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Case Report Open Access

Co‑occurrence of clear cell renal cell carcinoma and bladder urothelial carcinoma: A case report and literature review

  • Authors:
    • Shuo Wu
    • Yuliang Zuo
    • Meihong Ye
    • Kuan Wang
    • Xiaolong Wang
    • Xudong Yang
    • Chaoming Wang
  • View Affiliations

    Affiliations: Department of Urology, Huanghe Sanmenxia Hospital Affiliated to Henan University of Science and Technology, Sanmenxia, Henan 472000, P.R. China, Department of Pathology, Huanghe Sanmenxia Hospital Affiliated to Henan University of Science and Technology, Sanmenxia, Henan 472000, P.R. China
  • Published online on: October 23, 2024     https://doi.org/10.3892/ol.2024.14768
  • Article Number: 21
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The co‑occurrence of clear cell renal cell carcinoma (ccRCC) and bladder urothelial carcinoma (bUC) is rare, and owing to the lack of a unified treatment plan, the prognosis is poor. The present report describes the case of a 65‑year‑old male patient with a history of smoking and no history of malignant tumors who presented with hematuria at the Huanghe Sanmenxia Hospital Affiliated to Henan University of Science and Technology (Sanmenxia, China) in July 2021. Urinary system computed tomography urography revealed a right renal tumor, and cystoscopy revealed intravesical lesions. The patient underwent transurethral resection of a bladder tumor + laparoscopic partial nephrectomy + laparoscopic radical cystectomy and bilateral ureterostomy. Pathological examination revealed right‑sided ccRCC (pT1aN0M0) and high‑grade invasive bUC (pT2N0M0). After surgery, the patient underwent bilateral ureteral single J tube replacement in the outpatient clinic every 3 months. In September 2022, the patient presented with a mass on the right side of the neck. Further examination revealed a space‑occupying lesion in the lower part of the left kidney and space‑occupying lesions in the neck, axilla, mediastinal lymph nodes and liver. A neck lymph node puncture biopsy suggested UC, and the patient was diagnosed with metastatic UC (T4N0M1). The patient received tislelizumab (200 mg once every 3 weeks) + sunitinib (50 mg/day, administered for 4 weeks with a 2‑week interval) for a total of 2 months and died of an advanced tumor in January 2023. In addition, the data of 36 patients with ccRCC and bUC from the literature were analyzed for the present report. The results showed that the median age at first onset was 56.5 years (range, 31‑82 years) and the male‑to‑female ratio was 6:1. Smoking and male sex may be risk factors for this disease, which has a median survival time of 47.5 months. The survival analysis results showed that the pathological stage of bladder cancer may be associated with its prognosis. The present study reviews the potential risks, clinicopathological characteristics and treatment methods of co‑occurrence of clear ccRCC and bUC. In conclusion, the high‑risk factors for the co‑occurrence of ccRCC and bUC were smoking and male sex, and the median survival time was 47.5 months. The pathological stage of bladder cancer may be related to the prognosis.
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1 

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I and Jemal A: Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 74:229–263. 2024. View Article : Google Scholar

2 

Patard JJ, Leray E, Rioux-Leclercq N, Cindolo L, Ficarra V, Zisman A, De La Taille A, Tostain J, Artibani W, Abbou CC, et al: Prognostic value of histologic subtypes in renal cell carcinoma: A multicenter experience. J Clin Oncol. 23:2763–2771. 2005. View Article : Google Scholar

3 

Motzer RJ, Jonasch E, Agarwal N, Alva A, Bagshaw H, Baine M, Beckermann K, Carlo MI, Choueiri TK, Costello BA, et al: NCCN guidelines® insights: Kidney cancer, version 2.2024. J Natl Compr Canc Netw. 22:4–16. 2024. View Article : Google Scholar

4 

Mohanty SK, Lobo A and Cheng L: The 2022 revision of the World Health Organization classification of tumors of the urinary system and male genital organs: Advances and challenges. Hum Pathol. 136:123–143. 2023. View Article : Google Scholar

