Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2025 Volume 29 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2025 Volume 29 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Clinical outcome analysis of different first‑ and second‑generation EGFR‑tyrosine kinase inhibitors in untreated patients with EGFR‑mutated non‑small cell lung cancer with baseline brain metastasis

  • Authors:
    • Chen-Chuan Hsu
    • Li-Chung Chiu
    • How-Wen Ko
    • Chiao-En Wu
    • Scott Chih‑Hsi Kuo
    • Jia-Shiuan Ju
    • Allen Chung‑Cheng Huang
    • Chin-Chou Wang
    • Cheng-Ta Yang
    • Ping-Chih Hsu
  • View Affiliations / Copyright

    Affiliations: Division of Thoracic Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan, R.O.C., Department of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan, R.O.C.
    Copyright: © Hsu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 201
    |
    Published online on: February 26, 2025
       https://doi.org/10.3892/ol.2025.14947
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Currently, the clinical outcomes of patients with epidermal growth factor receptor (EGFR)‑mutated non‑small cell lung cancer (NSCLC) with baseline brain metastasis receiving first‑ and second‑generation EGFR‑tyrosine kinase inhibitors (TKIs) are not clear. The present study aimed to assess the clinical outcomes of patients with EGFR‑mutated NSCLC with baseline brain metastasis who received first‑line first‑ and second‑generation EGFR‑TKIs. In the present study, a retrospective analysis of clinical charts was performed to investigate first‑ and second‑generation EGFR‑TKIs in patients with EGFR‑mutated NSCLC with baseline brain metastasis. Data from 197 patients with EGFR‑mutated NSCLC with baseline brain metastasis who received first‑line gefitinib, erlotinib or afatinib between May 2013 and January 2020 were retrieved from the Cancer Center database of Chang Gung Memorial Hospital at Linkou for analysis. The systemic objective response rate and intracranial response rate to first‑line EGFR‑TKIs were 75.1 and 76.1%, respectively. The median progression‑free survival (PFS) with first‑line EGFR‑TKIs, brain metastasis PFS (BMPFS) and overall survival (OS) of all the included patients were 13.07 [95% confidence interval (CI), 11.43‑14.70], 24.63 (95% CI, 20.98‑28.28) and 28.13 months (95% CI, 23.53‑32.74), respectively. According to multivariate analysis, a greater number of brain metastases (>3) and the presence of leptomeningeal carcinomatosis (LMC) were independent predictors of a shorter PFS. Patients with a greater number of brain metastases or LMC also had markedly shorter BMPFS and OS than those with fewer brain metastases or no LMC. First‑ and second‑generation EGFR‑TKIs were effective for treating previously untreated patients with EGFR‑mutated NSCLC with baseline brain metastasis. In conclusion, for patients whose unfavorable factors [a greater number of brain metastases (>3) and LMCs] are associated with worse clinical outcomes, upfront osimertinib therapy, alone or in combination with other therapeutic strategies and procedures, should be considered.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Sharma SV, Bell DW, Settleman J and Haber DA: Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer. 7:169–181. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Liu SV, Elkins IB, Feldman J and Goldberg SB: EGFR mutations are not all the same: The importance of biomarker testing in non-small cell lung cancer (NSCLC)-A podcast discussion between patients and oncologists. Oncol Ther. 11:419–431. 2023. View Article : Google Scholar : PubMed/NCBI

3 

Li K, Yang M, Liang N and Li S: Determining EGFR-TKI sensitivity of G719X and other uncommon EGFR mutations in non-small cell lung cancer: Perplexity and solution (Review). Oncol Rep. 37:1347–1358. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Hsu PC, Lee SH, Chiu LC, Lee CS, Wu CE, Kuo SC, Ju JS, Huang AC, Li SH, Ko HW, et al: Afatinib in untreated stage IIIB/IV lung adenocarcinoma with major uncommon epidermal growth factor receptor (EGFR) mutations (G719X/L861Q/S768I): A multicenter observational study in Taiwan. Target Oncol. 18:195–207. 2023. View Article : Google Scholar : PubMed/NCBI

