Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2025 Volume 29 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2025 Volume 29 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Carfilzomib inhibits the progression of hepatocellular cancer by upregulating GADD45α expression

  • Authors:
    • Mingxun Chen
    • Xu Chen
    • Yifang Shui
    • Chunyong Ji
    • Wenzhi Guo
  • View Affiliations / Copyright

    Affiliations: Liver Transplantation Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Hepatobiliary and Pancreatic Minimally Invasive Surgery, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 208
    |
    Published online on: March 4, 2025
       https://doi.org/10.3892/ol.2025.14955
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hepatocellular carcinoma (HCC) ranks among the most prevalent and lethal cancers affecting humans. Currently, there are limited effective treatments available for HCC. Carfilzomib, a proteasome inhibitor, is known to exert anti‑HCC activities; however, its underlying mechanisms of action remain unclear. In the present study, the efficacy of carfilzomib against HCC was evaluated and its underlying mechanisms were explored. Cell Counting Kit‑8, 5‑ethynyl‑2‑deoxyuridine staining and colony formation assays were employed to analyze the antiproliferative effect of carfilzomib on MHCC‑97H and Huh7 cells. Additionally, flow cytometry was used to assess the effect of carfilzomib on the cell cycle and Transwell assays were used to evaluate the effect of carfilzomib on cell migration and invasion. Western blotting was utilized to examine the protein expression levels associated with cell cycle arrest. Furthermore, short hairpin RNA (shRNA) transfection was used to investigate the role of DNA damage inducible α (GADD45α) on carfilzomib‑induced cell cycle arrest. A xenograft tumor model using nude mice was employed to evaluate the anti‑HCC activity of carfilzomib in vivo. The findings demonstrated that carfilzomib inhibited proliferation, invasion and migration in both MHCC‑97H and Huh7 cells. In addition, carfilzomib caused cell cycle arrest by suppressing the expression of cyclin A2, cyclin E1 and cyclin‑dependent kinases 2 and 4. Carfilzomib also upregulated the expression of GADD45α, activated the MAPK pathway and inhibited GADD45α through shRNA abolished carfilzomib‑induced cell cycle arrest in HCC cells. In addition, carfilzomib inhibited Huh7 cell growth in vivo. To conclude, the present research revealed that carfilzomib inhibits the progression of HCC cells by upregulating GADD45α expression, suggesting that carfilzomib could be a potential chemotherapeutic agent against HCC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I and Jemal A: Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 74:229–263. 2024. View Article : Google Scholar : PubMed/NCBI

2 

Eguia E, Baker T and Baker M: Hepatocellular carcinoma: Surgical management and evolving therapies. Cancer Treat Res. 192:185–206. 2024. View Article : Google Scholar : PubMed/NCBI

3 

Wang H and Li W: Recent update on comprehensive therapy for advanced hepatocellular carcinoma. World J Gastrointest Oncol. 13:845–855. 2021. View Article : Google Scholar : PubMed/NCBI

4 

Peng TR, Weng YF, Wu TW, Wu CC, Chou YC and Hsu CS: Efficacy and safety of sorafenib or lenvatinib for advanced hepatocellular carcinoma after failure of first-line atezolizumab plus bevacizumab: A systematic review and meta-analysis. Cancers (Basel). 16:28132024. View Article : Google Scholar : PubMed/NCBI

5 

Luo X, He X, Zhang X, Zhao X, Zhang Y, Shi Y and Hua S: Hepatocellular carcinoma: Signaling pathways, targeted therapy, and immunotherapy. MedComm (2020). 5:e4742024. View Article : Google Scholar : PubMed/NCBI

6 

Childs A, Aidoo-Micah G, Maini MK and Meyer T: Immunotherapy for hepatocellular carcinoma. JHEP Rep. 6:1011302024. View Article : Google Scholar : PubMed/NCBI

7 

Zhang C, Kuo JC, Huang Y, Hu Y, Deng L, Yung BC, Zhao X, Zhang Z, Pan J, Ma Y and Lee RJ: Optimized liposomal delivery of bortezomib for advancing treatment of multiple myeloma. Pharmaceutics. 15:26742023. View Article : Google Scholar : PubMed/NCBI

8 

Wahl K, Siegemund M, Lehner F, Vondran F, Nüssler A, Länger F, Krech T, Kontermann R, Manns MP, Schulze-Osthoff K, et al: Increased apoptosis induction in hepatocellular carcinoma by a novel tumor-targeted TRAIL fusion protein combined with bortezomib. Hepatology. 57:625–636. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Alwahsh M, Farhat J, Talhouni S, Hamadneh L and Hergenröder R: Bortezomib advanced mechanisms of action in multiple myeloma, solid and liquid tumors along with its novel therapeutic applications. EXCLI J. 22:146–168. 2023.PubMed/NCBI

