Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2025 Volume 29 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2025 Volume 29 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Potential antitumor effect of polysaccharides extracted from Polygonatum sibiricum on human prostate cancer PC‑3 cells

  • Authors:
    • Guobin Zhao
    • Yan Zhou
    • Yuhong Tang
    • Muhammad Abbas
    • Shaowen Dong
    • Xinyang Zhao
    • Xin Liu
    • Xinmei Wang
    • Chen Li
    • Chenxi Liu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075000, P.R. China, Department of Immunology, Hebei North University, Zhangjiakou, Hebei 075000, P.R. China, Department of Urology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075000, P.R. China, Graduate School, Hebei North University, Zhangjiakou, Hebei 075000, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 28
    |
    Published online on: October 25, 2024
       https://doi.org/10.3892/ol.2024.14774
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Polygonatum sibiricum polysaccharides (PSP) are a traditional herbal medicine component with potential therapeutic effects on several diseases. The present study aimed to assess the role of PSP in the treatment of human prostate cancer using a PC‑3 cell line by Cell CK‑8, transwell and wound healing assays, then elucidate the potential underlying mechanisms by western blot and quantitative Real‑time RT‑PCR. Different concentrations of PSP were applied to PC‑3 cells, and the proliferation, invasion and migration of PC‑3 cells were demonstrated to be significantly inhibited with increasing concentrations of PSP. Additionally, cell apoptosis rate and expression of caspase‑3 increased with higher PSP concentrations, and the cell cycle was arrested in the S phase. Furthermore, it was demonstrated that the expression of the multidrug resistance‑1 gene and its encoded protein P‑glycoprotein in PC‑3 cells decreased following PSP treatment, suggesting that PSP may have the potential to reverse multidrug resistance in PC‑3 cells. The present study also evaluated the possible mechanism of PSP action on PC‑3 cells. The results revealed that phosphorylated P65, PI3K and AKT decreased in a concentration‑dependent manner. As key molecules in the NF‑κB and PI3K/Akt signaling pathways, this finding suggests that the potential mechanism of the effect of PSP on prostate cancer cells may involve simultaneous mediation of the PI3K/Akt and NF‑κB signaling pathways. The present study demonstrated that PSP inhibit the proliferation, invasion and migration of PC‑3 cells in vitro, as well as reverse MDR in these cells. The underlying mechanism may involve the simultaneous regulation of the PI3K/Akt and NF‑κB signaling pathways.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Silk N, Reich J, Sinha R, Chawla S, Geary K and Zhang D: The effects of resveratrol on prostate cancer through targeting the tumor microenvironment. J Xenobiot. 11:16–32. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Penezić L, Kuliš T, Hudolin T, Zekulić T, Saić H and Kaštelan Ž: Laparoscopic radical prostatectomy: Single center case series. Acta Clin Croat. 61 (Suppl 3):S15–S20. 2022.PubMed/NCBI

3 

Stoykova GE and Schlaepfer IR: Lipid metabolism and endocrine resistance in prostate cancer, and new opportunities for therapy. Int J Mol Sci. 20:26262019. View Article : Google Scholar : PubMed/NCBI

4 

Cai M, Song XL, Li XA, Chen M, Guo J, Yang DH, Chen Z and Zhao SC: Current therapy and drug resistance in metastatic castration-resistant prostate cancer. Drug Resist Updat. 68:1009622023. View Article : Google Scholar : PubMed/NCBI

5 

Cui X, Wang S, Cao H, Guo H, Li Y, Xu F, Zheng M, Xi X and Han C: A Review: The bioactivities and pharmacological applications of polygonatumsibiricum polysaccharides. Molecules. 23:11702018. View Article : Google Scholar : PubMed/NCBI

