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The role of lnc‑MAPKAPK5‑AS1 in immune cell infiltration in hepatocellular carcinoma: Bioinformatics analysis and validation

  • Authors:
    • Xiangzhi Hu
    • Dedong Wang
    • Jinbin Chen
    • Boheng Liang
    • Lin Zhang
    • Pengzhe Qin
    • Di Wu
  • View Affiliations / Copyright

    Affiliations: Guangzhou Center for Disease Control and Prevention, School of Public Health, Guangzhou Medical University, Guangzhou, Guangdong 511436, P.R. China, Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 141
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    Published online on: January 14, 2025
       https://doi.org/10.3892/ol.2025.14887
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Abstract

The oncogenic and tumor suppressor roles of lnc‑MAPKAPK5‑AS1 in multiple cancers suggest its complexity in modulating cancer progression. The expression and promoter methylation level of lnc‑MAPKAPK5‑AS1 in hepatocellular carcinoma (HCC) was investigated through data mining from The Cancer Genome Atlas and Gene Expression Omnibus and its significance in prognosis and immunity was explored. lnc‑MAPKAPK5‑AS1 was co‑expressed with its protein‑coding gene MAPKAPK5 in HCC and exhibited upregulation in HCC tissues as a result of hypomethylation of its promoter region. High expression of lnc‑MAPKAPK5‑AS1 was associated with poor prognosis. Enrichment analysis revealed that lnc‑MAPKAPK5‑AS1 is involved in immune and metabolic‑related pathways. Changes in the expression of lnc‑MAPKAPK5‑AS1 affected plasma cells, T cells CD4+ memory resting, NK cells, macrophages M0/M1, and mast cells resting in the tumor microenvironment. lnc‑MAPKAPK5‑AS1 was found to correlate with multiple immune checkpoints. Analysis of the Sangerbox database revealed positive relationships between expression of lnc‑MAPKAPK5‑AS1, tumor mutational burden and microsatellite instability, which suggested that immunotherapy may be effective in tumors with high expression of lnc‑MAPKAPK5‑AS1. The expression of lnc‑MAPKAPK5‑AS1 was verified to indicate sensitivity to 16 common targeted drugs. Immunohistochemistry confirmed the expression of MAPKAPK5 protein in HCC and its prognostic significance. Weighted gene co‑expression network analysis was applied to identify hub genes related to both immunoreactive score and gene expression. These results revealed that lnc‑MAPKAPK5‑AS1 may be involved in the occurrence and development of HCC as an oncogene and may represent a potential therapeutic target through modulating the substance metabolism and immune response.
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1 

Xie DY, Ren ZG, Zhou J, Fan J and Gao Q: 2019 Chinese clinical guidelines for the management of hepatocellular carcinoma: Updates and insights. Hepatobiliary Surg Nutr. 9:452–463. 2020. View Article : Google Scholar : PubMed/NCBI

2 

Xu XF, Xing H, Han J, Li ZL, Lau WY, Zhou YH, Gu WM, Wang H, Chen TH, Zeng YY, et al: Risk factors, patterns, and outcomes of late recurrence after liver resection for hepatocellular carcinoma: A multicenter study from China. JAMA Surg. 154:209–217. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Ahn JC, Lee YT, Agopian VG, Zhu Y, You S, Tseng HR and Yang JD: Hepatocellular carcinoma surveillance: Current practice and future directions. Hepatoma Res. 8:102022.PubMed/NCBI

4 

Mercer TR, Dinger ME and Mattick JS: Long non-coding RNAs: Insights into functions. Nat Rev Genet. 10:155–159. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Luo S, Lu JY, Liu L, Yin Y, Chen C, Han X, Wu B, Xu R, Liu W, Yan P, et al: Divergent lncRNAs regulate gene expression and lineage differentiation in pluripotent cells. Cell Stem Cell. 18:637–652. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Wang H, Shi Y, Chen CH, Wen Y, Zhou Z, Yang C, Sun J, Du G, Wu J, Mao X, et al: KLF5-induced lncRNA IGFL2-AS1 promotes basal-like breast cancer cell growth and survival by upregulating the expression of IGFL1. Cancer Lett. 515:49–62. 2021. View Article : Google Scholar : PubMed/NCBI

