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Review Open Access

Circular RNAs in gynecological cancer: From molecular mechanisms to clinical applications (Review)

  • Authors:
    • Ying Liu
    • Hao Ai
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 291
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    Published online on: April 11, 2025
       https://doi.org/10.3892/ol.2025.15037
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Abstract

Circular RNAs (circRNAs) have emerged as promising biomarkers and therapeutic targets in gynecological cancer. The present review explored developments in circRNA research in ovarian, endometrial and cervical cancer. circRNA biogenesis, functions and roles in cancer pathogenesis have been discussed, focusing on their potential as diagnostic and prognostic markers. Furthermore, circRNAs mechanisms of action, including miRNA sponging, protein scaffolding and peptide encoding were examined, highlighting specific circRNAs implicated in each cancer type and their clinical significance. The unique properties of circRNAs, such as stability and tissue‑specific expression, make them ideal candidates for biomarker development. By synthesizing the currently available literature and identifying future research directions, the present review underscored circRNAs potential to improve gynecological cancer management through novel diagnostic tools, prognostic markers and targeted therapies.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Y and Ai H: Circular RNAs in gynecological cancer: From molecular mechanisms to clinical applications (Review). Oncol Lett 29: 291, 2025.
APA
Liu, Y., & Ai, H. (2025). Circular RNAs in gynecological cancer: From molecular mechanisms to clinical applications (Review). Oncology Letters, 29, 291. https://doi.org/10.3892/ol.2025.15037
MLA
Liu, Y., Ai, H."Circular RNAs in gynecological cancer: From molecular mechanisms to clinical applications (Review)". Oncology Letters 29.6 (2025): 291.
Chicago
Liu, Y., Ai, H."Circular RNAs in gynecological cancer: From molecular mechanisms to clinical applications (Review)". Oncology Letters 29, no. 6 (2025): 291. https://doi.org/10.3892/ol.2025.15037
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y and Ai H: Circular RNAs in gynecological cancer: From molecular mechanisms to clinical applications (Review). Oncol Lett 29: 291, 2025.
APA
Liu, Y., & Ai, H. (2025). Circular RNAs in gynecological cancer: From molecular mechanisms to clinical applications (Review). Oncology Letters, 29, 291. https://doi.org/10.3892/ol.2025.15037
MLA
Liu, Y., Ai, H."Circular RNAs in gynecological cancer: From molecular mechanisms to clinical applications (Review)". Oncology Letters 29.6 (2025): 291.
Chicago
Liu, Y., Ai, H."Circular RNAs in gynecological cancer: From molecular mechanisms to clinical applications (Review)". Oncology Letters 29, no. 6 (2025): 291. https://doi.org/10.3892/ol.2025.15037
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