5 

Valley CC, Arndt-Jovin DJ, Karedla N, Steinkamp MP, Chizhik AI, Hlavacek WS, Wilson BS, Lidke KA and Lidke DS: Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer. Mol Biol Cell. 26:4087–4099. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Hsu PC, Chang JW, Chang CF, Huang CY, Yang CT, Kuo CS, Fang YF and Wu CE: Sequential treatment in advanced non-small cell lung cancer harboring EGFR mutations. Ther Adv Respir Dis. 16:175346662211327312022. View Article : Google Scholar : PubMed/NCBI

7 

Lin CY, Chou YT, Su PL, Lin CC, Chang JW, Huang CY, Fang YF, Chang CF, Kuo CS, Hsu PC, et al: Generation and validation of a predictive model for estimating survival among patients with EGFR-mutant non-small cell lung cancer. Am J Cancer Res. 13:4208–4221. 2023.PubMed/NCBI

8 

Morimoto K, Yamada T, Takeda T, Shiotsu S, Date K, Tamiya N, Goto Y, Kanda H, Chihara Y, Kunimatsu Y, et al: Clinical efficacy and safety of first- or second-generation EGFR-TKIs after osimertinib resistance for EGFR mutated lung cancer: A prospective exploratory study. Target Oncol. 18:657–665. 2023. View Article : Google Scholar : PubMed/NCBI

9 

Huang AC, Huang CH, Ju JS, Chiu TH, Tung PH, Wang CC, Liu CY, Chung FT, Fang YF, Guo YK, et al: First- or second-generation epidermal growth factor receptor tyrosine kinase inhibitors in a large, real-world cohort of patients with non-small cell lung cancer. Ther Adv Med Oncol. 13:175883592110357102021. View Article : Google Scholar : PubMed/NCBI

10 

Marin-Acevedo JA, Pellini B, Kimbrough EO, Hicks JK and Chiappori A: Treatment strategies for non-small cell lung cancer with common EGFR mutations: A review of the history of EGFR TKIs approval and emerging data. Cancers (Basel). 15:6292023. View Article : Google Scholar : PubMed/NCBI

11 

Hsu PC, Miao J, Huang Z, Yang YL, Xu Z, You J, Dai Y, Yeh CC, Chan G, Liu S, et al: Inhibition of yes-associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model. J Cell Mol Med. 22:3073–3085. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Hsu PC, Chiu LC, Chen KT, Wang CC, Wu CT, Wu CE, Ko HW, Kuo SC, Lin YC, Wang CC and Yang CT: Clinical outcome analysis of non-small cell lung cancer patients with brain metastasis receiving metastatic brain tumor resection surgery: A multicenter observational study. Am J Cancer Res. 13:3607–3617. 2023.PubMed/NCBI

13 

Shin DY, Na II, Kim CH, Park S, Baek H and Yang SH: EGFR mutation and brain metastasis in pulmonary adenocarcinomas. J Thorac Oncol. 9:195–199. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Park SJ, Kim HT, Lee DH, Kim KP, Kim SW, Suh C and Lee JS: Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 mutation. Lung Cancer. 77:556–560. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Li SH, Liu CY, Hsu PC, Fang YF, Wang CC, Kao KC, Tseng LC and Yang CT: Response to afatinib in treatment-naïve patients with advanced mutant epidermal growth factor receptor lung adenocarcinoma with brain metastases. Expert Rev Anticancer Ther. 18:81–89. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Huang SF, Liu HP, Li LH, Ku YC, Fu YN, Tsai HY, Chen YT, Lin YF, Chang WC, Kuo HP, et al: High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan. Clin Cancer Res. 10:8195–8203. 2004. View Article : Google Scholar : PubMed/NCBI

17 

National Cancer Institute Common Terminology, . Criteria for adverse events (version 3.0).