10 

Lara PN Jr, Longmate J, Reckamp K, Gitlitz B, Argiris A, Ramalingam S, Belani CP, Mack PC, Lau DH, Koczywas M, et al: Randomized phase II trial of concurrent versus sequential bortezomib plus docetaxel in advanced non-small-cell lung cancer: A California cancer consortium trial. Clin Lung Cancer. 12:33–37. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Chen KF, Yu HC, Liu TH, Lee SS, Chen PJ and Cheng AL: Synergistic interactions between sorafenib and bortezomib in hepatocellular carcinoma involve PP2A-dependent Akt inactivation. J Hepatol. 52:88–95. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Honma Y, Shimizu S, Takehara T and Harada M: Sorafenib enhances proteasome inhibitor-induced cell death via inactivation of Akt and stress-activated protein kinases. J Gastroenterol. 49:517–526. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Tan CRC, Abdul-Majeed S, Cael B and Barta SK: Clinical pharmacokinetics and pharmacodynamics of bortezomib. Clin Pharmacokinet. 58:157–168. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Dimopoulos MA, Moreau P, Palumbo A, Joshua D, Pour L, Hájek R, Facon T, Ludwig H, Oriol A, Goldschmidt H, et al: Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): A randomised, phase 3, open-label, multicentre study. Lancet Oncol. 17:27–38. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Mansour MA, Aljoufi MA, Al-Hosaini K, Al-Rikabi AC and Nagi MN: Possible role of selective, irreversible, proteasome inhibitor (carfilzomib) in the treatment of rat hepatocellular carcinoma. Chem Biol Interact. 215:17–24. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Hu B, Gao J, Shi J, Wen P, Guo W and Zhang S: m6A reader YTHDF3 triggers the progression of hepatocellular carcinoma through the YTHDF3/m6 A-EGFR/STAT3 axis and EMT. Mol Carcinog. 62:1599–1614. 2023. View Article : Google Scholar : PubMed/NCBI

17 

Jiang M, Qi F, Zhang K, Zhang X, Ma J, Xia S, Chen L, Yu Z, Chen J and Chen D: MARCKSL1-2 reverses docetaxel-resistance of lung adenocarcinoma cells by recruiting SUZ12 to suppress HDAC1 and elevate miR-200b. Mol Cancer. 21:1502022. View Article : Google Scholar : PubMed/NCBI

18 

Guo D, Zhang M, Wei T, Zhang X, Shi X, Tang H, Ding M, Li J, Zhang S and Guo W: NFKBIZ regulates NFκB signaling pathway to mediate tumorigenesis and metastasis of hepatocellular carcinoma by direct interaction with TRIM16. Cell Mol Life Sci. 81:1672024. View Article : Google Scholar : PubMed/NCBI

19 

Zhang F, Gao J, Liu X, Sun Y, Liu L, Hu B, Wang Z, Shi J, Guo W and Zhang S: LATS-regulated nuclear-cytoplasmic translocation of SREBP2 inhibits hepatocellular carcinoma cell migration and invasion via epithelial-mesenchymal transition. Mol Carcinog. 62:963–974. 2023. View Article : Google Scholar : PubMed/NCBI

20 

Ding L, Ren C, Yang L, Wu Z, Li F, Jiang D, Zhu Y and Lu J: OSU-03012 disrupts Akt signaling and prevents endometrial carcinoma progression in vitro and in vivo. Drug Des Devel Ther. 15:1797–1810. 2021. View Article : Google Scholar : PubMed/NCBI

21 

Gao J, Shi X, Sun Y, Liu X, Zhang F, Shi C, Yu X, Yan Z, Liu L, Yu S, et al: Deficiency of betaine-homocysteine methyltransferase activates glucose-6-phosphate dehydrogenase (G6PD) by decreasing arginine methylation of G6PD in hepatocellular carcinogenesis. Sci China Life Sci. 67:1648–1665. 2024. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Roberts A, Trapnell C, Donaghey J, Rinn JL and Pachter L: Improving RNA-Seq expression estimates by correcting for fragment bias. Genome Biol. 12:R222011. View Article : Google Scholar : PubMed/NCBI

