Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2026 Volume 31 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2026 Volume 31 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Successful treatment with tepotinib followed by pembrolizumab in pulmonary pleomorphic carcinoma harbouring a MET exon 14 skipping mutation: A case report

  • Authors:
    • Susumu Tanaka
    • Yu Saida
    • Yumi Ando
    • Jun Arinami
    • Ryo Yamazaki
    • Tomoya Wakabayashi
    • Hiroki Watanabe
    • Kohei Kushiro
    • Ryo Suzuki
    • Naohiro Yanagimura
    • Masashi Arita
    • Miyuki Sato
    • Tomohiro Tanaka
    • Koichiro Nozaki
    • Satoshi Watanabe
    • Shuhei Kondo
    • Hajime Umezu
    • Toshiaki Kikuchi
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951‑8510, Japan, Division of Pathology, Niigata University Medical and Dental Hospital, Niigata 951‑8510, Japan
  • Article Number: 138
    |
    Published online on: February 12, 2026
       https://doi.org/10.3892/ol.2026.15491
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:


Abstract

Pulmonary pleomorphic carcinoma (PPC) is a subtype of sarcomatoid carcinoma that accounts for 0.1‑0.3% of all lung cancer cases. PPC is typically resistant to chemotherapy and radiotherapy, and no standard treatment protocols are currently established. Moreover, to the best of our knowledge, the effectiveness of the MET inhibitor tepotinib in the treatment of PPC has not yet been reported. Herein, the present study describes the case of a 75‑year‑old woman with PPC harbouring a MET exon 14 skipping mutation who was successfully treated with tepotinib as first‑line systemic therapy, followed by pembrolizumab as subsequent immune checkpoint inhibitor therapy. Although the tumour relapsed 4 months postoperatively, treatment with tepotinib resulted in a favourable response and subsequent pembrolizumab therapy achieved a durable response. This case suggests that patients with sarcomatoid carcinoma, which is generally associated with a poor prognosis, may experience improved outcomes with the use of molecular targeted therapies and immune checkpoint inhibitors.
View Figures

Figure 1

Computed tomography images over the
clinical course. (A) Primary tumour of the left upper lobe shown on
lung window. (B) Pleural dissemination of the left diaphragm at the
time of postoperative recurrence, 26 mm in diameter. (C) Pleural
dissemination of the left diaphragm decreased to 5 mm in diameter 2
months after tepotinib initiation. (D) Pleural dissemination of the
left diaphragm had grown to 93 mm in diameter prior to the
initiation of pembrolizumab. (E) Pleural dissemination of the left
diaphragm decreased to 25 mm in diameter 5 months after initiation
of pembrolizumab. (F) Primary tumour of the left upper lobe shown
on mediastinal window. (G) Left adrenal metastasis at the time of
postoperative recurrence, 21 mm in diameter. (H) Left adrenal
metastasis decreased to 12 mm in diameter 2 months after initiation
of tepotinib. (I) Size of left adrenal metastasis remained largely
unchanged, measuring 13 mm before initiation of pembrolizumab. (J)
Size of left adrenal metastasis remained unchanged, measuring 13 mm
5 months after initiation of pembrolizumab. Nab-PTX, nanoparticle
albumin-bound paclitaxel; CEA, carcinoembryonic antigen; SLX,
Sialyl Lewis X antigen; CYFRA, cytokeratin 19 fragment.

Figure 2

Histological findings of the surgical
specimens. H&E staining of (A) spindle cells component, (B)
giant cells component and (C) adenocarcinoma component.
Immunohistochemical staining for TTF-1 was (D) weakly positive in
the spindle cells component, (E) weakly positive in the giant cells
component and (F) positive in the adenocarcinoma component.
Immunohistochemical staining for Vimentin was (G) positive in
spindle cells component, (H) positive in giant cells component and
(I) negative in adenocarcinoma component. Black bar, 50 µm.
H&E, haematoxylin and eosin; TTF-1, thyroid transcription
factor-1
View References

