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Review

Development and challenges in the treatment of advanced gallbladder cancer (Review)

  • Authors:
    • Bo Zhou
    • Shi-Ran Zhang
    • Geng Chen
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Daping Hospital, Army Medical University, Chongqing 400042, P.R. China, Department of Hepatobiliary Surgery, Daping Hospital, Army Medical University, Chongqing 400042, P.R. China
  • Article Number: 382
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    Published online on: June 3, 2025
       https://doi.org/10.3892/ol.2025.15128
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Abstract

Gallbladder cancer (GBC) is a highly lethal disease and the most common cancer of the biliary tract. Numerous patients are diagnosed at an advanced stage, limiting surgical options and necessitating local or systemic treatment. Despite advancements in cancer treatment, 5‑year survival rates remain low. Various therapeutic methods are available for the treatment of advanced GBC, including local therapy, chemoradiotherapy, immunotherapy and targeted therapy. Although these treatments offer hope and broader prospects for patients, challenges persist. Through a systematic review of the literature from PubMed and Web of Science over the past decade, a summary and analysis of treatment trends, existing challenges and the latest research developments in advanced GBC were provided.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou B, Zhang S and Chen G: Development and challenges in the treatment of advanced gallbladder cancer (Review). Oncol Lett 30: 382, 2025.
APA
Zhou, B., Zhang, S., & Chen, G. (2025). Development and challenges in the treatment of advanced gallbladder cancer (Review). Oncology Letters, 30, 382. https://doi.org/10.3892/ol.2025.15128
MLA
Zhou, B., Zhang, S., Chen, G."Development and challenges in the treatment of advanced gallbladder cancer (Review)". Oncology Letters 30.2 (2025): 382.
Chicago
Zhou, B., Zhang, S., Chen, G."Development and challenges in the treatment of advanced gallbladder cancer (Review)". Oncology Letters 30, no. 2 (2025): 382. https://doi.org/10.3892/ol.2025.15128
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou B, Zhang S and Chen G: Development and challenges in the treatment of advanced gallbladder cancer (Review). Oncol Lett 30: 382, 2025.
APA
Zhou, B., Zhang, S., & Chen, G. (2025). Development and challenges in the treatment of advanced gallbladder cancer (Review). Oncology Letters, 30, 382. https://doi.org/10.3892/ol.2025.15128
MLA
Zhou, B., Zhang, S., Chen, G."Development and challenges in the treatment of advanced gallbladder cancer (Review)". Oncology Letters 30.2 (2025): 382.
Chicago
Zhou, B., Zhang, S., Chen, G."Development and challenges in the treatment of advanced gallbladder cancer (Review)". Oncology Letters 30, no. 2 (2025): 382. https://doi.org/10.3892/ol.2025.15128
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