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Effects of circulating RNAs on tumor metabolism in lung cancer (Review)

  • Authors:
    • Pengfei Zhao
    • Zhengfeng Zhu
    • Xinzhe Zheng
    • Yongxiang Song
    • Cheng Chen
    • Gang Xu
    • Xixian Ke
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 204
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    Published online on: February 27, 2025
       https://doi.org/10.3892/ol.2025.14950
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Abstract

During the development and progression of lung cancer, cell metabolism function is altered. Thus, cells rely on aerobic glycolysis and abnormal lipid and amino acid metabolism to obtain energy and nutrients for growth, proliferation and drug resistance. Circular RNAs (circRNAs), a class of non‑coding RNAs, serve important biological roles in the growth and development of tumors. Functionally, circRNAs act as molecular sponges that absorb microRNAs (miRNAs) and RNA‑binding proteins and as protein scaffolds that regulate gene transcription and translation through the maintenance of mRNA stability. In addition, circRNAs are important regulators of tumor metabolism and promote tumor progression through mediating tumor cell proliferation, metastasis and the induction of chemoresistance. Results of previous studies reveal that circRNAs may serve a key role in regulating tumor metabolic processes in lung cancer, through miRNA sponging and alternative mechanisms. Thus, circRNAs demonstrate potential as therapeutic targets for lung cancer. The present study aimed to review the effects of circRNAs on lung cancer cell metabolism and provide novel insights into the clinical treatment of lung cancer. The present review may also provide a novel theoretical basis for the development of lung cancer drug targets.
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1 

Siegel RL, Miller KD, Wagle NS and Jemal A: Cancer statistics, 2023. CA Cancer J Clin. 73:17–48. 2023. View Article : Google Scholar : PubMed/NCBI

2 

Chen R, Manochakian R, James L, Azzouqa AG, Shi H, Zhang Y, Zhao Y, Zhou K and Lou Y: Emerging therapeutic agents for advanced non-small cell lung cancer. J Hematol Oncol. 13:582020. View Article : Google Scholar : PubMed/NCBI

3 

Osmani L, Askin F, Gabrielson E and Li QK: Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy. Semin Cancer Biol. 52:103–109. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Cheng C, Wang P, Yang Y, Du X, Xia H, Liu J, Lu L, Wu H and Liu Q: Smoking-induced M2-TAMs, via circEML4 in EVs, promote the progression of NSCLC through ALKBH5-regulated m6A modification of SOCS2 in NSCLC cells. Adv Sci (Weinh). 10:e23009532023. View Article : Google Scholar : PubMed/NCBI

5 

Li Y, Liu T, Wang X, Jia Y and Cui H: Autophagy and glycometabolic reprograming in the malignant progression of lung cancer: A review. Technol Cancer Res Treat. 22:153303382311905452023. View Article : Google Scholar : PubMed/NCBI

6 

Feng XY, Zhu SX, Pu KJ, Huang HJ, Chen YQ and Wang WT: New insight into circRNAs: Characterization, strategies, and biomedical applications. Exp Hematol Oncol. 12:912023. View Article : Google Scholar : PubMed/NCBI

7 

Alkhathami AG, Sahib AS, Al Fayi MS, Fadhil AA, Jawad MA, Shafik SA, Sultan SJ, Almulla AF and Shen M: Glycolysis in human cancers: Emphasis circRNA/glycolysis axis and nanoparticles in glycolysis regulation in cancer therapy. Environ Res. 234:1160072023. View Article : Google Scholar : PubMed/NCBI

8 

Kim J: Circular RNAs: Novel players in cancer mechanisms and therapeutic strategies. Int J Mol Sci. 25:101212024. View Article : Google Scholar : PubMed/NCBI

9 

Du Z: CircNRIP1: An emerging star in multiple cancers. Pathol Res Pract. 241:1542812023. View Article : Google Scholar : PubMed/NCBI

10 

Yang J, Hu Z, Ru X, He M, Hu Z, Qin X, Xiao S, Liu D, Huang H and Wei Q: Hsa_circ_0002005 aggravates osteosarcoma by increasing cell proliferation, migration, and invasion. Gene. 942:1492212025. View Article : Google Scholar : PubMed/NCBI

11 

Hu Y, Cai ZR, Huang RZ, Wang DS, Ju HQ and Chen DL: Circular RNA circPHLPP2 promotes tumor growth and anti-PD-1 resistance through binding ILF3 to regulate IL36γ transcription in colorectal cancer. Mol Cancer. 23:2722024. View Article : Google Scholar : PubMed/NCBI

