Open Access

Complete remission of recurrent uterine angiosarcoma following long‑term systemic chemotherapy with paclitaxel and carboplatin: A case report

  • Authors:
    • Yuta Inoue
    • Yasunori Hashiguchi
    • Yuko Kuwae
    • Akira Yamamoto
    • Masayasu Koyama
    • Kumio Yamamoto
    • Kazutomi Tamura
  • View Affiliations

  • Published online on: June 18, 2025     https://doi.org/10.3892/ol.2025.15146
  • Article Number: 400
  • Copyright: © Inoue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Angiosarcoma (AS) is a rare and aggressive malignancy of vascular endothelial origin, accounting for 2‑5% of all soft tissue sarcomas. Primary uterine AS is extremely rare, with only ~30 cases reported in English literature. Its prognosis remains poor, with a 5‑year survival rate of <35%, and there is currently no standard systemic chemotherapy established for unresectable or recurrent cases. This study presents the case of a 57‑year‑old woman with a 27x20 cm uterine mass causing severe anemia (hemoglobin 4.5 g/dl). Following total hysterectomy and bilateral salpingo‑oophorectomy, histopathological analysis confirmed primary uterine AS (T1NXM0). Despite complete surgical resection, three new intra‑abdominal tumors appeared within 1 month. The patient underwent 21 cycles of intravenous paclitaxel and carboplatin every 3‑4 weeks, achieving complete disappearance of all metastatic lesions. The patient was still alive 31 months after the initial surgery without any sign of recurrence or metastasis. This case demonstrates the potential efficacy of paclitaxel and carboplatin combination chemotherapy for recurrent uterine AS, contributing valuable data to guide future therapeutic strategies for this rare malignancy with typically poor prognosis.6
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August-2025
Volume 30 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Inoue Y, Hashiguchi Y, Kuwae Y, Yamamoto A, Koyama M, Yamamoto K and Tamura K: Complete remission of recurrent uterine angiosarcoma following long‑term systemic chemotherapy with paclitaxel and carboplatin: A case report. Oncol Lett 30: 400, 2025.
APA
Inoue, Y., Hashiguchi, Y., Kuwae, Y., Yamamoto, A., Koyama, M., Yamamoto, K., & Tamura, K. (2025). Complete remission of recurrent uterine angiosarcoma following long‑term systemic chemotherapy with paclitaxel and carboplatin: A case report. Oncology Letters, 30, 400. https://doi.org/10.3892/ol.2025.15146
MLA
Inoue, Y., Hashiguchi, Y., Kuwae, Y., Yamamoto, A., Koyama, M., Yamamoto, K., Tamura, K."Complete remission of recurrent uterine angiosarcoma following long‑term systemic chemotherapy with paclitaxel and carboplatin: A case report". Oncology Letters 30.2 (2025): 400.
Chicago
Inoue, Y., Hashiguchi, Y., Kuwae, Y., Yamamoto, A., Koyama, M., Yamamoto, K., Tamura, K."Complete remission of recurrent uterine angiosarcoma following long‑term systemic chemotherapy with paclitaxel and carboplatin: A case report". Oncology Letters 30, no. 2 (2025): 400. https://doi.org/10.3892/ol.2025.15146