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Case Report Open Access

Immunotherapy for primary squamous cell carcinoma of the liver: A case report

  • Authors:
    • Jian Jiang
    • Guomin Dong
    • Suoni Li
    • Jiequn Ma
    • Jie Bai
    • Jinzi Hui
    • Hongbian Gao
    • Zheng Zhao
  • View Affiliations / Copyright

    Affiliations: Graduate School, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, P.R. China, Department of Internal Medicine, Shaanxi Provincial Cancer Hospital, Xi'an, Shaanxi 710061, P.R. China, Department of Nuclear Medicine, Shaanxi Provincial Cancer Hospital, Xi'an, Shaanxi 710061, P.R. China, Department of Pathology, Shaanxi Provincial Cancer Hospital, Xi'an, Shaanxi 710061, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 279
    |
    Published online on: April 7, 2025
       https://doi.org/10.3892/ol.2025.15025
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Abstract

The present study reports an exceedingly rare case of primary squamous cell carcinoma of the liver (PSCCL), a malignancy that has been documented in only ~30 cases worldwide, with both diagnosis and treatment presenting significant challenges. A 72‑year‑old man presented with right upper abdominal discomfort was admitted to Shaanxi Provincial Cancer Hospital (Xi'an, China). Computed tomography (CT) imaging revealed a space‑occupying lesion in the liver. A subsequent percutaneous liver biopsy confirmed a diagnosis of PSCCL. Positron emission tomography/CT was performed to exclude metastasis from other primary sites and confirmed the diagnosis of PSCCL. The patient received combination therapy of envafolimab and albumin‑paclitaxel plus cisplatin. Telephone follow‑up continued until December 2024 (a total of 18 months), during which the patient achieved and maintained a sustained partial response. The uniqueness of the present case lies in the patient's receipt of an innovative therapeutic regimen combining envafolimab with albumin‑paclitaxel and cisplatin, achieving a sustained partial response over an 18‑month follow‑up period. This outcome not only offers novel insights for the clinical management of PSCCL but also underscores the importance of multidisciplinary comprehensive treatment in rare tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang J, Dong G, Li S, Ma J, Bai J, Hui J, Gao H and Zhao Z: Immunotherapy for primary squamous cell carcinoma of the liver: A case report. Oncol Lett 29: 279, 2025.
APA
Jiang, J., Dong, G., Li, S., Ma, J., Bai, J., Hui, J. ... Zhao, Z. (2025). Immunotherapy for primary squamous cell carcinoma of the liver: A case report. Oncology Letters, 29, 279. https://doi.org/10.3892/ol.2025.15025
MLA
Jiang, J., Dong, G., Li, S., Ma, J., Bai, J., Hui, J., Gao, H., Zhao, Z."Immunotherapy for primary squamous cell carcinoma of the liver: A case report". Oncology Letters 29.6 (2025): 279.
Chicago
Jiang, J., Dong, G., Li, S., Ma, J., Bai, J., Hui, J., Gao, H., Zhao, Z."Immunotherapy for primary squamous cell carcinoma of the liver: A case report". Oncology Letters 29, no. 6 (2025): 279. https://doi.org/10.3892/ol.2025.15025
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang J, Dong G, Li S, Ma J, Bai J, Hui J, Gao H and Zhao Z: Immunotherapy for primary squamous cell carcinoma of the liver: A case report. Oncol Lett 29: 279, 2025.
APA
Jiang, J., Dong, G., Li, S., Ma, J., Bai, J., Hui, J. ... Zhao, Z. (2025). Immunotherapy for primary squamous cell carcinoma of the liver: A case report. Oncology Letters, 29, 279. https://doi.org/10.3892/ol.2025.15025
MLA
Jiang, J., Dong, G., Li, S., Ma, J., Bai, J., Hui, J., Gao, H., Zhao, Z."Immunotherapy for primary squamous cell carcinoma of the liver: A case report". Oncology Letters 29.6 (2025): 279.
Chicago
Jiang, J., Dong, G., Li, S., Ma, J., Bai, J., Hui, J., Gao, H., Zhao, Z."Immunotherapy for primary squamous cell carcinoma of the liver: A case report". Oncology Letters 29, no. 6 (2025): 279. https://doi.org/10.3892/ol.2025.15025
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