6 

Zhang H, Li H, Pan B, Zhang S, Su X, Sun W, Zhang T, Zhang Z, Lv S and Cui H: Integrated 16S rRNA sequencing and untargeted metabolomics analysis to reveal the protective mechanisms of polygonatum sibiricum polysaccharide on type 2 diabetes mellitus model rats. Curr Drug Metab. 24:270–282. 2023. View Article : Google Scholar : PubMed/NCBI

7 

Wang Y, Lan C, Liao X, Chen D, Song W and Zhang Q: Polygonatum sibiricum polysaccharide potentially attenuates diabetic retinal injury in a diabetic rat model. J Diabetes Investig. 10:915–924. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Yang JX, Wu S, Huang XL, Hu XQ and Zhang Y: Hypolipidemic Activity and Anti-atherosclerotic Effect of Polysaccharide of Polygonatum sibiricum in Rabbit Model and Related Cellular Mechanisms. Evid Based Complement Alternat Med. 2015:3910652015. View Article : Google Scholar : PubMed/NCBI

9 

Ye G, Zhao Y, Zhu J, Zhang Z, Wang Q, Jiang X and Wang Z: Synergistic effect of polydatin and polygonatum sibiricum polysaccharides in combating atherosclerosis via suppressing TLR4-Mediated NF-κB Activation in ApoE-Deficient Mice. Evid Based Complement Alternat Med. 2022:38851532022. View Article : Google Scholar : PubMed/NCBI

10 

Du L, Nong MN, Zhao JM, Peng XM, Zong SH and Zeng GF: Polygonatum sibiricum polysaccharide inhibits osteoporosis by promoting osteoblast formation and blocking osteoclastogenesis through Wnt/β-catenin signaling pathway. Sci Rep. 6:322612016. View Article : Google Scholar : PubMed/NCBI

11 

Long T, Liu Z, Shang J, Zhou X, Yu S, Tian H and Bao Y: Polygonatum sibiricum polysaccharides play anti-cancer effect through TLR4-MAPK/NF-kappaB signaling pathways. Int J Biol Macromol. 111:813–821. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Xu Y, Guo Y, Lu C, Yu L, Fang C and Li C: Polygonatum sibiricum polysaccharide inhibited liver cancer in a simulated tumor microenvironment by eliminating TLR4/STAT3 pathway. Biol Pharm Bull. 46:1249–1259. 2023. View Article : Google Scholar : PubMed/NCBI

13 

Han SY, Hu MH, Qi GY, Ma CX, Wang YY, Ma FL, Tao N and Qin ZH: Polysaccharides from Polygonatum Inhibit the Proliferation of Prostate Cancer-Associated Fibroblasts. Asian Pac J Cancer Prev. 17:3829–3833. 2016.PubMed/NCBI

14 

Li M, Liu Y, Zhang H, Liu Y, Wang W, You S, Hu X, Song M, Wu R and Wu J: Anti-cancer Potential of Polysaccharide Extracted From Polygonatum sibiricum on HepG2 cells via cell cycle arrest and apoptosis. Front Nutr. 9:9382902022. View Article : Google Scholar : PubMed/NCBI

15 

Li L, Tian LN, Ren ZX and Long ZJ: Research progress on the structural analysis and functional activity of polysaccharides. Chin J Exp Tradit Med Fromul. 21:231–234. 2015.(In Chinese).

16 

Tewari D, Patni P and Bishayee A, Sah AN and Bishayee A: Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy. Semin Cancer Biol. 80:1–17. 2022. View Article : Google Scholar : PubMed/NCBI

17 

Hashemi M, Taheriazam A, Daneii P, Hassanpour A, Kakavand A, Rezaei S, Hejazi ES, Aboutalebi M, Gholamrezaie H, Saebfar H, et al: Targeting PI3K/Akt signaling in prostate cancer therapy. J Cell Commun Signal. 17:423–443. 2023. View Article : Google Scholar : PubMed/NCBI

