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Review Open Access

Lycopene as a potential anticancer agent: Current evidence on synergism, drug delivery systems and epidemiology (Review)

  • Authors:
    • Siliang Yin
    • Xiuqing Xu
    • Yi Li
    • Heng Fang
    • Junling Ren
  • View Affiliations / Copyright

    Affiliations: Pharmaceutical Research Institute, Guangshengyuan Traditional Chinese Medicine Co., Ltd., Datong, Shanxi 037000, P.R. China, GAP Center, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China
    Copyright: © Yin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 462
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    Published online on: July 28, 2025
       https://doi.org/10.3892/ol.2025.15208
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Abstract

Plant‑derived natural compounds are an important source of anticancer drugs. Lycopene, commonly referred to as ‘plant gold’, is a powerful antioxidant with multiple health benefits. It may be associated with a reduction in the morbidity and mortality of several types of cancer, making it a promising anticancer agent. The present review summarizes the synergistic effects of lycopene as a dietary supplement with other chemotherapy drugs or nutrients, for the enhancement of anticancer effects or the reduction of side effects from chemotherapy drugs. Moreover, due to its low water solubility, the development of novel drug delivery systems may improve the bioavailability of lycopene. By summarizing epidemiological research, the present review highlights the current clinical research status and limitations of lycopene, with the aim to provide useful information and guidance for future research on the anticancer effects of lycopene.
View Figures

Figure 1

Main plant sources of lycopene.

Figure 2

Biological effects of lycopene. ROS,
reactive oxygen species; UV, ultraviolet. This figure was created
with BioRender.com.

Figure 3

Main anticancer mechanism of
lycopene. This figure was created with BioRender.com. The red lines
represent inhibitory effects and the black lines activation effect.
ROS, reactive oxygen species; P, phosphorylation; AP-1, activator
protein 1; BID, BH3 interacting domain death agonist; c-Fos,
cellular FBJ osteosarcoma viral oncogene homolog; FASR, Fas
receptor; JAK, janus kinase; IGF-1R, insulin-like growth factor-1
receptor; IRS-1, insulin receptor substrate-1; Keap1, kelch-like
ECH-associated protein 1; LRP, low-density lipoprotein
receptor-related protein; Nrf2, nuclear factor erythroid 2-related
factor 2; PDGFR, platelet-derived growth factor receptor; SP-1,
specificity protein-1.
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Copy and paste a formatted citation
Spandidos Publications style
Yin S, Xu X, Li Y, Fang H and Ren J: Lycopene as a potential anticancer agent: Current evidence on synergism, drug delivery systems and epidemiology (Review). Oncol Lett 30: 462, 2025.
APA
Yin, S., Xu, X., Li, Y., Fang, H., & Ren, J. (2025). Lycopene as a potential anticancer agent: Current evidence on synergism, drug delivery systems and epidemiology (Review). Oncology Letters, 30, 462. https://doi.org/10.3892/ol.2025.15208
MLA
Yin, S., Xu, X., Li, Y., Fang, H., Ren, J."Lycopene as a potential anticancer agent: Current evidence on synergism, drug delivery systems and epidemiology (Review)". Oncology Letters 30.4 (2025): 462.
Chicago
Yin, S., Xu, X., Li, Y., Fang, H., Ren, J."Lycopene as a potential anticancer agent: Current evidence on synergism, drug delivery systems and epidemiology (Review)". Oncology Letters 30, no. 4 (2025): 462. https://doi.org/10.3892/ol.2025.15208
Copy and paste a formatted citation
x
Spandidos Publications style
Yin S, Xu X, Li Y, Fang H and Ren J: Lycopene as a potential anticancer agent: Current evidence on synergism, drug delivery systems and epidemiology (Review). Oncol Lett 30: 462, 2025.
APA
Yin, S., Xu, X., Li, Y., Fang, H., & Ren, J. (2025). Lycopene as a potential anticancer agent: Current evidence on synergism, drug delivery systems and epidemiology (Review). Oncology Letters, 30, 462. https://doi.org/10.3892/ol.2025.15208
MLA
Yin, S., Xu, X., Li, Y., Fang, H., Ren, J."Lycopene as a potential anticancer agent: Current evidence on synergism, drug delivery systems and epidemiology (Review)". Oncology Letters 30.4 (2025): 462.
Chicago
Yin, S., Xu, X., Li, Y., Fang, H., Ren, J."Lycopene as a potential anticancer agent: Current evidence on synergism, drug delivery systems and epidemiology (Review)". Oncology Letters 30, no. 4 (2025): 462. https://doi.org/10.3892/ol.2025.15208
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