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Case Report Open Access

Utidelone combined with anti‑angiogenic therapy for the treatment of anthracycline/taxane‑treated and endocrine‑resistant HR+/HER2‑ refractory breast cancer with brain metastases: A case report

  • Authors:
    • Xue Bai
    • Meidi Liu
    • Xuelian Chen
    • Lin Song
    • Jiaxian Zhang
    • Qing Song
    • Xiaofeng Xie
    • Xiaofeng Lan
    • Liping Chen
    • Jiayi Huang
    • Caiwen Du
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, Guangdong 518116, P.R. China
    Copyright: © Bai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 25
    |
    Published online on: October 23, 2024
       https://doi.org/10.3892/ol.2024.14771
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Abstract

For patients with hormone receptor‑positive (HR+) and human epidermal growth factor receptor 2‑negative (HER2‑) metastatic breast cancer (mBC), the treatment choices become more complex after progression on first‑line CDK4/6 inhibitors combined with endocrine therapy. Currently, there are no guidelines that provide a unified standard protocol for this situation. Almost half of patients with mBC develop brain metastases (BMs), and once BMs occur, the survival of the patient is often significantly reduced. An anti‑angiogenic drug and chemotherapy combination of has demonstrated synergistic effects in an mBC cell line. Anti‑angiogenic drugs have shown therapeutic efficacy in the treatment of mBC, and utidelone has shown the ability to cross the blood‑brain barrier and achieve a high concentration in brain tissue in preclinical studies. The present case report describes a patient with HR+/HER2‑ mBC and BMs that developed resistance to two CDK4/6 inhibitors and treatments with anthracyclines/taxanes. The patient received a fourth‑line treatment regimen combining utidelone with a small‑molecule anti‑angiogenic drug, namely apatinib or anlotinib. The patient achieved a partial response with this combined regimen, and a progression‑free survival (PFS) of 7.6 months, which was the best therapeutic outcome in the entire course of the illness. This result was superior to the second‑line treatment with nab‑paclitaxel, which resulted in a PFS of 8 months and best overall response of stable disease with slight shrinkage. The present case indicates that a combination of utidelone with apatinib/anlotinib exhibited antitumor activity in a patient with HR+/HER2‑ mBC with BMs. Therefore, this combination offers a promising therapeutic option for the clinical treatment of patients with breast cancer and BMs.
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Copy and paste a formatted citation
Spandidos Publications style
Bai X, Liu M, Chen X, Song L, Zhang J, Song Q, Xie X, Lan X, Chen L, Huang J, Huang J, et al: Utidelone combined with anti‑angiogenic therapy for the treatment of anthracycline/taxane‑treated and endocrine‑resistant HR<sup>+/</sup>HER2<sup>‑</sup> refractory breast cancer with brain metastases: A case report. Oncol Lett 29: 25, 2025.
APA
Bai, X., Liu, M., Chen, X., Song, L., Zhang, J., Song, Q. ... Du, C. (2025). Utidelone combined with anti‑angiogenic therapy for the treatment of anthracycline/taxane‑treated and endocrine‑resistant HR<sup>+/</sup>HER2<sup>‑</sup> refractory breast cancer with brain metastases: A case report. Oncology Letters, 29, 25. https://doi.org/10.3892/ol.2024.14771
MLA
Bai, X., Liu, M., Chen, X., Song, L., Zhang, J., Song, Q., Xie, X., Lan, X., Chen, L., Huang, J., Du, C."Utidelone combined with anti‑angiogenic therapy for the treatment of anthracycline/taxane‑treated and endocrine‑resistant HR<sup>+/</sup>HER2<sup>‑</sup> refractory breast cancer with brain metastases: A case report". Oncology Letters 29.1 (2025): 25.
Chicago
Bai, X., Liu, M., Chen, X., Song, L., Zhang, J., Song, Q., Xie, X., Lan, X., Chen, L., Huang, J., Du, C."Utidelone combined with anti‑angiogenic therapy for the treatment of anthracycline/taxane‑treated and endocrine‑resistant HR<sup>+/</sup>HER2<sup>‑</sup> refractory breast cancer with brain metastases: A case report". Oncology Letters 29, no. 1 (2025): 25. https://doi.org/10.3892/ol.2024.14771
Copy and paste a formatted citation
x
Spandidos Publications style
Bai X, Liu M, Chen X, Song L, Zhang J, Song Q, Xie X, Lan X, Chen L, Huang J, Huang J, et al: Utidelone combined with anti‑angiogenic therapy for the treatment of anthracycline/taxane‑treated and endocrine‑resistant HR<sup>+/</sup>HER2<sup>‑</sup> refractory breast cancer with brain metastases: A case report. Oncol Lett 29: 25, 2025.
APA
Bai, X., Liu, M., Chen, X., Song, L., Zhang, J., Song, Q. ... Du, C. (2025). Utidelone combined with anti‑angiogenic therapy for the treatment of anthracycline/taxane‑treated and endocrine‑resistant HR<sup>+/</sup>HER2<sup>‑</sup> refractory breast cancer with brain metastases: A case report. Oncology Letters, 29, 25. https://doi.org/10.3892/ol.2024.14771
MLA
Bai, X., Liu, M., Chen, X., Song, L., Zhang, J., Song, Q., Xie, X., Lan, X., Chen, L., Huang, J., Du, C."Utidelone combined with anti‑angiogenic therapy for the treatment of anthracycline/taxane‑treated and endocrine‑resistant HR<sup>+/</sup>HER2<sup>‑</sup> refractory breast cancer with brain metastases: A case report". Oncology Letters 29.1 (2025): 25.
Chicago
Bai, X., Liu, M., Chen, X., Song, L., Zhang, J., Song, Q., Xie, X., Lan, X., Chen, L., Huang, J., Du, C."Utidelone combined with anti‑angiogenic therapy for the treatment of anthracycline/taxane‑treated and endocrine‑resistant HR<sup>+/</sup>HER2<sup>‑</sup> refractory breast cancer with brain metastases: A case report". Oncology Letters 29, no. 1 (2025): 25. https://doi.org/10.3892/ol.2024.14771
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