5 

Jones RJ, Crabb SJ, Linch M, Birtle AJ, Mcgrane J, Enting D, Stevenson R, Liu K, Kularatne B and Hussain SA: Systemic anticancer therapy for urothelial carcinoma: UK oncologists' perspective. Br J Cancer. 130:897–907. 2024. View Article : Google Scholar

6 

Lopez-Beltran A, Cookson MS, Guercio BJ and Cheng L: Advances in diagnosis and treatment of bladder cancer. BMJ. 384:e0767432024. View Article : Google Scholar

7 

Rouprêt M, Seisen T, Birtle AJ, Capoun O, Compérat EM, Dominguez-Escrig JL, Andersson IG, Liedberg F, Mariappan P, Mostafid AH, et al: European association of urology guidelines on upper urinary tract urothelial carcinoma: 2023 Update. Eur Urol. 84:49–64. 2023. View Article : Google Scholar

8 

Wu K, Liu X, Wang Y, Wang X and Li X: Clinicopathological characteristics and outcomes of synchronous renal cell carcinoma and urothelial carcinoma: A population-based analysis. Front Public Health. 10:9943512022. View Article : Google Scholar

9 

Qi N, Chen Y, Gong K and Li H: Concurrent renal cell carcinoma and urothelial carcinoma: Long-term follow-up study of 27 cases. World J Surg Oncol. 16:162018. View Article : Google Scholar

10 

Council L and Hameed O: Differential expression of immunohistochemical markers in bladder smooth muscle and myofibroblasts, and the potential utility of desmin, smoothelin, and vimentin in staging of bladder carcinoma. Mod Pathol. 22:639–650. 2009. View Article : Google Scholar

11 

Olivier M, Hollstein M and Hainaut P: TP53 mutations in human cancers: Origins, consequences, and clinical use. Cold Spring Harb Perspect Biol. 2:a0010082010. View Article : Google Scholar

12 

Borowczak J, Szczerbowski K, Maniewski M, Zdrenka M, Słupski P, Andrusewicz H, Bysik-Miśkurka J, Rutkiewicz P, Bodnar M and Szylberg A: The prognostic role of p53 and its correlation with CDK9 in urothelial carcinoma. Clin Transl Oncol. 25:830–840. 2023. View Article : Google Scholar

13 

Vlachou E, Johnson BR, Baraban E, Nadal R and Hoffman-Censits J: Current advances in the management of nonurothelial subtypes of bladder cancer. Am Soc Clin Oncol Educ Book. 44:e4386402024. View Article : Google Scholar

14 

Naik M, Rao BV, Challa S, Fonseca D, Sudha SM, Giridhar A, Sharma R, Raju KVVN and Rao TS: Utility of GATA-3 and associated immunohistochemical markers in the differential diagnosis of poorly differentiated urothelial carcinoma. J Cancer Res Ther. 19 (Suppl):S02023. View Article : Google Scholar

15 

Zhou J, Yang X, Zhou L, Zhang P and Wang C: Combined immunohistochemistry for the ‘three 7’ markers (CK7, CD117, and claudin-7) is useful in the diagnosis of chromophobe renal cell carcinoma and for the exclusion of mimics: Diagnostic experience from a single institution. Dis Markers. 2019:47081542019. View Article : Google Scholar

16 

Barr ML, Jilaveanu LB, Camp RL, Adeniran AJ, Kluger HM and Shuch B: PAX-8 expression in renal tumours and distant sites: A useful marker of primary and metastatic renal cell carcinoma? J Clin Pathol. 68:12–17. 2014. View Article : Google Scholar

17 

Gorbokon N, Baltruschat S, Lennartz M, Luebke AM, Höflmayer D, Kluth M, Hube-Magg C, Hinsch A, Fraune C, Lebok P, et al: PAX8 expression in cancerous and non-neoplastic tissue: A tissue microarray study on more than 17,000 tumors from 149 different tumor entities. Virchows Arch. 485:491–507. 2024. View Article : Google Scholar

18 

Leroy X, Copin MC, Devisme L, Buisine MP, Aubert JP, Gosselin B and Porchet N: Expression of human mucin genes in normal kidney and renal cell carcinoma. Histopathology. 40:450–457. 2002. View Article : Google Scholar

19 

Yan WX, Cao WR, Zhao J, Zhang W, Wang XL, Yuan Q and Dang SQ: Clear cell papillary renal cell carcinoma: A clinicopathologic analysis of 6 cases. Int J Clin Exp Pathol. 8:4595–4599. 2015.

