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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April-2026 Volume 31 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

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An International Open Access Journal Devoted to General Medicine.

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Case Report

Successful treatment with tepotinib followed by pembrolizumab in pulmonary pleomorphic carcinoma harbouring a MET exon 14 skipping mutation: A case report

  • Authors:
    • Susumu Tanaka
    • Yu Saida
    • Yumi Ando
    • Jun Arinami
    • Ryo Yamazaki
    • Tomoya Wakabayashi
    • Hiroki Watanabe
    • Kohei Kushiro
    • Ryo Suzuki
    • Naohiro Yanagimura
    • Masashi Arita
    • Miyuki Sato
    • Tomohiro Tanaka
    • Koichiro Nozaki
    • Satoshi Watanabe
    • Shuhei Kondo
    • Hajime Umezu
    • Toshiaki Kikuchi

  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951‑8510, Japan, Division of Pathology, Niigata University Medical and Dental Hospital, Niigata 951‑8510, Japan
  • Article Number: 138
    |
    Published online on: February 12, 2026
       https://doi.org/10.3892/ol.2026.15491
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Abstract

Pulmonary pleomorphic carcinoma (PPC) is a subtype of sarcomatoid carcinoma that accounts for 0.1‑0.3% of all lung cancer cases. PPC is typically resistant to chemotherapy and radiotherapy, and no standard treatment protocols are currently established. Moreover, to the best of our knowledge, the effectiveness of the MET inhibitor tepotinib in the treatment of PPC has not yet been reported. Herein, the present study describes the case of a 75‑year‑old woman with PPC harbouring a MET exon 14 skipping mutation who was successfully treated with tepotinib as first‑line systemic therapy, followed by pembrolizumab as subsequent immune checkpoint inhibitor therapy. Although the tumour relapsed 4 months postoperatively, treatment with tepotinib resulted in a favourable response and subsequent pembrolizumab therapy achieved a durable response. This case suggests that patients with sarcomatoid carcinoma, which is generally associated with a poor prognosis, may experience improved outcomes with the use of molecular targeted therapies and immune checkpoint inhibitors.

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Copy and paste a formatted citation
Spandidos Publications style
Tanaka S, Saida Y, Ando Y, Arinami J, Yamazaki R, Wakabayashi T, Watanabe H, Kushiro K, Suzuki R, Yanagimura N, Yanagimura N, et al: <p>Successful treatment with tepotinib followed by pembrolizumab in pulmonary pleomorphic carcinoma harbouring a <em>MET</em> exon 14 skipping mutation: A case report</p>. Oncol Lett 31: 138, 2026.
APA
Tanaka, S., Saida, Y., Ando, Y., Arinami, J., Yamazaki, R., Wakabayashi, T. ... Kikuchi, T. (2026). <p>Successful treatment with tepotinib followed by pembrolizumab in pulmonary pleomorphic carcinoma harbouring a <em>MET</em> exon 14 skipping mutation: A case report</p>. Oncology Letters, 31, 138. https://doi.org/10.3892/ol.2026.15491
MLA
Tanaka, S., Saida, Y., Ando, Y., Arinami, J., Yamazaki, R., Wakabayashi, T., Watanabe, H., Kushiro, K., Suzuki, R., Yanagimura, N., Arita, M., Sato, M., Tanaka, T., Nozaki, K., Watanabe, S., Kondo, S., Umezu, H., Kikuchi, T."<p>Successful treatment with tepotinib followed by pembrolizumab in pulmonary pleomorphic carcinoma harbouring a <em>MET</em> exon 14 skipping mutation: A case report</p>". Oncology Letters 31.4 (2026): 138.
Chicago
Tanaka, S., Saida, Y., Ando, Y., Arinami, J., Yamazaki, R., Wakabayashi, T., Watanabe, H., Kushiro, K., Suzuki, R., Yanagimura, N., Arita, M., Sato, M., Tanaka, T., Nozaki, K., Watanabe, S., Kondo, S., Umezu, H., Kikuchi, T."<p>Successful treatment with tepotinib followed by pembrolizumab in pulmonary pleomorphic carcinoma harbouring a <em>MET</em> exon 14 skipping mutation: A case report</p>". Oncology Letters 31, no. 4 (2026): 138. https://doi.org/10.3892/ol.2026.15491
Copy and paste a formatted citation
x
Spandidos Publications style
Tanaka S, Saida Y, Ando Y, Arinami J, Yamazaki R, Wakabayashi T, Watanabe H, Kushiro K, Suzuki R, Yanagimura N, Yanagimura N, et al: <p>Successful treatment with tepotinib followed by pembrolizumab in pulmonary pleomorphic carcinoma harbouring a <em>MET</em> exon 14 skipping mutation: A case report</p>. Oncol Lett 31: 138, 2026.
APA
Tanaka, S., Saida, Y., Ando, Y., Arinami, J., Yamazaki, R., Wakabayashi, T. ... Kikuchi, T. (2026). <p>Successful treatment with tepotinib followed by pembrolizumab in pulmonary pleomorphic carcinoma harbouring a <em>MET</em> exon 14 skipping mutation: A case report</p>. Oncology Letters, 31, 138. https://doi.org/10.3892/ol.2026.15491
MLA
Tanaka, S., Saida, Y., Ando, Y., Arinami, J., Yamazaki, R., Wakabayashi, T., Watanabe, H., Kushiro, K., Suzuki, R., Yanagimura, N., Arita, M., Sato, M., Tanaka, T., Nozaki, K., Watanabe, S., Kondo, S., Umezu, H., Kikuchi, T."<p>Successful treatment with tepotinib followed by pembrolizumab in pulmonary pleomorphic carcinoma harbouring a <em>MET</em> exon 14 skipping mutation: A case report</p>". Oncology Letters 31.4 (2026): 138.
Chicago
Tanaka, S., Saida, Y., Ando, Y., Arinami, J., Yamazaki, R., Wakabayashi, T., Watanabe, H., Kushiro, K., Suzuki, R., Yanagimura, N., Arita, M., Sato, M., Tanaka, T., Nozaki, K., Watanabe, S., Kondo, S., Umezu, H., Kikuchi, T."<p>Successful treatment with tepotinib followed by pembrolizumab in pulmonary pleomorphic carcinoma harbouring a <em>MET</em> exon 14 skipping mutation: A case report</p>". Oncology Letters 31, no. 4 (2026): 138. https://doi.org/10.3892/ol.2026.15491
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