18 

Wang Q, Wu S, Gu Y, Liang H, He F, Wang X, He D and Wu K: RASAL2 regulates the cell cycle and cyclin D1 expression through PI3K/AKT signalling in prostate tumorigenesis. Cell Death Discov. 8:2752022. View Article : Google Scholar : PubMed/NCBI

19 

Gu Y and Liang C: TRAIP suppressed apoptosis and cell cycle to promote prostate cancer proliferation via TRAF2-PI3K-AKT pathway activation. Int Urol Nephrol. 56:1639–1648. 2024. View Article : Google Scholar : PubMed/NCBI

20 

Raja Singh P, Sugantha Priya E, Balakrishnan S, Arunkumar R, Sharmila G, Rajalakshmi M and Arunakaran J: Inhibition of cell survival and proliferation by nimbolide in human androgen-independent prostate cancer (PC-3) cells: Involvement of the PI3K/Akt pathway. Mol Cell Biochem. 427:69–79. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Chen H, Zhou L, Wu X, Li R, Wen J, Sha J and Wen X: The PI3K/AKT pathway in the pathogenesis of prostate cancer. Front Biosci (Landmark Ed). 21:1084–1091. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Davoudi Z, Akbarzadeh A, Rahmatiyamchi M, Movassaghpour AA, Alipour M, Nejati-Koshki K, Sadeghi Z, Dariushnejad H and Zarghami N: Molecular Target Therapy of AKT and NF-kB Signaling Pathways and Multidrug Resistance by Specific Cell Penetrating Inhibitor Peptides in HL-60 Cells. Asian Pac J Cancer Prev. 15:4353–4358. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Duan C, Yu M, Xu J, Li BY, Zhao Y and Kankala RK: Overcoming Cancer Multi-drug Resistance (MDR): Reasons, mechanisms, nanotherapeutic solutions, and challenges. Biomed Pharmacother. 162:1146432023. View Article : Google Scholar : PubMed/NCBI

25 

Liu D, Tang W, Han C and Nie S: Advances in Polygonatum sibiricum polysaccharides: Extraction, purification, structure, biosynthesis, and bioactivity. Front Nutr. 9:10746712022. View Article : Google Scholar : PubMed/NCBI

26 

Ji Y, Li XY, Qi Y, Zhao J, Zhang W and Qu P: Anlotinib exerts inhibitory effects against cisplatin-resistant ovarian cancer in vitro and in vivo. Molecules. 27:88732022. View Article : Google Scholar : PubMed/NCBI

27 

Liao YD, Grobholz R, Abel U, Trojan L, Michel MS, Angel P and Mayer D: Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancer. Int J Cancer. 107:676–680. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Malik SN, Brattain M, Ghosh PM, Troyer DA, Prihoda T, Bedolla R and Kreisberg JI: Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer. Clin Cancer Res. 8:1168–1171. 2002.PubMed/NCBI

29 

Lien EC, Dibble CC and Toker A: PI3K signaling in cancer: Beyond AKT. CurrOpin Cell Biol. 45:62–71. 2017.

30 

Zhu S, Jiao W, Xu Y, Hou L, Li H, Shao J, Zhang X, Wang R and Kong D: Palmitic acid inhibits prostate cancer cell proliferation and metastasis by suppressing the PI3K/Akt pathway. Life Sci. 286:1200462021. View Article : Google Scholar : PubMed/NCBI

31 

Zhang L, Shao L, Creighton CJ, Zhang Y, Xin L, Ittmann M and Wang J: Function of phosphorylation of NF-kB p65 ser536 in prostate cancer oncogenesis. Oncotarget. 6:6281–6294. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Erdogan S, Serttas R, Turkekul K and Dibirdik I: The synergistic anticancer effect of salinomycin combined with cabazitaxel in CD44+ prostate cancer cells by downregulating wnt, NF-κB and AKT signaling. Mol Biol Rep. 49:4873–4884. 2022. View Article : Google Scholar : PubMed/NCBI

