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Advances of signal transducer and activator of transcription 3 inhibitors in acute myeloid leukemia (Review)

  • Authors:
    • Hui Cheng
    • Li Chen
    • Chongmei Huang
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    Affiliations: Department of Hematology, First Affiliated Hospital, Naval Medical University, Shanghai 200433, P.R. China, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China
    Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 134
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    Published online on: January 8, 2025
       https://doi.org/10.3892/ol.2025.14881
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Abstract

Signal transducer and activator of transcription 3 (STAT3), a crucial transcription factor, exerts a notable influence by hyperactivating or acquiring functional mutations in the occurrence and progression of cancers. Hyperactive STAT3 is also implicated in a range of hematopoietic malignancies, especially acute myeloid leukemia (AML). The function of STAT3 is associated with the phosphorylated parallel dimer structure, enabling them to stimulate the transcription of specific genes. AML is a highly heterogeneous hematological malignancy, which is challenging in terms of therapy. The current efficacy of chemotherapy and targeted therapy remains suboptimal. Targeted inhibition of STAT3 has the potential to enhance the efficacy of AML treatment, thereby possibly improving the prognosis of individuals suffering from AML. The present review summarizes the development of inhibitors against STAT3 and discusses their applicability as AML therapeutics, which could inspire new possibilities for enhancing AML treatment strategies.
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Spandidos Publications style
Cheng H, Chen L and Huang C: Advances of signal transducer and activator of transcription 3 inhibitors in acute myeloid leukemia (Review). Oncol Lett 29: 134, 2025.
APA
Cheng, H., Chen, L., & Huang, C. (2025). Advances of signal transducer and activator of transcription 3 inhibitors in acute myeloid leukemia (Review). Oncology Letters, 29, 134. https://doi.org/10.3892/ol.2025.14881
MLA
Cheng, H., Chen, L., Huang, C."Advances of signal transducer and activator of transcription 3 inhibitors in acute myeloid leukemia (Review)". Oncology Letters 29.3 (2025): 134.
Chicago
Cheng, H., Chen, L., Huang, C."Advances of signal transducer and activator of transcription 3 inhibitors in acute myeloid leukemia (Review)". Oncology Letters 29, no. 3 (2025): 134. https://doi.org/10.3892/ol.2025.14881
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Spandidos Publications style
Cheng H, Chen L and Huang C: Advances of signal transducer and activator of transcription 3 inhibitors in acute myeloid leukemia (Review). Oncol Lett 29: 134, 2025.
APA
Cheng, H., Chen, L., & Huang, C. (2025). Advances of signal transducer and activator of transcription 3 inhibitors in acute myeloid leukemia (Review). Oncology Letters, 29, 134. https://doi.org/10.3892/ol.2025.14881
MLA
Cheng, H., Chen, L., Huang, C."Advances of signal transducer and activator of transcription 3 inhibitors in acute myeloid leukemia (Review)". Oncology Letters 29.3 (2025): 134.
Chicago
Cheng, H., Chen, L., Huang, C."Advances of signal transducer and activator of transcription 3 inhibitors in acute myeloid leukemia (Review)". Oncology Letters 29, no. 3 (2025): 134. https://doi.org/10.3892/ol.2025.14881
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