18 

Baik CS, Chamberlain MC and Chow LQL: Targeted therapy for brain metastases in EGFR-mutated and ALK-rearranged non-small-cell lung cancer. J Thorac Oncol. 10:1268–1278. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Zeng Y, Su X, Zhao Y, Zhou Y, Guo T, Chu X, Chu L, Yang X, Ni J and Zhu Z: Rationale and value of consolidative cranial local therapy in EGFR-mutant non-small cell lung cancer patients with baseline brain metastasis treated with first-line EGFR-TKIs. Ther Adv Med Oncol. 15:175883592311699752023. View Article : Google Scholar : PubMed/NCBI

20 

Mahajan A, Ahmed S, McAleer MF, Weinberg JS, Li J, Brown P, Settle S, Prabhu SS, Lang FF, Levine N, et al: Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: A single-centre, randomised, controlled, phase 3 trial. Lancet Oncol. 18:1040–1048. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Tsui DCC, Camidge DR and Rusthoven CG: Managing central nervous system spread of lung cancer: The state of the art. J Clin Oncol. 40:642–660. 2022. View Article : Google Scholar : PubMed/NCBI

22 

Linh DM, Thinh TH, Hieu NV and Duc NM: Treatment outcomes of EGFR-TKI with or without locoregional brain therapy in advanced EGFR-mutant non-small cell lung cancer patients with brain metastases. Contemp Oncol (Pozn). 27:71–79. 2023.PubMed/NCBI

23 

Colclough N, Chen K, Johnström P, Strittmatter N, Yan Y, Wrigley GL, Schou M, Goodwin R, Varnäs K, Adua SJ, et al: Preclinical comparison of the blood-brain barrier permeability of osimertinib with other EGFR TKIs. Clin Cancer Res. 27:189–201. 2021. View Article : Google Scholar : PubMed/NCBI

24 

Soria JC, Ohe Y, Vansteenkiste J, Reungwetwattana T, Chewaskulyong B, Lee KH, Dechaphunkul A, Imamura F, Nogami N, Kurata T, et al: Osimertinib in untreated EGFR-mutated advanced non-small-cell lung cancer. N Engl J Med. 378:113–125. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Huang YH, Hsu KH, Tseng JS, Yang TY, Chen KC, Su KY, Yu SL, Chen JJW and Chang GC: The difference in clinical outcomes between osimertinib and afatinib for first-line treatment in patients with advanced and recurrent EGFR-mutant non-small cell lung cancer in Taiwan. Target Oncol. 17:295–306. 2022. View Article : Google Scholar : PubMed/NCBI

26 

Holleman MS, Al MJ, Zaim R, Groen HJM and Uyl-de Groot CA: Cost-effectiveness analysis of the first-line EGFR-TKIs in patients with non-small cell lung cancer harbouring EGFR mutations. Eur J Health Econ. 21:153–164. 2020. View Article : Google Scholar : PubMed/NCBI

27 

Guan H, Wang C, Chen C, Han S and Zhao Z: Cost-effectiveness of 12 first-line treatments for patients with advanced EGFR mutated NSCLC in the United Kingdom and China. Front Oncol. 12:8196742022. View Article : Google Scholar : PubMed/NCBI

28 

Shah PP, Franke JL, Medikonda R, Jackson CM, Srivastava S, Choi J, Forde PM, Brahmer JR, Ettinger DS, Feliciano JL, et al: Mutation status and postresection survival of patients with non-small cell lung cancer brain metastasis: Implications of biomarker-driven therapy. J Neurosurg. 136:56–66. 2021. View Article : Google Scholar : PubMed/NCBI

29 

Perng PS, Hsu HP, Lee PH, Huang CC, Lin CC and Lee JS: Correlation of EGFR mutation subtypes and survival in surgically treated brain metastasis from non-small-cell lung cancer. Asian J Surg. 46:269–276. 2023. View Article : Google Scholar : PubMed/NCBI

