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Case Report Open Access

Perioperative serplulimab‑based chemoimmunotherapy in stage IV large cell neuroendocrine carcinoma of the lung: A case report

  • Authors:
    • Shuliang Zhang
    • Jianting Du
    • Chuanquan Lin
    • Maohui Chen
    • Yizhou Huang
    • Chun Chen
    • Bin Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 547
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    Published online on: September 12, 2024
       https://doi.org/10.3892/ol.2024.14680
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Abstract

Large cell neuroendocrine carcinoma (LCNEC) is a rare and enigmatic tumor, characterized by neuroendocrine features and a poor prognosis similar to small cell lung cancer (SCLC). The present report details the case of a 45‑year‑old male with oligometastatic stage IV LCNEC who achieved clinical cure after undergoing perioperative immunochemotherapy. Despite the typical non‑recommendation of surgery for stage IV cases, based on the insistence of the patient, the present study initiated three cycles of neoadjuvant therapy combining serplulimab (a programmed cell death protein 1 inhibitor) with chemotherapy, resulting in the radiological disappearance of the tumor. Pathological complete response was confirmed following resection of the primary tumor. The treatment continued with three cycles of adjuvant therapy using serplulimab and chemotherapy, followed by maintenance therapy with serplulimab alone. After 17 cycles of maintenance therapy, a positron emission tomography‑computed tomography scan revealed a complete metabolic response of the metastasis, and radiological scans revealed no visible tumor or distant metastasis, indicating a clinical cure. Event‑free survival has exceeded 11 months, and overall survival has exceeded 14 months. The present case highlights the efficacy of immunochemotherapy in treating advanced LCNEC.
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1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Deng C, Wu SG and Tian Y: Lung large cell neuroendocrine carcinoma: An analysis of patients from the surveillance, epidemiology, and End-Results (SEER) database. Med Sci Monit. 25:3636–3646. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Fasano M, Della Corte CM, Papaccio F, Ciardiello F and Morgillo F: Pulmonary large-cell neuroendocrine carcinoma: From epidemiology to therapy. J Thorac Oncol. 10:1133–1141. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Kinslow CJ, May MS, Saqi A, Shu CA, Chaudhary KR, Wang TJC and Cheng SK: Large-Cell neuroendocrine carcinoma of the lung: A population-based study. Clin Lung Cancer. 21:e99–e113. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Derks JL, Hendriks LE, Buikhuisen WA, Groen HJ, Thunnissen E, van Suylen RJ, Houben R, Damhuis RA, Speel EJ and Dingemans AM: Clinical features of large cell neuroendocrine carcinoma: A population-based overview. Eur Respir J. 47:615–624. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Fisseler-Eckhoff A and Demes M: Neuroendocrine tumors of the lung. Cancers (Basel). 4:777–798. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Iyoda A, Hiroshima K, Moriya Y, Iwadate Y, Takiguchi Y, Uno T, Nakatani Y and Yoshino I: Postoperative recurrence and the role of adjuvant chemotherapy in patients with pulmonary large-cell neuroendocrine carcinoma. J Thorac Cardiovasc Surg. 138:446–453. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Raez LE, Cassileth PA, Schlesselman JJ, Sridhar K, Padmanabhan S, Fisher EZ, Baldie PA and Podack ER: Allogeneic vaccination with a B7.1 HLA-A gene-modified adenocarcinoma cell line in patients with advanced non-small-cell lung cancer. J Clin Oncol. 22:2800–2807. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Lahiri A, Maji A, Potdar PD, Singh N, Parikh P, Bisht B, Mukherjee A and Paul MK: Lung cancer immunotherapy: Progress, pitfalls, and promises. Mol Cancer. 22:402023. View Article : Google Scholar : PubMed/NCBI

10 

Steven A, Fisher SA and Robinson BW: Immunotherapy for lung cancer. Respirology. 21:821–833. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Ettinger DS, Wood DE, Aisner DL, Akerley W, Bauman JR, Bharat A, Bruno DS, Chang JY, Chirieac LR, DeCamp M, et al: NCCN Guidelines® Insights: Non-Small cell lung cancer, version 2.2023. J Natl Compr Canc Netw. 21:340–350. 2023. View Article : Google Scholar : PubMed/NCBI