1 

Steuer CE, Behera M, Liu Y, Fu C, Gillespie TW, Saba NF, Shin DM, Pillai RN, Pakkala S, Owonikoko TK, et al: Pulmonary sarcomatoid carcinoma: An analysis of the national cancer data base. Clin Lung Cancer. 18:286–292. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Chang YL, Lee YC, Shih JY and Wu CT: Pulmonary pleomorphic (spindle) cell carcinoma: Peculiar clinicopathologic manifestations different from ordinary non-small cell carcinoma. Lung Cancer. 34:91–97. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Nicholson AG, Tsao MS, Beasley MB, Borczuk AC, Brambilla E, Cooper WA, Dacic S, Jain D, Kerr KM, Lantuejoul S, et al: The 2021 WHO classification of lung tumors: Impact of advances since 2015. J Thorac Oncol. 17:362–387. 2022. View Article : Google Scholar : PubMed/NCBI

4 

Tamura Y, Fujiwara Y, Yamamoto N, Nokihara H, Horinouchi H, Kanda S, Goto Y, Kubo E, Kitahara S, Tsuruoka K, et al: Retrospective analysis of the efficacy of chemotherapy and molecular targeted therapy for advanced pulmonary pleomorphic carcinoma. BMC Res Notes. 8:8002015. View Article : Google Scholar : PubMed/NCBI

5 

Rossi G, Cavazza A, Sturm N, Migaldi M, Facciolongo N, Longo L, Maiorana A and Brambilla E: Pulmonary carcinomas with pleomorphic, sarcomatoid, or sarcomatous elements: A clinicopathologic and immunohistochemical study of 75 cases. Am J Surg Pathol. 27:311–324. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Yuki T, Sakuma T, Ohbayashi C, Yoshimura M, Tsubota N, Okita Y and Okada M: Pleomorphic carcinoma of the lung: A surgical outcome. J Thorac Cardiovasc Surg. 134:399–404. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Awad MM, Oxnard GR, Jackman DM, Savukoski DO, Hall D, Shivdasani P, Heng JC, Dahlberg SE, Jänne PA, Verma S, et al: MET Exon 14 mutations in non-small-cell lung cancer are associated with advanced age and stage-dependent MET genomic amplification and c-Met overexpression. J Clin Oncol. 34:721–730. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Fishback NF, Travis WD, Moran CA, Guinee DG Jr, McCarthy WF and Koss MN: Pleomorphic (spindle/giant cell) carcinoma of the lung. A clinicopathologic correlation of 78 cases. Cancer. 73:2936–2945. 1994. View Article : Google Scholar : PubMed/NCBI

9 

Frampton GM, Ali SM, Rosenzweig M, Chmielecki J, Lu X, Bauer TM, Akimov M, Bufill JA, Lee C, Jentz D, et al: Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors. Cancer Discov. 5:850–859. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Tong JH, Yeung SF, Chan AWH, Chung LY, Chau SL, Lung RWM, Tong CY, Chow C, Tin EKY, Yu YH, et al: MET amplification and exon 14 splice site mutation define unique molecular subgroups of non-small cell lung carcinoma with poor prognosis. Clin Cancer Res. 22:3048–3056. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Riely GJ, Wood DE, Aisner DL, Loo BW Jr, Axtell AL, Bauman JR, Bharat A, Chang JY, Desai A, Dilling TJ, et al: NCCN guidelines® insights: Non-small cell lung cancer, version 7.2025. J Natl Compr Canc Netw. 23:354–362. 2025. View Article : Google Scholar : PubMed/NCBI

12 

Reuss JE, Kuruvilla S, Ismaila N, Azar IH, Feldman J, Furuya N, Wheatley-Price P, Roof L, Velazquez AI, Wang Y and Leighl NB: Therapy for stage IV non-small cell lung cancer with driver alterations: ASCO living guideline, version 2025.1. J Clin Oncol. 43:e31–e44. 2025. View Article : Google Scholar : PubMed/NCBI

