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Integrated analysis of non‑coding RNAs (HOTAIR and miR‑130a) and their cross‑talk with TGF‑β1, SIRT1 and E‑cadherin as potential biomarkers in colorectal cancer

  • Authors:
    • Ghada Ayeldeen
    • Bahaa Mohammed Badr
    • Olfat G. Shaker
    • Khaled Diab
    • Tarek I. Ahmed
    • Essam A. Hassan
    • Raghda A. Nagaty
    • Shaymaa Galal
    • Nabil A. Hasona
  • View Affiliations / Copyright

    Affiliations: Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Giza 12613, Egypt, Department of Basic Medical and Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa 13110, Jordan, Department of General Surgery, Faculty of Medicine, Fayoum University, Fayoum 63514, Egypt, Department of Internal Medicine, Faculty of Medicine, Fayoum University, Fayoum 63514, Egypt, Department of Tropical Medicine, Faculty of Medicine, Fayoum University, Fayoum 63514, Egypt, Clinical and Chemical Pathology Research Institute of Ophthalmology, Ministry of Higher Education and Scientific Research, Cairo 11694, Egypt, Department of Biochemistry, Modern University for Technology and Information, Cairo 11792, Egypt, Department of Biochemistry, Faculty of Science, Beni‑Suef University, Beni‑Suef 62511, Egypt
    Copyright: © Ayeldeen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 116
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    Published online on: January 3, 2025
       https://doi.org/10.3892/ol.2025.14863
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Abstract

Molecular changes have a substantial impact on the onset of colorectal cancer (CRC). Complexes of HOTAIR and miRNAs disrupt several cellular functions during carcinogenesis, primarily by disrupting several carcinogenic signaling pathways. In the present study, the relationships between the serum levels of transforming growth factor‑β1 (TGF‑β1), sirtuin‑1 (SIRT1) and E‑cadherin and those of HOX transcript antisense intergenic RNA (HOTAIR) and microRNA‑130a (miR‑130a) in individuals with CRC were analyzed, including their correlations and diagnostic potential. Patients with colon cancer and healthy volunteers were enrolled in the study. Blood samples were collected from 70 patients with CRC and 30 age‑matched healthy control volunteers and reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used to determine the serum levels of HOTAIR and miR‑130a. In addition, the levels of TGF‑β1, SIRT1 and E‑cadherin were determined utilizing enzyme‑linked immunosorbent assays. Patients with CRC were found to have significantly higher TGF‑β1, SIRT1, HOTAIR and miR‑130a serum levels than those of healthy participants. In addition, patients with high‑grade CRC had significantly higher levels of TGF‑β1, SIRT1, HOTAIR and miR‑130a compared with those of patients with low‑grade CRC. A significant reduction in the serum levels of E‑cadherin was observed in participants with CRC compared with healthy participants, but no significant difference was detected according to the grade of CRC. Positive correlations were found between HOTAIR and miR‑130a, as well as TGF‑β1 and SIRT1. By contrast, negative correlations were noted between E‑cadherin and HOTAIR, miR‑130a, TGF‑β1 and SIRT1. Therefore, it may be concluded that the miR‑130a/HOTAIR and TGF‑β1/SIRT1/E‑cadherin axes may serve as novel biomarkers for the early diagnosis of CRC.
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View References

1 

Sharma R, Abbasi-Kangevari M, Abd-Rabu R, Abidi H, Abu-Gharbieh E, Acuna JM, Adhikari S, Advani SM, Afzal MS, Aghaie Meybodi M, et al: Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: A systematic analysis for the global burden of disease study 2019. Lancet Gastroenterol Hepatol. 7:627–647. 2022. View Article : Google Scholar : PubMed/NCBI

2 

Goïta AA and Guenot D: Colorectal cancer: The contribution of CXCL12 and its receptors CXCR4 and CXCR7. Cancers (Basel). 14:18102022. View Article : Google Scholar : PubMed/NCBI

