Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2025 Volume 29 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2025 Volume 29 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Identification of GDP as a small inhibitory molecule in HepG2 cells by non‑targeted metabolomics analysis

  • Authors:
    • Zhilin Peng
    • Siting Xu
    • Haocheng Wang
    • Yanli Huang
    • Siyuan Liu
    • Zhongbei Jiao
    • Mei Lin
    • Ping Zhu
    • Yu Chen
    • Yan Shi
    • Yuequn Wang
    • Yongqing Li
    • Wuzhou Yuan
    • Xiushan Wu
    • Zhigang Jiang
    • Fang Li
    • Xiongwei Fan
  • View Affiliations / Copyright

    Affiliations: The Center for Heart Development, College of Life Science, Hunan Normal University, Changsha, Hunan 410081, P.R. China, Guangdong Provincial Key Laboratory of Pathogenesis, Targeted Prevention and Treatment of Heart Disease, Guangdong Provincial People's Hospital Affiliated to Southern Medical University, Guangzhou, Guangdong 510100, P.R. China
    Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 178
    |
    Published online on: February 11, 2025
       https://doi.org/10.3892/ol.2025.14924
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Identifying the mechanism by which lipid metabolism regulates cancer may offer a novel approach for therapeutic intervention. It has previously been identified that a lipid metabolism‑related factor, namely fatty acid hydroxylase domain containing 2 (FAXDC2), is downregulated in various types of cancer, and inhibits the proliferation and migration of liver cancer cells through a mechanism associated with ERK. The liver is important for lipid metabolism, and FAXDC2 is involved in the synthesis of cholesterol and sphingomyelin. However, the functional mechanism by which FAXDC2 influences liver cancer cells through metabolic processes and ERK signaling remains unclear. Therefore, the present study induced the overexpression of FAXDC2 in HepG2 liver cancer cells and performed a metabolomics analysis. This identified guanosine diphosphate (GDP) as a significantly altered metabolite. Using AlphaFold3, a robust interaction was predicted between FAXDC2 and GDP, which lead to the hypothesis that GDP may mediate the inhibitory effects of FAXDC2 on liver cancer cells by directly modulating the functional properties of the cells, thereby influencing their behavior and progression. Cell Counting Kit‑8 assays were used to study the impact of elevated GDP concentrations on HepG2 cell growth. The results revealed a gradual reduction in the viability of HepG2 cells as the GDP concentration increased. In addition, western blotting showed that GDP treatment was accompanied by a significant downregulation of cyclin dependent kinase 4 and cyclin D1 expression levels, and Transwell experiments revealed that GDP treatment significantly decreased the invasion of HepG2 cells. Treatment with GDP also significantly inhibited the expression of ERK. In summary, the present study is the first to indicate that GDP is a metabolic small molecule with inhibitory activity in cancer cells, which has previously been overlooked in tumor metabolic reprogramming. The study findings offer new insights and strategies for the diagnosis and treatment of liver cancer, and potentially other types of cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Siegel RL, Miller KD, Wagle NS and Jemal A: Cancer statistics, 2023. CA Cancer J Clin. 73:17–48. 2023. View Article : Google Scholar : PubMed/NCBI

2 

Gao S, Gang J, Yu M, Xin G and Tan H: Computational analysis for identification of early diagnostic biomarkers and prognostic biomarkers of liver cancer based on GEO and TCGA databases and studies on pathways and biological functions affecting the survival time of liver cancer. BMC cancer. 21:7912021. View Article : Google Scholar : PubMed/NCBI

3 

Yang WS, Zeng XF, Liu ZN, Zhao QH, Tan YT, Gao J, Li HL and Xiang YB: Diet and liver cancer risk: A narrative review of epidemiological evidence. Br J Nutr. 124:330–340. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Anwanwan D, Singh SK, Singh S, Saikam V and Singh R: Challenges in liver cancer and possible treatment approaches. Biochim Biophys Acta Rev Cancer. 1873:1883142020. View Article : Google Scholar : PubMed/NCBI

5 

Li S, Yin S, Ding H, Shao Y, Zhou S, Pu W, Han L, Wang T and Yu H: Polyphenols as potential metabolism mechanisms regulators in liver protection and liver cancer prevention. Cell Prolif. 56:e133462023. View Article : Google Scholar : PubMed/NCBI

