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Case Report Open Access

Durvalumab‑induced type 1 diabetes mellitus in lung adenocarcinoma: A case report and literature review

  • Authors:
    • Huijing Dong
    • Shengfu Li
    • Yanmei Peng
    • Xu Zhang
    • Jiabin Zheng
    • Chongxiang Xue
    • Yumin Zheng
    • Yixuan Yu
    • Xingyu Lu
    • Zixin Hu
    • Huijuan Cui
  • View Affiliations / Copyright

    Affiliations: China‑Japan Friendship Clinical Medical College, Beijing University of Chinese Medicine, Beijing 100029, P.R. China, Department of Tuberculosis, Tai Yuan Fourth Peoples (Tuberculosis) Hospital, Taiyuan, Shanxi 030053, P.R. China, Department of Oncology, Fangshan Hospital Beijing University of Chinese Medicine, Beijing 102400, P.R. China, Department of Integrative Oncology, China‑Japan Friendship Hospital, Beijing 100029, P.R. China
    Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 277
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    Published online on: April 7, 2025
       https://doi.org/10.3892/ol.2025.15023
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Abstract

Immune checkpoint inhibitor‑induced type 1 diabetes mellitus (ICI‑T1DM) is a rare adverse reaction associated with durvalumab. Among the adverse reactions to durvalumab, the incidence of new‑onset diabetes is relatively rare, occurring in ~0.2% of cases. The present study reports the case of a 62‑year‑old woman who developed ICI‑T1DM following two cycles of durvalumab, presenting with thirst, polydipsia and polyuria. Laboratory examinations (glycated hemoglobin and glutamic acid decarboxylase antibody), along with consultations from an endocrinologist, led to the patient being diagnosed with ICI‑T1DM. Immunotherapy was discontinued, and insulin replacement therapy was initiated. Blood glucose levels were closely monitored using a subcutaneous meter. The onset of diabetic ketoacidosis (DKA) was prevented due to timely treatment. In conclusion, medical oncologists need to be aware that durvalumab, an immunotherapy agent, can induce ICI‑T1DM. Therefore, regular monitoring of blood glucose levels and collaborative consultations with endocrinologists are essential for an accurate diagnosis when elevated blood sugar levels are detected. The prompt diagnosis of ICI‑T1DM is crucial to prevent the occurrence of DKA.
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Copy and paste a formatted citation
Spandidos Publications style
Dong H, Li S, Peng Y, Zhang X, Zheng J, Xue C, Zheng Y, Yu Y, Lu X, Hu Z, Hu Z, et al: Durvalumab‑induced type 1 diabetes mellitus in lung adenocarcinoma: A case report and literature review. Oncol Lett 29: 277, 2025.
APA
Dong, H., Li, S., Peng, Y., Zhang, X., Zheng, J., Xue, C. ... Cui, H. (2025). Durvalumab‑induced type 1 diabetes mellitus in lung adenocarcinoma: A case report and literature review. Oncology Letters, 29, 277. https://doi.org/10.3892/ol.2025.15023
MLA
Dong, H., Li, S., Peng, Y., Zhang, X., Zheng, J., Xue, C., Zheng, Y., Yu, Y., Lu, X., Hu, Z., Cui, H."Durvalumab‑induced type 1 diabetes mellitus in lung adenocarcinoma: A case report and literature review". Oncology Letters 29.6 (2025): 277.
Chicago
Dong, H., Li, S., Peng, Y., Zhang, X., Zheng, J., Xue, C., Zheng, Y., Yu, Y., Lu, X., Hu, Z., Cui, H."Durvalumab‑induced type 1 diabetes mellitus in lung adenocarcinoma: A case report and literature review". Oncology Letters 29, no. 6 (2025): 277. https://doi.org/10.3892/ol.2025.15023
Copy and paste a formatted citation
x
Spandidos Publications style
Dong H, Li S, Peng Y, Zhang X, Zheng J, Xue C, Zheng Y, Yu Y, Lu X, Hu Z, Hu Z, et al: Durvalumab‑induced type 1 diabetes mellitus in lung adenocarcinoma: A case report and literature review. Oncol Lett 29: 277, 2025.
APA
Dong, H., Li, S., Peng, Y., Zhang, X., Zheng, J., Xue, C. ... Cui, H. (2025). Durvalumab‑induced type 1 diabetes mellitus in lung adenocarcinoma: A case report and literature review. Oncology Letters, 29, 277. https://doi.org/10.3892/ol.2025.15023
MLA
Dong, H., Li, S., Peng, Y., Zhang, X., Zheng, J., Xue, C., Zheng, Y., Yu, Y., Lu, X., Hu, Z., Cui, H."Durvalumab‑induced type 1 diabetes mellitus in lung adenocarcinoma: A case report and literature review". Oncology Letters 29.6 (2025): 277.
Chicago
Dong, H., Li, S., Peng, Y., Zhang, X., Zheng, J., Xue, C., Zheng, Y., Yu, Y., Lu, X., Hu, Z., Cui, H."Durvalumab‑induced type 1 diabetes mellitus in lung adenocarcinoma: A case report and literature review". Oncology Letters 29, no. 6 (2025): 277. https://doi.org/10.3892/ol.2025.15023
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