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Article Open Access

Nobiletin and 5‑demethylnobiletin ameliorate hypopharyngeal squamous cell carcinoma by suppressing TGF‑β‑mediated epithelial‑mesenchymal transition

  • Authors:
    • Gloria Gutiérrez-Venegas
    • Marisol Rosas-Martínez
  • View Affiliations / Copyright

    Affiliations: Biochemistry Laboratory of The Division of Graduate Studies and Research, Faculty of Dentistry, National Autonomous University of Mexico, Mexico City 04510, Mexico
    Copyright: © Gutiérrez-Venegas et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 176
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    Published online on: February 7, 2025
       https://doi.org/10.3892/ol.2025.14922
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Abstract

Hypopharynx squamous cell carcinoma accounts for 5% of all diseases diagnosed in Mexico. It is associated with poor oral hygiene, alcohol consumption and tobacco use and is usually diagnosed at an advanced stage, with metastasis to the lymph nodes. Metastasis from primary tumors occurs via a complex process called epithelial‑mesenchymal transition (EMT), in which epithelial cells gradually acquire characteristics of mesenchymal cells, enabling their spread. Flavonoids have anticancer effects. In the present study, the effects of the polymethoxyflavones nobiletin (Nob) and 5‑demethylnobiletin (5‑DMN) on transforming growth factor (TGF)‑β1‑induced EMT in hypopharyngeal squamous cell carcinoma cells were evaluated. Either polymethoxyflavone alone inhibited cell proliferation and combined treatment had no synergistic effect. The two flavonoids inhibited EMT by reversing the effects of TGF‑β on morphological changes, migration and the expression of the markers E‑cadherin, N‑cadherin, Slug and Snail. Thus, Nob and 5‑DMN are potential candidates for use in the treatment of oral squamous cell carcinoma.
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1 

Ali J, Sabiha B, Jan HU, Haider SA, Khan AA and Ali SS: Genetic etiology of oral cancer. Oral Oncol. 70:23–28. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA CancerJ Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Jansen L, Buttmann-Schweiger N, Listl S, Ressing M, Holleczek B, Katalinic A, Luttmann S, Kraywinkel K and Brenner H; GEKID Cancer Survival Working Group, : Differences in incidence and survival of oral cavity and pharyngeal cancers between Germany and the United States depend on the HPV-association of the cancer site. Oral Oncol. 76:8–15. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE and Grandis JR: Head and neck squamous cell carcinoma. Nat Rev Dis Primers. 6:922020. View Article : Google Scholar : PubMed/NCBI

5 

Aires FT, Lin CS, Matos LL, Kulcsar MAV and Cernea CR: Risk factors for distant metastasis in patients with oral cavity squamous cell carcinoma undergoing surgical treatment. ORL J Otorhinolaryngol Relat Spec. 79:347–355. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Chi AC, Day TA and Neville BW: Oral cavity and oropharyngeal squamous cell carcinoma-an update. CA Cancer J Clin. 65:401–421. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Zhang Y and Weinberg RA: Epithelial-to-mesenchymal transition in cancer: Complexity and opportunities. Front Med. 12:361–373. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Gloushankova NA, Zhitnyak IY and Rubtsova SN: Role of epithelial-mesenchymal transition in tumor progression. Biochemistry (Mosc). 83:1469–1476. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Pastushenko I, Brisebarre A, Sifrim A, Fioramonti M, Revenco T, Boumahdi S, Van Keymeulen A, Brown D, Moers V, Lemaire S, et al: Identification of the tumour transition states occurring during EMT. Nature. 556:463–468. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Nieto MA, Huang RY, Jackson RA and Thiery JP: EMT: 2016. Cell. 166:21–45. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Feng XL, Ho SC, Mo XF, Lin FY, Zhang NQ, Luo H, Zhang X and Zhang CX: Association between flavonoids, flavonoid subclasses intake and breast cancer risk: A case-control study in China. Eur J Cancer Prev. 29:493–500. 2020. View Article : Google Scholar : PubMed/NCBI

12 

Surichan S, Arroo RR, Ruparelia K, Tsatsakis AM and Androutsopoulos VP: Nobiletin bioactivation in MDA-MB-468 breast cancer cells by cytochrome P450 CYP1 enzymes. Food Chem Toxicol. 113:228–235. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Chen M, Li H, Zheng S, Shen J, Chen Y, Li Y, Yuan M, Wu J and Sun Q: Nobiletin targets SREBP1/ACLY to induce autophagy-dependent cell death of gastric cancer cells through PI3K/Akt/mTOR signaling pathway. Phytomedicine. 128:1553602024. View Article : Google Scholar : PubMed/NCBI

