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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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May-2026 Volume 31 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Case Report Open Access

Primary clear‑cell carcinoma of the liver with gastric antrum metastasis: Integrated management with targeted therapy, immunotherapy and salvage surgery: A case report

  • Authors:
    • Lianshan Zhan
    • Qianwei Li
    • Tian Tian
    • Long Wang

  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Guiqian International Hospital, Guiyang, Guizhou 551008, P.R. China, Department of Pathology, Guiqian International Hospital, Guiyang, Guizhou 551008, P.R. China
    Copyright: © Zhan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 163
    |
    Published online on: March 6, 2026
       https://doi.org/10.3892/ol.2026.15516
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Abstract

This study reports the case of a patient diagnosed with primary clear‑cell carcinoma of the liver (PCCCL). Intrahepatic metastasis transpired 1 month subsequent to the resection of the intrahepatic primary lesion. Subsequently, the patient commenced systemic treatment utilizing a combination of targeted drugs and programmed cell death‑1 inhibitor. Immune‑related adverse events (irAEs) manifested during the treatment process, encompassing persistent myelosuppression, hypothyroidism and a substantial elevation of adrenocorticotropic hormone levels. Rare gastric metastasis was identified during the follow‑up course. Through multidisciplinary collaboration, entailing the sequential or combined implementation of surgery, targeted therapy and immunotherapy, along with the effective management of irAEs, the primary tumor, intrahepatic metastases and gastric metastasis in the patient were all effectively controlled. At the final follow‑up, no signs of recurrence or metastasis were observed. This case underscores the highly invasive attributes of PCCCL, the diverse metastatic modalities (particularly the rare gastric metastasis), the actual efficacy of systemic treatment and the importance of complex irAE management, thus offering key guidelines for clinical practice.

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Copy and paste a formatted citation
Spandidos Publications style
Zhan L, Li Q, Tian T and Wang L: Primary clear‑cell carcinoma of the liver with gastric antrum metastasis: Integrated management with targeted therapy, immunotherapy and salvage surgery: A case report. Oncol Lett 31: 163, 2026.
APA
Zhan, L., Li, Q., Tian, T., & Wang, L. (2026). Primary clear‑cell carcinoma of the liver with gastric antrum metastasis: Integrated management with targeted therapy, immunotherapy and salvage surgery: A case report. Oncology Letters, 31, 163. https://doi.org/10.3892/ol.2026.15516
MLA
Zhan, L., Li, Q., Tian, T., Wang, L."Primary clear‑cell carcinoma of the liver with gastric antrum metastasis: Integrated management with targeted therapy, immunotherapy and salvage surgery: A case report". Oncology Letters 31.5 (2026): 163.
Chicago
Zhan, L., Li, Q., Tian, T., Wang, L."Primary clear‑cell carcinoma of the liver with gastric antrum metastasis: Integrated management with targeted therapy, immunotherapy and salvage surgery: A case report". Oncology Letters 31, no. 5 (2026): 163. https://doi.org/10.3892/ol.2026.15516
Copy and paste a formatted citation
x
Spandidos Publications style
Zhan L, Li Q, Tian T and Wang L: Primary clear‑cell carcinoma of the liver with gastric antrum metastasis: Integrated management with targeted therapy, immunotherapy and salvage surgery: A case report. Oncol Lett 31: 163, 2026.
APA
Zhan, L., Li, Q., Tian, T., & Wang, L. (2026). Primary clear‑cell carcinoma of the liver with gastric antrum metastasis: Integrated management with targeted therapy, immunotherapy and salvage surgery: A case report. Oncology Letters, 31, 163. https://doi.org/10.3892/ol.2026.15516
MLA
Zhan, L., Li, Q., Tian, T., Wang, L."Primary clear‑cell carcinoma of the liver with gastric antrum metastasis: Integrated management with targeted therapy, immunotherapy and salvage surgery: A case report". Oncology Letters 31.5 (2026): 163.
Chicago
Zhan, L., Li, Q., Tian, T., Wang, L."Primary clear‑cell carcinoma of the liver with gastric antrum metastasis: Integrated management with targeted therapy, immunotherapy and salvage surgery: A case report". Oncology Letters 31, no. 5 (2026): 163. https://doi.org/10.3892/ol.2026.15516
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