20 

Amin MB, Edge SB, Greene FL and Brierley JD: AJCC cancer staging manual. 8th edition. New York: Springer; 2017

21 

Pandey J and Syed W: Renal cancer. StatPearls [Internet] Treasure Island (FL): StatPearls Publishing; 2024

22 

Kaseb H, Leslie SW, Soon-Sutton TL and Aeddula NR: Bladder cancer. StatPearls Treasure Island: StatPearls Publishing; 2023

23 

Kim HL, Seligson D, Liu X, Janzen N, Bui MHT, Yu H, Shi T, Belldegrun AS, Horvath S and Figlin RA: Using tumor markers to predict the survival of patients with metastatic renal cell carcinoma. J Urol. 173:1496–1501. 2005. View Article : Google Scholar

24 

Gailey MP and Bellizzi AM: Immunohistochemistry for the novel markers glypican 3, PAX8, and p40 (ΔNp63) in squamous cell and urothelial carcinoma. Am J Clin Pathol. 140:872–880. 2013. View Article : Google Scholar

25 

Queipo FJ, Unamunzaga GM, Negro BF, Fuertes SG, Cortés MÁ, Tejedor EC, Mañas CMB, Ariño AB, Sjödahl G and Beorlegui C: Immunohistochemistry subtyping of urothelial carcinoma is feasible in the daily practice. Virchows Arch. 481:191–200. 2022. View Article : Google Scholar

26 

Huang J and Zhang X: Chinese guidelines for diagnosis and treatment of urology and andrology diseases (2022 edition). 2022.

27 

Motzer RJ, Michaelson MD, Redman BG, Hudes GR, Wilding G, Figlin RA, Ginsberg MS, Kim ST, Baum CM, DePrimo SE, et al: Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol. 24:16–24. 2006. View Article : Google Scholar

28 

Guo J, Ma J, Sun Y, Qin S, Ye D, Zhou F, He Z, Sheng X, Bi F, Cao D, et al: Chinese guidelines on the management of renal cell carcinoma (2015 edition). Chin Clin Oncol. 5:122016. View Article : Google Scholar

29 

Ye D, Liu J, Zhou A, Zou Q, Li H, Fu C, Hu H, Huang J, Zhu S, Jin J, et al: Tislelizumab in Asian patients with previously treated locally advanced or metastatic urothelial carcinoma. Cancer Sci. 112:305–313. 2021. View Article : Google Scholar

30 

Liu Y, Liu Q, Huang L, Ren X, Huang J and Feng YF: A programmed death receptor-1 inhibitor-Tislelizumab. Clin Med J. 20:37–42. 2022.(In Chinese).

31 

Hong Y, Feng Y, Sun H, Zhang B, Wu H, Zhu Q, Li Y, Zhang T, Zhang Y, Cui X, et al: Tislelizumab uniquely binds to the CC' loop of PD-1 with slow-dissociated rate and complete PD-L1 blockage. FEBS Open Bio. 11:782–792. 2021. View Article : Google Scholar

32 

Yokoyama I, Berman E, Rickert RR and Bastidas J: Simultaneous occurrence of renal cell adenocarcinoma and urothelial carcinoma of the renal pelvis in the same kidney diagnosed by preoperative angiography. Cancer. 48:2762–2766. 1981. View Article : Google Scholar

33 

Oka H, Kobayashi S, Kobayashi T, Shugino Y, Matsui Y, Fujikawa K, Iwamura H, Hukuzawa S, Soeda A and Takeuchi H: Multiple primary cancers limited to the urological field. Hinyokika Kiyo. 47:405–409. 2001.(In Japanese).

