Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February-2025 Volume 29 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2025 Volume 29 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Comparison of apparent diffusion coefficients of resectable mid‑high rectal adenocarcinoma and distal paracancerous tissue

  • Authors:
    • Hui Luo
    • Yue-Qin Gou
    • Yue-Su Wang
    • Hui-Lin Qin
    • Hai-Ying Zhou
    • Xiao-Ming Zhang
    • Tian-Wu Chen
  • View Affiliations / Copyright

    Affiliations: Medical Imaging Key Laboratory of Sichuan Province, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China, Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China
    Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 97
    |
    Published online on: December 10, 2024
       https://doi.org/10.3892/ol.2024.14843
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Paracancerous tissues actively communicate with the tumor and undergo molecular alterations associated with tumorigenesis. Apparent diffusion coefficient (ADC) can help distinguish between rectal adenocarcinoma (RA), tumor‑adjacent and tumor‑distant tissues. Preoperative determining optimal distal resection margin (DRM) is crucial for formulating surgical options. The present study aimed to assess ADC differences between RA and 1 cm‑layer distal paracancerous tissues, providing a potential reference basis for preoperatively determining optimal DRM. A total of 110 consecutive patients with mid‑high RA undergoing preoperative diffusion‑weighted imaging were included. ADCs of RA and distal paracancerous tissues located ~1, 2 and 3 cm from the tumor margin (defined as D1, D2 and D3, respectively) were measured using five b‑value pairs (0 and 50; 0 and 100; 0 and 800; 0 and 1,000; and 0 and 1,500 sec/mm2). Differences in ADCs between RA, D1, D2 and D3 were compared using the Friedman test with a post hoc Bonferroni correction. Variables that demonstrated statistical differences in multiple pairwise comparisons underwent receiver operating characteristic (ROC) analysis to assess diagnostic performance of ADCs in distinguishing between tissues. ADC at all b‑value pairs demonstrated satisfactory performance in distinguishing RA from D1, D2 and D3 [areas under the ROC curves (AUCs), 0.838 to 0.996)]. When the maximum b‑value was ≥800 sec/mm2, the ADC of D1 was significantly lower compared with those of D2 and D3 (P<0.001). ADC exhibited an optimal performance in differentiating D1 from D2 at b‑values of 0 and 800 sec/mm2, and D1 from D3 at b‑values of 0 and 1,000 sec/mm2 (AUCs: 0.652 and 0.692, respectively). However, ADCs of D2 and D3 demonstrated no differences at all b‑value pairs (all P>0.05). In conclusion, ADC may distinguish RA from D1, D2 and D3, and D1 from D2/D3, but cannot distinguish between D2 and D3.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Siegel RL, Wagle NS, Cercek A, Smith RA and Jemal A: Colorectal cancer statistics, 2023. CA Cancer J Clin. 73:233–254. 2023. View Article : Google Scholar : PubMed/NCBI

2 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

3 

Islam SMA, Patel R, Bommareddy RR, Khalid KM and Acevedo-Duncan M: The modulation of actin dynamics via atypical protein kinase-C activated cofilin regulates metastasis of colorectal cancer cells. Cell Adh Migr. 13:106–120. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Dekker E, Tanis PJ, Vleugels JLA, Kasi PM and Wallace MB: Colorectal cancer. Lancet. 394:1467–1480. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Kosuge M, Eto K, Sasaki S, Sugano H, Yatabe S, Takeda Y, Ito D, Ohkuma M and Yanaga K: Clinical factors affecting the distal margin in rectal cancer surgery. Surg Today. 50:743–748. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Ekkarat P, Boonpipattanapong T, Tantiphlachiva K and Sangkhathat S: Factors determining low anterior resection syndrome after rectal cancer resection: A study in Thai patients. Asian J Surg. 39:225–231. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Song SH, Park JS, Choi GS, Seo AN, Park SY, Kim HJ, Lee SM and Yoon G: Impact of the distal resection margin on local recurrence after neoadjuvant chemoradiation and rectal excision for locally advanced rectal cancer. Sci Rep. 11:229432021. View Article : Google Scholar : PubMed/NCBI

8 

Trujillo KA, Hines WC, Vargas KM, Jones AC, Joste NE, Bisoffi M and Griffith JK: Breast field cancerization: Isolation and comparison of telomerase-expressing cells in tumor and tumor adjacent, histologically normal breast tissue. Mol Cancer Res. 9:1209–1221. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Guo H, Zeng W, Feng L, Yu X, Li P, Zhang K, Zhou Z and Cheng S: Integrated transcriptomic analysis of distance-related field cancerization in rectal cancer patients. Oncotarget. 8:61107–61117. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Braakhuis BJ, Tabor MP, Kummer JA, Leemans CR and Brakenhoff RH: A genetic explanation of Slaughter's concept of field cancerization: Evidence and clinical implications. Cancer Res. 63:1727–1730. 2003.PubMed/NCBI

