Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2025 Volume 29 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2025 Volume 29 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Case Report Open Access

Hyalinizing trabecular tumor of the thyroid: A case report

  • Authors:
    • Luyao Zhang
    • Qiang Ma
    • Zhixin Shen
    • Lu Guo
  • View Affiliations / Copyright

    Affiliations: Department of Thyroid and Breast Surgery, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong 261042, P.R. China, Department of Pathology, Sunshine Union Hospital, Weifang, Shandong 261000, P.R. China, Department of Oncology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong 261042, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 118
    |
    Published online on: January 3, 2025
       https://doi.org/10.3892/ol.2025.14865
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

A hyalinizing trabecular tumor (HTT), characterized by a trabecular growth pattern and notable hyalinization within the trabeculae, occurs at a rate of ~1%. As patients with HTT may be asymptomatic, accurate diagnosis is a challenge. Due to its resemblance to other tumors, such as papillary thyroid carcinoma and medullary thyroid carcinoma, a precise diagnosis necessitates both pathological and molecular examinations. Additionally, HTT is potentially malignant. The present study described the clinicopathological diagnosis of a patient with HTT; highlighting how an understanding of the clinical and pathological features of HTT is needed to provide an accurate differential diagnosis and thus tailor the treatment approach in order to effectively manage the disease.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Carney JA, Ryan J and Goellner JR: Hyalinizing trabecular adenoma of the thyroid gland. Am J Surg Pathol. 11:583–591. 1987. View Article : Google Scholar : PubMed/NCBI

2 

Hayashi S, Bandoh N, Baba S, Hayashi M, Goto T, Takahara M, Kato Y, Aimono E and Nishihara H: A case of hyalinizing trabecular tumor of the thyroid: Diagnostic significance of PAX8-GLIS3 fusion. Thyroid Res. 17:92024. View Article : Google Scholar : PubMed/NCBI

3 

Nielsen L, Gallardo AMC, Alonso PP, Medina LO, García EL, Del Arco CD, Jiménez RB, García LA, Blanco MC, González JV, et al: Diagnostic clues for hyalinizing trabecular tumor on fine needle aspiration cytology. Cytojournal. 20:192023. View Article : Google Scholar : PubMed/NCBI

4 

Alsogair O, Alalawi AA, Alzahim AF, Saleem MA, Aljohani FM and Alahmadi LS: Hyalinizing trabecular tumor of the thyroid gland: A case report and literature review. Cureus. 15:e378452023.PubMed/NCBI

5 

Umekita Y, Umeki K, Kawano F, Tanaka H and Kataoka H: Unusual papillary thyroid carcinoma with hyalinizing trabecular tumor-like feature in a young female patient: A case report. J Med Case Rep. 17:1122023. View Article : Google Scholar : PubMed/NCBI

6 

Casey MB, Sebo TJ and Carney JA: Hyalinizing trabecular adenoma of the thyroid gland identification through MIB-1 staining of fine-needle aspiration biopsy smears. Am J Clin Pathol. 122:506–510. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Nikiforova MN, Nikiforov YE and Ohori NP: GLIS rearrangements in thyroid nodules: A key to preoperative diagnosis of hyalinizing trabecular tumor. Cancer Cytopathol. 127:560–566. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Ito Y, Hirokawa M, Kousaka K, Ito M, Kihara M, Miya A and Miyauchi A: Diagnosis and management of hyalinizing trabecular tumor of the thyroid: A single-institution experience. Endocr J. 68:1403–1409. 2021. View Article : Google Scholar : PubMed/NCBI

9 

An FX, Zhao Y, Liu HG, Wen WJ and Yin YH: Fine Needle aspiration cytology of hyalinizing trabecular tumor of the thyroid. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 44:1040–1044. 2002.(In Chinese). PubMed/NCBI

10 

Zhou J, Yin L, Wei X, Zhang S, Song Y, Luo B, Li J, Qian L, Cui L, Chen W, et al: 2020 Chinese guidelines for ultrasound malignancy risk stratification of thyroid nodules: The C-TIRADS. Endocrine. 70:256–279. 2020. View Article : Google Scholar : PubMed/NCBI

11 

Ma JM, Wu LF, Wang G and Sun B: Progress in diagnosis and treatment of thyroid hyaline beam tumor. Chin J Pract Surg. 38:575–577. 2018.(In Chinese).