7 

Ji H, Hui B, Wang J, Zhu Y, Tang L, Peng P, Wang T, Wang L, Xu S, Li J and Wang K: Long noncoding RNA MAPKAPK5-AS1s promotes colorectal cancer proliferation by partly silencing p21 expression. Cancer Sci. 110:72–85. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Yang T, Chen WC, Shi PC, Liu MR, Jiang T, Song H, Wang JQ, Fan RZ, Pei DS and Song J: Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer progression by cis-regulating the nearby gene MK5 and acting as a let-7f-1-3p sponge. J Exp Clin Cancer Res. 39:1392020. View Article : Google Scholar : PubMed/NCBI

9 

Zhang H, Wang Y and Lu J: Identification of lung-adenocarcinoma-related long non-coding RNAs by random walking on a competing endogenous RNA network. Ann Transl Med. 7:3392019. View Article : Google Scholar : PubMed/NCBI

10 

Gao GF, Parker JS, Reynolds SM, Silva TC, Wang LB, Zhou W, Akbani R, Bailey M, Balu S, Berman BP, et al: Before and after: Comparison of legacy and harmonized TCGA genomic data commons' data. Cell Syst. 9:24–34.e10. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al: NCBI GEO: Archive for functional genomics data sets-update. Nucleic Acids Res. 41((Database issue)): D991–D995. 2013.PubMed/NCBI

12 

Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C and Chanda SK: Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 10:15232019. View Article : Google Scholar : PubMed/NCBI

13 

Newman AM, Liu CL, Green MR, Gentles AJ, Feng W, Xu Y, Hoang CD, Diehn M and Alizadeh AA: Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 12:453–457. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES and Mesirov JP: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 102:15545–15550. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Li H, Liu C, Huang S, Wang X, Cao M, Gu T, Ou X, Pan S, Lin Z, Wang X, et al: Multi-omics analyses demonstrate the modulating role of gut microbiota on the associations of unbalanced dietary intake with gastrointestinal symptoms in children with autism spectrum disorder. Gut Microbes. 15:22813502023. View Article : Google Scholar : PubMed/NCBI

16 

Song J, Ren K, Zhang D, Lv X, Sun L, Deng Y and Zhu H: A novel signature combing cuproptosis- and ferroptosis-related genes in sepsis-induced cardiomyopathy. Front Genet. 14:11707372023. View Article : Google Scholar : PubMed/NCBI

17 

Rukhsan A, Supty AT, Hussain M and Lee Y: STK3 higher expression association with clinical characteristics in intrinsic subtypes of breast cancer invasive ductal carcinoma patients. Breast Cancer Res Treat. 206:119–129. 2024. View Article : Google Scholar : PubMed/NCBI

18 

Reimand J, Isserlin R, Voisin V, Kucera M, Tannus-Lopes C, Rostamianfar A, Wadi L, Meyer M, Wong J, Xu C, et al: Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, cytoscape and EnrichmentMap. Nat Protoc. 14:482–517. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Li T, Fan J, Wang B, Traugh N, Chen Q, Liu JS, Li B and Liu XS: TIMER: A web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 77:e108–e110. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Samstein RM, Lee CH, Shoushtari AN, Hellmann MD, Shen R, Janjigian YY, Barron DA, Zehir A, Jordan EJ, Omuro A, et al: Tumor mutational load predicts survival after immunotherapy across multiple cancer types. Nat Genet. 51:202–206. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Klein O, Kee D, Markman B, Carlino MS, Underhill C, Palmer J, Power D, Cebon J and Behren A: Evaluation of TMB as a predictive biomarker in patients with solid cancers treated with anti-PD-1/CTLA-4 combination immunotherapy. Cancer Cell. 39:592–593. 2021. View Article : Google Scholar : PubMed/NCBI

