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Case Report Open Access

Pembrolizumab as an effective treatment for diffuse malignant peritoneal mesothelioma with long‑term survival: A case report and literature review

  • Authors:
    • Chongxiang Xue
    • Zhe Dong
    • Kexin Tan
    • Xu Zhang
    • Yixuan Yu
    • Shuo Wang
    • Jiabin Zheng
    • Huijuan Cui
  • View Affiliations / Copyright

    Affiliations: School of Clinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, P.R. China, Center for Coronary Artery Disease, Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, P.R. China, Department of Traditional Chinese Medicine/Integrative Medicine, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan 410006, P.R. China, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China, Intensive Care Unit, Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, Zhejiang 322000, P.R. China, Department of Integrative Oncology, China‑Japan Friendship Hospital, Beijing 100029, P.R. China
    Copyright: © Xue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 187
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    Published online on: February 13, 2025
       https://doi.org/10.3892/ol.2025.14933
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Abstract

Primary diffuse malignant peritoneal mesothelioma (MPEM) is a malignant disease without standard treatments recommended. Recently, immunotherapy has revolutionized the field of tumor therapy. According to current clinical evidence, advanced MPEM may gain potential clinical benefits from immune checkpoint inhibitors. The present study reported a 61‑year‑old female patient with persistent low fever as the initial symptom, who was eventually diagnosed with MPEM. This patient obtained significant clinical benefits from pembrolizumab, with disappearance of symptoms, a lasting stable disease response with a progression‑free survival of 10.0 months and a long overall survival of 26.2 months. The application of pembrolizumab was explored as an emerging effective treatment for patients with MPEM. In addition, the clinical characteristics, diagnosis, treatment, pathogenesis and target regulation in MPEM were discussed and previous studies were reviewed. Further evidence is needed from future extensive clinical trials.
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Xue C, Dong Z, Tan K, Zhang X, Yu Y, Wang S, Zheng J and Cui H: Pembrolizumab as an effective treatment for diffuse malignant peritoneal mesothelioma with long‑term survival: A case report and literature review. Oncol Lett 29: 187, 2025.
APA
Xue, C., Dong, Z., Tan, K., Zhang, X., Yu, Y., Wang, S. ... Cui, H. (2025). Pembrolizumab as an effective treatment for diffuse malignant peritoneal mesothelioma with long‑term survival: A case report and literature review. Oncology Letters, 29, 187. https://doi.org/10.3892/ol.2025.14933
MLA
Xue, C., Dong, Z., Tan, K., Zhang, X., Yu, Y., Wang, S., Zheng, J., Cui, H."Pembrolizumab as an effective treatment for diffuse malignant peritoneal mesothelioma with long‑term survival: A case report and literature review". Oncology Letters 29.4 (2025): 187.
Chicago
Xue, C., Dong, Z., Tan, K., Zhang, X., Yu, Y., Wang, S., Zheng, J., Cui, H."Pembrolizumab as an effective treatment for diffuse malignant peritoneal mesothelioma with long‑term survival: A case report and literature review". Oncology Letters 29, no. 4 (2025): 187. https://doi.org/10.3892/ol.2025.14933
Copy and paste a formatted citation
x
Spandidos Publications style
Xue C, Dong Z, Tan K, Zhang X, Yu Y, Wang S, Zheng J and Cui H: Pembrolizumab as an effective treatment for diffuse malignant peritoneal mesothelioma with long‑term survival: A case report and literature review. Oncol Lett 29: 187, 2025.
APA
Xue, C., Dong, Z., Tan, K., Zhang, X., Yu, Y., Wang, S. ... Cui, H. (2025). Pembrolizumab as an effective treatment for diffuse malignant peritoneal mesothelioma with long‑term survival: A case report and literature review. Oncology Letters, 29, 187. https://doi.org/10.3892/ol.2025.14933
MLA
Xue, C., Dong, Z., Tan, K., Zhang, X., Yu, Y., Wang, S., Zheng, J., Cui, H."Pembrolizumab as an effective treatment for diffuse malignant peritoneal mesothelioma with long‑term survival: A case report and literature review". Oncology Letters 29.4 (2025): 187.
Chicago
Xue, C., Dong, Z., Tan, K., Zhang, X., Yu, Y., Wang, S., Zheng, J., Cui, H."Pembrolizumab as an effective treatment for diffuse malignant peritoneal mesothelioma with long‑term survival: A case report and literature review". Oncology Letters 29, no. 4 (2025): 187. https://doi.org/10.3892/ol.2025.14933
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