6 

Raoul JL, Forner A, Bolondi L, Cheung TT, Kloeckner R and de Baere T: Updated use of TACE for hepatocellular carcinoma treatment: How and when to use it based on clinical evidence. Cancer Treat Rev. 72:28–36. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S, Lencioni R, Koike K, Zucman-Rossi J and Finn RS: Hepatocellular carcinoma. Nat Rev Dis Primers. 7:62021. View Article : Google Scholar : PubMed/NCBI

8 

Luo X, Cheng C, Tan Z, Li N, Tang M, Yang L and Cao Y: Emerging roles of lipid metabolism in cancer metastasis. Mol Cancer. 16:762017. View Article : Google Scholar : PubMed/NCBI

9 

Yi M, Li J, Chen S, Cai J, Ban Y, Peng Q, Zhou Y, Zeng Z, Peng S, Li X, et al: Emerging role of lipid metabolism alterations in cancer stem cells. J Exp Clin Cancer Res. 37:1182018. View Article : Google Scholar : PubMed/NCBI

10 

Medes G, Thomas A and Weinhouse S: Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res. 13:27–29. 1953.PubMed/NCBI

11 

Ookhtens M, Kannan R, Lyon I and Baker N: Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor. Am J Physiol. 247:R146–R153. 1984.PubMed/NCBI

12 

Yang H, Deng Q, Ni T, Liu Y, Lu L, Dai H, Wang H and Yang W: Targeted Inhibition of LPL/FABP4/CPT1 fatty acid metabolic axis can effectively prevent the progression of nonalcoholic steatohepatitis to liver cancer. Int J Biol Sci. 17:4207–4222. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Wu D, Yang Y, Hou Y, Zhao Z, Liang N, Yuan P, Yang T, Xing J and Li J: Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1. Cancer Commun (Lond). 42:37–55. 2022. View Article : Google Scholar : PubMed/NCBI

14 

Wang W, Bai L, Li W and Cui J: The lipid metabolic landscape of cancers and new therapeutic perspectives. Front Oncol. 10:6051542020. View Article : Google Scholar : PubMed/NCBI

15 

Beloribi-Djefaflia S, Vasseur S and Guillaumond F: Lipid metabolic reprogramming in cancer cells. Oncogenesis. 5:e1892016. View Article : Google Scholar : PubMed/NCBI

16 

Du D, Liu C, Qin M, Zhang X, Xi T, Yuan S, Hao H and Xiong J: Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma. Acta Pharm Sin B. 12:558–580. 2022. View Article : Google Scholar : PubMed/NCBI

17 

Sun Y, Liu WZ, Liu T, Feng X, Yang N and Zhou HF: Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis. J Recept Signal Transduct Res. 35:600–604. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Delire B and Stärkel P: The Ras/MAPK pathway and hepatocarcinoma: Pathogenesis and therapeutic implications. Eur J Clin Invest. 45:609–623. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Dimri M and Satyanarayana A: Molecular signaling pathways and therapeutic targets in hepatocellular carcinoma. Cancers (Basel). 12:4912020. View Article : Google Scholar : PubMed/NCBI

20 

Peng Y, Song Y and Wang H: Systematic elucidation of the aneuploidy landscape and identification of aneuploidy driver genes in prostate cancer. Front Cell Dev Biol. 9:7234662021. View Article : Google Scholar : PubMed/NCBI

21 

Zhang P, Ma K, Ke X, Liu L, Li Y, Liu Y and Wang Y: Development and validation of a Five-RNA-Based signature and identification of candidate drugs for neuroblastoma. Front Genet. 12:6856462021. View Article : Google Scholar : PubMed/NCBI

22 

Jin Q, Ren Y, Wang M, Suraneni PK, Li D, Crispino JD, Fan J and Huang Z: Novel function of FAXDC2 in megakaryopoiesis. Blood Cancer J. 6:e4782016. View Article : Google Scholar : PubMed/NCBI

23 

Peng Z, Xu S, Zhang Q, Yang X, Yuan W, Wang Y, Li Y, Zhu P, Wu X, Jiang Z, et al: FAXDC2 inhibits the proliferation and invasion of human liver cancer HepG2 cells. Exp Ther Med. 27:272024. View Article : Google Scholar : PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Rao G, Sui J and Zhang J: Metabolomics reveals significant variations in metabolites and correlations regarding the maturation of walnuts (Juglans regia L.). Biol Open. 5:829–836. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Boulesteix AL and Strimmer K: Partial least squares: A versatile tool for the analysis of high-dimensional genomic data. Brief Bioinform. 8:32–44. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Wen B, Mei Z, Zeng C and Liu S: metaX: A flexible and comprehensive software for processing metabolomics data. BMC Bioinformatics. 18:1832017. View Article : Google Scholar : PubMed/NCBI

