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Integrative intratumoral and peritumoral radiomic model for predicting endometrial cancer grade

  • Authors:
    • Jie Ren
    • Tingting Cui
    • Xingpeng Li
    • Yanxiao Zhang
    • Zhiwei Shen
    • Yunlong Yue
  • View Affiliations / Copyright

    Affiliations: Department of Medical Imaging, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China, Philips Healthcare, Beijing 100600, P.R. China
    Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 482
    |
    Published online on: August 13, 2025
       https://doi.org/10.3892/ol.2025.15228
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Abstract

Non‑invasive preoperative assessment of tumor grade serves an important role for clinical management. The aim of the present study was to assess the value of an intratumoral and an peritumoral radiomic model in predicting the histological grade of endometrial cancer (EC). A total of 107 patients with EC were retrospectively enrolled and randomly divided into the training (n=74) and test cohorts (n=33). Radiomic features were extracted from intratumoral and peritumoral regions (RT) with different expansion regions (1, 2 and 3 mm) using T2‑weighted and the 5 to 8th phase of contrast‑enhancement images. The diagnostic performance of several peritumoral features was compared with the maximum area under the curve (AUC) value. These intratumoral features were combined with peritumoral features to construct a fusion model. The AUCs for the RT model were 0.879 [95% confidence interval (CI), 0.797‑0.962] for the training cohort and 0.869 (95% CI, 0.590‑1.000) for the test cohort. The peritumoral model with a 3‑mm expansion (RT‑3) demonstrated superior performance, yielding AUCs of 0.934 (95% CI, 0.875‑0.994) in the training cohort and 0.875 (95% CI, 0.744‑1.000) in the test cohort. The fusion model incorporating features from both RT and RT‑3 achieved the highest diagnostic performance for distinguishing low‑grade from high‑grade EC, with AUCs of 0.955 (95% CI, 0.910‑1.000) and 0.885 (95% CI, 0.771‑1.000) in the training and test cohorts, respectively. In conclusion, the results of the present study indicate that radiomic features from magnetic resonance images incorporating both intratumoral and peritumoral regions can effectively predict low‑and high‑grade EC.
View Figures

Figure 1

Patient recruitment and selection
workflow. VOI, volume of interest.

Figure 2

Steps in the workflow of the present
study: Image acquisition, ROI delineation, feature extraction,
feature selection, feature fusion and Rad signature building. ROI,
region of interest; CE-T1WI, contrast enhancement T1-weighted
imaging; AUC, area under curve; RT, peritumoral region.

Figure 3

Radiomics feature selection using the
LASSO regression method. LASSO coefficient profiles of the
radiomics features in (A) RT, (B) RT-1, (C) RT-2 and (D) RT-3. A
vertical line was drawn at the value selected using 10-fold
cross-validation where optimal resulted non-zero coefficients
(λ=0.0450, λ=0.0687, λ=0.0791 and λ=0.0518). The tuning parameter λ
was selected using 10-fold cross-validation using the minimum
criteria in the LASSO model in (E) RT, (F) RT-1, (G) RT-2 and (H)
RT-3. The dashed line is the optimal λ. LASSO, least absolute
shrinkage and selection operator; RT, peritumoral region; MSE, mean
squared error.

Figure 4

Receiver operating characteristic
curves for the RT, RT-1, RT-2, RT-3 and RT+RT-3 models on the (A)
training and (B) test cohorts. Calibration curves for the RT-3 and
RT+RT-3 models on the (C) training and (D) test cohorts. RT,
peritumoral region; AUC, area under the curve; CI, confidence
interval.
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Copy and paste a formatted citation
Spandidos Publications style
Ren J, Cui T, Li X, Zhang Y, Shen Z and Yue Y: Integrative intratumoral and peritumoral radiomic model for predicting endometrial cancer grade. Oncol Lett 30: 482, 2025.
APA
Ren, J., Cui, T., Li, X., Zhang, Y., Shen, Z., & Yue, Y. (2025). Integrative intratumoral and peritumoral radiomic model for predicting endometrial cancer grade. Oncology Letters, 30, 482. https://doi.org/10.3892/ol.2025.15228
MLA
Ren, J., Cui, T., Li, X., Zhang, Y., Shen, Z., Yue, Y."Integrative intratumoral and peritumoral radiomic model for predicting endometrial cancer grade". Oncology Letters 30.4 (2025): 482.
Chicago
Ren, J., Cui, T., Li, X., Zhang, Y., Shen, Z., Yue, Y."Integrative intratumoral and peritumoral radiomic model for predicting endometrial cancer grade". Oncology Letters 30, no. 4 (2025): 482. https://doi.org/10.3892/ol.2025.15228
Copy and paste a formatted citation
x
Spandidos Publications style
Ren J, Cui T, Li X, Zhang Y, Shen Z and Yue Y: Integrative intratumoral and peritumoral radiomic model for predicting endometrial cancer grade. Oncol Lett 30: 482, 2025.
APA
Ren, J., Cui, T., Li, X., Zhang, Y., Shen, Z., & Yue, Y. (2025). Integrative intratumoral and peritumoral radiomic model for predicting endometrial cancer grade. Oncology Letters, 30, 482. https://doi.org/10.3892/ol.2025.15228
MLA
Ren, J., Cui, T., Li, X., Zhang, Y., Shen, Z., Yue, Y."Integrative intratumoral and peritumoral radiomic model for predicting endometrial cancer grade". Oncology Letters 30.4 (2025): 482.
Chicago
Ren, J., Cui, T., Li, X., Zhang, Y., Shen, Z., Yue, Y."Integrative intratumoral and peritumoral radiomic model for predicting endometrial cancer grade". Oncology Letters 30, no. 4 (2025): 482. https://doi.org/10.3892/ol.2025.15228
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