Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
June-2025 Volume 29 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2025 Volume 29 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Pancreatic liposarcoma: A case report

  • Authors:
    • Yan Zhao
    • Shikang Hu
    • Huajun Sun
    • Jiyun Yang
    • Tao Lu
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China, Department of Radiology, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, P.R. China, Department of Pathology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China, Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center of Medical Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 268
    |
    Published online on: April 7, 2025
       https://doi.org/10.3892/ol.2025.15014
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Primary liposarcoma (LPS) of the pancreas is extremely rare. The present report describes an additional case of primary pancreatic LPS and reviews the current literature. A 40‑year‑old female patient that initially presented with a fever was subsequently found to have a pancreatic tumor. CT was used to identify a heterogeneous mass in the pancreatic head and body, which had a notable absence of fat components. The tumor exhibited slightly heterogeneous enhancement during the arterial phase, moderate enhancement in the venous phase and persistent enhancement in the delayed phase, with encapsulation of the common hepatic artery, splenic vein and portal vein. The patient underwent a successful distal pancreatectomy and splenectomy. Pathological examination and next‑generation sequencing confirmed the diagnosis of dedifferentiated LPS (DDLPS). The present report elucidated the CT findings of this rare case of DDLPS of the pancreas, characterized by vascular invasion and progressive enhancement but without fat components, which can serve as a reference for the diagnosis of this uncommon tumor. The uncommon CT manifestation makes differentiation from pancreatic neuroendocrine tumors particularly challenging based on imaging characteristics.
View Figures

Figure 1

Figure 2

View References

1 

Ardakani AHG, Woollard A, Ware H and Gikas P: Soft tissue sarcoma: Recognizing a rare disease. Cleve Clin J Med. 89:73–80. 2022. View Article : Google Scholar : PubMed/NCBI

2 

Bourcier K, Le Cesne A, Tselikas L, Adam J, Mir O, Honore C and de Baere T: Basic knowledge in soft tissue sarcoma. Cardiovasc Intervent Radiol. 42:1255–1261. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Gamboa AC, Gronchi A and Cardona K: Soft-tissue sarcoma in adults: An update on the current state of histiotype-specific management in an era of personalized medicine. CA Cancer J Clin. 70:200–229. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Gilbert NF, Cannon CP, Lin PP and Lewis VO: Soft-tissue sarcoma. J Am Acad Orthop Surg. 17:40–47. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Lee ATJ, Thway K, Huang PH and Jones RL: Clinical and molecular spectrum of liposarcoma. J Clin Oncol. 36:151–159. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Sbaraglia M, Bellan E and Dei Tos AP: The 2020 WHO classification of soft tissue tumours: News and perspectives. Pathologica. 113:70–84. 2020. View Article : Google Scholar : PubMed/NCBI

7 

Thway K: Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review. Semin Diagn Pathol. 36:112–121. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Dehner CA, Hagemann IS and Chrisinger JSA: Retroperitoneal dedifferentiated liposarcoma. Am J Clin Pathol. 156:920–925. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Kammerer-Jacquet SF, Thierry S, Cabillic F, Lannes M, Burtin F, Henno S, Dugay F, Bouzillé G, Rioux-Leclercq N, Belaud-Rotureau MA and Stock N: Differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: Utility of p16 in combination with MDM2 and CDK4 immunohistochemistry. Hum Pathol. 59:34–40. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Tanabe M, Matsui H, Higashi M, Tokumitsu Y, Nagano H and Ito K: Pancreatic liposarcoma: A case report. Abdom Radiol (NY). 47:1912–1916. 2022. View Article : Google Scholar : PubMed/NCBI