28 

Abramson J, Adler J, Dunger J, Evans R, Green T, Pritzel A, Ronneberger O, Willmore L, Ballard AJ, Bambrick J, et al: Accurate structure prediction of biomolecular interactions with AlphaFold 3. Nature. 630:493–500. 2024. View Article : Google Scholar : PubMed/NCBI

29 

Wu M, Zhao Y, Tao M, Fu M, Wang Y, Liu Q, Lu Z and Guo J: Malate-based biodegradable scaffolds activate cellular energetic metabolism for accelerated wound healing. ACS Appl Mater Interfaces. 15:50836–50853. 2023. View Article : Google Scholar : PubMed/NCBI

30 

Adeva-Andany MM, Pérez-Felpete N, Fernández-Fernández C, Donapetry-García C and Pazos-García C: Liver glucose metabolism in humans. Biosci Rep. 36:e004162016. View Article : Google Scholar : PubMed/NCBI

31 

Vetter IR and Wittinghofer A: The guanine nucleotide-binding switch in three dimensions. Science. 294:1299–1304. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Traut TW: Physiological concentrations of purines and pyrimidines. Mol Cell Biochem. 140:1–22. 1994. View Article : Google Scholar : PubMed/NCBI

33 

Ni T, He Z, Dai Y, Yao J, Guo Q and Wei L: Oroxylin A suppresses the development and growth of colorectal cancer through reprogram of HIF1α-modulated fatty acid metabolism. Cell Death Dis. 8:e28652017. View Article : Google Scholar : PubMed/NCBI

34 

Ali HR, Michel CR, Lin YH, McKinsey TA, Jeong MY, Ambardekar AV, Cleveland JC, Reisdorph R, Reisdorph N, Woulfe KC and Fritz KS: Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy. J Mol Cell Cardiol. 138:304–317. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Cook SJ, Stuart K, Gilley R and Sale MJ: Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling. FEBS J. 284:4177–4195. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Llovet JM, Villanueva A, Lachenmayer A and Finn RS: Advances in targeted therapies for hepatocellular carcinoma in the genomic era. Nat Rev Clin Oncol. 12:408–424. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Wiesenauer CA, Yip-Schneider MT, Wang Y and Schmidt CM: Multiple anticancer effects of blocking MEK-ERK signaling in hepatocellular carcinoma. J Am Coll Surg. 198:410–421. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Yang J, Pan WH, Clawson GA and Richmond A: Systemic targeting inhibitor of kappaB kinase inhibits melanoma tumor growth. Cancer Res. 67:3127–3134. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Roy S, Luetterforst R, Harding A, Apolloni A, Etheridge M, Stang E, Rolls B, Hancock JF and Parton RG: Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains. Nat Cell Biol. 1:98–105. 1999. View Article : Google Scholar : PubMed/NCBI

40 

Higgins EM, Bos JM, Mason-Suares H, Tester DJ, Ackerman JP, MacRae CA, Sol-Church K, Gripp KW, Urrutia R and Ackerman MJ: Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy. JCI Insight. 2:e912252017. View Article : Google Scholar : PubMed/NCBI

41 

Xu J, Hedberg C, Dekker FJ, Li Q, Haigis KM, Hwang E, Waldmann H and Shannon K: Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras. Blood. 119:1032–1035. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Wang Y, Ji D, Lei C, Chen Y, Qiu Y, Li X, Li M, Ni D, Pu J, Zhang J, et al: Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins. Comput Struct Biotechnol J. 19:1184–1199. 2021. View Article : Google Scholar : PubMed/NCBI

43 

Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T and Shannon K: Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood. 117:2022–2032. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Kan Z, Jaiswal BS, Stinson J, Janakiraman V, Bhatt D, Stern HM, Yue P, Haverty PM, Bourgon R, Zheng J, et al: Diverse somatic mutation patterns and pathway alterations in human cancers. Nature. 466:869–873. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Garcia-Marcos M, Ghosh P and Farquhar MG: Molecular basis of a novel oncogenic mutation in GNAO1. Oncogene. 30:2691–2696. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Leyme A, Marivin A, Casler J, Nguyen LT and Garcia-Marcos M: Different biochemical properties explain why two equivalent Gα subunit mutants cause unrelated diseases. J Biol Chem. 289:21818–21827. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, et al: Long-term administration of nicotinamide mononucleotide mitigates Age-associated physiological decline in mice. Cell Metab. 24:795–806. 2016. View Article : Google Scholar : PubMed/NCBI