22 

Goodman AM, Kato S, Bazhenova L, Patel SP, Frampton GM, Miller V, Stephens PJ, Daniels GA and Kurzrock R: Tumor mutational burden as an independent predictor of response to immunotherapy in diverse cancers. Mol Cancer Ther. 16:2598–2608. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Feng D, Hui X, Shi-Chun L, Yan-Hua B, Li C, Xiao-Hui L and Jie-Yu Y: Initial experience of anti-PD1 therapy with nivolumab in advanced hepatocellular carcinoma. Oncotarget. 8:96649–96655. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Geeleher P, Cox NJ and Huang RS: Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines. Genome Biol. 15:R472014. View Article : Google Scholar : PubMed/NCBI

25 

Maeser D, Gruener RF and Huang RS: oncoPredict: An R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data. Brief Bioinform. 22:bbab2602021. View Article : Google Scholar : PubMed/NCBI

26 

Xiong Y, Wei Y, Gu Y, Zhang S, Lyu J, Zhang B, Chen C, Zhu J, Wang Y, Liu H and Zhang Y: DiseaseMeth version 2.0: A major expansion and update of the human disease methylation database. Nucleic Acids Res. 45((D1)): D888–D895. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

28 

Mas-Ponte D, Carlevaro-Fita J, Palumbo E, Hermoso Pulido T, Guigo R and Johnson R: LncATLAS database for subcellular localization of long noncoding RNAs. RNA. 23:1080–1087. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Li JH, Liu S, Zhou H, Qu LH and Yang JH: starBase v2.0: Decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 42((Database issue)): D92–D97. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Langfelder P and Horvath S: WGCNA: An R package for weighted correlation network analysis. BMC Bioinformatics. 9:5592008. View Article : Google Scholar : PubMed/NCBI

31 

Szklarczyk D, Morris JH, Cook H, Kuhn M, Wyder S, Simonovic M, Santos A, Doncheva NT, Roth A, Bork P, et al: The STRING database in 2017: Quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res. 45:D362–D368. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Wakiyama H, Masuda T, Motomura Y, Hu Q, Tobo T, Eguchi H, Sakamoto K, Hirakawa M, Honda H and Mimori K: Cytolytic activity (CYT) score is a prognostic biomarker reflecting host immune status in hepatocellular Carcinoma (HCC). Anticancer Res. 38:6631–6638. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Seiwert TY, Burtness B, Mehra R, Weiss J, Berger R, Eder JP, Heath K, McClanahan T, Lunceford J, Gause C, et al: Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): An open-label, multicentre, phase 1b trial. Lancet Oncol. 17:956–965. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Chandrashekar DS, Karthikeyan SK, Korla PK, Patel H, Shovon AR, Athar M, Netto GJ, Qin ZS, Kumar S, Manne U, et al: UALCAN: An update to the integrated cancer data analysis platform. Neoplasia. 25:18–27. 2022. View Article : Google Scholar : PubMed/NCBI

35 

Zheng Z, Liu J, Yang Z, Wu L, Xie H, Jiang C, Lin B, Chen T, Xing C, Liu Z, et al: MicroRNA-452 promotes stem-like cells of hepatocellular carcinoma by inhibiting Sox7 involving Wnt/β-catenin signaling pathway. Oncotarget. 7:28000–28012. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Bertucci F, Chaffanet M and Birnbaum D: An ICGC major achievement in breast cancer: A comprehensive catalog of mutations and mutational signatures. Chin Clin Oncol. 6:42017. View Article : Google Scholar : PubMed/NCBI