3 

Kumar A, Gautam V, Sandhu A, Rawat K, Sharma A and Saha L: Current and emerging therapeutic approaches for colorectal cancer: A comprehensive review. World J Gastrointest Surg. 15:495–519. 2023. View Article : Google Scholar : PubMed/NCBI

4 

Li Q, Geng S, Luo H, Wang W, Mo YQ, Luo Q, Wang L, Song GB, Sheng JP and Xu B: Signaling pathways involved in colorectal cancer: Pathogenesis and targeted therapy. Signal Transduct Target Ther. 9:2662024. View Article : Google Scholar : PubMed/NCBI

5 

Jayanthi P, Varun BR and Selvaraj J: Epithelial-mesenchymal transition in oral squamous cell carcinoma: An insight into molecular mechanisms and clinical implications. J Oral Maxillofac Pathol. 24:1892020. View Article : Google Scholar : PubMed/NCBI

6 

Xue VW, Chung JYF, Córdoba CAG, Cheung AH, Kang W, Lam EW, Leung KT, To KF, Lan HY and Tang PM: Transforming growth factor-β: A multifunctional regulator of cancer immunity. Cancers (Basel). 12:30992020. View Article : Google Scholar : PubMed/NCBI

7 

Baba AB, Rah B, Bhat GR, Mushtaq I, Parveen S, Hassan R, Hameed Zargar M and Afroze D: Transforming growth factor-beta (TGF-β) signaling in cancer-a betrayal within. Front Pharmacol. 13:7912722022. View Article : Google Scholar : PubMed/NCBI

8 

Jaiganesh A, Narui Y, Araya-Secchi R and Sotomayor M: Beyond cell-cell adhesion: Sensational cadherins for hearing and balance. Cold Spring Harb Perspect Biol. 10:a0292802018. View Article : Google Scholar : PubMed/NCBI

9 

Kaszak I, Witkowska-Piłaszewicz O, Niewiadomska Z, Dworecka-Kaszak B, Ngosa Toka F and Jurka P: Role of cadherins in cancer-a review. Int J Mol Sci. 21:76242020. View Article : Google Scholar : PubMed/NCBI

10 

Wu QJ, Zhang TN, Chen HH, Yu XF, Lv JL, Liu YY, Liu YS, Zheng G, Zhao JQ, Wei YF, et al: The sirtuin family in health and disease. Signal Transduct Target Ther. 7:4022022. View Article : Google Scholar : PubMed/NCBI

11 

Zhao L, Cao J, Hu K, He X, Yun D, Tong T and Han L: Sirtuins and their biological relevance in aging and age-related diseases. Aging Dis. 11:927–945. 2020. View Article : Google Scholar : PubMed/NCBI

12 

Lee GJ, Jung YH, Kim TJ, Chong Y, Jeong SW, Lee IK and Woo IS: Surtuin 1 as a potential prognostic biomarker in very elderly patients with colorectal cancer. Korean J Intern Med. 36 (Suppl 1):S235–S244. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Khalil EH, Shaker OG and Hasona NA: Impact of rs2107425 polymorphism and expression of lncH19 and miR-200a on the susceptibility of colorectal cancer. Indian J Clin Biochem. 38:331–337. 2023. View Article : Google Scholar : PubMed/NCBI

14 

Khalil EH, Shaker OG and Hasona NA: lncRNA H-19 and miR-200a implication and frequency of lncRNA H-19 rs2170425 SNP in ulcerative colitis and Crohn's disease. Comp Clin Pathol. 32:565–571. 2023. View Article : Google Scholar

15 

Colangelo T, Fucci A, Votino C, Sabatino L, Pancione M, Laudanna C, Binaschi M, Bigioni M, Maggi CA, Parente D, et al: MicroRNA-130b promotes tumor development and is associated with poor prognosis in colorectal cancer. Neoplasia. 15:1086–1099. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Khaliefa AK, Desouky EM, Hozayen WG, Shaaban SM and Hasona NA: miRNA-1246, HOTAIR, and IL-39 signature as potential diagnostic biomarkers in breast cancer. Noncoding RNA Res. 8:205–210. 2023. View Article : Google Scholar : PubMed/NCBI