34 

Srinath N, Dinesh US and Sharma GP: A case of synchronous renal cell carcinoma (Rt) and transitional cell carcinoma urinary bladder. Med J Armed Forces India. 62:190–191. 2011. View Article : Google Scholar

35 

Zhang H, Ye D, Yao X, Zhang S, Dai B, Shen Y, Zhu Y, Zhu Y, Shi G, et al: Clinical analysis of multiple primary malignant tumors and concurrent renal cell carcinoma. J Army Med Univ. 31:1261–1263. 2009.(In Chinese).

36 

Rotellini M, Fondi C, Paglierani M, Stomaci N and Raspollini MR: Clear cell carcinoma of the bladder in a patient with a earlier clear cell renal cell carcinoma: A case report with morphologic, immunohistochemical, and cytogenetical analysis. Appl Immunohistochem Mol Morphol. 18:396–399. 2010. View Article : Google Scholar

37 

Smith MT, Taylor FD, Gianakopoulus WP and Brown RR: Two separate synchronous primary genitourinary tumors. Rev Urol. 14:104–107. 2012.

38 

Zhu Q, Gu J, Zhang Y, Shi J, Sun F, Shen J, Yang Y and Wang N: Clinical analysis of 21 cases of multiple primary cancers associated with bladder cancer in elderly patients. Chin J Clin Oncol. 39:993–996. 2012.(In Chinese).

39 

Djafari AA, Moradi A, Rahnama H and Rahavian A: The first case report of synchronous primary papillary type 2 renal cell carcinoma of kidney and transitional cell carcinoma of bladder. Urol Case Rep. 37:1016012021. View Article : Google Scholar

40 

Dieckmann KP and Nekarda H: Triple malignancy of the genitourinary tract. Int Urol Nephrol. 20:485–488. 1988. View Article : Google Scholar

41 

Harima M, Narita K, Kobayakawa H, Tsujino T, Yamamoto S, Fukushima S and Kishimoto T: A case of synchronous triple primary cancers of prostate, kidney and bladder. Hinyokika Kiyo. 44:675–678. 1998.(In Japanese).

42 

Takada T, Honda M, Momohara C, Komori K and Fujioka H: Synchronous triple urogenital cancer (renal cancer, bladder cancer, prostatic cancer): A case report. Hinyokika Kiyo. 48:239–242. 2002.(In Japanese).

43 

Satoh H, Momma T, Saito S and Hirose S: A case of synchronous triple primary carcinomas of the kidney, bladder and prostate. Hinyokika Kiyo. 49:261–264. 2003.(In Japanese).

44 

Arikan-Sengul C, Pehlivan Y, Sevinc A, Karakok M, Kalender ME and Camci C: A case of metachronous triple primary urogenital cancer: Urinary bladder, prostate, and renal cancer. Onkologie. 32:122–124. 2009.

45 

Nishikawa K, Soga N, Kato M, Masui S, Hasegawa Y, Yamada Y, Kise H, Arima K and Sugimura Y: Case of bladder cancer following adjuvant external beam radiation for prostate cancer. Hinyokika Kiyo. 55:39–41. 2009.(In Japanese).

46 

Pérez MPM, Bazán AA, Dorrego JMA, Herrero, Ledo JC and de la Peña Barthel J: Simultaneous cystectomy and nephroureterectomy due to synchronous upper urinary tract tumors and invasive bladder cancer: Open and laparoscopic approaches. Curr Urol. 6:76–81. 2012. View Article : Google Scholar

47 

Tiwari P, Tripathi A, Bansal P, Vijay M, Gupta A and Kundu AK: Synchronous primary cancers of urinary bladder and kidney and prostate. Saudi J Kidney Dis Transpl. 23:786–789. 2012. View Article : Google Scholar

48 

Okumura A, Tsuritani S, Takagawa K and Fuse H: Case of heterochronous triple urogenital cancer (renal cell carcinoma, bladder cancer, prostatic cancer). Nihon Hinyokika Gakkai Zasshi. 104:702–705. 2013.(In Japanese).

