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Stereotactic body radiotherapy for early‑stage non‑small cell lung cancer: Comprehensive analysis of outcomes and recurrence from a single‑center experience

  • Authors:
    • Sangjoon Park
    • Jong Won Park
    • Eun Hye Lee
    • Young Joo Suh
    • Chang Young Lee
    • Byung Jo Park
    • Chang Geol Lee
    • Hong In Yoon
    • Sang Hoon Lee
    • Ronglan Cui
    • Eun Young Kim
    • Jaeho Cho
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea, Department of Internal Medicine, Division of Pulmonology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Gyeonggi 16995, Republic of Korea, Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea, Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul 03722, Republic of Korea, Department of Internal Medicine, Division of Pulmonology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea
    Copyright: © Park et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 314
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    Published online on: April 25, 2025
       https://doi.org/10.3892/ol.2025.15060
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Abstract

This study aimed to analyze prognostic factors in patients with early‑stage non‑small cell lung cancer (NSCLC) treated with stereotactic body radiotherapy (SBRT), focusing on symptomatic radiation pneumonitis (RP) and treatment failure patterns. This retrospective cohort study included 271 patients with early‑stage NSCLC (276 lesions) treated with SBRT from May 2012 to January 2022. SBRT was administered according to standardized protocols with doses ranging from 28.5 to 80 Gy in 1 to 10 fractions. Tumor recurrence, RP, and failure patterns were assessed through imaging and clinical evaluations. Prognostic factors for overall survival (OS) and local control (LC) were identified using Kaplan‑Meier survival analysis, Cox models, and logistic regression for RP risk. With a median follow‑up of 30.8 months, the 1‑, 2‑ and 3‑year OS rates were 96.1, 91.8, and 86.5%, respectively, and LC rates were 98.8, 96.5, and 92.9%, respectively. The Eastern Cooperative Oncology Group performance status (P=0.002) and higher fractional dose (P=0.041) were significant predictors of OS. Larger tumor size (P<0.001) and higher solid‑to‑total tumor ratio (P=0.028) were associated with increased local recurrence risk. Symptomatic RP (7.2% of lesions) was associated with solid tumor size (P=0.050). Larger tumors with a higher solid component had more in‑field recurrences, while marginal recurrences were often attributable to air space spread and pleural involvement. Higher fractional doses in SBRT benefit patients with early‑stage NSCLC, especially those with larger tumors or significant solid components, suggesting that dose escalation or more biologically effective therapies could enhance outcomes and optimize SBRT protocols.
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Copy and paste a formatted citation
Spandidos Publications style
Park S, Park JW, Lee EH, Suh YJ, Lee CY, Park BJ, Lee CG, Yoon HI, Lee SH, Cui R, Cui R, et al: Stereotactic body radiotherapy for early‑stage non‑small cell lung cancer: Comprehensive analysis of outcomes and recurrence from a single‑center experience. Oncol Lett 29: 314, 2025.
APA
Park, S., Park, J.W., Lee, E.H., Suh, Y.J., Lee, C.Y., Park, B.J. ... Cho, J. (2025). Stereotactic body radiotherapy for early‑stage non‑small cell lung cancer: Comprehensive analysis of outcomes and recurrence from a single‑center experience. Oncology Letters, 29, 314. https://doi.org/10.3892/ol.2025.15060
MLA
Park, S., Park, J. W., Lee, E. H., Suh, Y. J., Lee, C. Y., Park, B. J., Lee, C. G., Yoon, H. I., Lee, S. H., Cui, R., Kim, E. Y., Cho, J."Stereotactic body radiotherapy for early‑stage non‑small cell lung cancer: Comprehensive analysis of outcomes and recurrence from a single‑center experience". Oncology Letters 29.6 (2025): 314.
Chicago
Park, S., Park, J. W., Lee, E. H., Suh, Y. J., Lee, C. Y., Park, B. J., Lee, C. G., Yoon, H. I., Lee, S. H., Cui, R., Kim, E. Y., Cho, J."Stereotactic body radiotherapy for early‑stage non‑small cell lung cancer: Comprehensive analysis of outcomes and recurrence from a single‑center experience". Oncology Letters 29, no. 6 (2025): 314. https://doi.org/10.3892/ol.2025.15060
Copy and paste a formatted citation
x
Spandidos Publications style
Park S, Park JW, Lee EH, Suh YJ, Lee CY, Park BJ, Lee CG, Yoon HI, Lee SH, Cui R, Cui R, et al: Stereotactic body radiotherapy for early‑stage non‑small cell lung cancer: Comprehensive analysis of outcomes and recurrence from a single‑center experience. Oncol Lett 29: 314, 2025.
APA
Park, S., Park, J.W., Lee, E.H., Suh, Y.J., Lee, C.Y., Park, B.J. ... Cho, J. (2025). Stereotactic body radiotherapy for early‑stage non‑small cell lung cancer: Comprehensive analysis of outcomes and recurrence from a single‑center experience. Oncology Letters, 29, 314. https://doi.org/10.3892/ol.2025.15060
MLA
Park, S., Park, J. W., Lee, E. H., Suh, Y. J., Lee, C. Y., Park, B. J., Lee, C. G., Yoon, H. I., Lee, S. H., Cui, R., Kim, E. Y., Cho, J."Stereotactic body radiotherapy for early‑stage non‑small cell lung cancer: Comprehensive analysis of outcomes and recurrence from a single‑center experience". Oncology Letters 29.6 (2025): 314.
Chicago
Park, S., Park, J. W., Lee, E. H., Suh, Y. J., Lee, C. Y., Park, B. J., Lee, C. G., Yoon, H. I., Lee, S. H., Cui, R., Kim, E. Y., Cho, J."Stereotactic body radiotherapy for early‑stage non‑small cell lung cancer: Comprehensive analysis of outcomes and recurrence from a single‑center experience". Oncology Letters 29, no. 6 (2025): 314. https://doi.org/10.3892/ol.2025.15060
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