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Effects of first‑line therapies in patients with locally advanced gastrointestinal stromal tumors with KIT and PDGFRα gene mutations: A single‑center study

  • Authors:
    • Wei-Chih Su
    • Ching-Wen Huang
    • Yen-Cheng Chen
    • Tsung-Kun Chang
    • Po-Jung Chen
    • Yung-Sung Yeh
    • Tzu-Chieh Yin
    • Hsiang-Lin Tsai
    • Jaw-Yuan Wang
  • View Affiliations / Copyright

    Affiliations: Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, R.O.C., Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, R.O.C.
    Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 299
    |
    Published online on: April 14, 2025
       https://doi.org/10.3892/ol.2025.15045
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Abstract

Curative resection is typically recommended for treating gastrointestinal stromal tumors (GISTs). Exceptions are made for locally advanced GISTs (LAGISTs) where radical resection may be impossible. First‑line imatinib therapy can be employed to treat GISTs harboring mutations in the tyrosine‑protein kinase KIT (KIT) and platelet‑derived growth factor receptor α (PDGFRα) genes to reduce the tumor size to resectable levels and minimize surgical risks. The present study investigated the treatment outcomes of patients with LAGISTs with different KIT and PDGFRα gene mutations who received first‑line imatinib therapy. A total of 37 patients with LAGISTs who underwent first‑line imatinib treatment were included, and the median follow‑up period was 41 months. Treatment regimens included imatinib, with subsequent therapies, such as sunitinib and regorafenib, administered upon imatinib failure. The genetic profiles of KIT and PDGFRα were analyzed. Of the 37 patients, 24 (64.9%) successfully underwent curative resection. The median progression‑free survival (PFS) was 36 months and the median overall survival (OS) was 41 months. Patients presented with tumors with various genetic mutations, which differentially affected their PFS and OS and adverse events were typically manageable. However, the gene mutation status was not significantly associated with treatment response or surgical resectability (both P>0.05). The present study elucidated the effects of first‑line therapy on LAGISTs with genetic mutations, underscoring the effectiveness of imatinib treatment and the value of continual patient monitoring. Additional studies with long‑term follow‑up are required to evaluate treatment outcomes.
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Copy and paste a formatted citation
Spandidos Publications style
Su W, Huang C, Chen Y, Chang T, Chen P, Yeh Y, Yin T, Tsai H and Wang J: Effects of first‑line therapies in patients with locally advanced gastrointestinal stromal tumors with <em>KIT</em> and <em>PDGFR&alpha;</em> gene mutations: A single‑center study. Oncol Lett 29: 299, 2025.
APA
Su, W., Huang, C., Chen, Y., Chang, T., Chen, P., Yeh, Y. ... Wang, J. (2025). Effects of first‑line therapies in patients with locally advanced gastrointestinal stromal tumors with <em>KIT</em> and <em>PDGFR&alpha;</em> gene mutations: A single‑center study. Oncology Letters, 29, 299. https://doi.org/10.3892/ol.2025.15045
MLA
Su, W., Huang, C., Chen, Y., Chang, T., Chen, P., Yeh, Y., Yin, T., Tsai, H., Wang, J."Effects of first‑line therapies in patients with locally advanced gastrointestinal stromal tumors with <em>KIT</em> and <em>PDGFR&alpha;</em> gene mutations: A single‑center study". Oncology Letters 29.6 (2025): 299.
Chicago
Su, W., Huang, C., Chen, Y., Chang, T., Chen, P., Yeh, Y., Yin, T., Tsai, H., Wang, J."Effects of first‑line therapies in patients with locally advanced gastrointestinal stromal tumors with <em>KIT</em> and <em>PDGFR&alpha;</em> gene mutations: A single‑center study". Oncology Letters 29, no. 6 (2025): 299. https://doi.org/10.3892/ol.2025.15045
Copy and paste a formatted citation
x
Spandidos Publications style
Su W, Huang C, Chen Y, Chang T, Chen P, Yeh Y, Yin T, Tsai H and Wang J: Effects of first‑line therapies in patients with locally advanced gastrointestinal stromal tumors with <em>KIT</em> and <em>PDGFR&alpha;</em> gene mutations: A single‑center study. Oncol Lett 29: 299, 2025.
APA
Su, W., Huang, C., Chen, Y., Chang, T., Chen, P., Yeh, Y. ... Wang, J. (2025). Effects of first‑line therapies in patients with locally advanced gastrointestinal stromal tumors with <em>KIT</em> and <em>PDGFR&alpha;</em> gene mutations: A single‑center study. Oncology Letters, 29, 299. https://doi.org/10.3892/ol.2025.15045
MLA
Su, W., Huang, C., Chen, Y., Chang, T., Chen, P., Yeh, Y., Yin, T., Tsai, H., Wang, J."Effects of first‑line therapies in patients with locally advanced gastrointestinal stromal tumors with <em>KIT</em> and <em>PDGFR&alpha;</em> gene mutations: A single‑center study". Oncology Letters 29.6 (2025): 299.
Chicago
Su, W., Huang, C., Chen, Y., Chang, T., Chen, P., Yeh, Y., Yin, T., Tsai, H., Wang, J."Effects of first‑line therapies in patients with locally advanced gastrointestinal stromal tumors with <em>KIT</em> and <em>PDGFR&alpha;</em> gene mutations: A single‑center study". Oncology Letters 29, no. 6 (2025): 299. https://doi.org/10.3892/ol.2025.15045
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