12 

Chen X, Gu J, Huang J, Wen K, Zhang G, Chen Z and Wang Z: Characterization of circRNAs in established osimertinib-resistant non-small cell lung cancer cell lines. Int J Mol Med. 52:1022023. View Article : Google Scholar : PubMed/NCBI

13 

Kamali MJ, Salehi M, Mostafavi M, Morovatshoar R, Akbari M, Latifi N, Barzegari O, Ghadimi F and Daraei A: Hijacking and rewiring of host CircRNA/miRNA/mRNA competitive endogenous RNA (ceRNA) regulatory networks by oncoviruses during development of viral cancers. Rev Med Virol. 34:e25302024. View Article : Google Scholar : PubMed/NCBI

14 

Wang MH, Liu ZH, Zhang HX, Liu HC and Ma LH: Hsa_circRNA_000166 accelerates breast cancer progression via the regulation of the miR-326/ELK1 and miR-330-5p/ELK1 axes. Ann Med. 56:24245152024. View Article : Google Scholar : PubMed/NCBI

15 

Li X, Wang Y, Cheng J, Qiu L, Wang R, Zhang Y and Wang H: METTL3 -mediated m6A modification of circ_0000620 regulates cisplatin sensitivity and apoptosis in lung adenocarcinoma via the MiR-216b-5p/KRAS axis. Cell Signal. 123:1113492024. View Article : Google Scholar : PubMed/NCBI

16 

Lu H, Han X, Ren J, Ren K, Li Z and Sun Z: Circular RNA HIPK3 induces cell proliferation and inhibits apoptosis in non-small cell lung cancer through sponging miR-149. Cancer Biol Ther. 21:113–121. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Gadaleta E, Thorn GJ, Ross-Adams H, Jones LJ and Chelala C: Field cancerization in breast cancer. J Pathol. 257:561–574. 2022. View Article : Google Scholar : PubMed/NCBI

18 

Bi W, Huang J, Nie C, Liu B, He G, Han J, Pang R, Ding Z, Xu J and Zhang J: CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of β-catenin pathway. J Exp Clin Cancer Res. 37:2752018. View Article : Google Scholar : PubMed/NCBI

19 

Yu S, Su S, Wang P, Li J, Chen C, Xin H, Gong Y, Wang H, Ye X, Mao L, et al: Tumor-associated macrophage-induced circMRCKα encodes a peptide to promote glycolysis and progression in hepatocellular carcinoma. Cancer Lett. 591:2168722024. View Article : Google Scholar : PubMed/NCBI

20 

Sun X, Zhao X, Xu Y, Yan Y, Han L, Wei M and He M: Potential therapeutic strategy for cancer: Multi-dimensional cross-talk between circRNAs and parental genes. Cancer Lett. 588:2167942024. View Article : Google Scholar : PubMed/NCBI

21 

Li Z, Yin S, Yang K, Zhang B, Wu X, Zhang M and Gao D: CircRNA regulation of t cells in cancer: Unraveling potential targets. Int J Mol Sci. 25:63832024. View Article : Google Scholar : PubMed/NCBI

22 

Huang M, Sun J, Jiang Q, Zhao X, Huang H, Lei M, Jiang S, Yuan F and Liu Z: CircKIAA0182-YBX1 axis: A key driver of lung cancer progression and chemoresistance. Cancer Lett. 612:2174942025. View Article : Google Scholar : PubMed/NCBI

23 

Jin J, Zhao Q, Wei Z, Chen K, Su Y, Hu X and Peng X: Glycolysis-cholesterol metabolic axis in immuno-oncology microenvironment: Emerging role in immune cells and immunosuppressive signaling. Cell Biosci. 13:1892023. View Article : Google Scholar : PubMed/NCBI

24 

Chen X, Hao Y, Liu Y, Zhong S, You Y, Ao K, Chong T, Luo X, Yin M, Ye M, et al: NAT10/ac4C/FOXP1 promotes malignant progression and facilitates immunosuppression by reprogramming glycolytic metabolism in cervical cancer. Adv Sci (Weinh). 10:e23027052023. View Article : Google Scholar : PubMed/NCBI

25 

Zhang Y, Sun S, Qi Y, Dai Y, Hao Y, Xin M, Xu R, Chen H, Wu X, Liu Q, et al: Characterization of tumour microenvironment reprogramming reveals invasion in epithelial ovarian carcinoma. J Ovarian Res. 16:2002023. View Article : Google Scholar : PubMed/NCBI