37 

Li Z, Lin Y, Cheng B, Zhang Q and Cai Y: Identification and analysis of potential key genes associated with hepatocellular carcinoma based on integrated bioinformatics methods. Front Genet. 12:5712312021. View Article : Google Scholar : PubMed/NCBI

38 

Cui XY, Zhan JK and Liu YS: Roles and functions of antisense lncRNA in vascular aging. Ageing Res Rev. 72:1014802021. View Article : Google Scholar : PubMed/NCBI

39 

Wang J, Su Z, Lu S, Fu W, Liu Z, Jiang X and Tai S: LncRNA HOXA-AS2 and its molecular mechanisms in human cancer. Clin Chim Acta. 485:229–233. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Wang Y, Yang L, Chen T, Liu X, Guo Y, Zhu Q, Tong X, Yang W, Xu Q, Huang D and Tu K: A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis. Mol Cancer. 18:282019. View Article : Google Scholar : PubMed/NCBI

41 

Zhang JY, Weng MZ, Song FB, Xu YG, Liu Q, Wu JY, Qin J, Jin T and Xu JM: Long noncoding RNA AFAP1-AS1 indicates a poor prognosis of hepatocellular carcinoma and promotes cell proliferation and invasion via upregulation of the RhoA/Rac2 signaling. Int J Oncol. 48:1590–1598. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Cheng M, Zhang J, Cao PB and Zhou GQ: Prognostic and predictive value of the hypoxia-associated long non-coding RNA signature in hepatocellular carcinoma. Yi Chuan. 44:153–167. 2022.PubMed/NCBI

43 

Wang W, Zhao Z, Yang F, Wang H, Wu F, Liang T, Yan X, Li J, Lan Q, Wang J and Zhao J: An immune-related lncRNA signature for patients with anaplastic gliomas. J Neurooncol. 136:263–271. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Zhang J, Fan D, Jian Z, Chen GG and Lai PB: Cancer specific long noncoding RNAs show differential expression patterns and competing endogenous RNA potential in hepatocellular carcinoma. PLoS One. 10:e01410422015. View Article : Google Scholar : PubMed/NCBI

45 

Yang J, Xu QC, Wang ZY, Lu X, Pan LK, Wu J and Wang C: Integrated analysis of an lncRNA-associated ceRNA network reveals potential biomarkers for hepatocellular carcinoma. J Computat Biol. 28:330–344. 2021. View Article : Google Scholar

46 

Peng Z, Ouyang X, Wang Y and Fan Q: MAPKAPK5-AS1 drives the progression of hepatocellular carcinoma via regulating miR-429/ZEB1 axis. BMC Mol Cell Biol. 23:212022. View Article : Google Scholar : PubMed/NCBI

47 

Wedemeyer H, Hofmann WP, Lueth S, Malinski P, Thimme R, Tacke F and Wiegand J: (ALT screening for chronic liver diseases: Scrutinizing the evidence). Z Gastroenterol. 48:46–55. 2010.(In German). View Article : Google Scholar : PubMed/NCBI

48 

Han P, Lei Y, Liu J, Liu J, Huang H, Tian D and Yan W: Cell adhesion molecule BVES functions as a suppressor of tumor cells extrusion in hepatocellular carcinoma metastasis. Cell Commun Signal. 20:1492022. View Article : Google Scholar : PubMed/NCBI

49 

Xu Y, Feng K, Zhao H, Di L, Wang L and Wang R: Tumor-derived extracellular vesicles as messengers of natural products in cancer treatment. Theranostics. 12:1683–1714. 2022. View Article : Google Scholar : PubMed/NCBI

50 

Luu M, Riester Z, Baldrich A, Reichardt N, Yuille S, Busetti A, Klein M, Wempe A, Leister H, Raifer H, et al: Microbial short-chain fatty acids modulate CD8(+) T cell responses and improve adoptive immunotherapy for cancer. Nat Commun. 12:40772021. View Article : Google Scholar : PubMed/NCBI