24 

Chen S, Zhou Y, Chen Y and Gu J: fastp: An ultra-fast all-in-one FASTQ preprocessor. Bioinformatics. 34:i884–i890. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Guo N, Xia Y, He N, Cheng H, Zhang L and Liu J: IRGM deficiency exacerbates sepsis-induced acute lung injury by inhibiting autophagy through the AKT/mTOR signaling pathway. J Inflamm Res. 17:10255–10272. 2024. View Article : Google Scholar : PubMed/NCBI

26 

Wang X, Kuang J, Li XT, Hu X, Liu YH, Hu CP, Wang M, Wang Q and Zhang Z: Dimethyl fumarate is repurposed to ameliorate aortic aneurysm and dissection in mice. Eur J Pharmacol. 988:1772152025. View Article : Google Scholar : PubMed/NCBI

27 

Yu Q, Zhang J, Li J, Song Y, Pan J, Mei C, Cui M, He Q, Wang H, Li H, et al: Sirtuin 5-mediated desuccinylation of ALDH2 alleviates mitochondrial oxidative stress following acetaminophen-induced acute liver injury. Adv Sci (Weinh). 11:e24027102024. View Article : Google Scholar : PubMed/NCBI

28 

Menyhárt O, Nagy Á and Győrffy B: Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma. R Soc Open Sci. 5:1810062018. View Article : Google Scholar : PubMed/NCBI

29 

Győrffy B: Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors. Innovation (Camb). 5:1006252024.PubMed/NCBI

30 

Lin Y, Zhong W, Lin Q, Ye Y, Li S, Chen H, Liu H, Xu L, Zhuang W, Chen S, et al: SFPQ promotes the proliferation, migration and invasion of hepatocellular carcinoma cells and is associated with poor prognosis. Am J Cancer Res. 13:2269–2284. 2023.PubMed/NCBI

31 

Oshima J and Campisi J: Fundamentals of cell proliferation: Control of the cell cycle. J Dairy Sci. 74:2778–2787. 1991. View Article : Google Scholar : PubMed/NCBI

32 

Evan GI and Vousden KH: Proliferation, cell cycle and apoptosis in cancer. Nature. 411:342–348. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Deng Y, Li Y, Yang M, Gao Y, Luo X, Chen H, Guo M, Yang X, Liu Y, He J, et al: Carfilzomib activates ER stress and JNK/p38 MAPK signaling to promote apoptosis in hepatocellular carcinoma cells. Acta Biochim Biophys Sin (Shanghai). 56:697–708. 2024.PubMed/NCBI

34 

Tang W, Chen Z, Zhang W, Cheng Y, Zhang B, Wu F, Wang Q, Wang S, Rong D, Reiter FP, et al: The mechanisms of sorafenib resistance in hepatocellular carcinoma: Theoretical basis and therapeutic aspects. Signal Transduct Target Ther. 5:872020. View Article : Google Scholar : PubMed/NCBI

35 

Lv Z, Liu L, You J, Zhou P, Su Y, Zhao K, Zhang J and Zhu F: Small HBV surface antigen drives regorafenib resistance in HCC via KIAA1429-dependent m6A modification of CCR9. J Med Virol. 96:e298942024. View Article : Google Scholar : PubMed/NCBI

36 

Leowattana W, Leowattana T and Leowattana P: Systemic treatment for unresectable hepatocellular carcinoma. World J Gastroenterol. 29:1551–1568. 2023. View Article : Google Scholar : PubMed/NCBI

37 

Arnold SM, Chansky K, Leggas M, Thompson MA, Villano JL, Hamm J, Sanborn RE, Weiss GJ, Chatta G and Baggstrom MQ: Phase 1b trial of proteasome inhibitor carfilzomib with irinotecan in lung cancer and other irinotecan-sensitive malignancies that have progressed on prior therapy (Onyx IST reference number: CAR-IST-553). Invest New Drugs. 35:608–615. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Wu H, Li L, Ai Z, Yin J and Chen L: Pristimerin induces apoptosis of oral squamous cell carcinoma cells via G1 phase arrest and MAPK/Erk1/2 and Akt signaling inhibition. Oncol Lett. 17:3017–3025. 2019.PubMed/NCBI

39 

Wang B, Li R, Wu S, Liu X, Ren J, Li J, Bi K, Wang Y and Jia H: Breast cancer resistance to cyclin-dependent kinases 4/6 inhibitors: Intricacy of the molecular mechanisms. Front Oncol. 11:6515412021. View Article : Google Scholar : PubMed/NCBI

40 

Desvoyes B and Gutierrez C: Roles of plant retinoblastoma protein: Cell cycle and beyond. EMBO J. 39:e1058022020. View Article : Google Scholar : PubMed/NCBI

