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A meta‑analysis assessing the cytotoxicity of nanoparticles on MCF7 breast cancer cells

  • Authors:
    • Elcin Yenidunya Konuk
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    Affiliations: Department of Medical Biology, Bakircay University School of Medicine, Menemen, İzmir 35665, Turkey
    Copyright: © Konuk et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 551
    |
    Published online on: September 17, 2024
       https://doi.org/10.3892/ol.2024.14684
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Abstract

The present study summarizes the current available literature regarding the viability of MCF7 breast cancer cells treated with gold (Au), silver (Ag) or zinc oxide (ZnO) nanoparticles at varying doses for 48 h. The data for this study were obtained from diverse research articles published between 2013 and 2023 using Preferred Reporting Items for Systematic Reviews and Meta‑Analyses (PRISMA) 2020 guidelines. The evaluation focused on 20 PRISMA‑compliant articles concerning MCF7 cells, yielding 137 outcome measures for meta‑analysis. A generalized linear mixed model meta‑analysis approach was employed to glean insights into the effects of novel nanoparticles on MCF7 breast cancer cells. The analysis covered a wide range of concentrations: Ag nanoparticles from 1.25 to 1,000 µg/ml, Au nanoparticles from 50 to 150 µg/ml, and ZnO nanoparticles from 1 to 1,000 µg/ml. Both intra‑nanoparticle and inter‑nanoparticle comparisons were conducted to detect differences. The findings showed that when concentrations reached or exceeded 60 µg/ml, considerable variation of cell viability was observed: Treatment with Ag nanoparticles resulted in cell viability ranging from 9 to 45%, ZnO nanoparticles resulted in cell viability ranging from 20 to 40%, and Au nanoparticles resulted in cell viability ranging from 3 to 58%. These findings indicated the significance of thoroughly exploring nanoparticle dosage to acquire a comprehensive understanding of their influence on cell viability.
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Copy and paste a formatted citation
Spandidos Publications style
Konuk EY: A meta‑analysis assessing the cytotoxicity of nanoparticles on MCF7 breast cancer cells. Oncol Lett 28: 551, 2024.
APA
Konuk, E.Y. (2024). A meta‑analysis assessing the cytotoxicity of nanoparticles on MCF7 breast cancer cells. Oncology Letters, 28, 551. https://doi.org/10.3892/ol.2024.14684
MLA
Konuk, E. Y."A meta‑analysis assessing the cytotoxicity of nanoparticles on MCF7 breast cancer cells". Oncology Letters 28.5 (2024): 551.
Chicago
Konuk, E. Y."A meta‑analysis assessing the cytotoxicity of nanoparticles on MCF7 breast cancer cells". Oncology Letters 28, no. 5 (2024): 551. https://doi.org/10.3892/ol.2024.14684
Copy and paste a formatted citation
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Spandidos Publications style
Konuk EY: A meta‑analysis assessing the cytotoxicity of nanoparticles on MCF7 breast cancer cells. Oncol Lett 28: 551, 2024.
APA
Konuk, E.Y. (2024). A meta‑analysis assessing the cytotoxicity of nanoparticles on MCF7 breast cancer cells. Oncology Letters, 28, 551. https://doi.org/10.3892/ol.2024.14684
MLA
Konuk, E. Y."A meta‑analysis assessing the cytotoxicity of nanoparticles on MCF7 breast cancer cells". Oncology Letters 28.5 (2024): 551.
Chicago
Konuk, E. Y."A meta‑analysis assessing the cytotoxicity of nanoparticles on MCF7 breast cancer cells". Oncology Letters 28, no. 5 (2024): 551. https://doi.org/10.3892/ol.2024.14684
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