26 

Li S, Peng M, Tan S, Oyang L, Lin J, Xia L, Wang J, Wu N, Jiang X, Peng Q, et al: The roles and molecular mechanisms of non-coding RNA in cancer metabolic reprogramming. Cancer Cell Int. 24:372024. View Article : Google Scholar : PubMed/NCBI

27 

Hsu CY, Faisal A, Jumaa SS, Gilmanova NS, Ubaid M, Athab AH, Mirzaei R and Karampoor S: Exploring the impact of circRNAs on cancer glycolysis: Insights into tumor progression and therapeutic strategies. Noncoding RNA Res. 9:970–994. 2024. View Article : Google Scholar : PubMed/NCBI

28 

Geng Y, Jiang J and Wu C: Function and clinical significance of circRNAs in solid tumors. J Hematol Oncol. 11:982018. View Article : Google Scholar : PubMed/NCBI

29 

Jiang C, Zeng X, Shan R, Wen W, Li J, Tan J, Li L and Wan R: The emerging picture of the roles of CircRNA-CDR1as in cancer. Front Cell Dev Biol. 8:5904782020. View Article : Google Scholar : PubMed/NCBI

30 

Yang Y, Yujiao W, Fang W, Linhui Y, Ziqi G, Zhichen W, Zirui W and Shengwang W: The roles of miRNA, lncRNA and circRNA in the development of osteoporosis. Biol Res. 53:402020. View Article : Google Scholar : PubMed/NCBI

31 

Lin H, Conn VM and Conn SJ: Past, present, and future strategies for detecting and quantifying circular RNA variants. FEBS J. Feb 11–2025.(Epub ahead of print). View Article : Google Scholar

32 

Yang X, Xia J, Peng C and Cai W: Expression of plasma exosomal circLPAR1 in patients with gastric cancer and its clinical application value. Am J Cancer Res. 13:4269–4276. 2023.PubMed/NCBI

33 

Liang Y, Wang H, Chen B, Mao Q, Xia W, Zhang T, Song X, Zhang Z, Xu L, Dong G and Jiang F: circDCUN1D4 suppresses tumor metastasis and glycolysis in lung adenocarcinoma by stabilizing TXNIP expression. Mol Ther Nucleic Acids. 23:355–368. 2020. View Article : Google Scholar : PubMed/NCBI

34 

Yang Y, Fan X, Mao M, Song X, Wu P, Zhang Y, Jin Y, Yang Y, Chen LL, Wang Y, et al: Extensive translation of circular RNAs driven by N6-methyladenosine. Cell Res. 27:626–641. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Yang Y, Gao X, Zhang M, Yan S, Sun C, Xiao F, Huang N, Yang X, Zhao K, Zhou H, et al: Novel role of FBXW7 circular RNA in repressing glioma tumorigenesis. J Natl Cancer Inst. 110:304–315. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Jiang B, Zhang J, Sun X, Yang C, Cheng G, Xu M, Li S and Wang L: Circulating exosomal hsa_circRNA_0039480 is highly expressed in gestational diabetes mellitus and may be served as a biomarker for early diagnosis of GDM. J Transl Med. 20:52022. View Article : Google Scholar : PubMed/NCBI

37 

Safi A, Saberiyan M, Sanaei MJ, Adelian S, Davarani Asl F, Zeinaly M, Shamsi M and Ahmadi R: The role of noncoding RNAs in metabolic reprogramming of cancer cells. Cell Mol Biol Lett. 28:372023. View Article : Google Scholar : PubMed/NCBI

38 

Wang C, Tan S, Liu WR, Lei Q, Qiao W, Wu Y, Liu X, Cheng W, Wei YQ, Peng Y and Li W: RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma. Mol Cancer. 18:1342019. View Article : Google Scholar : PubMed/NCBI

39 

Huijbers A, Tollenaar RAEM, v Pelt GW, Zeestraten ECM, Dutton S, McConkey CC, Domingo E, Smit VTHBM, Midgley R, Warren BF, et al: The proportion of tumor-stroma as a strong prognosticator for stage II and III colon cancer patients: Validation in the VICTOR trial. Ann Oncol. 24:179–185. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Zhang T, Xu J, Shen H, Dong W, Ni Y and Du J: Tumor-stroma ratio is an independent predictor for survival in NSCLC. Int J Clin Exp Pathol. 8:11348–11355. 2015.PubMed/NCBI

41 

Gujam FJA, Edwards J, Mohammed ZMA, Going JJ and McMillan DC: The relationship between the tumour stroma percentage, clinicopathological characteristics and outcome in patients with operable ductal breast cancer. Br J Cancer. 111:157–165. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Riester M, Xu Q, Moreira A, Zheng J, Michor F and Downey RJ: The Warburg effect: Persistence of stem-cell metabolism in cancers as a failure of differentiation. Ann Oncol. 29:264–270. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Hanahan D: Hallmarks of cancer: New dimensions. Cancer Discov. 12:31–46. 2022. View Article : Google Scholar : PubMed/NCBI