12 

Travis WD: Advances in neuroendocrine lung tumors. Ann Oncol. 21 (Suppl 7):vii65–vii71. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Asamura H, Kameya T, Matsuno Y, Noguchi M, Tada H, Ishikawa Y, Yokose T, Jiang SX, Inoue T, Nakagawa K, et al: Neuroendocrine neoplasms of the lung: A prognostic spectrum. J Clin Oncol. 24:70–76. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Nicholson AG, Tsao MS, Beasley MB, Borczuk AC, Brambilla E, Cooper WA, Dacic S, Jain D, Kerr KM, Lantuejoul S, et al: The 2021 WHO classification of lung tumors: Impact of advances since 2015. J Thorac Oncol. 17:362–387. 2022. View Article : Google Scholar : PubMed/NCBI

15 

Kupeli M and Koseoglu RD: Large cell carcinoma with adenocarcinoma in lung. J Coll Physicians Surg Pak. 28:240–242. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Welter S, Aigner C and Roesel C: The role of surgery in high grade neuroendocrine tumours of the lung. J Thorac Dis. 9 (Suppl 15):S1474–S1483. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Eichhorn F, Dienemann H, Muley T, Warth A and Hoffmann H: Predictors of survival after operation among patients with large cell neuroendocrine carcinoma of the lung. Ann Thorac Surg. 99:983–989. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Iyoda A, Hiroshima K, Toyozaki T, Haga Y, Fujisawa T and Ohwada H: Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology. Cancer. 91:1992–2000. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Travis WD: Pathology and diagnosis of neuroendocrine tumors: Lung neuroendocrine. Thorac Surg Clin. 24:257–266. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Peifer M, Fernandez-Cuesta L, Sos ML, George J, Seidel D, Kasper LH, Plenker D, Leenders F, Sun R, Zander T, et al: Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet. 44:1104–1110. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Yang L, Fan Y and Lu H: Pulmonary large cell neuroendocrine carcinoma. Pathol Oncol Res. 28:16107302022. View Article : Google Scholar : PubMed/NCBI

22 

Sturm N, Lantuejoul S, Laverriere MH, Papotti M, Brichon PY, Brambilla C and Brambilla E: Thyroid transcription factor 1 and cytokeratins 1, 5, 10, 14 (34betaE12) expression in basaloid and large-cell neuroendocrine carcinomas of the lung. Hum Pathol. 32:918–925. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Liu C, Qin Q and Cong H: Research progress on the relationship between mitochondrial deoxyguanosine kinase and apoptosis and autophagy in lung adenocarcinoma cells. Cancer Insight. 1:53–62. 2022. View Article : Google Scholar

24 

Carbone DP, Reck M, Paz-Ares L, Creelan B, Horn L, Steins M, Felip E, van den Heuvel MM, Ciuleanu TE, Badin F, et al: First-Line nivolumab in Stage IV or recurrent Non-Small-Cell lung cancer. N Engl J Med. 376:2415–2426. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Hellmann MD, Ciuleanu TE, Pluzanski A, Lee JS, Otterson GA, Audigier-Valette C, Minenza E, Linardou H, Burgers S, Salman P, et al: Nivolumab plus ipilimumab in lung cancer with a high tumor mutational burden. N Engl J Med. 378:2093–2104. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Sun LY, Cen WJ, Tang WT, Long YK, Yang XH, Ji XM, Yang JJ, Zhang RJ, Wang F, Shao JY, et al: Smoking status combined with tumor mutational burden as a prognosis predictor for combination immune checkpoint inhibitor therapy in non-small cell lung cancer. Cancer Med. 10:6610–6617. 2021. View Article : Google Scholar : PubMed/NCBI

