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[68Ga]‑DOTA‑conjugated somatostatin receptor‑targeting peptide PET for the differentiation between meningioma and glioblastoma: A case report and review of the literature

  • Authors:
    • Laurèl Rauschenbach
    • Felix M. Gerach
    • Christoph Berliner
    • Tobias Blau
    • Sied Kebir
    • Celia Dobersalske
    • Cornelius Deuschl
    • Ulrich Sure
    • Ken Herrmann
    • Philipp Dammann
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery and Spine Surgery, University Hospital Essen, D-45147 Essen, Germany, Department of Nuclear Medicine, University Hospital Essen, D-45147 Essen, Germany, Institute of Neuropathology, University Hospital Essen, D-45147 Essen, Germany, DKFZ Division of Translational Neurooncology at The West German Cancer Center (WTZ), German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, A Partnership Between DKFZ and University Hospital Essen, University Duisburg‑Essen, D-45147 Essen, Germany, Institute for Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, D-45147 Essen, Germany
    Copyright: © Rauschenbach et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 199
    |
    Published online on: February 24, 2025
       https://doi.org/10.3892/ol.2025.14945
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Abstract

[68Ga]‑tetraazacyclododecanetetraacetic acid (DOTA)‑conjugated positron emission tomography (PET) is widely used to identify meningiomas due to their high expression of somatostatin receptor type 2 (SSTR2). However, recent evidence suggests that this tracer may also show uptake in high‑grade gliomas, raising concerns about its diagnostic specificity. The current study presents a challenging case of a 56‑year‑old man who was initially diagnosed with a right temporal glioblastoma. Follow‑up imaging revealed a local recurrence and a new extra‑axial lesion suggestive of meningioma on magnetic resonance imaging and [68Ga]‑DOTA‑octreotide (DOTATOC) PET. Unexpectedly, histopathological analysis following resection confirmed both lesions as glioblastomas, indicating that SSTR2 uptake is not exclusive to meningiomas. A systematic literature review further supports the fact that high‑grade gliomas can exhibit [68Ga]‑DOTA tracer uptake, though generally at lower levels than meningiomas. These findings suggest that while [68Ga]‑DOTA PET provides useful diagnostic information, interpreting results requires caution in cases where glioblastoma might mimic meningioma. Future research should focus on establishing clear thresholds to reliably distinguish between meningiomas and high‑grade gliomas, enhancing diagnostic precision and treatment planning in neuro‑oncology.
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Copy and paste a formatted citation
Spandidos Publications style
Rauschenbach L, Gerach FM, Berliner C, Blau T, Kebir S, Dobersalske C, Deuschl C, Sure U, Herrmann K, Dammann P, Dammann P, et al: [<sup>68</sup>Ga]‑DOTA‑conjugated somatostatin receptor‑targeting peptide PET for the differentiation between meningioma and glioblastoma: A case report and review of the literature. Oncol Lett 29: 199, 2025.
APA
Rauschenbach, L., Gerach, F.M., Berliner, C., Blau, T., Kebir, S., Dobersalske, C. ... Dammann, P. (2025). [<sup>68</sup>Ga]‑DOTA‑conjugated somatostatin receptor‑targeting peptide PET for the differentiation between meningioma and glioblastoma: A case report and review of the literature. Oncology Letters, 29, 199. https://doi.org/10.3892/ol.2025.14945
MLA
Rauschenbach, L., Gerach, F. M., Berliner, C., Blau, T., Kebir, S., Dobersalske, C., Deuschl, C., Sure, U., Herrmann, K., Dammann, P."[<sup>68</sup>Ga]‑DOTA‑conjugated somatostatin receptor‑targeting peptide PET for the differentiation between meningioma and glioblastoma: A case report and review of the literature". Oncology Letters 29.4 (2025): 199.
Chicago
Rauschenbach, L., Gerach, F. M., Berliner, C., Blau, T., Kebir, S., Dobersalske, C., Deuschl, C., Sure, U., Herrmann, K., Dammann, P."[<sup>68</sup>Ga]‑DOTA‑conjugated somatostatin receptor‑targeting peptide PET for the differentiation between meningioma and glioblastoma: A case report and review of the literature". Oncology Letters 29, no. 4 (2025): 199. https://doi.org/10.3892/ol.2025.14945
Copy and paste a formatted citation
x
Spandidos Publications style
Rauschenbach L, Gerach FM, Berliner C, Blau T, Kebir S, Dobersalske C, Deuschl C, Sure U, Herrmann K, Dammann P, Dammann P, et al: [<sup>68</sup>Ga]‑DOTA‑conjugated somatostatin receptor‑targeting peptide PET for the differentiation between meningioma and glioblastoma: A case report and review of the literature. Oncol Lett 29: 199, 2025.
APA
Rauschenbach, L., Gerach, F.M., Berliner, C., Blau, T., Kebir, S., Dobersalske, C. ... Dammann, P. (2025). [<sup>68</sup>Ga]‑DOTA‑conjugated somatostatin receptor‑targeting peptide PET for the differentiation between meningioma and glioblastoma: A case report and review of the literature. Oncology Letters, 29, 199. https://doi.org/10.3892/ol.2025.14945
MLA
Rauschenbach, L., Gerach, F. M., Berliner, C., Blau, T., Kebir, S., Dobersalske, C., Deuschl, C., Sure, U., Herrmann, K., Dammann, P."[<sup>68</sup>Ga]‑DOTA‑conjugated somatostatin receptor‑targeting peptide PET for the differentiation between meningioma and glioblastoma: A case report and review of the literature". Oncology Letters 29.4 (2025): 199.
Chicago
Rauschenbach, L., Gerach, F. M., Berliner, C., Blau, T., Kebir, S., Dobersalske, C., Deuschl, C., Sure, U., Herrmann, K., Dammann, P."[<sup>68</sup>Ga]‑DOTA‑conjugated somatostatin receptor‑targeting peptide PET for the differentiation between meningioma and glioblastoma: A case report and review of the literature". Oncology Letters 29, no. 4 (2025): 199. https://doi.org/10.3892/ol.2025.14945
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