30 

Cheng H and Perez-Soler R: Leptomeningeal metastases in non-small-cell lung cancer. Lancet Oncol. 19:e43–e55. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Hong Y, Miao Q, Zheng X, Xu Y, Huang Y, Chen S, Huang Z, Xu H, Jiang K, Zhong Q, et al: Effects of intrathecal pemetrexed on the survival of patients with leptomeningeal metastasis from lung adenocarcinoma: A propensity score matching analysis. J Neurooncol. 165:301–312. 2023. View Article : Google Scholar : PubMed/NCBI

32 

Feng PH, Chen KY, Huang YC, Luo CS, Wu SM, Chen TT, Lee CN, Yeh CT, Chuang HC, Han CL, et al: Bevacizumab reduces S100A9-positive MDSCs linked to intracranial control in patients with EGFR-mutant lung adenocarcinoma. J Thorac Oncol. 13:958–9567. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Lee SH, Lin YC, Chiu LC, Ju JS, Tung PH, Huang AC, Li SH, Fang YF, Chen CH, Kuo SC, et al: Comparison of afatinib and erlotinib combined with bevacizumab in untreated stage IIIB/IV epidermal growth factor receptor-mutated lung adenocarcinoma patients: A multicenter clinical analysis study. Ther Adv Med Oncol. 14:175883592211132782022. View Article : Google Scholar : PubMed/NCBI

34 

Bar J, Peled N, Schokrpur S, Wolner M, Rotem O, Girard N, Aboubakar Nana F, Derijcke S, Kian W, Patel S, et al: UNcommon EGFR Mutations: International Case Series on Efficacy of Osimertinib in Real-Life Practice in First-LiNe Setting (UNICORN). J Thorac Oncol. 18:169–180. 2023. View Article : Google Scholar : PubMed/NCBI

35 

Hsu PC, Chang JW, Chiu LC, Yang CT, Kuo SC, Fang YF and Wu CE: Analysis of genomic alternations in epidermal growth factor receptor (EGFR)-T790M-mutated non-small cell lung cancer (NSCLC) patients with acquired resistance to osimertinib therapy. Clin Transl Oncol. Sep 24;doi: 10.1007/s12094-024-03727-7 (Epub ahead of print).

36 

Shalata W, Abu Jama A, Dudnik Y, Abu Saleh O, Shalata S, Tourkey L, Sheva K, Meirovitz A and Yakobson A: Adverse events in osimertinib treatment for EGFR-Mutated Non-Small-Cell lung cancer: Unveiling Rare Life-threatening myelosuppression. Medicina (Kaunas). 60:12702024. View Article : Google Scholar : PubMed/NCBI

37 

Zhou S, Kishi N, Alerasool P and Rohs NC: Adverse event profile of epidermal growth factor receptor tyrosine kinase inhibitors for Non-small cell lung cancer: An updated Meta-analysis. Target Oncol. 19:547–564. 2024. View Article : Google Scholar : PubMed/NCBI

38 

Marrett E, Kwong WJ and Chow LQ: Factors associated with time to EGFR TKI treatment in patients with non-squamous metastatic non-small-cell lung cancer. Future Oncol. 18:1535–1544. 2022. View Article : Google Scholar : PubMed/NCBI

39 

Ju JS, Huang AC, Tung PH, Huang CH, Chiu TH, Wang CC, Ko HW, Chung FT, Hsu PC, Fang YF, et al: Brain metastasis, EGFR mutation subtype and generation of EGFR-TKI jointly influence the treatment outcome of patient with EGFR-mutant NSCLC. Sci Rep. 13:203232023. View Article : Google Scholar : PubMed/NCBI