41 

Humayun A and Fornace AJ Jr: GADD45 in stress signaling, cell cycle control, and apoptosis. Adv Exp Med Biol. 1360:1–22. 2022. View Article : Google Scholar : PubMed/NCBI

42 

Palomer X, Salvador JM, Griñán-Ferré C, Barroso E, Pallàs M and Vázquez-Carrera M: GADD45A: With or without you. Med Res Rev. 44:1375–1403. 2024. View Article : Google Scholar : PubMed/NCBI

43 

Li Y, Qian H, Li X, Wang H, Yu J, Liu Y, Zhang X, Liang X, Fu M, Zhan Q and Lin C: Adenoviral-mediated gene transfer of Gadd45a results in suppression by inducing apoptosis and cell cycle arrest in pancreatic cancer cell. J Gene Med. 11:3–13. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Kim EK and Choi EJ: Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta. 1802:396–405. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Wang M, Tian B, Shen J, Xu S, Liu C, Guan L, Guo M and Dou J: Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathway. Chin J Nat Med. 21:36–46. 2023.PubMed/NCBI

46 

Wang Y, Gao H, Cao X, Li Z, Kuang Y, Ji Y and Li Y: Role of GADD45A in myocardial ischemia/reperfusion through mediation of the JNK/p38 MAPK and STAT3/VEGF pathways. Int J Mol Med. 50:1442022. View Article : Google Scholar : PubMed/NCBI

47 

Wang HH, Chang TY, Lin WC, Wei KC and Shin JW: GADD45A plays a protective role against temozolomide treatment in glioblastoma cells. Sci Rep. 7:88142017. View Article : Google Scholar : PubMed/NCBI

48 

Peretz G, Bakhrat A and Abdu U: Expression of the Drosophila melanogaster GADD45 homolog (CG11086) affects egg asymmetric development that is mediated by the c-Jun N-terminal kinase pathway. Genetics. 177:1691–1702. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Geifman-Holtzman O, Xiong Y and Holtzman EJ: Gadd45 stress sensors in preeclampsia. Adv Exp Med Biol. 793:121–129. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Hildesheim J, Bulavin DV, Anver MR, Alvord WG, Hollander MC, Vardanian L and Fornace AJ Jr: Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53. Cancer Res. 62:7305–7315. 2002.PubMed/NCBI

51 

Yang P, Wen H, Zhong T, Hu H, Zhu B, Xia K, Xu M and Bian M: GADD45α is involved in the apoptosis of lymphocytes induced by riboflavin and ultraviolet light. Transfusion. 57:646–656. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen M, Chen X, Shui Y, Ji C and Guo W: Carfilzomib inhibits the progression of hepatocellular cancer by upregulating GADD45α expression. Oncol Lett 29: 208, 2025.
APA
Chen, M., Chen, X., Shui, Y., Ji, C., & Guo, W. (2025). Carfilzomib inhibits the progression of hepatocellular cancer by upregulating GADD45α expression. Oncology Letters, 29, 208. https://doi.org/10.3892/ol.2025.14955
MLA
Chen, M., Chen, X., Shui, Y., Ji, C., Guo, W."Carfilzomib inhibits the progression of hepatocellular cancer by upregulating GADD45α expression". Oncology Letters 29.4 (2025): 208.
Chicago
Chen, M., Chen, X., Shui, Y., Ji, C., Guo, W."Carfilzomib inhibits the progression of hepatocellular cancer by upregulating GADD45α expression". Oncology Letters 29, no. 4 (2025): 208. https://doi.org/10.3892/ol.2025.14955
Copy and paste a formatted citation
x
Spandidos Publications style
Chen M, Chen X, Shui Y, Ji C and Guo W: Carfilzomib inhibits the progression of hepatocellular cancer by upregulating GADD45α expression. Oncol Lett 29: 208, 2025.
APA
Chen, M., Chen, X., Shui, Y., Ji, C., & Guo, W. (2025). Carfilzomib inhibits the progression of hepatocellular cancer by upregulating GADD45α expression. Oncology Letters, 29, 208. https://doi.org/10.3892/ol.2025.14955
MLA
Chen, M., Chen, X., Shui, Y., Ji, C., Guo, W."Carfilzomib inhibits the progression of hepatocellular cancer by upregulating GADD45α expression". Oncology Letters 29.4 (2025): 208.
Chicago
Chen, M., Chen, X., Shui, Y., Ji, C., Guo, W."Carfilzomib inhibits the progression of hepatocellular cancer by upregulating GADD45α expression". Oncology Letters 29, no. 4 (2025): 208. https://doi.org/10.3892/ol.2025.14955
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team