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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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January-2026 Volume 31 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

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An International Open Access Journal Devoted to General Medicine.

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Review Open Access

Advancements in research regarding the influence of the tumor microenvironment on the proliferation and metastasis of osteosarcoma (Review)

  • Authors:
    • Tao Shi
    • Jianping Kang
    • Qiyang Wang
    • Jiamei Song
    • Xiaofeng He

  • View Affiliations

    Affiliations: Department of Pain, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, P.R. China, Department of Orthopedic Surgery, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, P.R. China, Department of Orthopedic Surgery, Yunnan Province Spinal Cord Disease Clinical Medical Center, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650000, P.R. China, Department of Reproductive Medicine, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, P.R. China
  • Published online on: November 4, 2025     https://doi.org/10.3892/ol.2025.15373
  • Article Number: 20

  • Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteosarcoma (OS), a common primary malignant bone tumor in children and young adults, is significantly influenced by a complex tumor microenvironment (TME) that includes bone cells, stromal cells, vascular cells, immune cells and a mineralized extracellular matrix (ECM). In recent years, the role of the TME in OS progression has garnered increasing attention. The TME not only provides the physical and biochemical support necessary for tumor cell growth, invasion and metastasis, but also promotes the maintenance of the malignant tumor phenotype through mechanisms such as immune suppression, angiogenesis and metabolic reprogramming. The present review discusses how various cellular and non‑cellular components within the OS TME interact to drive tumor progression. Consequently, targeting the TME has emerged as a promising therapeutic strategy to overcome the limitations of conventional treatments, particularly for metastatic or recurrent OS. The present review underscores the potential of TME‑targeted therapies and highlights the need for further research into the heterogeneity of the TME to improve clinical outcomes.

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Copy and paste a formatted citation
Spandidos Publications style
Shi T, Kang J, Wang Q, Song J and He X: Advancements in research regarding the influence of the tumor microenvironment on the proliferation and metastasis of osteosarcoma (Review). Oncol Lett 31: 20, 2026.
APA
Shi, T., Kang, J., Wang, Q., Song, J., & He, X. (2026). Advancements in research regarding the influence of the tumor microenvironment on the proliferation and metastasis of osteosarcoma (Review). Oncology Letters, 31, 20. https://doi.org/10.3892/ol.2025.15373
MLA
Shi, T., Kang, J., Wang, Q., Song, J., He, X."Advancements in research regarding the influence of the tumor microenvironment on the proliferation and metastasis of osteosarcoma (Review)". Oncology Letters 31.1 (2026): 20.
Chicago
Shi, T., Kang, J., Wang, Q., Song, J., He, X."Advancements in research regarding the influence of the tumor microenvironment on the proliferation and metastasis of osteosarcoma (Review)". Oncology Letters 31, no. 1 (2026): 20. https://doi.org/10.3892/ol.2025.15373
Copy and paste a formatted citation
x
Spandidos Publications style
Shi T, Kang J, Wang Q, Song J and He X: Advancements in research regarding the influence of the tumor microenvironment on the proliferation and metastasis of osteosarcoma (Review). Oncol Lett 31: 20, 2026.
APA
Shi, T., Kang, J., Wang, Q., Song, J., & He, X. (2026). Advancements in research regarding the influence of the tumor microenvironment on the proliferation and metastasis of osteosarcoma (Review). Oncology Letters, 31, 20. https://doi.org/10.3892/ol.2025.15373
MLA
Shi, T., Kang, J., Wang, Q., Song, J., He, X."Advancements in research regarding the influence of the tumor microenvironment on the proliferation and metastasis of osteosarcoma (Review)". Oncology Letters 31.1 (2026): 20.
Chicago
Shi, T., Kang, J., Wang, Q., Song, J., He, X."Advancements in research regarding the influence of the tumor microenvironment on the proliferation and metastasis of osteosarcoma (Review)". Oncology Letters 31, no. 1 (2026): 20. https://doi.org/10.3892/ol.2025.15373
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