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Clinical significance of cachexia index determined by bioelectrical impedance analysis in patients with gastrointestinal cancer

  • Authors:
    • Tomoya Ohara
    • Naoto Iwai
    • Kohei Oka
    • Kengo Okabe
    • Hiroaki Sakai
    • Toshifumi Tsuji
    • Takashi Okuda
    • Junichi Sakagami
    • Keizo Kagawa
    • Toshifumi Doi
    • Ken Inoue
    • Osamu Dohi
    • Naohisa Yoshida
    • Kanji Yamaguchi
    • Michihisa Moriguchi
    • Kazuhiko Uchiyama
    • Takeshi Ishikawa
    • Tomohisa Takagi
    • Hideyuki Konishi
    • Yoshito Itoh
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, Fukuchiyama City Hospital, Kyoto, Kansai 620‑0056, Japan, Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Kansai 602‑8566, Japan
    Copyright: © Ohara et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 114
    |
    Published online on: December 31, 2024
       https://doi.org/10.3892/ol.2024.14860
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Abstract

Cancer cachexia is a complex disorder characterized by skeletal muscle loss, which may influence the prognosis of patients with cancer. The cachexia index (CXI) is a new index for cachexia. The present study aimed to assess whether the CXI determined by bioelectrical impedance analysis (BIA) is valuable for predicting survival in patients with gastrointestinal cancer. A total of 54 patients with gastrointestinal cancer undergoing BIA at the time of diagnosis at Fukuchiyama City Hospital (Kyoto, Japan) were retrospectively recruited. CXI values were calculated as follows: CXI=skeletal muscle index (SMI) x serum albumin concentration/neutrophil‑to‑lymphocyte ratio. The SMI was measured using BIA values. The patients were classified into low‑ and high‑CXI groups. The median patient age was 72 years and 63.0% of patients were male. A total of 20 patients with colorectal cancer were enrolled, 12 with pancreatic cancer, 11 with gastric cancer, 6 with esophageal cancer, 4 with biliary tract cancer and 1 with liver cancer. The cumulative one‑year overall survival (OS) rate was significantly worse in the low‑CXI group compared with that in the high‑CXI group (58.3 vs. 88.5%; P=0.012). By contrast, the SMI had no significant effect on OS. Thus, CXI values using BIA may predict survival in patients with gastrointestinal cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Ohara T, Iwai N, Oka K, Okabe K, Sakai H, Tsuji T, Okuda T, Sakagami J, Kagawa K, Doi T, Doi T, et al: Clinical significance of cachexia index determined by bioelectrical impedance analysis in patients with gastrointestinal cancer. Oncol Lett 29: 114, 2025.
APA
Ohara, T., Iwai, N., Oka, K., Okabe, K., Sakai, H., Tsuji, T. ... Itoh, Y. (2025). Clinical significance of cachexia index determined by bioelectrical impedance analysis in patients with gastrointestinal cancer. Oncology Letters, 29, 114. https://doi.org/10.3892/ol.2024.14860
MLA
Ohara, T., Iwai, N., Oka, K., Okabe, K., Sakai, H., Tsuji, T., Okuda, T., Sakagami, J., Kagawa, K., Doi, T., Inoue, K., Dohi, O., Yoshida, N., Yamaguchi, K., Moriguchi, M., Uchiyama, K., Ishikawa, T., Takagi, T., Konishi, H., Itoh, Y."Clinical significance of cachexia index determined by bioelectrical impedance analysis in patients with gastrointestinal cancer". Oncology Letters 29.3 (2025): 114.
Chicago
Ohara, T., Iwai, N., Oka, K., Okabe, K., Sakai, H., Tsuji, T., Okuda, T., Sakagami, J., Kagawa, K., Doi, T., Inoue, K., Dohi, O., Yoshida, N., Yamaguchi, K., Moriguchi, M., Uchiyama, K., Ishikawa, T., Takagi, T., Konishi, H., Itoh, Y."Clinical significance of cachexia index determined by bioelectrical impedance analysis in patients with gastrointestinal cancer". Oncology Letters 29, no. 3 (2025): 114. https://doi.org/10.3892/ol.2024.14860
Copy and paste a formatted citation
x
Spandidos Publications style
Ohara T, Iwai N, Oka K, Okabe K, Sakai H, Tsuji T, Okuda T, Sakagami J, Kagawa K, Doi T, Doi T, et al: Clinical significance of cachexia index determined by bioelectrical impedance analysis in patients with gastrointestinal cancer. Oncol Lett 29: 114, 2025.
APA
Ohara, T., Iwai, N., Oka, K., Okabe, K., Sakai, H., Tsuji, T. ... Itoh, Y. (2025). Clinical significance of cachexia index determined by bioelectrical impedance analysis in patients with gastrointestinal cancer. Oncology Letters, 29, 114. https://doi.org/10.3892/ol.2024.14860
MLA
Ohara, T., Iwai, N., Oka, K., Okabe, K., Sakai, H., Tsuji, T., Okuda, T., Sakagami, J., Kagawa, K., Doi, T., Inoue, K., Dohi, O., Yoshida, N., Yamaguchi, K., Moriguchi, M., Uchiyama, K., Ishikawa, T., Takagi, T., Konishi, H., Itoh, Y."Clinical significance of cachexia index determined by bioelectrical impedance analysis in patients with gastrointestinal cancer". Oncology Letters 29.3 (2025): 114.
Chicago
Ohara, T., Iwai, N., Oka, K., Okabe, K., Sakai, H., Tsuji, T., Okuda, T., Sakagami, J., Kagawa, K., Doi, T., Inoue, K., Dohi, O., Yoshida, N., Yamaguchi, K., Moriguchi, M., Uchiyama, K., Ishikawa, T., Takagi, T., Konishi, H., Itoh, Y."Clinical significance of cachexia index determined by bioelectrical impedance analysis in patients with gastrointestinal cancer". Oncology Letters 29, no. 3 (2025): 114. https://doi.org/10.3892/ol.2024.14860
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