27 

Garassino MC, Gelibter AJ, Grossi F, Chiari R, Soto Parra H, Cascinu S, Cognetti F, Turci D, Blasi L, Bengala C, et al: Italian nivolumab expanded access program in nonsquamous non-Small cell lung cancer patients: Results in Never-Smokers and EGFR-mutant patients. J Thorac Oncol. 13:1146–1155. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Iyoda A, Makino T, Koezuka S, Otsuka H and Hata Y: Treatment options for patients with large cell neuroendocrine carcinoma of the lung. Gen Thorac Cardiovasc Surg. 62:351–356. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Yoshida A, Kobayashi E, Kubo T, Kodaira M, Motoi T, Motoi N, Yonemori K, Ohe Y, Watanabe SI, Kawai A, et al: Clinicopathological and molecular characterization of SMARCA4-deficient thoracic sarcomas with comparison to potentially related entities. Mod Pathol. 30:797–809. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Sarkaria IS, Iyoda A, Roh MS, Sica G, Kuk D, Sima CS, Pietanza MC, Park BJ, Travis WD and Rusch VW: Neoadjuvant and adjuvant chemotherapy in resected pulmonary large cell neuroendocrine carcinomas: A single institution experience. Ann Thorac Surg. 92:1180–1187. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Tokito T, Kenmotsu H, Watanabe R, Ito I, Shukuya T, Ono A, Nakamura Y, Tsuya A, Naito T, Murakami H, et al: Comparison of chemotherapeutic efficacy between LCNEC diagnosed using large specimens and possible LCNEC diagnosed using small biopsy specimens. Int J Clin Oncol. 19:63–67. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Sun JM, Ahn MJ, Ahn JS, Um SW, Kim H, Kim HK, Choi YS, Han J, Kim J, Kwon OJ, et al: Chemotherapy for pulmonary large cell neuroendocrine carcinoma: Similar to that for small cell lung cancer or non-small cell lung cancer? Lung Cancer. 77:365–370. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Shah MH, Goldner WS, Benson AB, Bergsland E, Blaszkowsky LS, Brock P, Chan J, Das S, Dickson PV, Fanta P, et al: Neuroendocrine and adrenal tumors, version 2.2021, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 19:839–868. 2021. View Article : Google Scholar : PubMed/NCBI

34 

De Pas TM, Giovannini M, Manzotti M, Trifiro G, Toffalorio F, Catania C, Spaggiari L, Labianca R and Barberis M: Large-cell neuroendocrine carcinoma of the lung harboring EGFR mutation and responding to gefitinib. J Clin Oncol. 29:e819–e822. 2011. View Article : Google Scholar : PubMed/NCBI

35 

George J, Walter V, Peifer M, Alexandrov LB, Seidel D, Leenders F, Maas L, Muller C, Dahmen I, Delhomme TM, et al: Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors. Nat Commun. 9:10482018. View Article : Google Scholar : PubMed/NCBI

36 

Peters S, Camidge DR, Shaw AT, Gadgeel S, Ahn JS, Kim DW, Ou SI, Perol M, Dziadziuszko R, Rosell R, et al: Alectinib versus Crizotinib in untreated ALK-positive non-small-cell lung cancer. N Engl J Med. 377:829–838. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Hayashi N, Fujita A, Saikai T, Takabatake H, Sotoshiro M, Sekine K and Kawana A: Large cell neuroendocrine carcinoma harboring an anaplastic lymphoma kinase (ALK) rearrangement with response to alectinib. Intern Med. 57:713–716. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Iyoda A, Travis WD, Sarkaria IS, Jiang SX, Amano H, Sato Y, Saegusa M, Rusch VW and Satoh Y: Expression profiling and identification of potential molecular targets for therapy in pulmonary large-cell neuroendocrine carcinoma. Exp Ther Med. 2:1041–1045. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Wang VE, Urisman A, Albacker L, Ali S, Miller V, Aggarwal R and Jablons D: Checkpoint inhibitor is active against large cell neuroendocrine carcinoma with high tumor mutation burden. J Immunother Cancer. 5:752017. View Article : Google Scholar : PubMed/NCBI

