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Role, mechanisms and effects of Radix Bupleuri in anti‑breast cancer (Review)

  • Authors:
    • Shiting Jiang
    • Chengxia Li
    • Dan Liu
    • Fancai Zeng
    • Wenli Wei
    • Tao He
    • Wenli Yang
  • View Affiliations / Copyright

    Affiliations: Institute for Cancer Medicine, School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China, Laboratory of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 166
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    Published online on: January 30, 2025
       https://doi.org/10.3892/ol.2025.14912
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Abstract

The prevalence of breast cancer among women has led to a growing need for innovative anti‑breast cancer medications and an in‑depth investigation into their molecular mechanisms of action, both of which are essential tactics in clinical intervention. In the clinical practice of Traditional Chinese Medicine, Radix Bupleuri and its active components have shown promise as potential anti‑breast cancer agents due to their ability to target multiple pathways, exhibit synergistic effects and reduce toxicity. These compounds are considered to enhance the prognosis of patients with cancer, prolong survival and combat chemotherapy resistance. The present review aimed to delve into the anti‑breast cancer properties of Radix Bupleuri and its active ingredients, highlighting their mechanisms, such as inhibition of cell proliferation, promotion of apoptosis, metastasis prevention, microenvironment improvement and synergy with certain chemotherapeutic agents. These findings may provide a scientific rationale for combining Radix Bupleuri and its active components with traditional chemotherapy agents for the management of breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang S, Li C, Liu D, Zeng F, Wei W, He T and Yang W: Role, mechanisms and effects of <em>Radix Bupleuri</em> in anti‑breast cancer (Review). Oncol Lett 29: 166, 2025.
APA
Jiang, S., Li, C., Liu, D., Zeng, F., Wei, W., He, T., & Yang, W. (2025). Role, mechanisms and effects of <em>Radix Bupleuri</em> in anti‑breast cancer (Review). Oncology Letters, 29, 166. https://doi.org/10.3892/ol.2025.14912
MLA
Jiang, S., Li, C., Liu, D., Zeng, F., Wei, W., He, T., Yang, W."Role, mechanisms and effects of <em>Radix Bupleuri</em> in anti‑breast cancer (Review)". Oncology Letters 29.4 (2025): 166.
Chicago
Jiang, S., Li, C., Liu, D., Zeng, F., Wei, W., He, T., Yang, W."Role, mechanisms and effects of <em>Radix Bupleuri</em> in anti‑breast cancer (Review)". Oncology Letters 29, no. 4 (2025): 166. https://doi.org/10.3892/ol.2025.14912
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang S, Li C, Liu D, Zeng F, Wei W, He T and Yang W: Role, mechanisms and effects of <em>Radix Bupleuri</em> in anti‑breast cancer (Review). Oncol Lett 29: 166, 2025.
APA
Jiang, S., Li, C., Liu, D., Zeng, F., Wei, W., He, T., & Yang, W. (2025). Role, mechanisms and effects of <em>Radix Bupleuri</em> in anti‑breast cancer (Review). Oncology Letters, 29, 166. https://doi.org/10.3892/ol.2025.14912
MLA
Jiang, S., Li, C., Liu, D., Zeng, F., Wei, W., He, T., Yang, W."Role, mechanisms and effects of <em>Radix Bupleuri</em> in anti‑breast cancer (Review)". Oncology Letters 29.4 (2025): 166.
Chicago
Jiang, S., Li, C., Liu, D., Zeng, F., Wei, W., He, T., Yang, W."Role, mechanisms and effects of <em>Radix Bupleuri</em> in anti‑breast cancer (Review)". Oncology Letters 29, no. 4 (2025): 166. https://doi.org/10.3892/ol.2025.14912
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