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Review Open Access

Clinical value of emerging peripheral blood protein biomarkers in prostate cancer (Review)

  • Authors:
    • Mengli Chen
    • Feng Wang
    • Weixi Wang
    • Kangle Feng
    • Kaihua Xiang
    • Xubo Gong
    • Zhihua Tao
    • Weiwei Liu
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang 310009, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 11
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    Published online on: October 29, 2025
       https://doi.org/10.3892/ol.2025.15364
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Abstract

Prostate cancer (PCa) remains among the most common genitourinary tumors in elderly men, as PCa diagnosis and treatment remain major challenges. Liquid biopsy is a minimally invasive method that causes minor harm to patients with cancer. Peripheral blood protein biomarkers provide real‑time PCa information and are easily accessible. The present review summarizes recent progress in identifying candidate peripheral blood protein biomarkers of PCa, including pentraxin‑3, soluble E‑cadherin, serum T‑cell immunoglobulin, serum B‑ and T‑lymphocyte attenuator, myeloid differentiation factor‑2, pleiotrophin, spondin 2, filamin A, soluble urokinase plasminogen activator receptor, laminin subunit β‑1, Golgi membrane protein 1, vitamin D‑binding protein, tumor necrosis factor receptor superfamily member 9, activated leukocyte cell adhesion molecule and trophoblastic cell‑surface antigen. Notably, the present review summarizes and discusses the clinical value of these proteins in PCa prediction, diagnosis, prognosis and drug resistance monitoring. These emerging peripheral blood protein biomarkers are promising for improving PCa stratification and management.
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Copy and paste a formatted citation
Spandidos Publications style
Chen M, Wang F, Wang W, Feng K, Xiang K, Gong X, Tao Z and Liu W: Clinical value of emerging peripheral blood protein biomarkers in prostate cancer (Review). Oncol Lett 31: 11, 2026.
APA
Chen, M., Wang, F., Wang, W., Feng, K., Xiang, K., Gong, X. ... Liu, W. (2026). Clinical value of emerging peripheral blood protein biomarkers in prostate cancer (Review). Oncology Letters, 31, 11. https://doi.org/10.3892/ol.2025.15364
MLA
Chen, M., Wang, F., Wang, W., Feng, K., Xiang, K., Gong, X., Tao, Z., Liu, W."Clinical value of emerging peripheral blood protein biomarkers in prostate cancer (Review)". Oncology Letters 31.1 (2026): 11.
Chicago
Chen, M., Wang, F., Wang, W., Feng, K., Xiang, K., Gong, X., Tao, Z., Liu, W."Clinical value of emerging peripheral blood protein biomarkers in prostate cancer (Review)". Oncology Letters 31, no. 1 (2026): 11. https://doi.org/10.3892/ol.2025.15364
Copy and paste a formatted citation
x
Spandidos Publications style
Chen M, Wang F, Wang W, Feng K, Xiang K, Gong X, Tao Z and Liu W: Clinical value of emerging peripheral blood protein biomarkers in prostate cancer (Review). Oncol Lett 31: 11, 2026.
APA
Chen, M., Wang, F., Wang, W., Feng, K., Xiang, K., Gong, X. ... Liu, W. (2026). Clinical value of emerging peripheral blood protein biomarkers in prostate cancer (Review). Oncology Letters, 31, 11. https://doi.org/10.3892/ol.2025.15364
MLA
Chen, M., Wang, F., Wang, W., Feng, K., Xiang, K., Gong, X., Tao, Z., Liu, W."Clinical value of emerging peripheral blood protein biomarkers in prostate cancer (Review)". Oncology Letters 31.1 (2026): 11.
Chicago
Chen, M., Wang, F., Wang, W., Feng, K., Xiang, K., Gong, X., Tao, Z., Liu, W."Clinical value of emerging peripheral blood protein biomarkers in prostate cancer (Review)". Oncology Letters 31, no. 1 (2026): 11. https://doi.org/10.3892/ol.2025.15364
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