17 

DiStefano JK and Gerhard GS: Long noncoding RNAs and human liver disease. Annu Rev Pathol. 17:1–21. 2022. View Article : Google Scholar : PubMed/NCBI

18 

Gao Y, Wang JW, Ren JY, Guo M, Guo CW, Ning SW and Yu S: Long noncoding RNAs in gastric cancer: From molecular dissection to clinical application. World J Gastroenterol. 26:3401–3412. 2020. View Article : Google Scholar : PubMed/NCBI

19 

Chen S, Zhang C and Feng M: Prognostic Value of LncRNA HOTAIR in colorectal cancer: A meta-analysis. Open Med (Wars). 15:76–83. 2020. View Article : Google Scholar : PubMed/NCBI

20 

Zhang J, Qiu WQ, Zhu H, Liu H, Sun JH, Chen Y, Shen H, Qian CL and Shen ZY: HOTAIR contributes to the carcinogenesis of gastric cancer via modulating cellular and exosomal miRNAs level. Cell Death Dis. 11:7802020. View Article : Google Scholar : PubMed/NCBI

21 

Jass JR, Sobin LH and Watanabe H: The World Health Organization's histologic classification of gastrointestinal tumors. A commentary on the second edition. Cancer. 66:2162–2167. 1990. View Article : Google Scholar : PubMed/NCBI

22 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Ayeldeen G, Shaker OG, Khairy AM, Elfert AY and Hasona NA: Signature of micro RNA 146a/215 and IL-6/TGF-β levels in a cross-link axis between obesity and colorectal cancer. Noncoding RNA Res. 8:187–191. 2023. View Article : Google Scholar : PubMed/NCBI

24 

Abdel Hameed NA, Shaker OG and Hasona NA: Significance of LINC00641 and miR-378 as a potential biomarker for colorectal cancer. Comp Clin Pathol. 31:807–814. 2022. View Article : Google Scholar

25 

Ratti M, Lampis A, Ghidini M, Salati M, Mirchev MB, Valeri N and Hahne JC: MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as new tools for cancer therapy: First steps from bench to bedside. Target Oncol. 15:261–278. 2020. View Article : Google Scholar : PubMed/NCBI

26 

Wang JY, Yang Y, Ma Y, Wang F, Xue A, Zhu J, Yang H, Chen Q, Chen M, Ye L, et al: Potential regulatory role of lncRNA-miRNA-mRNA axis in osteosarcoma. Biomed Pharmacother. 121:1096272020. View Article : Google Scholar : PubMed/NCBI

27 

Statello L, Guo CJ, Chen LL and Huarte M: Gene regulation by long non-coding RNAs and its biological functions. Nat Rev Mol Cell Biol. 22:96–118. 2021. View Article : Google Scholar : PubMed/NCBI

28 

Shengnan J, Dafei X, Hua J, Sunfu F, Xiaowei W and Liang X: Long non-coding RNA HOTAIR as a competitive endogenous RNA to sponge miR-206 to promote colorectal cancer progression by activating CCL2. J Cancer. 11:4431–4441. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Chen W, Tong K and Yu J: MicroRNA-130a is upregulated in colorectal cancer and promotes cell growth and motility by directly targeting forkhead box F2. Mol Med Rep. 16:5241–5248. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Liu L, Nie J, Chen L, Dong G, Du X, Wu X, Tang Y and Han W: The oncogenic role of microRNA-130a/301a/454 in human colorectal cancer via targeting Smad4 expression. PLoS One. 8:e555322013. View Article : Google Scholar : PubMed/NCBI

31 

Zhang M, Wu K, Zhang P, Qiu Y, Bai F and Chen H: HOTAIR Facilitates endocrine resistance in breast cancer through ESR1/miR-130b-3p axis: Comprehensive analysis of mRNA-miRNA-lncRNA network. Int J Gen Med. 14:4653–4663. 2021. View Article : Google Scholar : PubMed/NCBI

