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Case Report Open Access

Pulmonary artery intimal sarcoma mimicking pulmonary thromboembolism: A case report and literature review

  • Authors:
    • Yan Huang
    • Yiming Wang
    • Biko Kong
    • Feng Zheng
    • Yi Ding
    • Boamah Hayford
    • Junfang Guo
    • Rong Qin
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Jiangsu University Affiliated People's Hospital, Zhenjiang Clinical Medical College of Nanjing Medical University, Zhenjiang, Jiangsu 212002, P.R. China, Department of Ultrasound, Jiangsu University Affiliated People's Hospital, Zhenjiang, Jiangsu 212002, P.R. China, Department of Medical Imaging, Jiangsu University Affiliated People's Hospital, Zhenjiang, Jiangsu 212002, P.R. China, Research Center of Fluid Machinery Engineering and Technology, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China, Department of Medical Oncology, Jiangsu University Affiliated People's Hospital, Zhenjiang, Jiangsu 212002, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 169
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    Published online on: February 4, 2025
       https://doi.org/10.3892/ol.2025.14915
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Abstract

Pulmonary artery intimal sarcoma (PAIS) is a rare and highly aggressive form of hemangiosarcoma. The non‑specific clinical manifestations, signs and routine imaging findings of this sarcoma often mimic those of pulmonary thromboembolism (PTE), resulting in frequent misdiagnosis as PTE prior to pathological confirmation in most patients. This delay in achieving an accurate diagnosis poses challenges for promptly initiating optimal treatment and further contributes to the unfavorable prognosis. The current study presents the case of a 68‑year‑old female who presented with acute chest tightness and dyspnea. Transthoracic echocardiography revealed the presence of atypical echogenic structures within the primary pulmonary artery, while computed tomography pulmonary angiography showed marked filling defects in the main trunk and branches of the pulmonary artery. The patient was initially misdiagnosed with PTE but did not respond well to anticoagulant therapy. Subsequent surgical resection confirmed the diagnosis of PAIS through pathological examination. Despite postoperative treatment with molecular‑targeted antitumor drugs, the patient experienced tumor recurrence and intrapulmonary metastasis, ultimately succumbing to disease progression. This exceptional case is being presented to enhance the clinical understanding of PAIS, to encourage further extensive research for reliable diagnostic approaches and to provide further data that will help form efficacious therapeutic strategies to ameliorate the unfavorable prognosis of affected patients.
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Copy and paste a formatted citation
Spandidos Publications style
Huang Y, Wang Y, Kong B, Zheng F, Ding Y, Hayford B, Guo J and Qin R: Pulmonary artery intimal sarcoma mimicking pulmonary thromboembolism: A case report and literature review. Oncol Lett 29: 169, 2025.
APA
Huang, Y., Wang, Y., Kong, B., Zheng, F., Ding, Y., Hayford, B. ... Qin, R. (2025). Pulmonary artery intimal sarcoma mimicking pulmonary thromboembolism: A case report and literature review. Oncology Letters, 29, 169. https://doi.org/10.3892/ol.2025.14915
MLA
Huang, Y., Wang, Y., Kong, B., Zheng, F., Ding, Y., Hayford, B., Guo, J., Qin, R."Pulmonary artery intimal sarcoma mimicking pulmonary thromboembolism: A case report and literature review". Oncology Letters 29.4 (2025): 169.
Chicago
Huang, Y., Wang, Y., Kong, B., Zheng, F., Ding, Y., Hayford, B., Guo, J., Qin, R."Pulmonary artery intimal sarcoma mimicking pulmonary thromboembolism: A case report and literature review". Oncology Letters 29, no. 4 (2025): 169. https://doi.org/10.3892/ol.2025.14915
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Y, Wang Y, Kong B, Zheng F, Ding Y, Hayford B, Guo J and Qin R: Pulmonary artery intimal sarcoma mimicking pulmonary thromboembolism: A case report and literature review. Oncol Lett 29: 169, 2025.
APA
Huang, Y., Wang, Y., Kong, B., Zheng, F., Ding, Y., Hayford, B. ... Qin, R. (2025). Pulmonary artery intimal sarcoma mimicking pulmonary thromboembolism: A case report and literature review. Oncology Letters, 29, 169. https://doi.org/10.3892/ol.2025.14915
MLA
Huang, Y., Wang, Y., Kong, B., Zheng, F., Ding, Y., Hayford, B., Guo, J., Qin, R."Pulmonary artery intimal sarcoma mimicking pulmonary thromboembolism: A case report and literature review". Oncology Letters 29.4 (2025): 169.
Chicago
Huang, Y., Wang, Y., Kong, B., Zheng, F., Ding, Y., Hayford, B., Guo, J., Qin, R."Pulmonary artery intimal sarcoma mimicking pulmonary thromboembolism: A case report and literature review". Oncology Letters 29, no. 4 (2025): 169. https://doi.org/10.3892/ol.2025.14915
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