13 

Hendriks LEL, Cortiula F, Martins-Branco D, Mariamidze E, Popat S and Reck M; ESMO Guidelines Committee. Electronic address, : simpleclinicalguidelines@esmo.org: Updated treatment recommendations for systemic treatment: From the ESMO oncogene-addicted metastatic NSCLC living guideline. Ann Oncol. 36:1227–1231. 2025. View Article : Google Scholar : PubMed/NCBI

14 

Paik PK, Felip E, Veillon R, Sakai H, Cortot AB, Garassino MC, Mazieres J, Viteri S, Senellart H, Van Meerbeeck J, et al: Tepotinib in non-small-cell lung cancer with MET exon 14 skipping mutations. N Engl J Med. 383:931–943. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Wolf J, Seto T, Han JY, Reguart N, Garon EB, Groen HJM, Tan DSW, Hida T, de Jonge M, Orlov SV, et al: Capmatinib in MET exon 14-mutated or MET-amplified non-small-cell lung cancer. N Engl J Med. 383:944–957. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Lu S, Fang J, Li X, Cao L, Zhou J, Guo Q, Liang Z, Cheng Y, Jiang L, Yang N, et al: Once-daily savolitinib in Chinese patients with pulmonary sarcomatoid carcinomas and other non-small-cell lung cancers harbouring MET exon 14 skipping alterations: A multicentre, single-arm, open-label, phase 2 study. Lancet Respir Med. 9:1154–1164. 2021. View Article : Google Scholar : PubMed/NCBI

17 

Nagano M, Kohsaka S, Hayashi T, Ueno T, Kojima S, Shinozaki-Ushiku A, Morita S, Tsuda M, Tanaka S, Shinohara T, et al: Comprehensive molecular profiling of pulmonary pleomorphic carcinoma. NPJ Precis Oncol. 5:572021. View Article : Google Scholar : PubMed/NCBI

18 

Fujino T, Kobayashi Y, Suda K, Koga T, Nishino M, Ohara S, Chiba M, Shimoji M, Tomizawa K, Takemoto T and Mitsudomi T: Sensitivity and resistance of MET exon 14 mutations in lung cancer to eight MET tyrosine kinase inhibitors in vitro. J Thorac Oncol. 14:1753–1765. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Yao Y, Yang H, Zhu B, Wang S, Pang J, Wu X, Xu Y, Zhang J, Zhang J, Ou Q, et al: Mutations in the MET tyrosine kinase domain and resistance to tyrosine kinase inhibitors in non-small-cell lung cancer. Respir Res. 24:282023. View Article : Google Scholar : PubMed/NCBI

20 

Vieira T, Antoine M, Hamard C, Fallet V, Duruisseaux M, Rabbe N, Rodenas A, Cadranel J and Wislez M: Sarcomatoid lung carcinomas show high levels of programmed death ligand-1 (PD-L1) and strong immune-cell infiltration by TCD3 cells and macrophages. Lung Cancer. 98:51–58. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Hazama D, Nakahama K, Kodama H, Miyazaki A, Azuma K, Kawashima Y, Sato Y, Ito K, Shiraishi Y, Miura K, et al: Effectiveness and safety of immune checkpoint inhibitors alone or in combination with chemotherapy in pulmonary sarcomatoid carcinoma. JTO Clin Res Rep. 5:1006132024.PubMed/NCBI