49 

Kurose H, Ueda K, Nakiri M, Matsuo M, Suekane S and Igawa T: Synchronous primary triple urogenital malignant tumors of kidney, prostate and bladder. Urol Case Rep. 33:1012772020. View Article : Google Scholar

50 

Zhang G, Liao H, Liu L, Tang D and Zhang F: A case report of synchronous triple cancers in the urinary and male reproductive system. Chin J Urol. 44:861–862. 2023.(In Chinese).

51 

Kinbara H, Suzuki S, Nakano S, Yamakawa K, Hioki T, Okabe S, Sugimura Y, Tajima K, Tochigi H and Kawamura J: A case of renal cell carcinoma and bladder carcinoma associated with von Hippel-Lindau disease. Hinyokika Kiyo. 36:823–826. 1990.(In Japanese).

52 

Nakano S, Suzuki S, Kinbara H, Maeda Y, Yanagawa M, Tajima K, Tochigi H, Kawamura J, Hounoki S and Yamamoto I: A case of double cancer: Renal cell carcinoma and transitional cell carcinoma of urinary bladder. Hinyokika Kiyo. 36:831–835. 1990.(In Japanese).

53 

Soda T, Nishimura K, Kobayashi Y, Kato T, Tokugawa S, Kishikawa H, Ihara H and Ichikawa Y: A case of synchronous contralateral renal cell carcinoma and urothelial carcinoma. Hinyokika Kiyo. 55:491–494. 2009.(In Japanese).

54 

Ando M, Arisawa C and Okano T: A case of renal cell carcinoma associated with synchronous contralateral renal pelvic cancer and bladder tumor. Int J Urol. 3:310–312. 1996. View Article : Google Scholar

55 

Lian Y, Wang D, Chen Q, Zhang Y, Shangguan Z, Jiang M, Hu K and Hao W: A clinical analysis for 9 cases of multiple primary malignant neoplasms associated with renal cell carcinoma. Oncol Prog. 18:815–818. 2020.(In Chinese).

56 

Tsujimura A, Takahara S and Koide T: A case of synchronous ipsilateral renal cell carcinoma and transitional cell carcinoma. Hinyokika Kiyo. 37:1303–1306. 1991.(In Japanese).

57 

Chuang HC, Chuang CK and Ng KF: Simultaneous development of renal cell carcinoma and multifocal urothelial carcinoma. Chang Gung Med J. 31:515–519. 2008.

58 

Morikawa Y, Shiomi K, Ishihara Y and Matsuura N: Triple primary cancers involving kidney, urinary bladder, and liver in a dye worker. Am J Ind Med. 31:44–49. 1997. View Article : Google Scholar

59 

Kamota S, Harabayashi T, Suzuki S, Takeyama Y, Mitsui T, Mouri G, Hashimoto A, Nakamura M, Shinohara N, Nonomura K and Koyanagi T: Ureteral and bladder metastases of renal cell carcinoma following synchronous renal cell carcinoma and bladder cancer; a case report. Nihon Hinyokika Gakkai Zasshi. 94:705–708. 2003.(In Japanese).

60 

Gönül II, Cakr A, Sözen S, Ataoglu O and Alkibay T: A case of tubulocystic carcinoma simultaneously occurring with clear cell type renal cell carcinoma and micropapillary urothelial carcinoma of bladder. South Med J. 102:754–757. 2009. View Article : Google Scholar

61 

Wang Y, Yu Z, He H, Wang X, Ge H and Xie X: Cancerization of ureteral inverted papilloma complicated with ipsilateral renal cell cancer and bladder transitional cell carcinoma: One case report. J Chin Oncol. 22:691–692. 2016.(In Chinese).

62 

Xu G, Bu S and Wang X: A case report of four primary malignant tumors. Cancer Res Prev Treat. 46:1141–1142. 2019.(In Chinese).

63 

Akan S and Ediz C: A rare association in a patient with non-muscle invasive bladder cancer: Ureteral fibroepithelial polyp and ipsilateral renal cell carcinoma: A case report. J Med Case Rep. 15:4752021. View Article : Google Scholar

64 

Mitchell K, El Naili R, Pillai L, Lopez EM, Riordan J, Marsh W, Luchey A and Hajiran A: Triple threat: Three primary malignancies simultaneously involving three genitourinary organs. Case Rep Urol. 2023:32429862023.