11 

Chavhan GB and Caro-Dominguez P: Diffusion-weighted imaging in pediatric body magnetic resonance imaging. Pediatr Radiol. 46:847–857. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Subhawong TK, Jacobs MA and Fayad LM: Diffusion-weighted MR imaging for characterizing musculoskeletal lesions. Radiographics. 34:1163–1177. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Ko CC, Yeh LR, Kuo YT and Chen JH: Imaging biomarkers for evaluating tumor response: RECIST and beyond. Biomark Res. 9:522021. View Article : Google Scholar : PubMed/NCBI

14 

Harold KM, MacCuaig WM, Holter-Charkabarty J, Williams K, Hill K, Arreola AX, Sekhri M, Carter S, Gomez-Gutierrez J, Salem G, et al: Advances in imaging of inflammation, fibrosis, and cancer in the gastrointestinal tract. Int J Mol Sci. 23:161092022. View Article : Google Scholar : PubMed/NCBI

15 

Marques MPM, Batista de Carvalho ALM, Mamede AP, Dopplapudi A, García Sakai V and Batista de Carvalho LAE: Role of intracellular water in the normal-to-cancer transition in human cells-insights from quasi-elastic neutron scattering. Struct Dyn. 7:054702020. View Article : Google Scholar : PubMed/NCBI

16 

Zhao Y, Guo M, Zhao F, Liu Q and Wang X: Colonic stem cells from normal tissues adjacent to tumor drive inflammation and fibrosis in colorectal cancer. Cell Commun Signal. 21:1862023. View Article : Google Scholar : PubMed/NCBI

17 

Chen XQ, Tan BG, Xu M, Zhou HY, Ou J, Zhang XM, Yu ZY and Chen TW: Apparent diffusion coefficient derived from diffusion-weighted imaging to differentiate between tumor, tumor-adjacent and tumor-distant tissues in resectable rectal adenocarcinoma. Eur J Radiol. 155:1105062022. View Article : Google Scholar : PubMed/NCBI

18 

Zhang S, Pan G, Liu Z, Kong Y and Wang D: Association of levels of metabolites with the safe margin of rectal cancer surgery: A metabolomics study. BMC Cancer. 22:10432022. View Article : Google Scholar : PubMed/NCBI

19 

Hashiguchi Y, Muro K, Saito Y, Ito Y, Ajioka Y, Hamaguchi T, Hasegawa K, Hotta K, Ishida H, Ishiguro M, et al: Japanese society for cancer of the colon and rectum. Japanese society for cancer of the colon and rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer. Int J Clin Oncol. 25:1–42. 2020. View Article : Google Scholar : PubMed/NCBI

20 

Benson AB, Venook AP, Al-Hawary MM, Azad N, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Garrido-Laguna I, et al: Rectal cancer, version 2.2022, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 20:1139–1167. 2022. View Article : Google Scholar : PubMed/NCBI

21 

Liu X, Wang Z, Ren H, Wang Z and Li J: Accuracy of magnetic resonance imaging in defining dentate line in anal fistula. BMC Med Imaging. 22:2012022. View Article : Google Scholar : PubMed/NCBI

22 

Kalisz KR, Enzerra MD and Paspulati RM: MRI evaluation of the response of rectal cancer to neoadjuvant chemoradiation therapy. Radiographics. 39:538–556. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Ye Z, Yao S, Yang T, Li Q, Li Z and Song B: Abdominal diffusion-weighted MRI with simultaneous multi-slice acquisition: Agreement and reproducibility of apparent diffusion coefficients measurements. J Magn Reson Imaging. 59:1170–1178. 2024. View Article : Google Scholar : PubMed/NCBI

24 

Chen L, Shen F, Li Z, Lu H, Chen Y, Wang Z and Lu J: Diffusion-weighted imaging of rectal cancer on repeatability and cancer characterization: An effect of b-value distribution study. Cancer Imaging. 18:432018. View Article : Google Scholar : PubMed/NCBI

25 

Sumi M, Van Cauteren M, Sumi T, Obara M, Ichikawa Y and Nakamura T: Salivary gland tumors: Use of intravoxel incoherent motion MR imaging for assessment of diffusion and perfusion for the differentiation of benign from malignant tumors. Radiology. 263:770–777. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Palmucci S, Cappello G, Attinà G, Fuccio Sanzà G, Foti PV, Ettorre GC and Milone P: Diffusion-weighted MRI for the assessment of liver fibrosis: principles and applications. Biomed Res Int. 2015:8742012015. View Article : Google Scholar : PubMed/NCBI

