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Review Open Access

Progress in the development of cancer vaccines for lung cancer utilizing dendritic cells (Review)

  • Authors:
    • Hui Hu
    • Wen-Jun Chen
    • Chuang Sun
    • Jun-Ping Xie
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care, The Second Affiliated Hospital of Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Oncology, PLA Navy Anqing Hospital, Anqing, Anhui 246004, P.R. China, Department of Respiratory and Critical Care, Xinyu People's Hospital, Xinyu, Jiangxi 338099, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 298
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    Published online on: April 14, 2025
       https://doi.org/10.3892/ol.2025.15044
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Abstract

Lung cancer is a major global health concern in terms of both incidence and mortality. Despite substantial advancements in targeted therapy and immune checkpoint inhibitor treatments, their overall effectiveness is limited. Dendritic cells (DCs) are crucial in innate and acquired immune responses due to their effective presentation of antigens. DC‑based cancer vaccines have been identified as promising strategies for personalized cancer immunotherapy. The present review presents a thorough examination of the immunomodulation and associated mechanisms of DC vaccines in lung cancer, with a specific emphasis on the presentation of clinical trial data concerning the safety, feasibility and effectiveness of DC vaccines in the treatment of patients with lung cancer. The objective of this review is to highlight strategies and provide insights that may improve the development and clinical efficacy of DC vaccines for the treatment lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Hu H, Chen W, Sun C and Xie J: Progress in the development of cancer vaccines for lung cancer utilizing dendritic cells (Review). Oncol Lett 29: 298, 2025.
APA
Hu, H., Chen, W., Sun, C., & Xie, J. (2025). Progress in the development of cancer vaccines for lung cancer utilizing dendritic cells (Review). Oncology Letters, 29, 298. https://doi.org/10.3892/ol.2025.15044
MLA
Hu, H., Chen, W., Sun, C., Xie, J."Progress in the development of cancer vaccines for lung cancer utilizing dendritic cells (Review)". Oncology Letters 29.6 (2025): 298.
Chicago
Hu, H., Chen, W., Sun, C., Xie, J."Progress in the development of cancer vaccines for lung cancer utilizing dendritic cells (Review)". Oncology Letters 29, no. 6 (2025): 298. https://doi.org/10.3892/ol.2025.15044
Copy and paste a formatted citation
x
Spandidos Publications style
Hu H, Chen W, Sun C and Xie J: Progress in the development of cancer vaccines for lung cancer utilizing dendritic cells (Review). Oncol Lett 29: 298, 2025.
APA
Hu, H., Chen, W., Sun, C., & Xie, J. (2025). Progress in the development of cancer vaccines for lung cancer utilizing dendritic cells (Review). Oncology Letters, 29, 298. https://doi.org/10.3892/ol.2025.15044
MLA
Hu, H., Chen, W., Sun, C., Xie, J."Progress in the development of cancer vaccines for lung cancer utilizing dendritic cells (Review)". Oncology Letters 29.6 (2025): 298.
Chicago
Hu, H., Chen, W., Sun, C., Xie, J."Progress in the development of cancer vaccines for lung cancer utilizing dendritic cells (Review)". Oncology Letters 29, no. 6 (2025): 298. https://doi.org/10.3892/ol.2025.15044
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