65 

Huang J, Deng S, Li Q, Li J, Li W, Zhang X and Xue S: Multiple primary malignancies of the bladder, rectum and kidney: A case report. Chin J Urol. 44:383–384. 2023.(In Chinese).

66 

Lobo N, Afferi L, Moschini M, Mostafid H, Porten S, Psutka SP, Gupta S, Smith AB, Williams SB and Lotan Y: Epidemiology, screening, and prevention of bladder cancer. Eur Urol Oncol. 5:628–639. 2022. View Article : Google Scholar

67 

Dyrskjøt L, Hansel DE, Efstathiou JA, Knowles MA, Galsky MD, Teoh J and Theodorescu D: Bladder cancer. Nat Rev Dis Primers. 9:582023. View Article : Google Scholar

68 

Aminoltejari K and Black PC: Radical cystectomy: A review of techniques, developments and controversies. Transl Androl Urol. 9:3073–3081. 2020. View Article : Google Scholar

69 

Khan MS, Gan C, Ahmed K, Ismail AF, Watkins J, Summers JA, Peacock JL, Rimington P and Dasgupta P: A single-centre early phase randomised controlled three-arm trial of open, robotic, and laparoscopic radical cystectomy (CORAL). Eur Urol. 69:613–621. 2016. View Article : Google Scholar

70 

Dindo D, Demartines N and Clavien PA: Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 240:205–213. 2004. View Article : Google Scholar

71 

Griffiths G, Hall R, Sylvester R, Raghavan D and Parmar MK: International phase III trial assessing neoadjuvant cisplatin, methotrexate, and vinblastine chemotherapy for muscle-invasive bladder cancer: long-term results of the BA06 30894 trial. J Clin Oncol. 29:2171–2177. 2011. View Article : Google Scholar

72 

Advanced Bladder Cancer (ABC) Meta-analysis Collaboration, . Neoadjuvant chemotherapy in invasive bladder cancer: update of a systematic review and meta-analysis of individual patient data advanced bladder cancer (ABC) meta-analysis collaboration. Eur Urol. 48:202–206. 2005. View Article : Google Scholar

73 

van der Heijden MS, Sonpavde G, Powles T, Necchi A, Burotto M, Schenker M, Sade JP, Bamias A, Beuzeboc P, Bedke J, et al: Nivolumab plus gemcitabine-cisplatin in advanced urothelial carcinoma. N Engl J Med. 389:1778–1789. 2023. View Article : Google Scholar

74 

von der Maase H, Hansen SW, Roberts JT, Dogliotti L, Oliver T, Moore MJ, Bodrogi I, Albers P, Knuth A, Lippert CM, et al: Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: Results of a large, randomized, multinational, multicenter, phase III study. J Clin Oncol. 41:3881–3890. 2023. View Article : Google Scholar

75 

Powles T, Park SH, Voog E, Caserta C, Valderrama BP, Gurney H, Kalofonos H, Radulović S, Demey W, Ullén A, et al: Avelumab maintenance therapy for advanced or metastatic urothelial carcinoma. N Engl J Med. 383:1218–1230. 2020. View Article : Google Scholar

76 

Massari F, Santoni M, Takeshita H, Okada Y, Tapia JC, Basso U, Maruzzo M, Scagliarini S, Büttner T, Fornarini G, et al: Global real-world experiences with pembrolizumab in advanced urothelial carcinoma after platinum-based chemotherapy: The ARON-2 study. Cancer Immunol Immunother. 73:1062024. View Article : Google Scholar

77 

Chang SS, Bochner BH, Chou R, Dreicer R, Kamat AM, Lerner SP, Lotan Y, Meeks JJ, Michalski JM, Morgan TM, et al: Treatment of non-metastatic muscle-invasive bladder cancer: AUA/ASCO/ASTRO/SUO guideline. J Urol. 198:552–559. 2017. View Article : Google Scholar

