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Case Report Open Access

Efficacy of emapalumab in the management of anti‑CD19 chimeric antigen receptor T‑cell therapy‑associated cytokine release syndrome: A report of two cases

  • Authors:
    • Wenzhi Cai
    • Yutong Lu
    • Haiju He
    • Jiaqi Li
    • Shuangzhu Liu
    • Hongzhi Geng
    • Qin Yang
    • Liangyu Zeng
    • Depei Wu
    • Caixia Li
  • View Affiliations / Copyright

    Affiliations: National Clinical Research Center for Hematological Diseases, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
    Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 71
    |
    Published online on: November 22, 2024
       https://doi.org/10.3892/ol.2024.14817
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Abstract

Chimeric antigen receptor (CAR) T‑cell therapy is an effective treatment for diffuse large B‑cell lymphoma (DLBCL). However, it may activate the systemic immune system of the patient, resulting in cytokine release syndrome (CRS). Emapalumab is a human monoclonal antibody targeting interferon‑γ, inhibiting its interaction with cell surface receptors and the subsequent activation of inflammatory pathways. The present report describes the cases of 2 patients with relapsed DLBCL treated with CAR T‑cell therapy, in which the severe CRS associated with CAR T‑cell therapy was attenuated without compromising antitumor efficacy after receiving emapalumab. Further prospective clinical trials are warranted to determine the role of emapalumab in CAR T‑cell therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Cai W, Lu Y, He H, Li J, Liu S, Geng H, Yang Q, Zeng L, Wu D, Li C, Li C, et al: Efficacy of emapalumab in the management of anti‑CD19 chimeric antigen receptor T‑cell therapy‑associated cytokine release syndrome: A report of two cases. Oncol Lett 29: 71, 2025.
APA
Cai, W., Lu, Y., He, H., Li, J., Liu, S., Geng, H. ... Li, C. (2025). Efficacy of emapalumab in the management of anti‑CD19 chimeric antigen receptor T‑cell therapy‑associated cytokine release syndrome: A report of two cases. Oncology Letters, 29, 71. https://doi.org/10.3892/ol.2024.14817
MLA
Cai, W., Lu, Y., He, H., Li, J., Liu, S., Geng, H., Yang, Q., Zeng, L., Wu, D., Li, C."Efficacy of emapalumab in the management of anti‑CD19 chimeric antigen receptor T‑cell therapy‑associated cytokine release syndrome: A report of two cases". Oncology Letters 29.2 (2025): 71.
Chicago
Cai, W., Lu, Y., He, H., Li, J., Liu, S., Geng, H., Yang, Q., Zeng, L., Wu, D., Li, C."Efficacy of emapalumab in the management of anti‑CD19 chimeric antigen receptor T‑cell therapy‑associated cytokine release syndrome: A report of two cases". Oncology Letters 29, no. 2 (2025): 71. https://doi.org/10.3892/ol.2024.14817
Copy and paste a formatted citation
x
Spandidos Publications style
Cai W, Lu Y, He H, Li J, Liu S, Geng H, Yang Q, Zeng L, Wu D, Li C, Li C, et al: Efficacy of emapalumab in the management of anti‑CD19 chimeric antigen receptor T‑cell therapy‑associated cytokine release syndrome: A report of two cases. Oncol Lett 29: 71, 2025.
APA
Cai, W., Lu, Y., He, H., Li, J., Liu, S., Geng, H. ... Li, C. (2025). Efficacy of emapalumab in the management of anti‑CD19 chimeric antigen receptor T‑cell therapy‑associated cytokine release syndrome: A report of two cases. Oncology Letters, 29, 71. https://doi.org/10.3892/ol.2024.14817
MLA
Cai, W., Lu, Y., He, H., Li, J., Liu, S., Geng, H., Yang, Q., Zeng, L., Wu, D., Li, C."Efficacy of emapalumab in the management of anti‑CD19 chimeric antigen receptor T‑cell therapy‑associated cytokine release syndrome: A report of two cases". Oncology Letters 29.2 (2025): 71.
Chicago
Cai, W., Lu, Y., He, H., Li, J., Liu, S., Geng, H., Yang, Q., Zeng, L., Wu, D., Li, C."Efficacy of emapalumab in the management of anti‑CD19 chimeric antigen receptor T‑cell therapy‑associated cytokine release syndrome: A report of two cases". Oncology Letters 29, no. 2 (2025): 71. https://doi.org/10.3892/ol.2024.14817
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