40 

Weber MM and Fottner C: Immune checkpoint inhibitors in the treatment of patients with neuroendocrine neoplasia. Oncol Res Treat. 41:306–312. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Ferrara MG, Stefani A, Simbolo M, Pilotto S, Martini M, Lococo F, Vita E, Chiappetta M, Cancellieri A, D'Argento E, et al: Large Cell Neuro-Endocrine carcinoma of the lung: Current treatment options and potential future opportunities. Front Oncol. 11:6502932021. View Article : Google Scholar : PubMed/NCBI

42 

Fan Y, Ma K, Wang C, Ning J, Hu Y, Dong D, Dong X, Geng Q, Li E and Wu Y: Prognostic value of PD-L1 and PD-1 expression in pulmonary neuroendocrine tumors. Onco Targets Ther. 9:6075–6082. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Kim HS, Lee JH, Nam SJ, Ock CY, Moon JW, Yoo CW, Lee GK and Han JY: Association of PD-L1 Expression with Tumor-Infiltrating immune cells and mutation burden in high-grade neuroendocrine carcinoma of the lung. J Thorac Oncol. 13:636–648. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Tsuruoka K, Horinouchi H, Goto Y, Kanda S, Fujiwara Y, Nokihara H, Yamamoto N, Asakura K, Nakagawa K, Sakurai H, et al: PD-L1 expression in neuroendocrine tumors of the lung. Lung Cancer. 108:115–120. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Karim NA, Sendilnathan A, Eldessouki I, Orr-Asman MA, Xie C, Wang J and Elnakat H: PS06.06 immune checkpoint markers in lung large cell neuroendocrine carcinomas (L-LCNEC). J Thoracic Oncol. 12:1583–S1584. 2017. View Article : Google Scholar

46 

Chauhan A, Arnold SM, Kolesar J, Thomas HE, Evers M and Anthony L: Immune checkpoint inhibitors in large cell neuroendocrine carcinoma: Current status. Oncotarget. 9:14738–14740. 2018. View Article : Google Scholar : PubMed/NCBI

47 

Levra MG, Mazières J, Valette CA, Molinier O, Planchard D, Frappat V, Ferrer L, Toffart AC and Moro-Sibilot D: P1.07-012 efficacy of immune checkpoint inhibitors in large cell neuroendocrine lung cancer: Results from a french retrospective cohort. J Thoracic Oncol. S12 (Suppl):S702–S703. 2017. View Article : Google Scholar

48 

Agar C, Geier M, Leveiller G, Lamy R, Bizec JL, Tiercin M, Bernier C, Robinet G, Lena H, Ricordel C, et al: Brief report on the efficacy of nivolumab in patients with previously treated advanced Large-Cell neuroendocrine cancer of the lung. JTO Clin Res Rep. 2:1001292021.PubMed/NCBI

49 

Zhang X, Sun Y, Miao Y and Xu S: Immune checkpoint inhibitor therapy achieved complete response for drug-sensitive EGFR/ALK mutation-negative metastatic pulmonary large-cell neuroendocrine carcinoma with high tumor mutation burden: A case report. Onco Targets Ther. 13:8245–8250. 2020. View Article : Google Scholar : PubMed/NCBI

50 

Takimoto Sato M, Ikezawa Y, Sato M, Suzuki A and Kawai Y: Large cell neuroendocrine carcinoma of the lung that responded to nivolumab: A case report. Mol Clin Oncol. 13:43–47. 2020. View Article : Google Scholar : PubMed/NCBI

51 

Sherman S, Rotem O, Shochat T, Zer A, Moore A and Dudnik E: Efficacy of immune check-point inhibitors (ICPi) in large cell neuroendocrine tumors of lung (LCNEC). Lung Cancer. 143:40–46. 2020. View Article : Google Scholar : PubMed/NCBI

52 

Komiya T, Ravindra N and Powell E: Role of immunotherapy in stage IV large cell neuroendocrine carcinoma of the lung. Asian Pac J Cancer Prev. 22:365–370. 2021. View Article : Google Scholar : PubMed/NCBI