44 

Cai ZR, Hu Y, Liao K, Li H, Chen DL and Ju HQ: Circular RNAs: Emerging regulators of glucose metabolism in cancer. Cancer Lett. 552:2159782023. View Article : Google Scholar : PubMed/NCBI

45 

Yu T, Wang Y, Fan Y, Fang N, Wang T, Xu T and Shu Y: CircRNAs in cancer metabolism: A review. J Hematol Oncol. 12:902019. View Article : Google Scholar : PubMed/NCBI

46 

San-Millan I, Sparagna GC, Chapman HL, Warkins VL, Chatfield KC, Shuff SR, Martinez JL and Brooks GA: Chronic lactate exposure decreases mitochondrial function by inhibition of fatty acid uptake and cardiolipin alterations in neonatal rat cardiomyocytes. Front Nutr. 9:8094852022. View Article : Google Scholar : PubMed/NCBI

47 

Brooks GA: Lactate as a fulcrum of metabolism. Redox Biol. 35:1014542020. View Article : Google Scholar : PubMed/NCBI

48 

Qin R, Fan X, Huang Y, Chen S, Ding R, Yao Y, Wu R, Duan Y, Li X, Khan HU, et al: Role of glucose metabolic reprogramming in colorectal cancer progression and drug resistance. Transl Oncol. 50:1021562024. View Article : Google Scholar : PubMed/NCBI

49 

Watson MJ, Vignali PDA, Mullett SJ, Overacre-Delgoffe AE, Peralta RM, Grebinoski S, Menk AV, Rittenhouse NL, DePeaux K, Whetstone RD, et al: Metabolic support of tumour-infiltrating regulatory T cells by lactic acid. Nature. 591:645–651. 2021. View Article : Google Scholar : PubMed/NCBI

50 

Wang Y, Zhou H, Liu Y, Zhao X, Wang S and Lin Z: miR-485-5p/NQO1 axis drives colorectal cancer progression by regulating apoptosis and aerobic glycolysis. Cancer Cell Int. 25:412025. View Article : Google Scholar : PubMed/NCBI

51 

Liu X, Ren B, Ren J, Gu M, You L and Zhao Y: The significant role of amino acid metabolic reprogramming in cancer. Cell Commun Signal. 22:3802024. View Article : Google Scholar : PubMed/NCBI

52 

Lin Q, Jiang H and Lin D: Circular RNA ITCH downregulates GLUT1 and suppresses glucose uptake in melanoma to inhibit cancer cell proliferation. J Dermatolog Treat. 32:231–235. 2021. View Article : Google Scholar : PubMed/NCBI

53 

Cao L, Wang M, Dong Y, Xu B, Chen J, Ding Y, Qiu S, Li L, Karamfilova Zaharieva E, Zhou X and Xu Y: Circular RNA circRNF20 promotes breast cancer tumorigenesis and Warburg effect through miR-487a/HIF-1α/HK2. Cell Death Dis. 11:1452020. View Article : Google Scholar : PubMed/NCBI

54 

Li Q, Pan X, Zhu D, Deng Z, Jiang R and Wang X: Circular RNA MAT2B promotes glycolysis and malignancy of hepatocellular carcinoma through the miR-338-3p/PKM2 axis under hypoxic stress. Hepatology. 70:1298–1316. 2019. View Article : Google Scholar : PubMed/NCBI

55 

Yang B, Zhao F, Yao L, Zong Z and Xiao L: CircRNA circ_0006677 inhibits the progression and glycolysis in non-small-cell lung cancer by sponging miR-578 and Regulating SOCS2 expression. Front Pharmacol. 12:6570532021. View Article : Google Scholar : PubMed/NCBI

56 

DeBerardinis RJ and Thompson CB: Cellular metabolism and disease: What do metabolic outliers teach us? Cell. 148:1132–1144. 2012. View Article : Google Scholar : PubMed/NCBI

57 

Pascale RM, Calvisi DF, Simile MM, Feo CF and Feo F: The Warburg effect 97 years after its discovery. Cancers (Basel). 12:28192020. View Article : Google Scholar : PubMed/NCBI

58 

Dong G, Mao Q, Xia W, Xu Y, Wang J, Xu L and Jiang F: PKM2 and cancer: The function of PKM2 beyond glycolysis. Oncol Lett. 11:1980–1986. 2016. View Article : Google Scholar : PubMed/NCBI

