J Cancer Prev. 16:387–391. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Yoon SH, Kim KS, Kang SY, Song HS, Jo KS, Choi BH, Lee SJ, Yoon JK and An YS: Usefulness of (18)F-fluoride PET/CT in breast cancer patients with osteosclerotic bone metastases. Nucl Med Mol Imaging. 47:27–35. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Botsikas D, Bagetakos I, Picarra M, Da Cunha Afonso Barisits AC, Boudabbous S, Montet X, Lam GT, Mainta I, Kalovidouri A and Becker M: What is the diagnostic performance of 18-FDG-PET/MR compared to PET/CT for the N- and M-staging of breast cancer. Eur Radiol. 29:1787–1798. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Hu X, Li D, Liang Z, Liao Y, Yang L, Wang R, Wang P and Cai J: Indirect comparison of the diagnostic performance of 18F-FDG PET/CT and MRI in differentiating benign and malignant ovarian or adnexal tumors: A systematic review and meta-analysis. BMC Cancer. 21:10802021. View Article : Google Scholar : PubMed/NCBI

36 

Evangelista L, Panunzio A, Polverosi R, Ferretti A, Chondrogiannis S, Pomerri F, Rubello D and Muzzio PC: Early bone marrow metastasis detection: The additional value of FDG-PET/CT vs. CT imaging. Biomed Pharmacother. 66:448–453. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Han S and Choi JY: Impact of 18F-FDG PET, PET/CT, and PET/MRI on staging and management as an initial staging modality in breast cancer: A systematic review and meta-analysis. Clin Nucl Med. 46:271–282. 2021. View Article : Google Scholar : PubMed/NCBI

38 

Zhang X, Liu Y, Luo H and Zhang J: PET/CT and MRI for identifying axillary lymph node metastases in breast cancer patients: Systematic review and meta-Analysis. J Magn Reson Imaging. 52:1840–1851. 2020. View Article : Google Scholar : PubMed/NCBI

39 

Han S and Choi JY: Prognostic value of 18F-FDG PET and PET/CT for assessment of treatment response to neoadjuvant chemotherapy in breast cancer: A systematic review and meta-analysis. Breast Cancer Res. 22:1192020. View Article : Google Scholar : PubMed/NCBI

40 

Diao W, Tian F and Jia Z: The prognostic value of SUVmax measuring on primary lesion and ALN by 18F-FDG PET or PET/CT in patients with breast cancer. Eur J Radiol. 105:1–7. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Krüger S, Buck AK, Mottaghy FM, Hasenkamp E, Pauls S, Schumann C, Wibmer T, Merk T, Hombach V and Reske SN: Detection of bone metastases in patients with lung cancer: 99mTc-MDP planar bone scintigraphy, 18F-fluoride PET or 18F-FDG PET/CT. Eur J Nucl Med Mol Imaging. 36:1807–1812. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Grant FD, Fahey FH, Packard AB, Davis RT, Alavi A and Treves ST: Skeletal PET with 18F-fluoride: Applying new technology to an old tracer. J Nucl Med. 49:68–78. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Schirrmeister H, Guhlmann A, Kotzerke J, Santjohanser C, Kühn T, Kreienberg R, Messer P, Nüssle K, Elsner K, Glatting G, et al: Early detection and accurate description of extent of metastatic bone disease in breast cancer with fluoride ion and positron emission tomography. J Clin Oncol. 17:2381–2389. 1999. View Article : Google Scholar : PubMed/NCBI

44 

Bebbington NA, Zacho HD and Holdgaard PC: Lesion detection in 18F-sodium fluoride bone imaging: A comparison of attenuation-corrected versus nonattenuation-corrected PET reconstructions from modern PET-CT systems. Nucl Med Commun. 43:78–85. 2022. View Article : Google Scholar : PubMed/NCBI

45 

Capitanio S, Bongioanni F, Piccardo A, Campus C, Gonella R, Tixi L, Naseri M, Pennone M, Altrinetti V, Buschiazzo A, et al: Comparisons between glucose analogue 2-deoxy-2-((18)F)fluoro-D-glucose and (18)F-sodium fluoride positron emission tomography/computed tomography in breast cancer patients with bone lesions. World J Radiol. 8:200–209. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Balci TA, Koc ZP and Komek H: Bone scan or (18)f-fluorodeoxyglucose positron emission tomography/computed tomography; which modality better shows bone metastases of breast cancer. Breast Care (Basel). 7:389–393. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hu H, Hu X, Liang Z, Yang W, Li S, Li D and Cai J: Diagnostic performance of <sup>18</sup>F‑FDG PET/CT vs. <sup>18</sup>F‑NaF PET/CT in breast cancer with bone metastases: An indirect comparative meta‑analysis. Oncol Lett 28: 546, 2024.
APA
Hu, H., Hu, X., Liang, Z., Yang, W., Li, S., Li, D., & Cai, J. (2024). Diagnostic performance of <sup>18</sup>F‑FDG PET/CT vs. <sup>18</sup>F‑NaF PET/CT in breast cancer with bone metastases: An indirect comparative meta‑analysis. Oncology Letters, 28, 546. https://doi.org/10.3892/ol.2024.14679
MLA
Hu, H., Hu, X., Liang, Z., Yang, W., Li, S., Li, D., Cai, J."Diagnostic performance of <sup>18</sup>F‑FDG PET/CT vs. <sup>18</sup>F‑NaF PET/CT in breast cancer with bone metastases: An indirect comparative meta‑analysis". Oncology Letters 28.5 (2024): 546.
Chicago
Hu, H., Hu, X., Liang, Z., Yang, W., Li, S., Li, D., Cai, J."Diagnostic performance of <sup>18</sup>F‑FDG PET/CT vs. <sup>18</sup>F‑NaF PET/CT in breast cancer with bone metastases: An indirect comparative meta‑analysis". Oncology Letters 28, no. 5 (2024): 546. https://doi.org/10.3892/ol.2024.14679
Copy and paste a formatted citation
x
Spandidos Publications style
Hu H, Hu X, Liang Z, Yang W, Li S, Li D and Cai J: Diagnostic performance of <sup>18</sup>F‑FDG PET/CT vs. <sup>18</sup>F‑NaF PET/CT in breast cancer with bone metastases: An indirect comparative meta‑analysis. Oncol Lett 28: 546, 2024.
APA
Hu, H., Hu, X., Liang, Z., Yang, W., Li, S., Li, D., & Cai, J. (2024). Diagnostic performance of <sup>18</sup>F‑FDG PET/CT vs. <sup>18</sup>F‑NaF PET/CT in breast cancer with bone metastases: An indirect comparative meta‑analysis. Oncology Letters, 28, 546. https://doi.org/10.3892/ol.2024.14679
MLA
Hu, H., Hu, X., Liang, Z., Yang, W., Li, S., Li, D., Cai, J."Diagnostic performance of <sup>18</sup>F‑FDG PET/CT vs. <sup>18</sup>F‑NaF PET/CT in breast cancer with bone metastases: An indirect comparative meta‑analysis". Oncology Letters 28.5 (2024): 546.
Chicago
Hu, H., Hu, X., Liang, Z., Yang, W., Li, S., Li, D., Cai, J."Diagnostic performance of <sup>18</sup>F‑FDG PET/CT vs. <sup>18</sup>F‑NaF PET/CT in breast cancer with bone metastases: An indirect comparative meta‑analysis". Oncology Letters 28, no. 5 (2024): 546. https://doi.org/10.3892/ol.2024.14679
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team