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Case Report Open Access

Synchronous triple squamous cell carcinomas of the stomach, skin and gingiva with liver, lung, spleen, kidney, bone and brain metastases: A case report

  • Authors:
    • Mengyao Tang
    • Xiuxia Chen
    • Linger Liu
    • Baisong Chen
    • Wenwen Han
    • Xiaofeng Zhao
    • Yao Chen
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, School of Medicine, Shaoxing University, Shaoxing, Zhejiang 312000, P.R. China, Department of Pathology, Zhuji People's Hospital of Zhejiang Province, Zhuji, Zhejiang 311800, P.R. China, Department of Oncology, Zhuji People's Hospital of Zhejiang Province, Shaoxing University, Zhuji, Zhejiang 311800, P.R. China
    Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 278
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    Published online on: April 7, 2025
       https://doi.org/10.3892/ol.2025.15024
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Abstract

Synchronous multiple squamous cell carcinomas (SCCs) of the stomach, skin and gingiva are very rare. A 67‑year‑old male patient was admitted to hospital with progressive chest tightness and fatigue, accompanied by melena. Gastric and dermal biopsies revealed SCCs, and it was considered that triple primary SCCs of the skin, stomach and gingiva had metastasized to the cerebrum, liver, lung, spleen, kidney, bone and subcutaneous tissue. The patient received one cycle of camrelizumab, carboplatin and nab‑paclitaxel, followed by two cycles of camrelizumab monotherapy and best supporting care. However, his performance status deteriorated, and he had a very poor survival outcome, succumbing 3 months after diagnosis. Discriminating pathologically between synchronous SCCs in individual organs as metastases or primaries is challenging. In the present case, a diagnosis of triple primary SCCs of the skin, stomach and gingiva with multiple organ metastases was made based on epidemiologic features and clinical presentation. The results of the present case report suggested that anti‑programmed death 1 antibodies combined with platinum‑based chemotherapy may be a treatment option for metastatic SCC.
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Copy and paste a formatted citation
Spandidos Publications style
Tang M, Chen X, Liu L, Chen B, Han W, Zhao X and Chen Y: Synchronous triple squamous cell carcinomas of the stomach, skin and gingiva with liver, lung, spleen, kidney, bone and brain metastases: A case report. Oncol Lett 29: 278, 2025.
APA
Tang, M., Chen, X., Liu, L., Chen, B., Han, W., Zhao, X., & Chen, Y. (2025). Synchronous triple squamous cell carcinomas of the stomach, skin and gingiva with liver, lung, spleen, kidney, bone and brain metastases: A case report. Oncology Letters, 29, 278. https://doi.org/10.3892/ol.2025.15024
MLA
Tang, M., Chen, X., Liu, L., Chen, B., Han, W., Zhao, X., Chen, Y."Synchronous triple squamous cell carcinomas of the stomach, skin and gingiva with liver, lung, spleen, kidney, bone and brain metastases: A case report". Oncology Letters 29.6 (2025): 278.
Chicago
Tang, M., Chen, X., Liu, L., Chen, B., Han, W., Zhao, X., Chen, Y."Synchronous triple squamous cell carcinomas of the stomach, skin and gingiva with liver, lung, spleen, kidney, bone and brain metastases: A case report". Oncology Letters 29, no. 6 (2025): 278. https://doi.org/10.3892/ol.2025.15024
Copy and paste a formatted citation
x
Spandidos Publications style
Tang M, Chen X, Liu L, Chen B, Han W, Zhao X and Chen Y: Synchronous triple squamous cell carcinomas of the stomach, skin and gingiva with liver, lung, spleen, kidney, bone and brain metastases: A case report. Oncol Lett 29: 278, 2025.
APA
Tang, M., Chen, X., Liu, L., Chen, B., Han, W., Zhao, X., & Chen, Y. (2025). Synchronous triple squamous cell carcinomas of the stomach, skin and gingiva with liver, lung, spleen, kidney, bone and brain metastases: A case report. Oncology Letters, 29, 278. https://doi.org/10.3892/ol.2025.15024
MLA
Tang, M., Chen, X., Liu, L., Chen, B., Han, W., Zhao, X., Chen, Y."Synchronous triple squamous cell carcinomas of the stomach, skin and gingiva with liver, lung, spleen, kidney, bone and brain metastases: A case report". Oncology Letters 29.6 (2025): 278.
Chicago
Tang, M., Chen, X., Liu, L., Chen, B., Han, W., Zhao, X., Chen, Y."Synchronous triple squamous cell carcinomas of the stomach, skin and gingiva with liver, lung, spleen, kidney, bone and brain metastases: A case report". Oncology Letters 29, no. 6 (2025): 278. https://doi.org/10.3892/ol.2025.15024
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