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Article Open Access

Importance of driver gene mutation assessment and targeted therapy for patients with early‑stage non‑small cell lung cancer and non‑R0 resection

  • Authors:
    • Pei-Yi Shen
    • Cheng-Yen Chuang
    • Chih-Hung Lin
    • Yu-Wei Hsu
    • Yen-Hsiang Huang
    • Kuo-Hsuan Hsu
    • Jeng-Sen Tseng
    • Gee-Chen Chang
    • Tsung-Ying Yang
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Division of Chest Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan, R.O.C., Department of Surgery, Division of Thoracic Surgery, Taichung Veterans General Hospital, Taichung 407, Taiwan, R.O.C., Computer and Communications Center, Taichung Veterans General Hospital, Taichung 407, Taiwan, R.O.C., Lung Cancer Comprehensive Care and Research Center, Taichung Veterans General Hospital, Taichung 407, Taiwan, R.O.C., Institute of Biomedical Sciences, National Chung Hsing University, Taichung 621, Taiwan, R.O.C.
    Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 35
    |
    Published online on: October 29, 2024
       https://doi.org/10.3892/ol.2024.14780
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Abstract

Patients with non‑small cell lung cancer (NSCLC) and incomplete resection have poor clinical outcomes. The present study aimed to identify risk factors for disease progression and mortality. A total of 65 patients with early‑stage NSCLC that underwent operation but had a non‑R0 resection between August 2011 and December 2020 were included in the present study, and the clinicopathological features and driver gene mutation status were analyzed. The median follow‑up time was 36.2 months; 39 patients (60.0%) experienced disease progression and 3 patients (4.6%) died. In total, 22 patients (33.8%) harbored mutations in driver genes. Multivariate analysis demonstrated that the presence of driver gene mutations was associated with an increased risk of disease progression [adjusted odds ratio, 24.08; 95% confidence interval (CI), 2.77‑209.01; P=0.004]. Tumors classed as Eastern Cooperative Oncology Group performance status 2 [adjusted hazard ratio (HR), 3.49; 95% CI, 1.10‑11.03; P=0.033], stage II‑IIIB tumors (adjusted HR, 2.55; 95% CI, 1.06‑6.17; P=0.037) and the presence of a driver gene mutation (adjusted HR, 3.28; 95% CI, 1.55‑6.94; P=0.002) were associated with a significantly reduced progression‑free survival (PFS). Driver gene‑targeted therapy was associated with an increased post‑progression survival for patients that were reported to have disease progression (adjusted HR, 0.38; 95% CI, 0.16‑0.91; P=0.030). There was no significant impact of driver gene mutation status on the overall survival (OS) of patients. Although the presence of a driver gene mutation was associated with an increased risk of disease progression and a reduced PFS, it was demonstrated that patients with disease progression may benefit from driver gene‑targeted therapy, as patients with driver gene‑targeted therapy had a similar OS compared with that of patients with a driver gene‑negative or unknown status. Therefore, early comprehensive analysis of driver gene mutation status may be recommended for early‑stage NSCLC cancer patients experiencing non‑R0 resection.
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Copy and paste a formatted citation
Spandidos Publications style
Shen P, Chuang C, Lin C, Hsu Y, Huang Y, Hsu K, Tseng J, Chang G and Yang T: Importance of driver gene mutation assessment and targeted therapy for patients with early‑stage non‑small cell lung cancer and non‑R0 resection. Oncol Lett 29: 35, 2025.
APA
Shen, P., Chuang, C., Lin, C., Hsu, Y., Huang, Y., Hsu, K. ... Yang, T. (2025). Importance of driver gene mutation assessment and targeted therapy for patients with early‑stage non‑small cell lung cancer and non‑R0 resection. Oncology Letters, 29, 35. https://doi.org/10.3892/ol.2024.14780
MLA
Shen, P., Chuang, C., Lin, C., Hsu, Y., Huang, Y., Hsu, K., Tseng, J., Chang, G., Yang, T."Importance of driver gene mutation assessment and targeted therapy for patients with early‑stage non‑small cell lung cancer and non‑R0 resection". Oncology Letters 29.1 (2025): 35.
Chicago
Shen, P., Chuang, C., Lin, C., Hsu, Y., Huang, Y., Hsu, K., Tseng, J., Chang, G., Yang, T."Importance of driver gene mutation assessment and targeted therapy for patients with early‑stage non‑small cell lung cancer and non‑R0 resection". Oncology Letters 29, no. 1 (2025): 35. https://doi.org/10.3892/ol.2024.14780
Copy and paste a formatted citation
x
Spandidos Publications style
Shen P, Chuang C, Lin C, Hsu Y, Huang Y, Hsu K, Tseng J, Chang G and Yang T: Importance of driver gene mutation assessment and targeted therapy for patients with early‑stage non‑small cell lung cancer and non‑R0 resection. Oncol Lett 29: 35, 2025.
APA
Shen, P., Chuang, C., Lin, C., Hsu, Y., Huang, Y., Hsu, K. ... Yang, T. (2025). Importance of driver gene mutation assessment and targeted therapy for patients with early‑stage non‑small cell lung cancer and non‑R0 resection. Oncology Letters, 29, 35. https://doi.org/10.3892/ol.2024.14780
MLA
Shen, P., Chuang, C., Lin, C., Hsu, Y., Huang, Y., Hsu, K., Tseng, J., Chang, G., Yang, T."Importance of driver gene mutation assessment and targeted therapy for patients with early‑stage non‑small cell lung cancer and non‑R0 resection". Oncology Letters 29.1 (2025): 35.
Chicago
Shen, P., Chuang, C., Lin, C., Hsu, Y., Huang, Y., Hsu, K., Tseng, J., Chang, G., Yang, T."Importance of driver gene mutation assessment and targeted therapy for patients with early‑stage non‑small cell lung cancer and non‑R0 resection". Oncology Letters 29, no. 1 (2025): 35. https://doi.org/10.3892/ol.2024.14780
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