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Case Report Open Access

Primary mucinous cystadenocarcinoma of the breast: A case report and literature review

  • Authors:
    • Xi Cao
    • Yongchao Luo
    • Songjie Shen
    • Xinyu Ren
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China, Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China
    Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 60
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    Published online on: November 15, 2024
       https://doi.org/10.3892/ol.2024.14806
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Abstract

Mucinous cystadenocarcinoma (MCA) is a rare breast cancer. The present study reports a case of primary MCA of the breast with a comprehensive evaluation of this rare tumour. A 51‑year‑old woman sought medical attention for a mass in the left breast. A core needle biopsy revealed an infiltrating adenocarcinoma with mucus secretion and papillary formation. The macroscopic appearance was of a greyish‑white, tough and well‑circumscribed solid mass, without a notable cyst. Microscopically, the tumour consisted of ducts and cysts of varying sizes. Varying degrees of branching papillary structures were observed in the lumen and cyst cavities. The tumour cells were highly columnar in shape, with high‑grade nuclei arranged in a single‑layer. Immunohistochemistry revealed that the tumour was a basal‑like triple‑negative breast cancer with a high proliferation index and tumour protein p53 diffuse strong expression. Mutations in breast cancer 1‑associated RING domain 1 (BARD1), kinase domain containing receptor (KDR), mucin‑6 (MUC6), tumour protein 53 (TP53) and breast cancer 1‑interacting protein C‑terminal helicase 1 (BRIP1) were identified using DNA analysis. The patient was followed up for 26 months and showed no signs of recurrence or metastasis. In conclusion, the current study presents a case of MCA of breast accompanied by mutations in the BARD1, KDR, MUC6, TP53 and BRIP1 genes, with no recurrence after a 26‑month follow‑up. Combining this case with a review of the literature helps us to better understand the clinicopathological and genetic characteristics of MCA, and guide treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Cao X, Luo Y, Shen S and Ren X: Primary mucinous cystadenocarcinoma of the breast: A case report and literature review. Oncol Lett 29: 60, 2025.
APA
Cao, X., Luo, Y., Shen, S., & Ren, X. (2025). Primary mucinous cystadenocarcinoma of the breast: A case report and literature review. Oncology Letters, 29, 60. https://doi.org/10.3892/ol.2024.14806
MLA
Cao, X., Luo, Y., Shen, S., Ren, X."Primary mucinous cystadenocarcinoma of the breast: A case report and literature review". Oncology Letters 29.1 (2025): 60.
Chicago
Cao, X., Luo, Y., Shen, S., Ren, X."Primary mucinous cystadenocarcinoma of the breast: A case report and literature review". Oncology Letters 29, no. 1 (2025): 60. https://doi.org/10.3892/ol.2024.14806
Copy and paste a formatted citation
x
Spandidos Publications style
Cao X, Luo Y, Shen S and Ren X: Primary mucinous cystadenocarcinoma of the breast: A case report and literature review. Oncol Lett 29: 60, 2025.
APA
Cao, X., Luo, Y., Shen, S., & Ren, X. (2025). Primary mucinous cystadenocarcinoma of the breast: A case report and literature review. Oncology Letters, 29, 60. https://doi.org/10.3892/ol.2024.14806
MLA
Cao, X., Luo, Y., Shen, S., Ren, X."Primary mucinous cystadenocarcinoma of the breast: A case report and literature review". Oncology Letters 29.1 (2025): 60.
Chicago
Cao, X., Luo, Y., Shen, S., Ren, X."Primary mucinous cystadenocarcinoma of the breast: A case report and literature review". Oncology Letters 29, no. 1 (2025): 60. https://doi.org/10.3892/ol.2024.14806
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