59 

Fan C, Tang Y, Wang J, Xiong F, Guo C, Wang Y, Zhang S, Gong Z, Wei F, Yang L, et al: Role of long non-coding RNAs in glucose metabolism in cancer. Mol Cancer. 16:1302017. View Article : Google Scholar : PubMed/NCBI

60 

Yadav D, Yadav A, Bhattacharya S, Dagar A, Kumar V and Rani R: GLUT and HK: Two primary and essential key players in tumor glycolysis. Semin Cancer Biol. 100:17–27. 2024. View Article : Google Scholar : PubMed/NCBI

61 

Wu W, Xi W, Li H, Yang M and Yao X: Circular RNA circ-ACACA regulates proliferation, migration and glycolysis in non-small-cell lung carcinoma via miR-1183 and PI3K/PKB pathway. Int J Mol Med. 45:1814–1824. 2020.PubMed/NCBI

62 

Zhou J, Zhang S, Chen Z, He Z, Xu Y and Li Z: CircRNA-ENO1 promoted glycolysis and tumor progression in lung adenocarcinoma through upregulating its host gene ENO1. Cell Death Dis. 10:8852019. View Article : Google Scholar : PubMed/NCBI

63 

Xiong S, Li D, Wang D, Huang L, Liang G, Wu Z, Long J, Yang D, Teng Y, Lei S and Li Y: Circular RNA MYLK promotes glycolysis and proliferation of non-small cell lung cancer cells by sponging miR-195-5p and increasing glucose transporter member 3 expression. Cancer Manag Res. 12:5469–5478. 2020. View Article : Google Scholar : PubMed/NCBI

64 

Zhang W, Cai S, Qin L, Feng Y, Ding M, Luo Z, Shan J and Di L: Alkaloids of aconiti lateralis radix praeparata inhibit growth of non-small cell lung cancer by regulating PI3K/Akt-mTOR signaling and glycolysis. Commun Biol. 7:11182024. View Article : Google Scholar : PubMed/NCBI

65 

Starska K, Forma E, Jóźwiak P, Bryś M, Lewy-Trenda I, Brzezińska-Błaszczyk E and Krześlak A: Gene and protein expression of glucose transporter 1 and glucose transporter 3 in human laryngeal cancer-the relationship with regulatory hypoxia-inducible factor-1α expression, tumor invasiveness, and patient prognosis. Tumour Biol. 36:2309–2321. 2015. View Article : Google Scholar : PubMed/NCBI

66 

Gu F, Zhang J, Yan L and Li D: CircHIPK3/miR-381-3p axis modulates proliferation, migration, and glycolysis of lung cancer cells by regulating the AKT/mTOR signaling pathway. Open Life Sci. 15:683–695. 2020. View Article : Google Scholar : PubMed/NCBI

67 

Lan T, Gao F, Cai Y, Lv Y, Zhu J, Liu H, Xie S, Wan H, He H, Xie K, et al: The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment. Nat Commun. 16:3332025. View Article : Google Scholar : PubMed/NCBI

68 

Bian X, Liu R, Meng Y, Xing D, Xu D and Lu Z: Lipid metabolism and cancer. J Exp Med. 218:e202016062021. View Article : Google Scholar : PubMed/NCBI

69 

Gómez de Cedrón M and Ramírez de Molina A: Microtargeting cancer metabolism: Opening new therapeutic windows based on lipid metabolism. J Lipid Res. 57:193–206. 2016. View Article : Google Scholar : PubMed/NCBI

70 

Röhrig F and Schulze A: The multifaceted roles of fatty acid synthesis in cancer. Nat Rev Cancer. 16:732–749. 2016. View Article : Google Scholar : PubMed/NCBI

71 

Khan F, Elsori D, Verma M, Pandey S, Obaidur Rab S, Siddiqui S, Alabdallah NM, Saeed M and Pandey P: Unraveling the intricate relationship between lipid metabolism and oncogenic signaling pathways. Front Cell Dev Biol. 12:13990652024. View Article : Google Scholar : PubMed/NCBI

72 

Liu J, Shi Y, Wu M, Xu M, Zhang F, He Z and Tang M: JAG1 promotes migration, invasion, and adhesion of triple-negative breast cancer cells by promoting angiogenesis. Nan Fang Yi Ke Da Xue Xue Bao. 42:1100–1108. 2022.(In Chinese). PubMed/NCBI