11 

Liu Z, Fan WF, Li GC, Long J, Xu YH and Ma G: Huge primary dedifferentiated pancreatic liposarcoma mimicking carcinosarcoma in a young female: A case report. World J Clin Cases. 7:1344–1350. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Han T, Luan Y, Xu Y, Yang X, Li J, Liu R, Li Q and Zheng Z: Successful treatment of advanced pancreatic liposarcoma with apatinib: A case report and literature review. Cancer Biol Ther. 18:635–639. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Machado MCC, Fonseca GM, de Meirelles LR, Zacchi FFS and Bezerra ROF: Primary liposarcoma of the pancreas: A review illustrated by findings from a recent case. Pancreatology. 16:715–718. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Matthews M, Nelson S, Hari D and French S: Well differentiated liposarcoma, sclerosing type, of the pancreas a case report. Exp Mol Pathol. 101:320–322. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Dodo IM, Adamthwaite JA, Jain P, Roy A, Guillou PJ and Menon KV: Successful outcome following resection of a pancreatic liposarcoma with solitary metastasis. World J Gastroenterol. 11:7684–7685. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Cao D, Wang J and Guo L: Pancreatic liposarcoma: A rare cause of pancreatic mass in adult. J Gastroenterol Hepatol. 34:12752019. View Article : Google Scholar : PubMed/NCBI

17 

Kuramoto K, Hashimoto D, Abe S, Chikamoto A, Beppu T, Iyama K and Baba H: Hepatobiliary and pancreatic: Large pancreatic liposarcoma. J Gastroenterol Hepatol. 28:18002013. View Article : Google Scholar : PubMed/NCBI

18 

Elliott TE, Albertazzi VJ and Danto LA: Pancreatic liposarcoma. Case report with review of retroperitoneal liposarcomas. Cancer. 45:1720–1723. 1980. View Article : Google Scholar : PubMed/NCBI

19 

Improta L, Pasquali S, Iadecola S, Barisella M, Fiore M, Radaelli S, Colombo C, Alloni R, Callegaro D, Valeri S, et al: Organ infiltration and patient risk after multivisceral surgery for primary retroperitoneal liposarcomas. Ann Surg Oncol. 30:4500–4510. 2023. View Article : Google Scholar : PubMed/NCBI

20 

Tyler R, Wanigasooriya K, Taniere P, Almond M, Ford S, Desai A and Beggs A: A review of retroperitoneal liposarcoma genomics. Cancer Treat Rev. 86:1020132020. View Article : Google Scholar : PubMed/NCBI

21 

Coindre JM, Pédeutour F and Aurias A: Well-differentiated and dedifferentiated liposarcomas. Virchows Arch. 456:167–179. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Thway K, Flora R, Shah C, Olmos D and Fisher C: Diagnostic utility of p16, CDK4, and MDM2 as an immunohistochemical panel in distinguishing well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors. Am J Surg Pathol. 36:462–469. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Thway K, Wang J, Swansbury J, Min T and Fisher C: Fluorescence in situ hybridization for MDM2 amplification as a routine ancillary diagnostic tool for suspected well-differentiated and dedifferentiated liposarcomas: Experience at a tertiary center. Sarcoma. 2015:1–10. 2015. View Article : Google Scholar

24 

Sirvent N, Coindre JM, Maire G, Hostein I, Keslair F, Guillou L, Ranchere-Vince D, Terrier P and Pedeutour F: Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: Utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR. Am J Surg Pathol. 31:1476–1489. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Xu L, Xie X, Shi X, Zhang P, Liu A, Wang J and Zhang B: Potential application of genomic profiling for the diagnosis and treatment of patients with sarcoma. Oncol Lett. 21:3532021. View Article : Google Scholar : PubMed/NCBI

26 

Win TT, Jaafar H and Yusuf Y: Relationship of angiogenic and apoptotic activities in soft-tissue sarcoma. South Asian J Cancer. 3:171–174. 2020.PubMed/NCBI

27 

Park BK, Koh HD, Won SY, Cho YS, Seo JH, An C and Park S: Suspicious findings observed retrospectively on CT imaging performed before the diagnosis of pancreatic cancer. J Gastrointest Oncol. 14:1008–1018. 2023. View Article : Google Scholar : PubMed/NCBI

