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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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June-2025 Volume 29 Issue 6

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Case Report Open Access

Plasma cell myeloma with an evolving diagnostic complexity: A case report

  • Authors:
    • Siting Wu
    • Ning Zhao
    • Yunxing Liang
    • Tingting Sun
    • Fang Cui
    • Jiacai Lin
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, Hainan 572013, P.R. China, Department of Hospitalization and Medical Record Management, Hainan Hospital of Chinese PLA General Hospital, Sanya, Hainan 572013, P.R. China, Department of Orthopedics, Hainan Hospital of Chinese PLA General Hospital, Sanya, Hainan 572013, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 272
    |
    Published online on: April 7, 2025
       https://doi.org/10.3892/ol.2025.15018
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Abstract

Peripheral neuropathy is among the most prevalent neurological conditions; however, its etiology is frequently complex and varied, with a propensity for progression and recurrence. The present study describes a case of plasma cell myeloma featuring a protracted and complex diagnostic and therapeutic course, supported by extensive clinical, laboratory and imaging findings. The patient initially exhibited clinical features highly indicative of subacute combined degeneration and chronic inflammatory demyelinating polyneuropathy, which gradually progressed to manifestations of polyneuropathy, organomegaly, endocrine dysfunction, monoclonal plasma cell proliferation and skin changes syndrome. Ultimately, a biopsy confirmed a diagnosis of plasma cell myeloma. The patient has been followed up for 3.5 years since the final diagnosis. Owing to early diagnosis and timely comprehensive treatment, the patient can now independently manage their daily activities, and has markedly improved limb strength, with only minor residual sensory deficits. This case underscores the difficulties in diagnosing and treating plasma cell myeloma, given that early symptoms are similar to those of other condition.
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Copy and paste a formatted citation
Spandidos Publications style
Wu S, Zhao N, Liang Y, Sun T, Cui F and Lin J: Plasma cell myeloma with an evolving diagnostic complexity: A case report. Oncol Lett 29: 272, 2025.
APA
Wu, S., Zhao, N., Liang, Y., Sun, T., Cui, F., & Lin, J. (2025). Plasma cell myeloma with an evolving diagnostic complexity: A case report. Oncology Letters, 29, 272. https://doi.org/10.3892/ol.2025.15018
MLA
Wu, S., Zhao, N., Liang, Y., Sun, T., Cui, F., Lin, J."Plasma cell myeloma with an evolving diagnostic complexity: A case report". Oncology Letters 29.6 (2025): 272.
Chicago
Wu, S., Zhao, N., Liang, Y., Sun, T., Cui, F., Lin, J."Plasma cell myeloma with an evolving diagnostic complexity: A case report". Oncology Letters 29, no. 6 (2025): 272. https://doi.org/10.3892/ol.2025.15018
Copy and paste a formatted citation
x
Spandidos Publications style
Wu S, Zhao N, Liang Y, Sun T, Cui F and Lin J: Plasma cell myeloma with an evolving diagnostic complexity: A case report. Oncol Lett 29: 272, 2025.
APA
Wu, S., Zhao, N., Liang, Y., Sun, T., Cui, F., & Lin, J. (2025). Plasma cell myeloma with an evolving diagnostic complexity: A case report. Oncology Letters, 29, 272. https://doi.org/10.3892/ol.2025.15018
MLA
Wu, S., Zhao, N., Liang, Y., Sun, T., Cui, F., Lin, J."Plasma cell myeloma with an evolving diagnostic complexity: A case report". Oncology Letters 29.6 (2025): 272.
Chicago
Wu, S., Zhao, N., Liang, Y., Sun, T., Cui, F., Lin, J."Plasma cell myeloma with an evolving diagnostic complexity: A case report". Oncology Letters 29, no. 6 (2025): 272. https://doi.org/10.3892/ol.2025.15018
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