78 

Powles T, Bellmunt J, Comperat E, De Santis M, Huddart R, Loriot Y, Necchi A, Valderrama BP, Ravaud A, Shariat SF, et al: ESMO clinical practice guideline interim update on first-line therapy in advanced urothelial carcinoma. Ann Oncol. 35:485–490. 2024. View Article : Google Scholar

79 

Benjamin DJ, Rezazadeh KA and Prasad V: The overall survival benefit in EV-302: Is enfortumab vedotin plus pembrolizumab the new frontline standard of care for metastatic urothelial carcinoma? Eur Urol Oncol. 7:313–315. 2024. View Article : Google Scholar

80 

Cirillo L, Innocenti S and Becherucci F: Global epidemiology of kidney cancer. Nephrol Dial Transplant. 39:920–928. 2024. View Article : Google Scholar

81 

Deng J, Tu S, Li L, Li G and Zhang Y: Diagnostic, predictive and prognostic molecular biomarkers in clear cell renal cell carcinoma: A retrospective study. Cancer Rep (Hoboken). 7:e21162024. View Article : Google Scholar

82 

Safiri S, Hassanzadeh K, Jolfayi AG, Mousavi SE, Asghari KM, Nejadghaderi SA, Naghdi-Sedeh N, Noori M, Sullman MJM, Collins GS and Kolahi AA: Kidney cancer in the Middle East and North Africa region: A 30-year analysis (1990–2019). Sci Rep. 14:137102024. View Article : Google Scholar

83 

Hunt JD, van der Hel OL, Mcmillan GP, Boffetta P and Brennan P: Renal cell carcinoma in relation to cigarette smoking: Meta-analysis of 24 studies. Int J Cancer. 114:101–108. 2005. View Article : Google Scholar

84 

Chow WH, Dong LM and Devesa SS: Epidemiology and risk factors for kidney cancer. Nat Rev Urol. 7:245–257. 2010. View Article : Google Scholar

85 

Roskoski R Jr: Combination immune checkpoint and targeted protein kinase inhibitors for the treatment of renal cell carcinomas. Pharmacol Res. 203:1071812024. View Article : Google Scholar

86 

Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J and Ficarra V: Renal cell carcinoma. Nat Rev Dis Primers. 3:170092017. View Article : Google Scholar

87 

Goswamy R, Kalemoglu E, Master V and Bilen MA: Perioperative systemic treatments in renal cell carcinoma. Front Oncol. 14:13621722024. View Article : Google Scholar

88 

Gao B, Gorgen ARH, Bhatt R, Tano ZE, Morgan KL, Vo K, Zarandi SS, Ali SN, Jiang P, Patel RM, et al: Avoiding ‘Needless’ nephrectomy: What is the role of small renal mass biopsy in 2024? Urol Oncol. 42:236–244. 2024. View Article : Google Scholar

89 

Johnson DC, Vukina J, Smith AB, Meyer AM, Wheeler SB, Kuo TM, Tan HJ, Woods ME, Raynor MC, Wallen EM, et al: Preoperatively misclassified, surgically removed benign renal masses: A systematic review of surgical series and United States population level burden estimate. J Urol. 193:30–35. 2015. View Article : Google Scholar

90 

Warren S: Multiple primary malignant tumors, a survey of the literature and a statistical study. Am J Cancer. 16:1358–1414. 1932.

91 

Vogt A, Schmid S, Heinimann K, Frick H, Herrmann C, Cerny T and Omlin A: Multiple primary tumours: Challenges and approaches, a review. ESMO Open. 2:e0001722017. View Article : Google Scholar

92 

Gul ZG, Liaw CW and Mehrazin R: Gender differences in incidence, diagnosis, treatments, and outcomes in clinically localized bladder and renal cancer. Urology. 151:176–181. 2021. View Article : Google Scholar

93 

Czene K and Hemminki K: Familial papillary renal cell tumors and subsequent cancers: A nationwide epidemiological study from Sweden. J Urol. 169:1271–1275. 2003. View Article : Google Scholar

94 

Rabbani F, Reuter VE, Katz J and Russo P: Second primary malignancies associated with renal cell carcinoma: Influence of histologic type. Urology. 56:399–403. 2000. View Article : Google Scholar : PubMed/NCBI

