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Review Open Access

Astragalin: A promising herbal compound with broad anticancer potential (Review)

  • Authors:
    • Yu-Qian Fu
    • Chan Li
    • Dan-Ni Ding
    • Fang-Yuan Liu
    • Yu-Fei Zhu
    • Feng-Juan Han
  • View Affiliations / Copyright

    Affiliations: First Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China, Department 3 of Gynecology, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China
    Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 39
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    Published online on: November 20, 2025
       https://doi.org/10.3892/ol.2025.15392
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Abstract

In recent years, compounds that are active ingredients in herbal medicines have been investigated for their ability to treat cancer. Astragalin may exert anticancer effects through anti‑inflammatory, anti‑glycosylation, anti‑adipogenesis, antioxidant and neuroprotective effects; however, there has been no literature review on the specific mechanism of action of astragalin in cancer, to the best of our knowledge. Therefore, the present review searched and reviewed the literature related to astragalin and cancer, and summarized the possible mechanisms. The results revealed that astragalin affects the proliferation, invasion and angiogenesis of cancer cells through participating in signaling pathways, regulating apoptotic proteins, inactivating oncogenes and suppressor genes, as well as the tumor microenvironment, angiogenesis and other mechanisms of action. In turn, this exerts antitumor effects and reverses chemotherapy resistance. Astragalin is expected to serve a greater role in the prevention and treatment of malignant tumors in the future due to its availability, safety and economy, thus providing new hope for global cancer treatment.
View Figures

Figure 1

Molecular structural formula of
astragalin. Astragalin is also known as kaempferol
3-O-β-D-glucoside, where kaempferol binds to a glucose unit at the
3-position hydroxyl group and exhibits typical flavonoid glycoside
bioactivity. The figure was drawn using the KingDraw platform
(version v3.6.5; http://www.kingdraw.com/).

Figure 2

Astragalin exerts anticancer effects
through various mechanisms. The numbers shown for each type of
cancer on the right correspond to the mechanism numbers shown on
the left. The figure was drawn using Figdraw (version 2.0;
http://www.figdraw.com/static/index.html#/).

Figure 3

Future research directions of
astragalin for cancer treatment. The figure was drawn using Figdraw
(version 2.0; http://www.figdraw.com/static/index.html#/).
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Copy and paste a formatted citation
Spandidos Publications style
Fu Y, Li C, Ding D, Liu F, Zhu Y and Han F: Astragalin: A promising herbal compound with broad anticancer potential (Review). Oncol Lett 31: 39, 2026.
APA
Fu, Y., Li, C., Ding, D., Liu, F., Zhu, Y., & Han, F. (2026). Astragalin: A promising herbal compound with broad anticancer potential (Review). Oncology Letters, 31, 39. https://doi.org/10.3892/ol.2025.15392
MLA
Fu, Y., Li, C., Ding, D., Liu, F., Zhu, Y., Han, F."Astragalin: A promising herbal compound with broad anticancer potential (Review)". Oncology Letters 31.1 (2026): 39.
Chicago
Fu, Y., Li, C., Ding, D., Liu, F., Zhu, Y., Han, F."Astragalin: A promising herbal compound with broad anticancer potential (Review)". Oncology Letters 31, no. 1 (2026): 39. https://doi.org/10.3892/ol.2025.15392
Copy and paste a formatted citation
x
Spandidos Publications style
Fu Y, Li C, Ding D, Liu F, Zhu Y and Han F: Astragalin: A promising herbal compound with broad anticancer potential (Review). Oncol Lett 31: 39, 2026.
APA
Fu, Y., Li, C., Ding, D., Liu, F., Zhu, Y., & Han, F. (2026). Astragalin: A promising herbal compound with broad anticancer potential (Review). Oncology Letters, 31, 39. https://doi.org/10.3892/ol.2025.15392
MLA
Fu, Y., Li, C., Ding, D., Liu, F., Zhu, Y., Han, F."Astragalin: A promising herbal compound with broad anticancer potential (Review)". Oncology Letters 31.1 (2026): 39.
Chicago
Fu, Y., Li, C., Ding, D., Liu, F., Zhu, Y., Han, F."Astragalin: A promising herbal compound with broad anticancer potential (Review)". Oncology Letters 31, no. 1 (2026): 39. https://doi.org/10.3892/ol.2025.15392
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