14 

Uesato S, Yamashita H, Maeda R, Hirata Y, Yamamoto M, Matsue S, Nagaoka Y, Shibano M, Taniguchi M, Baba K and Ju-ichi M: Synergistic antitumor effect of a combination of paclitaxel and carboplatin with nobiletin from Citrus depressa on non-small-cell lung cancer cell lines. Planta Med. 80:452–457. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Ma X, Jin S, Zhang Y, Wan L, Zhao Y and Zhou L: Inhibitory effects of nobiletin on hepatocellular carcinoma in vitro and in vivo. Phytother Res. 28:560–567. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Cheng HL, Hsieh MJ, Yang JS, Lin CW, Lue KH, Lu KH and Yang SF: Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression. Oncotarget. 7:35208–35223. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Rosas-Martínez M, González Rosales JA and Gutiérrez-Venegas G: Nobiletin regulates invasion, migration and metastasis in hypopharyngeal squamous cell carcinoma. Cell Mol Biol (Noisy-le-grand). 69:1–6. 2023. View Article : Google Scholar : PubMed/NCBI

18 

Chiou YS, Zheng YN, Tsai ML, Lai CS, Ho CT and Pan MH: 5-Demethylnobiletin more potently inhibits colon cancer cell growth than nobiletin in vitro and in vivo. J Food Bioact. 2:91–97. 2018. View Article : Google Scholar

19 

Zheng J, Bi J, Johnson D, Sun Y, Song M, Qiu P, Dong P, Decker E and Xiao H: Analysis of 10 metabolites of polymethoxyflavones with high sensitivity by electrochemical detection in high-performance liquid chromatography. J Agric Food Chem. 63:509–516. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Yang F, Li T, Zhang XQ, Gong Y, Su H, Fan J, Wang L, Hu QD and Tan RZ: Screening of active components in Astragalus mongholicus Bunge and Panax notoginseng formula for anti-fibrosis in CKD: Nobiletin inhibits Lgals1/PI3K/AKT signaling to improve renal fibrosis. Ren Fail. 46:23750332024. View Article : Google Scholar : PubMed/NCBI

21 

Wu X, Song M, Qiu P, Li F, Wang M, Zheng J, Wang Q, Xu F and Xiao H: A metabolite of nobiletin, 4′-demethylnobiletin and atorvastatin synergistically inhibits human colon cancer cell growth by inducing G0/G1 cell cycle arrest and apoptosis. Food Funct. 9:87–95. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Qiu P, Dong P, Guan H, Li S, Ho CT, Pan MH, McClements DJ and Xiao H: Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells. Mol Nutr Food Res. 54 (Suppl 2):S244–S252. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Goh JXH, Tan LT, Goh JK, Chan KG, Pusparajah P, Lee LH and Goh BH: Nobiletin and derivatives: Functional compounds from citrus fruit peel for colon cancer chemoprevention. Cancers (Basel). 11:8672019. View Article : Google Scholar : PubMed/NCBI

24 

Moon JY, Manh Hung LV, Unno T and Cho SK: Nobiletin enhances chemosensitivity to adriamycin through modulation of the Akt/GSK3β/β-catenin/MYCN/MRP1 signaling pathway in A549 human non-small-cell lung cancer cells. Nutrients. 10:18292018. View Article : Google Scholar : PubMed/NCBI

25 

Jiang H, Chen H, Jin C, Mo J and Wang H: Nobiletin flavone inhibits the growth and metastasis of human pancreatic cancer cells via induction of autophagy, G0/G1 cell cycle arrest and inhibition of NF-kB signalling pathway. J BUON. 25:1070–1075. 2020.PubMed/NCBI

26 

Yang J, Yang Y, Wang L, Jin Q and Pan M: Nobiletin selectively inhibits oral cancer cell growth by promoting apoptosis and DNA damage in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol. 130:419–427. 2020. View Article : Google Scholar : PubMed/NCBI

27 

Chen Q, Gu Y, Tan C, Sundararajan B, Li Z, Wang D and Zhou Z: Comparative effects of five polymethoxyflavones purified from Citrus tangerina on inflammation and cancer. Front Nutr. 9:9636622022. View Article : Google Scholar : PubMed/NCBI