48 

de Picciotto NE, Gano LB, Johnson LC, Martens CR, Sindler AL, Mills KF, Imai S and Seals DR: Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell. 15:522–530. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Wang S, Liang X, Yang Q, Fu X, Zhu M, Rodgers BD, Jiang Q, Dodson MV and Du M: Resveratrol enhances brown adipocyte formation and function by activating AMP-activated protein kinase (AMPK) α1 in mice fed high-fat diet. Mol Nutr Food Res. 61:102017. View Article : Google Scholar : PubMed/NCBI

50 

Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, et al: Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 8:157–168. 2008. View Article : Google Scholar : PubMed/NCBI

51 

Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H, Taussig R, Brown AL, et al: Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell. 148:421–433. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Bernier M, Wahl D, Ali A, Allard J, Faulkner S, Wnorowski A, Sanghvi M, Moaddel R, Alfaras I, Mattison JA, et al: Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet. Aging (Albany NY). 8:899–916. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Liang QX, Lin YH, Zhang CH, Sun HM, Zhou L, Schatten H, Sun QY and Qian WP: Resveratrol increases resistance of mouse oocytes to postovulatory aging in vivo. Aging (Albany NY). 10:1586–1596. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Peng Z, Xu S, Wang H, Huang Y, Liu S, Jiao Z, Lin M, Zhu P, Chen Y, Shi Y, Shi Y, et al: Identification of GDP as a small inhibitory molecule in HepG2 cells by non‑targeted metabolomics analysis. Oncol Lett 29: 178, 2025.
APA
Peng, Z., Xu, S., Wang, H., Huang, Y., Liu, S., Jiao, Z. ... Fan, X. (2025). Identification of GDP as a small inhibitory molecule in HepG2 cells by non‑targeted metabolomics analysis. Oncology Letters, 29, 178. https://doi.org/10.3892/ol.2025.14924
MLA
Peng, Z., Xu, S., Wang, H., Huang, Y., Liu, S., Jiao, Z., Lin, M., Zhu, P., Chen, Y., Shi, Y., Wang, Y., Li, Y., Yuan, W., Wu, X., Jiang, Z., Li, F., Fan, X."Identification of GDP as a small inhibitory molecule in HepG2 cells by non‑targeted metabolomics analysis". Oncology Letters 29.4 (2025): 178.
Chicago
Peng, Z., Xu, S., Wang, H., Huang, Y., Liu, S., Jiao, Z., Lin, M., Zhu, P., Chen, Y., Shi, Y., Wang, Y., Li, Y., Yuan, W., Wu, X., Jiang, Z., Li, F., Fan, X."Identification of GDP as a small inhibitory molecule in HepG2 cells by non‑targeted metabolomics analysis". Oncology Letters 29, no. 4 (2025): 178. https://doi.org/10.3892/ol.2025.14924
Copy and paste a formatted citation
x
Spandidos Publications style
Peng Z, Xu S, Wang H, Huang Y, Liu S, Jiao Z, Lin M, Zhu P, Chen Y, Shi Y, Shi Y, et al: Identification of GDP as a small inhibitory molecule in HepG2 cells by non‑targeted metabolomics analysis. Oncol Lett 29: 178, 2025.
APA
Peng, Z., Xu, S., Wang, H., Huang, Y., Liu, S., Jiao, Z. ... Fan, X. (2025). Identification of GDP as a small inhibitory molecule in HepG2 cells by non‑targeted metabolomics analysis. Oncology Letters, 29, 178. https://doi.org/10.3892/ol.2025.14924
MLA
Peng, Z., Xu, S., Wang, H., Huang, Y., Liu, S., Jiao, Z., Lin, M., Zhu, P., Chen, Y., Shi, Y., Wang, Y., Li, Y., Yuan, W., Wu, X., Jiang, Z., Li, F., Fan, X."Identification of GDP as a small inhibitory molecule in HepG2 cells by non‑targeted metabolomics analysis". Oncology Letters 29.4 (2025): 178.
Chicago
Peng, Z., Xu, S., Wang, H., Huang, Y., Liu, S., Jiao, Z., Lin, M., Zhu, P., Chen, Y., Shi, Y., Wang, Y., Li, Y., Yuan, W., Wu, X., Jiang, Z., Li, F., Fan, X."Identification of GDP as a small inhibitory molecule in HepG2 cells by non‑targeted metabolomics analysis". Oncology Letters 29, no. 4 (2025): 178. https://doi.org/10.3892/ol.2025.14924
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team