51 

Ringelhan M, Pfister D, O'Connor T, Pikarsky E and Heikenwalder M: The immunology of hepatocellular carcinoma. Nat Immunol. 19:222–232. 2018. View Article : Google Scholar : PubMed/NCBI

52 

Gregory SN, Perati SR and Brown ZJ: Alteration in immune function in patients with fatty liver disease. Hepatoma Res. 8:312022. View Article : Google Scholar

53 

Zhang S, Liu Z, Wu D, Chen L and Xie L: Single-Cell RNA-Seq analysis reveals microenvironmental infiltration of plasma cells and hepatocytic prognostic markers in HCC with Cirrhosis. Front Oncol. 10:5963182020. View Article : Google Scholar : PubMed/NCBI

54 

Zong Z, Zou J, Mao R, Ma C, Li N, Wang J, Wang X, Zhou H, Zhang L and Shi Y: M1 macrophages induce PD-L1 expression in hepatocellular carcinoma cells through IL-1β signaling. Front Immunol. 10:16432019. View Article : Google Scholar : PubMed/NCBI

55 

Yao S and Chen L: PD-1 as an immune modulatory receptor. Cancer J. 20:262–264. 2014. View Article : Google Scholar : PubMed/NCBI

56 

Chen X, Du Y, Hu Q and Huang Z: Tumor-derived CD4+CD25+regulatory T cells inhibit dendritic cells function by CTLA-4. Pathol Res Pract. 213:245–249. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Rizvi H, Sanchez-Vega F, La K, Chatila W, Jonsson P, Halpenny D, Plodkowski A, Long N, Sauter JL, Rekhtman N, et al: Molecular determinants of response to anti-programmed cell death (PD)-1 and anti-programmed death-ligand 1 (PD-L1) blockade in patients with non-small-cell lung cancer profiled with targeted next-generation sequencing. J Clin Oncol. 36:633–641. 2018. View Article : Google Scholar : PubMed/NCBI

58 

Yarchoan M, Albacker LA, Hopkins AC, Montesion M, Murugesan K, Vithayathil TT, Zaidi N, Azad NS, Laheru DA, Frampton GM and Jaffee EM: PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers. JCI Insight. 4:e1269082019. View Article : Google Scholar : PubMed/NCBI

59 

Yarchoan M, Hopkins A and Jaffee EM: Tumor mutational burden and response rate to PD-1 inhibition. N Engl J Med. 377:2500–2501. 2017. View Article : Google Scholar : PubMed/NCBI

60 

Jiang J, Jin Z, Zhang Y, Peng L, Zhang Y, Zhu Z, Wang Y, Tong D, Yang Y, Wang J, et al: Robust prediction of immune checkpoint inhibition therapy for non-small cell lung cancer. Front Immunol. 12:6468742021. View Article : Google Scholar : PubMed/NCBI

61 

Cai H, Zhang Y, Zhang H, Cui C, Li C and Lu S: Prognostic role of tumor mutation burden in hepatocellular carcinoma after radical hepatectomy. J Surg Oncol. 121:1007–1014. 2020. View Article : Google Scholar : PubMed/NCBI

62 

Huo J, Wu L and Zang Y: A prognostic model of 15 immune-related gene pairs associated with tumor mutation burden for hepatocellular carcinoma. Front Mol Biosci. 7:5813542020. View Article : Google Scholar : PubMed/NCBI

63 

Tao L, Li D, Mu S, Tian G and Yan G: LncRNA MAPKAPK5_AS1 facilitates cell proliferation in hepatitis B virus -related hepatocellular carcinoma. Lab Invest. 102:494–504. 2022. View Article : Google Scholar : PubMed/NCBI

64 

Wang X, Wang J, Shen H, Luo Z and Lu X: Downregulation of TPX2 impairs the antitumor activity of CD8+ T cells in hepatocellular carcinoma. Cell Death Dis. 13:2232022. View Article : Google Scholar : PubMed/NCBI