28 

He C, Zhu L, Wang X, Dai M, Wu H, Xu Q, Sun Z, Liu J, Xue H and Jin Z: Presumed radiological diagnosis of solid pseudopapillary tumors: Do we really know what we are watching? Pancreatology. 23:120–128. 2023. View Article : Google Scholar : PubMed/NCBI

29 

Li DL, Li HS, Xu YK, Wang QS, Chen RY and Zhou F: Solid pseudopapillary tumor of the pancreas: Clinical features and imaging findings. Clin Imaging. 48:113–121. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Lo GC and Kambadakone A: MR imaging of pancreatic neuroendocrine tumors. Magn Reson Imaging Clin N Am. 26:391–403. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Wan Y, Hao H, Meng S, Li Z, Yu F, Chi M, Chao Q and Gao J: Application of low dose pancreas perfusion CT combined with enhancement scanning in diagnosis of pancreatic neuroendocrine tumors. Pancreatology. 21:240–245. 2021. View Article : Google Scholar : PubMed/NCBI

32 

Perri G, Prakash LR and Katz MHG: Pancreatic neuroendocrine tumors. Curr Opin Gastroenterol. 35:468–477. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Srisajjakul S, Prapaisilp P and Bangchokdee S: CT and MR features that can help to differentiate between focal chronic pancreatitis and pancreatic cancer. Radiol Med. 125:356–364. 2020. View Article : Google Scholar : PubMed/NCBI

34 

Crago AM and Dickson MA: Liposarcoma: Multimodality management and future targeted therapies. Surg Oncol Clin N Am. 25:761–773. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Gahvari Z and Parkes A: Dedifferentiated liposarcoma: Systemic therapy options. Curr Treat Options Oncol. 21:152020. View Article : Google Scholar : PubMed/NCBI

36 

Amer KM, Congiusta DV, Thomson JE, Elsamna S, Chaudhry I, Bozzo A, Amer R, Siracuse B, Ghert M and Beebe KS: Epidemiology and survival of liposarcoma and its subtypes: A dual database analysis. J Clin Orthop Trauma. 11:S479–S484. 2020. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao Y, Hu S, Sun H, Yang J and Lu T: Pancreatic liposarcoma: A case report. Oncol Lett 29: 268, 2025.
APA
Zhao, Y., Hu, S., Sun, H., Yang, J., & Lu, T. (2025). Pancreatic liposarcoma: A case report. Oncology Letters, 29, 268. https://doi.org/10.3892/ol.2025.15014
MLA
Zhao, Y., Hu, S., Sun, H., Yang, J., Lu, T."Pancreatic liposarcoma: A case report". Oncology Letters 29.6 (2025): 268.
Chicago
Zhao, Y., Hu, S., Sun, H., Yang, J., Lu, T."Pancreatic liposarcoma: A case report". Oncology Letters 29, no. 6 (2025): 268. https://doi.org/10.3892/ol.2025.15014
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Y, Hu S, Sun H, Yang J and Lu T: Pancreatic liposarcoma: A case report. Oncol Lett 29: 268, 2025.
APA
Zhao, Y., Hu, S., Sun, H., Yang, J., & Lu, T. (2025). Pancreatic liposarcoma: A case report. Oncology Letters, 29, 268. https://doi.org/10.3892/ol.2025.15014
MLA
Zhao, Y., Hu, S., Sun, H., Yang, J., Lu, T."Pancreatic liposarcoma: A case report". Oncology Letters 29.6 (2025): 268.
Chicago
Zhao, Y., Hu, S., Sun, H., Yang, J., Lu, T."Pancreatic liposarcoma: A case report". Oncology Letters 29, no. 6 (2025): 268. https://doi.org/10.3892/ol.2025.15014
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team