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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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October-2025 Volume 30 Issue 4

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Case Report

Dialysis independence for a young patient with refractory multiple myeloma treated with teclistamab: A case report

  • Authors:
    • Ioannis Ntanasis‑Stathopoulos
    • Ilias Katsadouros
    • Panagiotis Malandrakis
    • Erasmia Psimenou
    • Meletios-Athanasios Dimopoulos
    • Maria Gavriatopoulou
  • View Affiliations / Copyright

    Affiliations: Plasma Cell Dyscrasias Unit, Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece
  • Article Number: 474
    |
    Published online on: August 8, 2025
       https://doi.org/10.3892/ol.2025.15220
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Abstract

Teclistamab, a B‑cell maturation antigen‑targeting bispecific antibody, offers a promising treatment option for relapsed/refractory multiple myeloma (RRMM), even in patients with severe renal impairment. The present study describes the case of a 47‑year‑old woman with RRMM who achieved minimal residual disease negativity and dialysis independence following teclistamab treatment. Despite prior resistance to multiple therapies, including an anti‑CD38 monoclonal antibody (daratumumab), two proteasome inhibitors (bortezomib and carfilzomib), an immunomodulatory drug (lenalidomide), an exportin 1 inhibitor (selinexor), a BCL‑2 inhibitor (venetoclax) and dexamethasone, and post‑autologous stem cell transplantation relapse, teclistamab induced a deep hematological response. Cytokine release syndrome was manageable and no major complications occurred. The present case highlights the feasibility and effectiveness of teclistamab in patients with end‑stage renal disease.
View Figures

Figure 1

A schematic overview of the succession
of treatments and fluctuation of serum dFLC levels during the
disease course. FLC, free light chains; MR, minor response; PR,
partial response; VGPR, very good partial response; sCR, stringent
complete remission; MRD, minimal residual disease; PD, progressive
disease; Ven, venetoclax; Dara, daratumumab; V, bortezomib; R,
lenalidomide; d, dexamethasone; C, cyclophosphamide; HDM, high dose
melphalan; ASCT, autologous stem cell transplant; Sel, selinexor;
K, carfilzomib.
View References

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Copy and paste a formatted citation
Spandidos Publications style
Ntanasis‑Stathopoulos I, Katsadouros I, Malandrakis P, Psimenou E, Dimopoulos M and Gavriatopoulou M: Dialysis independence for a young patient with refractory multiple myeloma treated with teclistamab: A case report. Oncol Lett 30: 474, 2025.
APA
Ntanasis‑Stathopoulos, I., Katsadouros, I., Malandrakis, P., Psimenou, E., Dimopoulos, M., & Gavriatopoulou, M. (2025). Dialysis independence for a young patient with refractory multiple myeloma treated with teclistamab: A case report. Oncology Letters, 30, 474. https://doi.org/10.3892/ol.2025.15220
MLA
Ntanasis‑Stathopoulos, I., Katsadouros, I., Malandrakis, P., Psimenou, E., Dimopoulos, M., Gavriatopoulou, M."Dialysis independence for a young patient with refractory multiple myeloma treated with teclistamab: A case report". Oncology Letters 30.4 (2025): 474.
Chicago
Ntanasis‑Stathopoulos, I., Katsadouros, I., Malandrakis, P., Psimenou, E., Dimopoulos, M., Gavriatopoulou, M."Dialysis independence for a young patient with refractory multiple myeloma treated with teclistamab: A case report". Oncology Letters 30, no. 4 (2025): 474. https://doi.org/10.3892/ol.2025.15220
Copy and paste a formatted citation
x
Spandidos Publications style
Ntanasis‑Stathopoulos I, Katsadouros I, Malandrakis P, Psimenou E, Dimopoulos M and Gavriatopoulou M: Dialysis independence for a young patient with refractory multiple myeloma treated with teclistamab: A case report. Oncol Lett 30: 474, 2025.
APA
Ntanasis‑Stathopoulos, I., Katsadouros, I., Malandrakis, P., Psimenou, E., Dimopoulos, M., & Gavriatopoulou, M. (2025). Dialysis independence for a young patient with refractory multiple myeloma treated with teclistamab: A case report. Oncology Letters, 30, 474. https://doi.org/10.3892/ol.2025.15220
MLA
Ntanasis‑Stathopoulos, I., Katsadouros, I., Malandrakis, P., Psimenou, E., Dimopoulos, M., Gavriatopoulou, M."Dialysis independence for a young patient with refractory multiple myeloma treated with teclistamab: A case report". Oncology Letters 30.4 (2025): 474.
Chicago
Ntanasis‑Stathopoulos, I., Katsadouros, I., Malandrakis, P., Psimenou, E., Dimopoulos, M., Gavriatopoulou, M."Dialysis independence for a young patient with refractory multiple myeloma treated with teclistamab: A case report". Oncology Letters 30, no. 4 (2025): 474. https://doi.org/10.3892/ol.2025.15220
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