65 

He K, Xie M, Li J, He Y and Yin Y: CENPO is associated with immune cell infiltration and is a potential diagnostic and prognostic marker for hepatocellular carcinoma. Int J Gen Med. 15:7493–7510. 2022. View Article : Google Scholar : PubMed/NCBI

66 

Si T, Huang Z, Jiang Y, Walker-Jacobs A, Gill S, Hegarty R, Hamza M, Khorsandi SE, Jassem W, Heaton N and Ma Y: Expression levels of three key genes CCNB1, CDΧ20, and CENPF in HCC are associated with antitumor Immunity. Front Oncol. 11:7388412021. View Article : Google Scholar : PubMed/NCBI

67 

Xu D, Wang Y, Wu J, Zhang Z, Chen J, Xie M, Tang R, Chen C, Chen L, Lin S, et al: ECT2 overexpression promotes the polarization of tumor-associated macrophages in hepatocellular carcinoma via the ECT2/PLK1/PTEN pathway. Cell Death Dis. 12:1622021. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hu X, Wang D, Chen J, Liang B, Zhang L, Qin P and Wu D: The role of lnc‑MAPKAPK5‑AS1 in immune cell infiltration in hepatocellular carcinoma: Bioinformatics analysis and validation. Oncol Lett 29: 141, 2025.
APA
Hu, X., Wang, D., Chen, J., Liang, B., Zhang, L., Qin, P., & Wu, D. (2025). The role of lnc‑MAPKAPK5‑AS1 in immune cell infiltration in hepatocellular carcinoma: Bioinformatics analysis and validation. Oncology Letters, 29, 141. https://doi.org/10.3892/ol.2025.14887
MLA
Hu, X., Wang, D., Chen, J., Liang, B., Zhang, L., Qin, P., Wu, D."The role of lnc‑MAPKAPK5‑AS1 in immune cell infiltration in hepatocellular carcinoma: Bioinformatics analysis and validation". Oncology Letters 29.3 (2025): 141.
Chicago
Hu, X., Wang, D., Chen, J., Liang, B., Zhang, L., Qin, P., Wu, D."The role of lnc‑MAPKAPK5‑AS1 in immune cell infiltration in hepatocellular carcinoma: Bioinformatics analysis and validation". Oncology Letters 29, no. 3 (2025): 141. https://doi.org/10.3892/ol.2025.14887
Copy and paste a formatted citation
x
Spandidos Publications style
Hu X, Wang D, Chen J, Liang B, Zhang L, Qin P and Wu D: The role of lnc‑MAPKAPK5‑AS1 in immune cell infiltration in hepatocellular carcinoma: Bioinformatics analysis and validation. Oncol Lett 29: 141, 2025.
APA
Hu, X., Wang, D., Chen, J., Liang, B., Zhang, L., Qin, P., & Wu, D. (2025). The role of lnc‑MAPKAPK5‑AS1 in immune cell infiltration in hepatocellular carcinoma: Bioinformatics analysis and validation. Oncology Letters, 29, 141. https://doi.org/10.3892/ol.2025.14887
MLA
Hu, X., Wang, D., Chen, J., Liang, B., Zhang, L., Qin, P., Wu, D."The role of lnc‑MAPKAPK5‑AS1 in immune cell infiltration in hepatocellular carcinoma: Bioinformatics analysis and validation". Oncology Letters 29.3 (2025): 141.
Chicago
Hu, X., Wang, D., Chen, J., Liang, B., Zhang, L., Qin, P., Wu, D."The role of lnc‑MAPKAPK5‑AS1 in immune cell infiltration in hepatocellular carcinoma: Bioinformatics analysis and validation". Oncology Letters 29, no. 3 (2025): 141. https://doi.org/10.3892/ol.2025.14887
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