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Impact of bortezomib on 1q21+ in multiple myeloma: A meta-analysis of treatment outcomes and prognostic implications

  • Authors:
    • Xiaona Zheng
    • Siyu Lin
    • Kejie Lu
    • Jian Hou
    • Tingting Liu
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 610041 P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 18
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    Published online on: October 21, 2024
       https://doi.org/10.3892/ol.2024.14764
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Abstract

The gain of chromosomal region 1q21 is a significant risk factor in multiple myeloma (MM) and is associated with poor prognosis. The introduction of bortezomib has notably improved outcomes for patients with MM. However, recent studies have reported conflicting results regarding the efficacy of bortezomib in mitigating the adverse effects of 1q21 aberration in these patients. To address this, in the present study, a meta‑analysis was conducted based on 6 studies encompassing 1,575 patients with MM. The prognosis of patients with 1q21+ who underwent treatment with a bortezomib‑based regimen was evaluated in terms of complete response (CR), overall survival (OS) and progression‑free survival (PFS) rates. The results demonstrated that patients with 1q21 aberration were more likely to achieve CR than those without 1q21+ under bortezomib‑based treatment [odds ratio, 0.64; 95% confidence interval (CI), 0.49‑0.83; P=0.0008]. However, 1q21+ remained a high‑risk factor in patients with MM even after bortezomib treatment [PFS: hazard ratio (HR), 1.72; 95% CI, 1.53‑1.93; P<0.00001; and OS: HR, 1.95; 95% CI, 1.58‑2.42; P<0.00001]. In conclusion, although bortezomib improved the likelihood of achieving CR in patients with 1q21+, this genetic aberration continues to be considered a high‑risk factor in patients with MM treated with a bortezomib‑based regimen.
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Copy and paste a formatted citation
Spandidos Publications style
Zheng X, Lin S, Lu K, Hou J and Liu T: Impact of bortezomib on 1q21+ in multiple myeloma: A meta-analysis of treatment outcomes and prognostic implications. Oncol Lett 29: 18, 2025.
APA
Zheng, X., Lin, S., Lu, K., Hou, J., & Liu, T. (2025). Impact of bortezomib on 1q21+ in multiple myeloma: A meta-analysis of treatment outcomes and prognostic implications. Oncology Letters, 29, 18. https://doi.org/10.3892/ol.2024.14764
MLA
Zheng, X., Lin, S., Lu, K., Hou, J., Liu, T."Impact of bortezomib on 1q21+ in multiple myeloma: A meta-analysis of treatment outcomes and prognostic implications". Oncology Letters 29.1 (2025): 18.
Chicago
Zheng, X., Lin, S., Lu, K., Hou, J., Liu, T."Impact of bortezomib on 1q21+ in multiple myeloma: A meta-analysis of treatment outcomes and prognostic implications". Oncology Letters 29, no. 1 (2025): 18. https://doi.org/10.3892/ol.2024.14764
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng X, Lin S, Lu K, Hou J and Liu T: Impact of bortezomib on 1q21+ in multiple myeloma: A meta-analysis of treatment outcomes and prognostic implications. Oncol Lett 29: 18, 2025.
APA
Zheng, X., Lin, S., Lu, K., Hou, J., & Liu, T. (2025). Impact of bortezomib on 1q21+ in multiple myeloma: A meta-analysis of treatment outcomes and prognostic implications. Oncology Letters, 29, 18. https://doi.org/10.3892/ol.2024.14764
MLA
Zheng, X., Lin, S., Lu, K., Hou, J., Liu, T."Impact of bortezomib on 1q21+ in multiple myeloma: A meta-analysis of treatment outcomes and prognostic implications". Oncology Letters 29.1 (2025): 18.
Chicago
Zheng, X., Lin, S., Lu, K., Hou, J., Liu, T."Impact of bortezomib on 1q21+ in multiple myeloma: A meta-analysis of treatment outcomes and prognostic implications". Oncology Letters 29, no. 1 (2025): 18. https://doi.org/10.3892/ol.2024.14764
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