27 

Zhang G, Wang S, Wen D and Zhang J, Wei X, Ma W, Zhao W, Wang M, Wu G and Zhang J: Comparison of non-Gaussian and Gaussian diffusion models of diffusion weighted imaging of rectal cancer at 3.0 T MRI. Sci Rep. 6:387822016. View Article : Google Scholar : PubMed/NCBI

28 

Zhou M, Gong T, Chen M and Wang Y: High-resolution integrated dynamic shimming diffusion-weighted imaging (DWI) in the assessment of rectal cancer. Eur Radiol. 33:5769–5778. 2023. View Article : Google Scholar : PubMed/NCBI

29 

Liu J, Li Q, Tang L, Huang Z and Lin Q: Correlations of mean and mimimum apparent diffusion coefficient values with the clinicopathological features in rectal cancer. Acad Radiol. 28:S105–S111. 2021. View Article : Google Scholar : PubMed/NCBI

30 

Du JF, Lu BL, Huang SY, Mao R, Zhang ZW, Cao QH, Chen ZH, Li SY, Qin QL, Sun CH, et al: A novel identification system combining diffusion kurtosis imaging with conventional magnetic resonance imaging to assess intestinal strictures in patients with Crohn's disease. Abdom Radiol (NY). 46:936–947. 2021. View Article : Google Scholar : PubMed/NCBI

31 

Manegold P, Taukert J, Neeff H, Fichtner-Feigl S and Thomusch O: The minimum distal resection margin in rectal cancer surgery and its impact on local recurrence–A retrospective cohort analysis. Int J Surg. 70:1022019. View Article : Google Scholar

32 

Yan H, Wang PY, Wu YC and Liu YC: Is a distal resection margin of ≤ 1 cm safe in patients with intermediate- to low-lying rectal cancer? A systematic review and meta-analysis. J Gastrointest Surg. 26:1791–1803. 2022. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Luo H, Gou Y, Wang Y, Qin H, Zhou H, Zhang X and Chen T: Comparison of apparent diffusion coefficients of resectable mid‑high rectal adenocarcinoma and distal paracancerous tissue. Oncol Lett 29: 97, 2025.
APA
Luo, H., Gou, Y., Wang, Y., Qin, H., Zhou, H., Zhang, X., & Chen, T. (2025). Comparison of apparent diffusion coefficients of resectable mid‑high rectal adenocarcinoma and distal paracancerous tissue. Oncology Letters, 29, 97. https://doi.org/10.3892/ol.2024.14843
MLA
Luo, H., Gou, Y., Wang, Y., Qin, H., Zhou, H., Zhang, X., Chen, T."Comparison of apparent diffusion coefficients of resectable mid‑high rectal adenocarcinoma and distal paracancerous tissue". Oncology Letters 29.2 (2025): 97.
Chicago
Luo, H., Gou, Y., Wang, Y., Qin, H., Zhou, H., Zhang, X., Chen, T."Comparison of apparent diffusion coefficients of resectable mid‑high rectal adenocarcinoma and distal paracancerous tissue". Oncology Letters 29, no. 2 (2025): 97. https://doi.org/10.3892/ol.2024.14843
Copy and paste a formatted citation
x
Spandidos Publications style
Luo H, Gou Y, Wang Y, Qin H, Zhou H, Zhang X and Chen T: Comparison of apparent diffusion coefficients of resectable mid‑high rectal adenocarcinoma and distal paracancerous tissue. Oncol Lett 29: 97, 2025.
APA
Luo, H., Gou, Y., Wang, Y., Qin, H., Zhou, H., Zhang, X., & Chen, T. (2025). Comparison of apparent diffusion coefficients of resectable mid‑high rectal adenocarcinoma and distal paracancerous tissue. Oncology Letters, 29, 97. https://doi.org/10.3892/ol.2024.14843
MLA
Luo, H., Gou, Y., Wang, Y., Qin, H., Zhou, H., Zhang, X., Chen, T."Comparison of apparent diffusion coefficients of resectable mid‑high rectal adenocarcinoma and distal paracancerous tissue". Oncology Letters 29.2 (2025): 97.
Chicago
Luo, H., Gou, Y., Wang, Y., Qin, H., Zhou, H., Zhang, X., Chen, T."Comparison of apparent diffusion coefficients of resectable mid‑high rectal adenocarcinoma and distal paracancerous tissue". Oncology Letters 29, no. 2 (2025): 97. https://doi.org/10.3892/ol.2024.14843
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team