33 

Tian Y, Lei Y, Wang Y, Lai J, Wang J and Xia F: Mechanism of multidrug resistance to chemotherapy mediated by P-glycoprotein (Review). Int J Oncol. 63:1192023. View Article : Google Scholar : PubMed/NCBI

34 

Zhu YX, Jia HR, Duan QY and Wu FG: Nanomedicines for combating multidrug resistance of cancer. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 13:e17152021. View Article : Google Scholar : PubMed/NCBI

35 

Xu T, Guo P, He Y, Pi C, Wang Y, Feng X, Hou Y, Jiang Q, Zhao L and Wei Y: Application of curcumin and its derivatives in tumor multidrug resistance. Phytother Res. 34:2438–2458. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Chen T, Xiao Z, Liu X, Wang T, Wang Y, Ye F, Su J, Yao X, Xiong L and Yang DH: Natural products for combating multidrug resistance in cancer. Pharmacol Res. 202:1070992024. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao G, Zhou Y, Tang Y, Abbas M, Dong S, Zhao X, Liu X, Wang X, Li C, Liu C, Liu C, et al: Potential antitumor effect of polysaccharides extracted from <em>Polygonatum sibiricum</em> on human prostate cancer PC‑3 cells. Oncol Lett 29: 28, 2025.
APA
Zhao, G., Zhou, Y., Tang, Y., Abbas, M., Dong, S., Zhao, X. ... Liu, C. (2025). Potential antitumor effect of polysaccharides extracted from <em>Polygonatum sibiricum</em> on human prostate cancer PC‑3 cells. Oncology Letters, 29, 28. https://doi.org/10.3892/ol.2024.14774
MLA
Zhao, G., Zhou, Y., Tang, Y., Abbas, M., Dong, S., Zhao, X., Liu, X., Wang, X., Li, C., Liu, C."Potential antitumor effect of polysaccharides extracted from <em>Polygonatum sibiricum</em> on human prostate cancer PC‑3 cells". Oncology Letters 29.1 (2025): 28.
Chicago
Zhao, G., Zhou, Y., Tang, Y., Abbas, M., Dong, S., Zhao, X., Liu, X., Wang, X., Li, C., Liu, C."Potential antitumor effect of polysaccharides extracted from <em>Polygonatum sibiricum</em> on human prostate cancer PC‑3 cells". Oncology Letters 29, no. 1 (2025): 28. https://doi.org/10.3892/ol.2024.14774
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao G, Zhou Y, Tang Y, Abbas M, Dong S, Zhao X, Liu X, Wang X, Li C, Liu C, Liu C, et al: Potential antitumor effect of polysaccharides extracted from <em>Polygonatum sibiricum</em> on human prostate cancer PC‑3 cells. Oncol Lett 29: 28, 2025.
APA
Zhao, G., Zhou, Y., Tang, Y., Abbas, M., Dong, S., Zhao, X. ... Liu, C. (2025). Potential antitumor effect of polysaccharides extracted from <em>Polygonatum sibiricum</em> on human prostate cancer PC‑3 cells. Oncology Letters, 29, 28. https://doi.org/10.3892/ol.2024.14774
MLA
Zhao, G., Zhou, Y., Tang, Y., Abbas, M., Dong, S., Zhao, X., Liu, X., Wang, X., Li, C., Liu, C."Potential antitumor effect of polysaccharides extracted from <em>Polygonatum sibiricum</em> on human prostate cancer PC‑3 cells". Oncology Letters 29.1 (2025): 28.
Chicago
Zhao, G., Zhou, Y., Tang, Y., Abbas, M., Dong, S., Zhao, X., Liu, X., Wang, X., Li, C., Liu, C."Potential antitumor effect of polysaccharides extracted from <em>Polygonatum sibiricum</em> on human prostate cancer PC‑3 cells". Oncology Letters 29, no. 1 (2025): 28. https://doi.org/10.3892/ol.2024.14774
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team