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Article

Predictive factors of chemotherapy‑induced nausea and vomiting in elderly patients with gynecological cancer undergoing paclitaxel and carboplatin therapy: A retrospective study

  • Authors:
    • Fei Yao
    • Lijuan He
    • Xingyu Sun
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China, Department of Health Management Center, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China, Department of Gynecology, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China
  • Article Number: 167
    |
    Published online on: February 4, 2025
       https://doi.org/10.3892/ol.2025.14913
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Abstract

Chemotherapy‑induced nausea and vomiting (CINV) is a common and distressing adverse effect in elderly patients with gynecological cancer undergoing paclitaxel and carboplatin therapy. The present study aimed to identify predictors of CINV in this population. A retrospective analysis was conducted of 209 elderly patients with gynecological cancer treated with paclitaxel and carboplatin chemotherapy at The Affiliated Hospital, Southwest Medical University (Luzhou, China) between May 2019 and July 2023. The Multinational Association of Supportive Care in Cancer Antiemesis Tool (MAT) was used to assess the presence, frequency, and severity of CINV. Patients were categorized into the CINV group (n=76) and non‑CINV group (n=133) based on the MAT results. Age, hypertension, pre‑chemotherapy sleep duration and pre‑chemotherapy anxiety level were identified as significant predictors of CINV in the univariate analysis. In the multivariate analysis, age, pre‑chemotherapy sleep duration and pre‑chemotherapy anxiety level remained significant predictors. In conclusion, age, pre‑chemotherapy sleep duration and pre‑chemotherapy anxiety level are significant predictors of CINV in elderly patients with gynecological cancer undergoing paclitaxel and carboplatin therapy. These findings could help in tailoring preventative strategies for CINV in this population.
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Copy and paste a formatted citation
Spandidos Publications style
Yao F, He L and Sun X: Predictive factors of chemotherapy‑induced nausea and vomiting in elderly patients with gynecological cancer undergoing paclitaxel and carboplatin therapy: A retrospective study. Oncol Lett 29: 167, 2025.
APA
Yao, F., He, L., & Sun, X. (2025). Predictive factors of chemotherapy‑induced nausea and vomiting in elderly patients with gynecological cancer undergoing paclitaxel and carboplatin therapy: A retrospective study. Oncology Letters, 29, 167. https://doi.org/10.3892/ol.2025.14913
MLA
Yao, F., He, L., Sun, X."Predictive factors of chemotherapy‑induced nausea and vomiting in elderly patients with gynecological cancer undergoing paclitaxel and carboplatin therapy: A retrospective study". Oncology Letters 29.4 (2025): 167.
Chicago
Yao, F., He, L., Sun, X."Predictive factors of chemotherapy‑induced nausea and vomiting in elderly patients with gynecological cancer undergoing paclitaxel and carboplatin therapy: A retrospective study". Oncology Letters 29, no. 4 (2025): 167. https://doi.org/10.3892/ol.2025.14913
Copy and paste a formatted citation
x
Spandidos Publications style
Yao F, He L and Sun X: Predictive factors of chemotherapy‑induced nausea and vomiting in elderly patients with gynecological cancer undergoing paclitaxel and carboplatin therapy: A retrospective study. Oncol Lett 29: 167, 2025.
APA
Yao, F., He, L., & Sun, X. (2025). Predictive factors of chemotherapy‑induced nausea and vomiting in elderly patients with gynecological cancer undergoing paclitaxel and carboplatin therapy: A retrospective study. Oncology Letters, 29, 167. https://doi.org/10.3892/ol.2025.14913
MLA
Yao, F., He, L., Sun, X."Predictive factors of chemotherapy‑induced nausea and vomiting in elderly patients with gynecological cancer undergoing paclitaxel and carboplatin therapy: A retrospective study". Oncology Letters 29.4 (2025): 167.
Chicago
Yao, F., He, L., Sun, X."Predictive factors of chemotherapy‑induced nausea and vomiting in elderly patients with gynecological cancer undergoing paclitaxel and carboplatin therapy: A retrospective study". Oncology Letters 29, no. 4 (2025): 167. https://doi.org/10.3892/ol.2025.14913
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