28 

Miyata Y, Sato T, Imada K, Dobashi A, Yano M and Ito A: A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells. Biochem Biophys Res Commun. 366:168–173. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Da C, Liu Y, Zhan Y, Liu K and Wang R: Nobiletin inhibits epithelial-mesenchymal transition of human non-small cell lung cancer cells by antagonizing the TGF-β1/Smad3 signaling pathway. Oncol Rep. 35:2767–2774. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Gao XJ, Liu JW, Zhang QG, Zhang JJ, Xu HT and Liu HJ: Nobiletin inhibited hypoxia-induced epithelial-mesenchymal transition of lung cancer cells by inactivating of Notch-1 signa ling and switching on miR-200b. Pharmazie. 70:256–262. 2015.PubMed/NCBI

31 

Keshtkar S, Kaviani M, Jabbarpour Z, Geramizadeh B, Motevaseli E, Nikeghbalian S, Shamsaeefar A, Motazedian N, Al-Abdullah IH, Ghahremani MH and Azarpira N: Protective effect of nobiletin on isolated human islets survival and function against hypoxia and oxidative stress-induced apoptosis. Sci Rep. 9:117012019. View Article : Google Scholar : PubMed/NCBI

32 

Lin Z, Wu D, Huang L, Jiang C, Pan T, Kang X and Pan J: Nobiletin inhibits IL-1β-induced inflammation in chondrocytes via suppression of NF-κB signaling and attenuates osteoarthritis in mice. Front Pharmacol. 10:5702019. View Article : Google Scholar : PubMed/NCBI

33 

Youn K, Lee S and Jun M: Discovery of nobiletin from citrus peel as a potent inhibitor of β-amyloid peptide toxicity. Nutrients. 11:26482019. View Article : Google Scholar : PubMed/NCBI

34 

Tsuboi T, Lu R, Yonezawa T, Watanabe A, Woo JT, Abe-Dohmae S and Yokoyama S: Molecular mechanism for nobiletin to enhance ABCA1/G1 expression in mouse macrophages. Atherosclerosis. 297:32–39. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Zhang BF, Jiang H, Ch J, Guo X, Li Y, Hu Q and Yang S: Nobiletin ameliorates myocardial ischemia and reperfusion injury by attenuating endoplasmic reticulum stress-associated apoptosis through regulation of the PI3K/AKT signal pathway. Int Immunopharmacol. 73:98–107. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Yuk T, Kim Y, Yang J, Sung J, Jeong HS and Lee J: Nobiletin inhibits hepatic lipogenesis via activation of AMP-activated protein kinase. Evid Based Complement Altern Med. 2018:74202652018. View Article : Google Scholar : PubMed/NCBI

37 

Li S, Pan MH, Lai CS, Lo CY, Dushenkov S and Ho CT: Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines. Bioorg Med Chem. 15:3381–3389. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Xiao H, Yang CS, Li S, Jin H, Ho CT and Patel T: Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis. Mol Nutr Food Res. 53:398–406. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Asakawa T, Sagara H, Kanakogi M, Hiza A, Tsukaguchi Y, Ogawa T, Nakayama M, Ouchi H, Inai M and Kan T: Practical synthesis of polymethylated flavones: Nobiletin and its desmethyl derivatives. Org Process Res Dev. 23:595–602. 2019. View Article : Google Scholar

40 

Song M, Lan Y, Wu X, Han Y, Wang M, Zheng J, Li Z, Li F, Zhou J, Xiao J, et al: The chemopreventive effect of 5-demethylnobiletin, a unique citrus flavonoid, on colitis-driven colorectal carcinogenesis in mice is associated with its colonic metabolites. Food Funct. 11:4940–4952. 2020. View Article : Google Scholar : PubMed/NCBI