73 

Cheng X, Wang W, Zhang Z, Zhang H, Zhu P, He R, Wu M, Zhou T, Jiang Y, Jiang L, et al: Distinctly altered lipid components in hepatocellular carcinoma relate to impaired T cell-dependent antitumor immunity. Hepatol Int. 18:582–594. 2024. View Article : Google Scholar : PubMed/NCBI

74 

Hong X, Li Q, Li J, Chen K, He Q, Zhao Y, Liang Y, Zhao Y, Qiao H, Liu N, et al: CircIPO7 promotes nasopharyngeal carcinoma metastasis and cisplatin chemoresistance by facilitating YBX1 nuclear localization. Clin Cancer Res. 28:4521–4535. 2022. View Article : Google Scholar : PubMed/NCBI

75 

Li H, Luo F, Jiang X, Zhang W, Xiang T, Pan Q, Cai L, Zhao J, Weng D, Li Y, et al: CircITGB6 promotes ovarian cancer cisplatin resistance by resetting tumor-associated macrophage polarization toward the M2 phenotype. J Immunother Cancer. 10:e0040292022. View Article : Google Scholar : PubMed/NCBI

76 

Wu YL, Li HF, Chen HH and Lin H: Emergent roles of circular RNAs in metabolism and metabolic disorders. Int J Mol Sci. 23:10322022. View Article : Google Scholar : PubMed/NCBI

77 

Hang D, Zhou J, Qin N, Zhou W, Ma H, Jin G, Hu Z, Dai J and Shen H: A novel plasma circular RNA circFARSA is a potential biomarker for non-small cell lung cancer. Cancer Med. 7:2783–2791. 2018. View Article : Google Scholar : PubMed/NCBI

78 

Zhang X, Xu Y, Ma L, Yu K, Niu Y, Xu X, Shi Y, Guo S, Xue X, Wang Y, et al: Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma. Cancer Commun (Lond). 42:287–313. 2022. View Article : Google Scholar : PubMed/NCBI

79 

Zheng Y, Yao Y, Ge T, Ge S, Jia R, Song X and Zhuang A: Amino acid metabolism reprogramming: Shedding new light on T cell anti-tumor immunity. J Exp Clin Cancer Res. 42:2912023. View Article : Google Scholar : PubMed/NCBI

80 

Lv H, Shi Z, Sui A, Zhang Y, Peng L, Wang M and Zhang F: hsa_circ_0000518 facilitates non-small-cell lung cancer progression via moderating miR-330-3p and positively regulating SLC1A5. J Immunol Res. 2022:49969802022. View Article : Google Scholar : PubMed/NCBI

81 

Luo H, Peng J and Yuan Y: CircRNA OXCT1 promotes the malignant progression and glutamine metabolism of non-small cell lung cancer by absorbing miR-516b-5p and upregulating SLC1A5. Cell Cycle. 22:1182–1195. 2023. View Article : Google Scholar : PubMed/NCBI

82 

Feng Y, Pathria G, Heynen-Genel S, Jackson M, James B, Yin J, Scott DA and Ronai ZA: Identification and characterization of IMD-0354 as a glutamine carrier protein inhibitor in melanoma. Mol Cancer Ther. 20:816–832. 2021. View Article : Google Scholar : PubMed/NCBI

83 

Amelio I, Cutruzzolá F, Antonov A, Agostini M and Melino G: Serine and glycine metabolism in cancer. Trends Biochem Sci. 39:191–198. 2014. View Article : Google Scholar : PubMed/NCBI

84 

Qiu W, Zhang S, Yu W, Liu J and Wu H: Non-coding RNAs in hepatocellular carcinoma metastasis: Remarkable indicators and potential oncogenic mechanism. Comput Biol Med. 180:1088672024. View Article : Google Scholar : PubMed/NCBI

85 

Luo J, Ng W, Liu Y, Wang L, Gong C, Zhou Y, Fang C, Zhu S and Yao C: Rocaglamide promotes infiltration and differentiation of T cells and coordinates with PD-1 inhibitor to overcome checkpoint resistance in multiple tumor models. Cancer Immunol Immunother. 73:1372024. View Article : Google Scholar : PubMed/NCBI

86 

Faubert B, Solmonson A and DeBerardinis RJ: Metabolic reprogramming and cancer progression. Science. 368:eaaw54732020. View Article : Google Scholar : PubMed/NCBI

87 

Yu X, Tong H, Chen J, Tang C, Wang S, Si Y, Wang S and Tang Z: CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export. Cell Death Dis. 14:202023. View Article : Google Scholar : PubMed/NCBI