22 

Domblides C, Leroy K, Monnet I, Mazières J, Barlesi F, Gounant V, Baldacci S, Mennecier B, Toffart AC, Audigier-Valette C, et al: Efficacy of immune checkpoint inhibitors in lung sarcomatoid carcinoma. J Thorac Oncol. 15:860–866. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Kim M, Keam B, Ock CY, Kim SH, Kim YJ, Lim SM, Kim JS, Kim TM, Hong SH, Ahn MS, et al: Phase II study of durvalumab and tremelimumab in pulmonary sarcomatoid carcinoma: KCSG-LU16-07. Thorac Cancer. 11:3482–3489. 2020. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tanaka S, Saida Y, Ando Y, Arinami J, Yamazaki R, Wakabayashi T, Watanabe H, Kushiro K, Suzuki R, Yanagimura N, Yanagimura N, et al: Successful treatment with tepotinib followed by pembrolizumab in pulmonary pleomorphic carcinoma harbouring a <em>MET</em> exon 14 skipping mutation: A case report. Oncol Lett 31: 138, 2026.
APA
Tanaka, S., Saida, Y., Ando, Y., Arinami, J., Yamazaki, R., Wakabayashi, T. ... Kikuchi, T. (2026). Successful treatment with tepotinib followed by pembrolizumab in pulmonary pleomorphic carcinoma harbouring a <em>MET</em> exon 14 skipping mutation: A case report. Oncology Letters, 31, 138. https://doi.org/10.3892/ol.2026.15491
MLA
Tanaka, S., Saida, Y., Ando, Y., Arinami, J., Yamazaki, R., Wakabayashi, T., Watanabe, H., Kushiro, K., Suzuki, R., Yanagimura, N., Arita, M., Sato, M., Tanaka, T., Nozaki, K., Watanabe, S., Kondo, S., Umezu, H., Kikuchi, T."Successful treatment with tepotinib followed by pembrolizumab in pulmonary pleomorphic carcinoma harbouring a <em>MET</em> exon 14 skipping mutation: A case report". Oncology Letters 31.4 (2026): 138.
Chicago
Tanaka, S., Saida, Y., Ando, Y., Arinami, J., Yamazaki, R., Wakabayashi, T., Watanabe, H., Kushiro, K., Suzuki, R., Yanagimura, N., Arita, M., Sato, M., Tanaka, T., Nozaki, K., Watanabe, S., Kondo, S., Umezu, H., Kikuchi, T."Successful treatment with tepotinib followed by pembrolizumab in pulmonary pleomorphic carcinoma harbouring a <em>MET</em> exon 14 skipping mutation: A case report". Oncology Letters 31, no. 4 (2026): 138. https://doi.org/10.3892/ol.2026.15491
Copy and paste a formatted citation
x
Spandidos Publications style
Tanaka S, Saida Y, Ando Y, Arinami J, Yamazaki R, Wakabayashi T, Watanabe H, Kushiro K, Suzuki R, Yanagimura N, Yanagimura N, et al: Successful treatment with tepotinib followed by pembrolizumab in pulmonary pleomorphic carcinoma harbouring a <em>MET</em> exon 14 skipping mutation: A case report. Oncol Lett 31: 138, 2026.
APA
Tanaka, S., Saida, Y., Ando, Y., Arinami, J., Yamazaki, R., Wakabayashi, T. ... Kikuchi, T. (2026). Successful treatment with tepotinib followed by pembrolizumab in pulmonary pleomorphic carcinoma harbouring a <em>MET</em> exon 14 skipping mutation: A case report. Oncology Letters, 31, 138. https://doi.org/10.3892/ol.2026.15491
MLA
Tanaka, S., Saida, Y., Ando, Y., Arinami, J., Yamazaki, R., Wakabayashi, T., Watanabe, H., Kushiro, K., Suzuki, R., Yanagimura, N., Arita, M., Sato, M., Tanaka, T., Nozaki, K., Watanabe, S., Kondo, S., Umezu, H., Kikuchi, T."Successful treatment with tepotinib followed by pembrolizumab in pulmonary pleomorphic carcinoma harbouring a <em>MET</em> exon 14 skipping mutation: A case report". Oncology Letters 31.4 (2026): 138.
Chicago
Tanaka, S., Saida, Y., Ando, Y., Arinami, J., Yamazaki, R., Wakabayashi, T., Watanabe, H., Kushiro, K., Suzuki, R., Yanagimura, N., Arita, M., Sato, M., Tanaka, T., Nozaki, K., Watanabe, S., Kondo, S., Umezu, H., Kikuchi, T."Successful treatment with tepotinib followed by pembrolizumab in pulmonary pleomorphic carcinoma harbouring a <em>MET</em> exon 14 skipping mutation: A case report". Oncology Letters 31, no. 4 (2026): 138. https://doi.org/10.3892/ol.2026.15491
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team