41 

Song M, Wu X, Charoensinphon N, Wang M, Zheng J, Gao Z, Xu F, Li Z, Li F, Zhou J and Xiao H: Dietary 5-demethylnobiletin inhibits cigarette carcinogen NNK-induced lung tumorigenesis in mice. Food Funct. 8:954–963. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Nemoto K, Ikeda A, Yoshida C, Kimura J, Mori J, Fujiwara H, Yokosuka A, Mimaki Y, Ohizumi Y and Degawa M: Characteristics of nobiletin-mediated alteration of gene expression in cultured cell lines. Biochem Biophys Res Commun. 431:530–534. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Zhang X, Zheng K, Li C, Zhao Y, Li H, Liu X, Long Y and Yao J: Nobiletin inhibits invasion via inhibiting AKT/GSK3β/β-catenin signaling pathway in Slug-expressing glioma cells. Oncol Rep. 37:2847–2856. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Andugulapati SB, Gourishetti K, Tirunavalli SK, Shaikh TB and Sistla R: Biochanin-A ameliorates pulmonary fibrosis by suppressing the TGF-β mediated EMT, myofibroblasts differentiation and collagen deposition in in vitro and in vivo systems. Phytomedicine. 78:1532982020. View Article : Google Scholar : PubMed/NCBI

45 

Ma X, Xie Y, Gong Y, Hu C, Qiu K, Yang Y, Shen H, Zhou X, Long C and Lin X: Silibinin prevents TGFβ-induced EMT of RPE in proliferative vitreoretinopathy by inhibiting Stat3 and Smad3 phosphorylation. Invest Ophthalmol Vis Sci. 64:472023. View Article : Google Scholar : PubMed/NCBI

46 

Peng L, Wen L, Shi QF, Gao F, Huang B, Meng J, Hu CP and Wang CM: Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial-mesenchymal transition and inflammation. Cell Death Dis. 11:9782020. View Article : Google Scholar : PubMed/NCBI

47 

Liu F, Zhang S, Yin M, Guo L, Xu M and Wang Y: Nobiletin inhibits hypoxia-induced epithelial-mesenchymal transition in renal cell carcinoma cells. J Cell Biochem. 120:2039–2046. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gutiérrez-Venegas G and Rosas-Martínez M: Nobiletin and 5‑demethylnobiletin ameliorate hypopharyngeal squamous cell carcinoma by suppressing TGF‑β‑mediated epithelial‑mesenchymal transition. Oncol Lett 29: 176, 2025.
APA
Gutiérrez-Venegas, G., & Rosas-Martínez, M. (2025). Nobiletin and 5‑demethylnobiletin ameliorate hypopharyngeal squamous cell carcinoma by suppressing TGF‑β‑mediated epithelial‑mesenchymal transition. Oncology Letters, 29, 176. https://doi.org/10.3892/ol.2025.14922
MLA
Gutiérrez-Venegas, G., Rosas-Martínez, M."Nobiletin and 5‑demethylnobiletin ameliorate hypopharyngeal squamous cell carcinoma by suppressing TGF‑β‑mediated epithelial‑mesenchymal transition". Oncology Letters 29.4 (2025): 176.
Chicago
Gutiérrez-Venegas, G., Rosas-Martínez, M."Nobiletin and 5‑demethylnobiletin ameliorate hypopharyngeal squamous cell carcinoma by suppressing TGF‑β‑mediated epithelial‑mesenchymal transition". Oncology Letters 29, no. 4 (2025): 176. https://doi.org/10.3892/ol.2025.14922
Copy and paste a formatted citation
x
Spandidos Publications style
Gutiérrez-Venegas G and Rosas-Martínez M: Nobiletin and 5‑demethylnobiletin ameliorate hypopharyngeal squamous cell carcinoma by suppressing TGF‑β‑mediated epithelial‑mesenchymal transition. Oncol Lett 29: 176, 2025.
APA
Gutiérrez-Venegas, G., & Rosas-Martínez, M. (2025). Nobiletin and 5‑demethylnobiletin ameliorate hypopharyngeal squamous cell carcinoma by suppressing TGF‑β‑mediated epithelial‑mesenchymal transition. Oncology Letters, 29, 176. https://doi.org/10.3892/ol.2025.14922
MLA
Gutiérrez-Venegas, G., Rosas-Martínez, M."Nobiletin and 5‑demethylnobiletin ameliorate hypopharyngeal squamous cell carcinoma by suppressing TGF‑β‑mediated epithelial‑mesenchymal transition". Oncology Letters 29.4 (2025): 176.
Chicago
Gutiérrez-Venegas, G., Rosas-Martínez, M."Nobiletin and 5‑demethylnobiletin ameliorate hypopharyngeal squamous cell carcinoma by suppressing TGF‑β‑mediated epithelial‑mesenchymal transition". Oncology Letters 29, no. 4 (2025): 176. https://doi.org/10.3892/ol.2025.14922
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