88 

Wang L, Wu C, Xu J, Gong Z, Cao X, Huang J, Dong H, Zhu W, Huang F, Zhou C and Wang M: GC-MSC-derived circ_0024107 promotes gastric cancer cell lymphatic metastasis via fatty acid oxidation metabolic reprogramming mediated by the miR-5572/6855-5p/CPT1A axis. Oncol Rep. 50:1382023. View Article : Google Scholar : PubMed/NCBI

89 

Gao X, Sun Z, Liu X, Luo J, Liang X, Wang H, Zhou J, Yang C, Wang T and Li J: 127aa encoded by circSpdyA promotes FA synthesis and NK cell repression in breast cancers. Cell Death Differ. Oct 14–2024.(Epub ahead of print). View Article : Google Scholar

90 

Sabit H, Arneth B, Pawlik TM, Abdel-Ghany S, Ghazy A, Abdelazeem RM, Alqosaibi A, Al-Dhuayan IS, Almulhim J, Alrabiah NA and Hashash A: Leveraging single-cell multi-omics to decode tumor microenvironment diversity and therapeutic resistance. Pharmaceuticals (Basel). 18:752025. View Article : Google Scholar : PubMed/NCBI

91 

DeSouza NR, Nielsen KJ, Jarboe T, Carnazza M, Quaranto D, Kopec K, Suriano R, Islam HK, Tiwari RK and Geliebter J: Dysregulated expression patterns of circular RNAs in cancer: Uncovering molecular mechanisms and biomarker potential. Biomolecules. 14:3842024. View Article : Google Scholar : PubMed/NCBI

92 

Xie C, Hao X, Yuan H, Wang C, Sharif R and Yu H: Crosstalk between circRNA and tumor microenvironment of hepatocellular carcinoma: Mechanism, function and applications. Onco Targets Ther. 17:7–26. 2024. View Article : Google Scholar : PubMed/NCBI

93 

Yin WB, Yan MG, Fang X, Guo JJ, Xiong W and Zhang RP: Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection. Clin Chim Acta. 487:363–368. 2018. View Article : Google Scholar : PubMed/NCBI

94 

Wang C, Yu Q, Song T, Wang Z, Song L, Yang Y, Shao J, Li J, Ni Y, Chao N, et al: The heterogeneous immune landscape between lung adenocarcinoma and squamous carcinoma revealed by single-cell RNA sequencing. Signal Transduct Target Ther. 7:2892022. View Article : Google Scholar : PubMed/NCBI

95 

Nicot C: RNA-Seq reveal the circular RNAs landscape of lung cancer. Mol Cancer. 18:1832019. View Article : Google Scholar : PubMed/NCBI

96 

Qu L, Yi Z, Shen Y, Lin L, Chen F, Xu Y, Wu Z, Tang H, Zhang X, Tian F, et al: Circular RNA vaccines against SARS-CoV-2 and emerging variants. Cell. 185:1728–1744.e16. 2022. View Article : Google Scholar : PubMed/NCBI

97 

Li H, Peng K, Yang K, Ma W, Qi S, Yu X, He J, Lin X and Yu G: Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies. Theranostics. 12:6422–6436. 2022. View Article : Google Scholar : PubMed/NCBI

98 

Zhang W, Xu C, Yang Z, Zhou J, Peng W, Zhang X, Li H, Qu S and Tao K: Circular RNAs in tumor immunity and immunotherapy. Mol Cancer. 23:1712024. View Article : Google Scholar : PubMed/NCBI

99 

Zhou J, Xu H, Li X, Liu H, Sun Z, Li J, Tang Y, Gao H, Zhao K, Ding C and Gao X: Targeting tumorous Circ-E-Cadherinencoded C-E-Cad inhibits the recruitment and function of breast cancer-associated myeloid-derived suppressor cells. Pharmacol Res. 204:1072042024. View Article : Google Scholar : PubMed/NCBI

100 

Mu M, Niu W, Chu F, Dong Q, Hu S and Niu C: CircSOBP suppresses the progression of glioma by disrupting glycolysis and promoting the MDA5-mediated immune response. iScience. 26:1078972023. View Article : Google Scholar : PubMed/NCBI

101 

Cai J, Chen Z, Zhang Y, Wang J, Zhang Z, Wu J, Mao J and Zuo X: CircRHBDD1 augments metabolic rewiring and restricts immunotherapy efficacy via m6A modification in hepatocellular carcinoma. Mol Ther Oncolytics. 24:755–771. 2022. View Article : Google Scholar : PubMed/NCBI