53 

Barroso-Sousa R, Barry WT, Garrido-Castro AC, Hodi FS, Min L, Krop IE and Tolaney SM: Incidence of endocrine dysfunction following the use of different immune checkpoint inhibitor regimens: A systematic review and meta-analysis. JAMA Oncol. 4:173–182. 2018. View Article : Google Scholar : PubMed/NCBI

54 

Lee H, Hodi FS, Giobbie-Hurder A, Ott PA, Buchbinder EI, Haq R, Tolaney S, Barroso-Sousa R, Zhang K, Donahue H, et al: Characterization of thyroid disorders in patients receiving immune checkpoint inhibition therapy. Cancer Immunol Res. 5:1133–1140. 2017. View Article : Google Scholar : PubMed/NCBI

55 

Zhan L, Feng HF, Liu HQ, Guo LT, Chen C, Yao XL and Sun SR: Immune Checkpoint Inhibitors-Related thyroid dysfunction: Epidemiology, clinical presentation, possible pathogenesis, and management. Front Endocrinol (Lausanne). 12:6498632021. View Article : Google Scholar : PubMed/NCBI

56 

Wang Y, Wang X, Cheng L and Zhang G: Correlation analysis between thyroid function abnormality and efficacy in patients with advanced Non-small cell lung cancer after immunotherapy. Zhongguo Fei Ai Za Zhi. 26:369–376. 2023.(In Chinese). PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang S, Du J, Lin C, Chen M, Huang Y, Chen C and Zheng B: Perioperative serplulimab‑based chemoimmunotherapy in stage IV large cell neuroendocrine carcinoma of the lung: A case report. Oncol Lett 28: 547, 2024.
APA
Zhang, S., Du, J., Lin, C., Chen, M., Huang, Y., Chen, C., & Zheng, B. (2024). Perioperative serplulimab‑based chemoimmunotherapy in stage IV large cell neuroendocrine carcinoma of the lung: A case report. Oncology Letters, 28, 547. https://doi.org/10.3892/ol.2024.14680
MLA
Zhang, S., Du, J., Lin, C., Chen, M., Huang, Y., Chen, C., Zheng, B."Perioperative serplulimab‑based chemoimmunotherapy in stage IV large cell neuroendocrine carcinoma of the lung: A case report". Oncology Letters 28.5 (2024): 547.
Chicago
Zhang, S., Du, J., Lin, C., Chen, M., Huang, Y., Chen, C., Zheng, B."Perioperative serplulimab‑based chemoimmunotherapy in stage IV large cell neuroendocrine carcinoma of the lung: A case report". Oncology Letters 28, no. 5 (2024): 547. https://doi.org/10.3892/ol.2024.14680
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Spandidos Publications style
Zhang S, Du J, Lin C, Chen M, Huang Y, Chen C and Zheng B: Perioperative serplulimab‑based chemoimmunotherapy in stage IV large cell neuroendocrine carcinoma of the lung: A case report. Oncol Lett 28: 547, 2024.
APA
Zhang, S., Du, J., Lin, C., Chen, M., Huang, Y., Chen, C., & Zheng, B. (2024). Perioperative serplulimab‑based chemoimmunotherapy in stage IV large cell neuroendocrine carcinoma of the lung: A case report. Oncology Letters, 28, 547. https://doi.org/10.3892/ol.2024.14680
MLA
Zhang, S., Du, J., Lin, C., Chen, M., Huang, Y., Chen, C., Zheng, B."Perioperative serplulimab‑based chemoimmunotherapy in stage IV large cell neuroendocrine carcinoma of the lung: A case report". Oncology Letters 28.5 (2024): 547.
Chicago
Zhang, S., Du, J., Lin, C., Chen, M., Huang, Y., Chen, C., Zheng, B."Perioperative serplulimab‑based chemoimmunotherapy in stage IV large cell neuroendocrine carcinoma of the lung: A case report". Oncology Letters 28, no. 5 (2024): 547. https://doi.org/10.3892/ol.2024.14680
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