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Case Report Open Access

Long‑term survival after comprehensive treatment in a patient with advanced neuroendocrine neoplasm of the pancreas: A case report

  • Authors:
    • Lei Zhao
    • Xin Cheng
    • Hongbin Zhao
    • Haifei Zhao
    • Wenyu Di
    • Zhihong Mei
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China, Department of General Surgery, Huaihai Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi 046000, P.R. China, Department of Imaging, Huaihai Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi 046000, P.R. China, Department of Pathology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453100, P.R. China, Department of Radiotherapy, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453100, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 49
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    Published online on: November 8, 2024
       https://doi.org/10.3892/ol.2024.14795
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Abstract

Neuroendocrine neoplasms of the pancreas (pNENs) are rare. In February 2021, a 54‑year‑old woman was diagnosed with pNEN and multiple metastases within the liver. The patient, diagnosed with grade G2 neuroendocrine neoplasm (T4N0M1), underwent an ultrasonography‑guided liver biopsy and radiofrequency ablation. After receiving Sandostatin LAR in April 2021, side effects led to its discontinuation after seven cycles. Following two sessions of radiofrequency ablation, the patient's condition was stable. However, disease progression was noted in September 2023, resulting in hemodialysis and closed peritoneal drainage. Surufatinib was administered, stabilizing the tumor by November 2023. The patient underwent transarterial chemoembolization due to a large tumor burden, with subsequent MRCP showing stability from diagnosis in February 2021 to June 2024. The present case report highlights the role of tailored treatment strategies considering patient comorbidities and tumor biology, and the significance of secondary puncture biopsy, which, despite not being pursued by the patient in the present study due to the associated risks, may provide survival benefits for patients with advanced or metastatic pNEN.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao L, Cheng X, Zhao H, Zhao H, Di W and Mei Z: Long‑term survival after comprehensive treatment in a patient with advanced neuroendocrine neoplasm of the pancreas: A case report. Oncol Lett 29: 49, 2025.
APA
Zhao, L., Cheng, X., Zhao, H., Zhao, H., Di, W., & Mei, Z. (2025). Long‑term survival after comprehensive treatment in a patient with advanced neuroendocrine neoplasm of the pancreas: A case report. Oncology Letters, 29, 49. https://doi.org/10.3892/ol.2024.14795
MLA
Zhao, L., Cheng, X., Zhao, H., Zhao, H., Di, W., Mei, Z."Long‑term survival after comprehensive treatment in a patient with advanced neuroendocrine neoplasm of the pancreas: A case report". Oncology Letters 29.1 (2025): 49.
Chicago
Zhao, L., Cheng, X., Zhao, H., Zhao, H., Di, W., Mei, Z."Long‑term survival after comprehensive treatment in a patient with advanced neuroendocrine neoplasm of the pancreas: A case report". Oncology Letters 29, no. 1 (2025): 49. https://doi.org/10.3892/ol.2024.14795
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao L, Cheng X, Zhao H, Zhao H, Di W and Mei Z: Long‑term survival after comprehensive treatment in a patient with advanced neuroendocrine neoplasm of the pancreas: A case report. Oncol Lett 29: 49, 2025.
APA
Zhao, L., Cheng, X., Zhao, H., Zhao, H., Di, W., & Mei, Z. (2025). Long‑term survival after comprehensive treatment in a patient with advanced neuroendocrine neoplasm of the pancreas: A case report. Oncology Letters, 29, 49. https://doi.org/10.3892/ol.2024.14795
MLA
Zhao, L., Cheng, X., Zhao, H., Zhao, H., Di, W., Mei, Z."Long‑term survival after comprehensive treatment in a patient with advanced neuroendocrine neoplasm of the pancreas: A case report". Oncology Letters 29.1 (2025): 49.
Chicago
Zhao, L., Cheng, X., Zhao, H., Zhao, H., Di, W., Mei, Z."Long‑term survival after comprehensive treatment in a patient with advanced neuroendocrine neoplasm of the pancreas: A case report". Oncology Letters 29, no. 1 (2025): 49. https://doi.org/10.3892/ol.2024.14795
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