102 

Zang X, He XY, Xiao CM, Lin Q, Wang MY, Liu CY, Kong LY, Chen Z and Xia YZ: Circular RNA-encoded oncogenic PIAS1 variant blocks immunogenic ferroptosis by modulating the balance between SUMOylation and phosphorylation of STAT1. Mol Cancer. 23:2072024. View Article : Google Scholar : PubMed/NCBI

103 

Cai J, Qiu Z, Chi-Shing Cho W, Liu Z, Chen S, Li H, Chen K, Li Y, Zuo C and Qiu M: Synthetic circRNA therapeutics: Innovations, strategies, and future horizons. MedComm (2020). 5:e7202024. View Article : Google Scholar : PubMed/NCBI

104 

Dance A: Circular logic: Understanding RNA's strangest form yet. Nature. 635:511–513. 2024. View Article : Google Scholar : PubMed/NCBI

105 

Aquino-Jarquin G: CircRNA knockdown based on antisense strategies. Drug Discov Today. 29:1040662024. View Article : Google Scholar : PubMed/NCBI

106 

Zhao X, Zhong Y, Wang X, Shen J and An W: Advances in circular RNA and its applications. Int J Med Sci. 19:975–985. 2022. View Article : Google Scholar : PubMed/NCBI

107 

Chen YG, Kim MV, Chen X, Batista PJ, Aoyama S, Wilusz JE, Iwasaki A and Chang HY: Sensing self and foreign circular RNAs by intron identity. Mol Cell. 67:228–238.e5. 2017. View Article : Google Scholar : PubMed/NCBI

108 

Chen YG, Chen R, Ahmad S, Verma R, Kasturi SP, Amaya L, Broughton JP, Kim J, Cadena C, Pulendran B, et al: N6-methyladenosine modification controls circular RNA immunity. Mol Cell. 76:96–109.e9. 2019. View Article : Google Scholar : PubMed/NCBI

109 

Hashimoto K, Nishimura S and Akagi M: Lung adenocarcinoma presenting as a soft tissue metastasis to the shoulder: A case report. Medicina (Kaunas). 57:1812021. View Article : Google Scholar : PubMed/NCBI

110 

Cui YS, Zheng X, Wu YN, Yao YH, Wang J, Liu ZQ and Sun GG: The RNA binding protein QKI can promote gastric cancer by regulating cleavage of EMT-related gene transcripts to form circRNAs. Chin Pharmacol Bull. 40:1462–1473. 2024.(In Chinese).

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Copy and paste a formatted citation
Spandidos Publications style
Zhao P, Zhu Z, Zheng X, Song Y, Chen C, Xu G and Ke X: Effects of circulating RNAs on tumor metabolism in lung cancer (Review). Oncol Lett 29: 204, 2025.
APA
Zhao, P., Zhu, Z., Zheng, X., Song, Y., Chen, C., Xu, G., & Ke, X. (2025). Effects of circulating RNAs on tumor metabolism in lung cancer (Review). Oncology Letters, 29, 204. https://doi.org/10.3892/ol.2025.14950
MLA
Zhao, P., Zhu, Z., Zheng, X., Song, Y., Chen, C., Xu, G., Ke, X."Effects of circulating RNAs on tumor metabolism in lung cancer (Review)". Oncology Letters 29.4 (2025): 204.
Chicago
Zhao, P., Zhu, Z., Zheng, X., Song, Y., Chen, C., Xu, G., Ke, X."Effects of circulating RNAs on tumor metabolism in lung cancer (Review)". Oncology Letters 29, no. 4 (2025): 204. https://doi.org/10.3892/ol.2025.14950
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao P, Zhu Z, Zheng X, Song Y, Chen C, Xu G and Ke X: Effects of circulating RNAs on tumor metabolism in lung cancer (Review). Oncol Lett 29: 204, 2025.
APA
Zhao, P., Zhu, Z., Zheng, X., Song, Y., Chen, C., Xu, G., & Ke, X. (2025). Effects of circulating RNAs on tumor metabolism in lung cancer (Review). Oncology Letters, 29, 204. https://doi.org/10.3892/ol.2025.14950
MLA
Zhao, P., Zhu, Z., Zheng, X., Song, Y., Chen, C., Xu, G., Ke, X."Effects of circulating RNAs on tumor metabolism in lung cancer (Review)". Oncology Letters 29.4 (2025): 204.
Chicago
Zhao, P., Zhu, Z., Zheng, X., Song, Y., Chen, C., Xu, G., Ke, X."Effects of circulating RNAs on tumor metabolism in lung cancer (Review)". Oncology Letters 29, no. 4 (2025): 204. https://doi.org/10.3892/ol.2025.14950
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