32 

Li T, Liu N, Gao Y, Quan Z, Hao Y, Yu C, Li L, Yuan M, Niu L, Luo C and Wu X: Long noncoding RNA HOTAIR regulates the invasion and metastasis of prostate cancer by targeting hepaCAM. Br J Cancer. 124:247–258. 2021. View Article : Google Scholar : PubMed/NCBI

33 

Ren MM, Xu S, Wei YB, Yang JJ, Yang YN, Sun SS, Li YJ, Wang PY and Xie SY: Roles of HOTAIR in lung cancer susceptibility and prognosis. Mol Genet Genomic Med. 8:e12992020. View Article : Google Scholar : PubMed/NCBI

34 

Zhang X, Huang L, Zhao Y and Tan W: Downregulation of miR-130a contributes to cisplatin resistance in ovarian cancer cells by targeting X-linked inhibitor of apoptosis (XIAP) directly. Acta Biochim Biophys Sin (Shanghai). 45:995–1001. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Wang L, Ji F, Liu G, Wang W, Li Z, Yue Y and Wang Z: Upregulation of circulating miR130a is correlated with development of Barrett's esophagus and esophageal adenocarcinoma. Onco Targets Ther. 12:1–7. 2018. View Article : Google Scholar : PubMed/NCBI

36 

El-Naidany SS, Zid E, Reda FM, Nada A and Fouda EAM: Clinical significance of MiR-130b and MiR-125b as biomarkers in hepatocellular carcinoma. Asian Pac J Cancer Prev. 23:2687–2693. 2022. View Article : Google Scholar : PubMed/NCBI

37 

Hu W, Zheng X, Liu J, Zhang M, Liang Y and Song M: MicroRNA MiR-130a-3p promotes gastric cancer by targeting Glucosaminyl N-acetyl transferase 4 (GCNT4) to regulate the TGF-β1/SMAD3 pathway. Bioengineered. 12:11634–11647. 2021. View Article : Google Scholar : PubMed/NCBI

38 

Wang J, Zhao L, Peng X, Liu K, Zhang C, Chen X, Han Y and Lai Y: Evaluation of miR-130 family members as circulating biomarkers for the diagnosis of bladder cancer. J Clin Lab Anal. 34:e235172020. View Article : Google Scholar : PubMed/NCBI

39 

Waldner MJ and Neurath MF: TGFβ and the tumor microenvironment in colorectal cancer. Cells. 12:11392023. View Article : Google Scholar : PubMed/NCBI

40 

Chan MKK, Chan ELY, Ji ZZ, Chan ASW, Li C, Leung KT, To KF and Tang PMK: Transforming growth factor-β signaling: From tumor microenvironment to anticancer therapy. Explor Target Antitumor Ther. 4:316–343. 2023. View Article : Google Scholar : PubMed/NCBI

41 

Khalil M, Desouky EM, Khaliefa AK, Hozyen WG, Mohamed SS and Hasona NA: Insights into the crosstalk between miR-200a/lncRNA H-19 and IL-6/SIRT-1 axis in breast cancer. J Interferon Cytokine Res. 44:191–197. 2024. View Article : Google Scholar : PubMed/NCBI

42 

Yu DF, Jiang SJ, Pan ZP, Cheng WD, Zhang WJ, Yao XK, Li YC and Lun YZ: Expression and clinical significance of Sirt1 in colorectal cancer. Oncol Lett. 11:1167–1172. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Hydru SP and Das NM: Expression of E-cadherin in colorectal cancer and its association with morphological features. J Evolution Med Dent Sci. 11:163–168. 2022. View Article : Google Scholar

44 

Nagathihalli NS and Merchant NB: Src-mediated regulation of E-cadherin and EMT in pancreatic cancer. Front Biosci (Landmark Ed). 17:2059–2069. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Carafa V, Altucci L and Nebbioso A: Dual tumor suppressor and tumor promoter action of sirtuins in determining malignant phenotype. Front Pharmacol. 9:4166872019.