12 

Cheng CH: Hyalinizing trabecular tumor, a rare histologically unique tumor of the thyroid, coexisting with papillary thyroid carcinoma. Tzu Chi Med J. 33:198–199. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Rossi ED, Papotti M, Faquin W, Larocca LM and Pantanowitz L: The diagnosis of hyalinizing trabecular tumor: A difficult and controversial thyroid entity. Head Neck Pathol. 14:778–784. 2020. View Article : Google Scholar : PubMed/NCBI

14 

Hong B, Xu Y, Xiao Y and Yu X: Comparison of MIB-1-specific membrane staining in hyalinising trabecular tumor using mainstream automated immunohistochemical staining platforms. J Clin Lab Anal. 38:e251132024. View Article : Google Scholar : PubMed/NCBI

15 

Carney JA, Hirokawa M, Lloyd RV, Papotti M and Sebo TJ: Hyalinizing trabecular tumors of the thyroid gland are almost all benign. Am J Surg Pathol. 32:1877–1889. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Gowrishankar S, Pai SA and Carney JA: Hyalinizing trabecular carcinoma of the thyroid gland. Histopathology. 52:529–531. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Molberg K and Albores-Saavedra J: Hyalinizing trabecular carcinoma of the thyroid gland. Hum Pathol. 25:192–197. 1994. View Article : Google Scholar : PubMed/NCBI

18 

Sambade C, Franssila K, Cameselle-Teijeiro J, Nesland J and Sobrinho-Simões M: Hyalinizing trabecular adenoma: A misnomer for a peculiar tumor of the thyroid gland. Endocr Pathol. 2:83–91. 1991. View Article : Google Scholar : PubMed/NCBI

19 

Howard BE, Gnagi SH, Ocal IT and Hinni ML: Hyalinizing trabecular tumor masquerading as papillary thyroid carcinoma on fine-needle aspiration. ORL J Otorhinolaryngol Relat Spec. 75:309–313. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Chu S: Hyalinizing trabecular tumor of the thyroid: A case report. Asian J Surg. 46:5559–5560. 2023. View Article : Google Scholar : PubMed/NCBI

21 

Liu Y, Huang X, Hu Y, Wang F, Du T, He W, Chen L, Lang B, Pu Q and Chen H: Hyalinizing trabecular tumor of the thyroid: A clinicopathological analysis of four cases and review of the literature. Int J Clin Exp Pathol. 10:7616–7626. 2017.PubMed/NCBI

22 

Mahjabin F, Gonsalves C, Drew PA, Mukhtar F and Leon ME: Understanding and overcoming the pitfalls in cytopathological diagnosis of hyalinizing trabecular tumor of thyroid. Int J Surg Pathol. 32:91–96. 2024. View Article : Google Scholar : PubMed/NCBI

23 

Basili T, Dopeso H, Kim SH, Ferrando L, Pareja F, Da Cruz Paula A, da Silva EM, Stylianou A, Maroldi A, Marchiò C, et al: Oncogenic properties and signaling basis of the PAX8-GLIS3 fusion gene. Int J Cancer. 147:2253–2264. 2020. View Article : Google Scholar : PubMed/NCBI

24 

Stojanović S, Šelemetjev S, Đorić I, Janković Miljuš J, Tatić S, Živaljević V and Išić Denčić T: BRAFV600E, BANCR, miR-203a-3p and miR-204-3p in risk stratification of PTC patients. Biomedicines. 11:33382023. View Article : Google Scholar : PubMed/NCBI

25 

Sheu SY, Vogel E, Worm K, Grabellus F, Schwertheim S and Schmid KW: Hyalinizing trabecular tumour of the thyroid-differential expression of distinct miRNAs compared with papillary thyroid carcinoma. Histopathology. 56:632–640. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Jones DJ, Kieliszak CR, Patel SS and Selinsky CR: Hyalinizing trabecular tumor of the thyroid gland and its significant diagnostic issue. Thyroid Res. 10:72017. View Article : Google Scholar : PubMed/NCBI

27 

Podany P and Gilani SM: Hyalinizing trabecular tumor: Cytologic, histologic and molecular features and diagnostic considerations. Ann Diagn Pathol. 54:1518032021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Ma Q, Shen Z and Guo L: Hyalinizing trabecular tumor of the thyroid: A case report. Oncol Lett 29: 118, 2025.
APA
Zhang, L., Ma, Q., Shen, Z., & Guo, L. (2025). Hyalinizing trabecular tumor of the thyroid: A case report. Oncology Letters, 29, 118. https://doi.org/10.3892/ol.2025.14865
MLA
Zhang, L., Ma, Q., Shen, Z., Guo, L."Hyalinizing trabecular tumor of the thyroid: A case report". Oncology Letters 29.3 (2025): 118.
Chicago
Zhang, L., Ma, Q., Shen, Z., Guo, L."Hyalinizing trabecular tumor of the thyroid: A case report". Oncology Letters 29, no. 3 (2025): 118. https://doi.org/10.3892/ol.2025.14865
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Ma Q, Shen Z and Guo L: Hyalinizing trabecular tumor of the thyroid: A case report. Oncol Lett 29: 118, 2025.
APA
Zhang, L., Ma, Q., Shen, Z., & Guo, L. (2025). Hyalinizing trabecular tumor of the thyroid: A case report. Oncology Letters, 29, 118. https://doi.org/10.3892/ol.2025.14865
MLA
Zhang, L., Ma, Q., Shen, Z., Guo, L."Hyalinizing trabecular tumor of the thyroid: A case report". Oncology Letters 29.3 (2025): 118.
Chicago
Zhang, L., Ma, Q., Shen, Z., Guo, L."Hyalinizing trabecular tumor of the thyroid: A case report". Oncology Letters 29, no. 3 (2025): 118. https://doi.org/10.3892/ol.2025.14865
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team