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Case Report Open Access

Complete remission of recurrent uterine angiosarcoma following long‑term systemic chemotherapy with paclitaxel and carboplatin: A case report

  • Authors:
    • Yuta Inoue
    • Yasunori Hashiguchi
    • Yuko Kuwae
    • Akira Yamamoto
    • Masayasu Koyama
    • Kumio Yamamoto
    • Kazutomi Tamura
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Ishikiriseiki Hospital, Higashiosaka, Osaka 579‑8026, Japan, Department of Diagnostic Pathology, Ishikiriseiki Hospital, Higashiosaka, Osaka 579‑8026, Japan
    Copyright: © Inoue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 400
    |
    Published online on: June 18, 2025
       https://doi.org/10.3892/ol.2025.15146
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Abstract

Angiosarcoma (AS) is a rare and aggressive malignancy of vascular endothelial origin, accounting for 2‑5% of all soft tissue sarcomas. Primary uterine AS is extremely rare, with only ~30 cases reported in English literature. Its prognosis remains poor, with a 5‑year survival rate of <35%, and there is currently no standard systemic chemotherapy established for unresectable or recurrent cases. This study presents the case of a 57‑year‑old woman with a 27x20 cm uterine mass causing severe anemia (hemoglobin 4.5 g/dl). Following total hysterectomy and bilateral salpingo‑oophorectomy, histopathological analysis confirmed primary uterine AS (T1NXM0). Despite complete surgical resection, three new intra‑abdominal tumors appeared within 1 month. The patient underwent 21 cycles of intravenous paclitaxel and carboplatin every 3‑4 weeks, achieving complete disappearance of all metastatic lesions. The patient was still alive 31 months after the initial surgery without any sign of recurrence or metastasis. This case demonstrates the potential efficacy of paclitaxel and carboplatin combination chemotherapy for recurrent uterine AS, contributing valuable data to guide future therapeutic strategies for this rare malignancy with typically poor prognosis.6
View Figures

Figure 1

Magnetic resonance imaging. (A)
T2-weighted image. A 27×20 cm mass (white arrowhead) with
heterogeneous high and low signal areas in the uterus. (B)
Diffusion-weighted image. The solid part of the tumor showed a high
signal (white arrowhead). (C) Apparent diffusion coefficient map.
The solid part of the tumor showed a low signal (white arrowhead).
(D) Sagittal section. There was no invasion into the cervix or
malignant tumor of cervical origin (white arrowhead).

Figure 2

Radiological findings. (A) Computed
tomography scan. A heterogeneous, septate, mixed-density mass was
seen in the transverse section. (B) Positron emission
tomography-computed tomography. Hypermetabolism was seen in the
area where the presence of a malignant tumor was suggested by
magnetic resonance imaging (white arrowhead).

Figure 3

Macroscopic image. (A) Intraoperative
findings showed a smooth, enlarged uterus with numerous dilated
blood vessels, and strong adhesion (white arrowhead) between the
uterus and sigmoid colon. (B) A spongy, hemorrhagic tumor with
necrotic tissue.

Figure 4

Pathological findings. (A) Hematoxylin
and eosin stain. The atypical cells with enlarged nuclei and
distinct nucleoli formed a reticular structure like a vascular
cavity and exhibited signs of proliferation. Magnification, ×100.
(B) CD31 staining showed a strong positive signal in the malignant
cells. Magnification, ×100. (C) CD34 staining showed a partially
positive signal in the malignant cells. Magnification, ×200.

Figure 5

Computed tomography scan performed 1
month after surgery. The largest of the three new solid tumors that
had recurred in the abdominal cavity (maximum diameter 7 cm) (white
arrowhead).
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Copy and paste a formatted citation
Spandidos Publications style
Inoue Y, Hashiguchi Y, Kuwae Y, Yamamoto A, Koyama M, Yamamoto K and Tamura K: Complete remission of recurrent uterine angiosarcoma following long‑term systemic chemotherapy with paclitaxel and carboplatin: A case report. Oncol Lett 30: 400, 2025.
APA
Inoue, Y., Hashiguchi, Y., Kuwae, Y., Yamamoto, A., Koyama, M., Yamamoto, K., & Tamura, K. (2025). Complete remission of recurrent uterine angiosarcoma following long‑term systemic chemotherapy with paclitaxel and carboplatin: A case report. Oncology Letters, 30, 400. https://doi.org/10.3892/ol.2025.15146
MLA
Inoue, Y., Hashiguchi, Y., Kuwae, Y., Yamamoto, A., Koyama, M., Yamamoto, K., Tamura, K."Complete remission of recurrent uterine angiosarcoma following long‑term systemic chemotherapy with paclitaxel and carboplatin: A case report". Oncology Letters 30.2 (2025): 400.
Chicago
Inoue, Y., Hashiguchi, Y., Kuwae, Y., Yamamoto, A., Koyama, M., Yamamoto, K., Tamura, K."Complete remission of recurrent uterine angiosarcoma following long‑term systemic chemotherapy with paclitaxel and carboplatin: A case report". Oncology Letters 30, no. 2 (2025): 400. https://doi.org/10.3892/ol.2025.15146
Copy and paste a formatted citation
x
Spandidos Publications style
Inoue Y, Hashiguchi Y, Kuwae Y, Yamamoto A, Koyama M, Yamamoto K and Tamura K: Complete remission of recurrent uterine angiosarcoma following long‑term systemic chemotherapy with paclitaxel and carboplatin: A case report. Oncol Lett 30: 400, 2025.
APA
Inoue, Y., Hashiguchi, Y., Kuwae, Y., Yamamoto, A., Koyama, M., Yamamoto, K., & Tamura, K. (2025). Complete remission of recurrent uterine angiosarcoma following long‑term systemic chemotherapy with paclitaxel and carboplatin: A case report. Oncology Letters, 30, 400. https://doi.org/10.3892/ol.2025.15146
MLA
Inoue, Y., Hashiguchi, Y., Kuwae, Y., Yamamoto, A., Koyama, M., Yamamoto, K., Tamura, K."Complete remission of recurrent uterine angiosarcoma following long‑term systemic chemotherapy with paclitaxel and carboplatin: A case report". Oncology Letters 30.2 (2025): 400.
Chicago
Inoue, Y., Hashiguchi, Y., Kuwae, Y., Yamamoto, A., Koyama, M., Yamamoto, K., Tamura, K."Complete remission of recurrent uterine angiosarcoma following long‑term systemic chemotherapy with paclitaxel and carboplatin: A case report". Oncology Letters 30, no. 2 (2025): 400. https://doi.org/10.3892/ol.2025.15146
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