46 

Palmirotta R, Cives M, Della-Morte D, Capuani B, Lauro D, Guadagni F and Silvestris F: Sirtuins and cancer: Role in the epithelial-mesenchymal transition. Oxid Med Cell Longev. 2016:30314592016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ayeldeen G, Badr BM, Shaker OG, Diab K, Ahmed TI, Hassan EA, Nagaty RA, Galal S and Hasona NA: Integrated analysis of non‑coding RNAs (HOTAIR and miR‑130a) and their cross‑talk with TGF‑β1, SIRT1 and E‑cadherin as potential biomarkers in colorectal cancer. Oncol Lett 29: 116, 2025.
APA
Ayeldeen, G., Badr, B.M., Shaker, O.G., Diab, K., Ahmed, T.I., Hassan, E.A. ... Hasona, N.A. (2025). Integrated analysis of non‑coding RNAs (HOTAIR and miR‑130a) and their cross‑talk with TGF‑β1, SIRT1 and E‑cadherin as potential biomarkers in colorectal cancer. Oncology Letters, 29, 116. https://doi.org/10.3892/ol.2025.14863
MLA
Ayeldeen, G., Badr, B. M., Shaker, O. G., Diab, K., Ahmed, T. I., Hassan, E. A., Nagaty, R. A., Galal, S., Hasona, N. A."Integrated analysis of non‑coding RNAs (HOTAIR and miR‑130a) and their cross‑talk with TGF‑β1, SIRT1 and E‑cadherin as potential biomarkers in colorectal cancer". Oncology Letters 29.3 (2025): 116.
Chicago
Ayeldeen, G., Badr, B. M., Shaker, O. G., Diab, K., Ahmed, T. I., Hassan, E. A., Nagaty, R. A., Galal, S., Hasona, N. A."Integrated analysis of non‑coding RNAs (HOTAIR and miR‑130a) and their cross‑talk with TGF‑β1, SIRT1 and E‑cadherin as potential biomarkers in colorectal cancer". Oncology Letters 29, no. 3 (2025): 116. https://doi.org/10.3892/ol.2025.14863
Copy and paste a formatted citation
x
Spandidos Publications style
Ayeldeen G, Badr BM, Shaker OG, Diab K, Ahmed TI, Hassan EA, Nagaty RA, Galal S and Hasona NA: Integrated analysis of non‑coding RNAs (HOTAIR and miR‑130a) and their cross‑talk with TGF‑β1, SIRT1 and E‑cadherin as potential biomarkers in colorectal cancer. Oncol Lett 29: 116, 2025.
APA
Ayeldeen, G., Badr, B.M., Shaker, O.G., Diab, K., Ahmed, T.I., Hassan, E.A. ... Hasona, N.A. (2025). Integrated analysis of non‑coding RNAs (HOTAIR and miR‑130a) and their cross‑talk with TGF‑β1, SIRT1 and E‑cadherin as potential biomarkers in colorectal cancer. Oncology Letters, 29, 116. https://doi.org/10.3892/ol.2025.14863
MLA
Ayeldeen, G., Badr, B. M., Shaker, O. G., Diab, K., Ahmed, T. I., Hassan, E. A., Nagaty, R. A., Galal, S., Hasona, N. A."Integrated analysis of non‑coding RNAs (HOTAIR and miR‑130a) and their cross‑talk with TGF‑β1, SIRT1 and E‑cadherin as potential biomarkers in colorectal cancer". Oncology Letters 29.3 (2025): 116.
Chicago
Ayeldeen, G., Badr, B. M., Shaker, O. G., Diab, K., Ahmed, T. I., Hassan, E. A., Nagaty, R. A., Galal, S., Hasona, N. A."Integrated analysis of non‑coding RNAs (HOTAIR and miR‑130a) and their cross‑talk with TGF‑β1, SIRT1 and E‑cadherin as potential biomarkers in colorectal cancer". Oncology Letters 29, no. 3 (2025): 116. https://doi.org/10.3892/ol.2025.14863
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