95 

Antonelli A, Calza S, Arrighi N, Zani D, Corti S, Cozzoli A, Zanotelli T, Cunico SC and Simeone C: Clinical features and prognosis of patients with renal cancer and a second malignancy. Urol Oncol. 30:294–300. 2012. View Article : Google Scholar : PubMed/NCBI

96 

Lonati C, Simeone C, Suardi N, Spiess PE, Necchi A and Moschini M: Genitourinary manifestations of Lynch syndrome in the urological practice. Asian J Urol. 9:443–450. 2022. View Article : Google Scholar : PubMed/NCBI

97 

Umar A, Boland CR, Terdiman JP, Syngal S, de la Chapelle A, Rüschoff J, Fishel R, Lindor NM, Burgart LJ, Hamelin R, et al: Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst. 96:261–268. 2004. View Article : Google Scholar : PubMed/NCBI

98 

Nassour AJ, Jain A, Hui N, Siopis G, Symons J and Woo H: Relative risk of bladder and kidney cancer in lynch syndrome: Systematic review and meta-analysis. Cancers (Basel). 15:5062023. View Article : Google Scholar : PubMed/NCBI

99 

Wu KY, Cheong IS, Lai JN, Hu CY, Hung KC, Chen YT, Chiu LT, Tsai HT, Jou YC, Tzai TS and Tsai YS: Risk of secondary primary malignancies in survivors of upper tract urothelial carcinoma: A nationwide population-based analysis. Cancer Epidemiol. 89:1025362024. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu S, Zuo Y, Ye M, Wang K, Wang X, Yang X and Wang C: Co‑occurrence of clear cell renal cell carcinoma and bladder urothelial carcinoma: A case report and literature review. Oncol Lett 29: 21, 2025.
APA
Wu, S., Zuo, Y., Ye, M., Wang, K., Wang, X., Yang, X., & Wang, C. (2025). Co‑occurrence of clear cell renal cell carcinoma and bladder urothelial carcinoma: A case report and literature review. Oncology Letters, 29, 21. https://doi.org/10.3892/ol.2024.14768
MLA
Wu, S., Zuo, Y., Ye, M., Wang, K., Wang, X., Yang, X., Wang, C."Co‑occurrence of clear cell renal cell carcinoma and bladder urothelial carcinoma: A case report and literature review". Oncology Letters 29.1 (2025): 21.
Chicago
Wu, S., Zuo, Y., Ye, M., Wang, K., Wang, X., Yang, X., Wang, C."Co‑occurrence of clear cell renal cell carcinoma and bladder urothelial carcinoma: A case report and literature review". Oncology Letters 29, no. 1 (2025): 21. https://doi.org/10.3892/ol.2024.14768
Copy and paste a formatted citation
x
Spandidos Publications style
Wu S, Zuo Y, Ye M, Wang K, Wang X, Yang X and Wang C: Co‑occurrence of clear cell renal cell carcinoma and bladder urothelial carcinoma: A case report and literature review. Oncol Lett 29: 21, 2025.
APA
Wu, S., Zuo, Y., Ye, M., Wang, K., Wang, X., Yang, X., & Wang, C. (2025). Co‑occurrence of clear cell renal cell carcinoma and bladder urothelial carcinoma: A case report and literature review. Oncology Letters, 29, 21. https://doi.org/10.3892/ol.2024.14768
MLA
Wu, S., Zuo, Y., Ye, M., Wang, K., Wang, X., Yang, X., Wang, C."Co‑occurrence of clear cell renal cell carcinoma and bladder urothelial carcinoma: A case report and literature review". Oncology Letters 29.1 (2025): 21.
Chicago
Wu, S., Zuo, Y., Ye, M., Wang, K., Wang, X., Yang, X., Wang, C."Co‑occurrence of clear cell renal cell carcinoma and bladder urothelial carcinoma: A case report and literature review". Oncology Letters 29, no. 1 (2025): 21. https://doi.org/10.3892/ol.2024.14768
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