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Case Report Open Access

Diagnosis of primary meningeal natural killer/T‑cell lymphoma of the central nervous system using cerebrospinal fluid cytology: A case report

  • Authors:
    • Xiaoli Chen
    • Jin Feng
    • Weihua Zhang
    • Zhiqian Min
    • Shuqi Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710000, P.R. China, Department of Clinical Laboratory Diagnostics, Xi'an Medical University, Xi'an, Shaanxi 710068, P.R. China, Department of Hematology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710000, P.R. China, Department of Radiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710000, P.R. China, Institute of Hematological Research, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710000, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 113
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    Published online on: December 31, 2024
       https://doi.org/10.3892/ol.2024.14859
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Abstract

Primary central nervous system (CNS) lymphoma of the meninges is a rare tumor that originates in the meninges and does not show parenchymal or systemic spread. CNS involvement by natural killer (NK)/T‑cell lymphoma accounts for only 2% of all extranodal NK/T‑cell lymphomas, and primary NK/T‑cell lymphoma of the meninges is even rarer. The present study reports a case of a 55‑year‑old male patient with primary NK/T‑cell lymphoma. The patient presented with intermittent dizziness and headaches for the past 1 month prior to presentation. Magnetic resonance imaging of the head identified no overt abnormalities. However, cytological analysis of a Wright‑Giemsa‑stained cerebrospinal fluid (CSF) sample, demonstrated numerous atypical lymphocytes and lymphoma cells. Flow cytometry of the CSF was performed as an auxiliary method, and it showed that a large proportion of the cells in the CSF were of the NK/T‑cell lineage, to indicating a diagnosis of NK/T‑cell lymphoma. Mutations of 14 genes were detected, including JAK3 mutations, upon screening of the CSF for blood system diseases using next‑generation sequencing. Therefore, the present study demonstrated that a CSF cytological examination may be an important component of the diagnostic workup for patients suspected to have a primary meningeal CNS lymphoma.
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Copy and paste a formatted citation
Spandidos Publications style
Chen X, Feng J, Zhang W, Min Z and Zhao S: Diagnosis of primary meningeal natural killer/T‑cell lymphoma of the central nervous system using cerebrospinal fluid cytology: A case report. Oncol Lett 29: 113, 2025.
APA
Chen, X., Feng, J., Zhang, W., Min, Z., & Zhao, S. (2025). Diagnosis of primary meningeal natural killer/T‑cell lymphoma of the central nervous system using cerebrospinal fluid cytology: A case report. Oncology Letters, 29, 113. https://doi.org/10.3892/ol.2024.14859
MLA
Chen, X., Feng, J., Zhang, W., Min, Z., Zhao, S."Diagnosis of primary meningeal natural killer/T‑cell lymphoma of the central nervous system using cerebrospinal fluid cytology: A case report". Oncology Letters 29.3 (2025): 113.
Chicago
Chen, X., Feng, J., Zhang, W., Min, Z., Zhao, S."Diagnosis of primary meningeal natural killer/T‑cell lymphoma of the central nervous system using cerebrospinal fluid cytology: A case report". Oncology Letters 29, no. 3 (2025): 113. https://doi.org/10.3892/ol.2024.14859
Copy and paste a formatted citation
x
Spandidos Publications style
Chen X, Feng J, Zhang W, Min Z and Zhao S: Diagnosis of primary meningeal natural killer/T‑cell lymphoma of the central nervous system using cerebrospinal fluid cytology: A case report. Oncol Lett 29: 113, 2025.
APA
Chen, X., Feng, J., Zhang, W., Min, Z., & Zhao, S. (2025). Diagnosis of primary meningeal natural killer/T‑cell lymphoma of the central nervous system using cerebrospinal fluid cytology: A case report. Oncology Letters, 29, 113. https://doi.org/10.3892/ol.2024.14859
MLA
Chen, X., Feng, J., Zhang, W., Min, Z., Zhao, S."Diagnosis of primary meningeal natural killer/T‑cell lymphoma of the central nervous system using cerebrospinal fluid cytology: A case report". Oncology Letters 29.3 (2025): 113.
Chicago
Chen, X., Feng, J., Zhang, W., Min, Z., Zhao, S."Diagnosis of primary meningeal natural killer/T‑cell lymphoma of the central nervous system using cerebrospinal fluid cytology: A case report". Oncology Letters 29, no. 3 (2025): 113. https://doi.org/10.3892/ol.2024.14859
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