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Article Open Access

Integrated analysis of FANCE expression and its regulatory role in the immune microenvironment of oral squamous cell carcinoma

  • Authors:
    • Bo Lin
    • Yuling Chen
    • Xiaolian Li
    • Yuntao Lin
    • Jian Zhou
    • Hongyu Yang
    • Yuehong Shen
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Stomatological Center, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China, Department of Oral and Maxillofacial Surgery, Stomatological Center, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 160
    |
    Published online on: January 24, 2025
       https://doi.org/10.3892/ol.2025.14906
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Abstract

Oral squamous cell carcinoma (OSCC) presents a significant health challenge owing to its complex origin and limited treatment success. The precise function of Fanconi anemia complementation group E (FANCE), a key gene involved in DNA repair in OSCC, remains unclear. The present study performed bioinformatics analysis of The Cancer Genome Atlas dataset and cellular experiments to demonstrate that FANCE is significantly upregulated in OSCC. Enhanced FANCE expression was associated with poor survival outcome in patients with OSCC. Knockdown of FANCE inhibited OSCC cell proliferation and migration. Moreover, a negative correlation was observed between FANCE expression and immune cell markers. Collectively, these findings suggest that FANCE is a potential oncogene in OSCC and a prognostic biomarker that may play a role in modulating the OSCC microenvironment.
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Copy and paste a formatted citation
Spandidos Publications style
Lin B, Chen Y, Li X, Lin Y, Zhou J, Yang H and Shen Y: Integrated analysis of FANCE expression and its regulatory role in the immune microenvironment of oral squamous cell carcinoma. Oncol Lett 29: 160, 2025.
APA
Lin, B., Chen, Y., Li, X., Lin, Y., Zhou, J., Yang, H., & Shen, Y. (2025). Integrated analysis of FANCE expression and its regulatory role in the immune microenvironment of oral squamous cell carcinoma. Oncology Letters, 29, 160. https://doi.org/10.3892/ol.2025.14906
MLA
Lin, B., Chen, Y., Li, X., Lin, Y., Zhou, J., Yang, H., Shen, Y."Integrated analysis of FANCE expression and its regulatory role in the immune microenvironment of oral squamous cell carcinoma". Oncology Letters 29.3 (2025): 160.
Chicago
Lin, B., Chen, Y., Li, X., Lin, Y., Zhou, J., Yang, H., Shen, Y."Integrated analysis of FANCE expression and its regulatory role in the immune microenvironment of oral squamous cell carcinoma". Oncology Letters 29, no. 3 (2025): 160. https://doi.org/10.3892/ol.2025.14906
Copy and paste a formatted citation
x
Spandidos Publications style
Lin B, Chen Y, Li X, Lin Y, Zhou J, Yang H and Shen Y: Integrated analysis of FANCE expression and its regulatory role in the immune microenvironment of oral squamous cell carcinoma. Oncol Lett 29: 160, 2025.
APA
Lin, B., Chen, Y., Li, X., Lin, Y., Zhou, J., Yang, H., & Shen, Y. (2025). Integrated analysis of FANCE expression and its regulatory role in the immune microenvironment of oral squamous cell carcinoma. Oncology Letters, 29, 160. https://doi.org/10.3892/ol.2025.14906
MLA
Lin, B., Chen, Y., Li, X., Lin, Y., Zhou, J., Yang, H., Shen, Y."Integrated analysis of FANCE expression and its regulatory role in the immune microenvironment of oral squamous cell carcinoma". Oncology Letters 29.3 (2025): 160.
Chicago
Lin, B., Chen, Y., Li, X., Lin, Y., Zhou, J., Yang, H., Shen, Y."Integrated analysis of FANCE expression and its regulatory role in the immune microenvironment of oral squamous cell carcinoma". Oncology Letters 29, no. 3 (2025): 160. https://doi.org/10.3892/ol.2025.14906
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