40 

Gu Y, Xu Y, Zhuang H, Jiang W, Zhang H, Li X, Liu Y, Ma L, Zhao D, Cheng Y, et al: Value and significance of brain radiation therapy during first-line EGFR-TKI treatment in lung adenocarcinoma with EGFR sensitive mutation and synchronous brain metastasis: Appropriate timing and technique. Thorac Cancer. 12:3157–3168. 2021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hsu C, Chiu L, Ko H, Wu C, Kuo SC, Ju J, Huang AC, Wang C, Yang C, Hsu P, Hsu P, et al: Clinical outcome analysis of different first‑ and second‑generation EGFR‑tyrosine kinase inhibitors in untreated patients with EGFR‑mutated non‑small cell lung cancer with baseline brain metastasis. Oncol Lett 29: 201, 2025.
APA
Hsu, C., Chiu, L., Ko, H., Wu, C., Kuo, S.C., Ju, J. ... Hsu, P. (2025). Clinical outcome analysis of different first‑ and second‑generation EGFR‑tyrosine kinase inhibitors in untreated patients with EGFR‑mutated non‑small cell lung cancer with baseline brain metastasis. Oncology Letters, 29, 201. https://doi.org/10.3892/ol.2025.14947
MLA
Hsu, C., Chiu, L., Ko, H., Wu, C., Kuo, S. C., Ju, J., Huang, A. C., Wang, C., Yang, C., Hsu, P."Clinical outcome analysis of different first‑ and second‑generation EGFR‑tyrosine kinase inhibitors in untreated patients with EGFR‑mutated non‑small cell lung cancer with baseline brain metastasis". Oncology Letters 29.4 (2025): 201.
Chicago
Hsu, C., Chiu, L., Ko, H., Wu, C., Kuo, S. C., Ju, J., Huang, A. C., Wang, C., Yang, C., Hsu, P."Clinical outcome analysis of different first‑ and second‑generation EGFR‑tyrosine kinase inhibitors in untreated patients with EGFR‑mutated non‑small cell lung cancer with baseline brain metastasis". Oncology Letters 29, no. 4 (2025): 201. https://doi.org/10.3892/ol.2025.14947
Copy and paste a formatted citation
x
Spandidos Publications style
Hsu C, Chiu L, Ko H, Wu C, Kuo SC, Ju J, Huang AC, Wang C, Yang C, Hsu P, Hsu P, et al: Clinical outcome analysis of different first‑ and second‑generation EGFR‑tyrosine kinase inhibitors in untreated patients with EGFR‑mutated non‑small cell lung cancer with baseline brain metastasis. Oncol Lett 29: 201, 2025.
APA
Hsu, C., Chiu, L., Ko, H., Wu, C., Kuo, S.C., Ju, J. ... Hsu, P. (2025). Clinical outcome analysis of different first‑ and second‑generation EGFR‑tyrosine kinase inhibitors in untreated patients with EGFR‑mutated non‑small cell lung cancer with baseline brain metastasis. Oncology Letters, 29, 201. https://doi.org/10.3892/ol.2025.14947
MLA
Hsu, C., Chiu, L., Ko, H., Wu, C., Kuo, S. C., Ju, J., Huang, A. C., Wang, C., Yang, C., Hsu, P."Clinical outcome analysis of different first‑ and second‑generation EGFR‑tyrosine kinase inhibitors in untreated patients with EGFR‑mutated non‑small cell lung cancer with baseline brain metastasis". Oncology Letters 29.4 (2025): 201.
Chicago
Hsu, C., Chiu, L., Ko, H., Wu, C., Kuo, S. C., Ju, J., Huang, A. C., Wang, C., Yang, C., Hsu, P."Clinical outcome analysis of different first‑ and second‑generation EGFR‑tyrosine kinase inhibitors in untreated patients with EGFR‑mutated non‑small cell lung cancer with baseline brain metastasis". Oncology Letters 29, no. 4 (2025): 201. https://doi.org/10.3892/ol.2025.14947
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team