Comprehensive treatment for intracranial invasive sinonasal intestinal‑type adenocarcinoma with a focus on radiotherapy dosage and immunological combination therapy: A case report

Yang,Lianlian; Zhao,Qian; Yi,Fang; Guo,Wenyan; Zhang,Qiongwen; Zhou,Song; Li,Dong; Li,Zhihui

doi:10.3892/ol.2026.15571

June-2026 Volume 31 Issue 6

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June-2026 Volume 31 Issue 6

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Case Report Open Access

Comprehensive treatment for intracranial invasive sinonasal intestinal‑type adenocarcinoma with a focus on radiotherapy dosage and immunological combination therapy: A case report

Authors:
- Lianlian Yang
- Qian Zhao
- Fang Yi
- Wenyan Guo
- Qiongwen Zhang
- Song Zhou
- Dong Li
- Zhihui Li
View Affiliations / Copyright

Affiliations: Department of Oncology, The General Hospital of Western Theater Command, Chengdu, Sichuan 610083, P.R. China, Department of Oncology, Dazhu County People's Hospital, Dazhou, Sichuan 635199, P.R. China, Department of Ultrasound, The General Hospital of Western Theater Command, Chengdu, Sichuan 610083, P.R. China, Department of Head and Neck Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Neurosurgery, Dazhu County People's Hospital, Dazhou, Sichuan 635199, P.R. China

Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 216
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Published online on: April 2, 2026

https://doi.org/10.3892/ol.2026.15571
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Abstract

For sinonasal intestinal‑type adenocarcinoma (ITAC), no standardized treatment exists, particularly for cases with advanced‑stage disease with intracranial invasion or recurrence. The present study describes the case of a 60‑year‑old male patient with ITAC and intracranial invasion who underwent surgery followed by radiotherapy; however, this was terminated early after 25 of 30 sessions [equivalent dose in 2‑Gy fractions (EQD2), 54.72 Gy] due to the risk of damaging the optic nerve. The tumor recurred in the same place 12 months after the surgery. A biopsy revealed a combined positive score (CPS) of 5, indicating that the tumor was programmed death‑ligand 1‑positive (PD‑L1‑positive), leading to treatment with albumin‑bound paclitaxel, cisplatin and camrelizumab for 4 cycles, followed by 12 cycles of maintenance therapy with camrelizumab. The patient maintained progression‑free survival for 11 months. On the whole, the present case report highlights the need for sufficient radiotherapy (≥66 Gy EQD2) for ITAC in complex anatomical areas, highlighting the role of advanced techniques to overcome dose limitations. Moreover, the ‘chemo‑immuno induction plus immuno‑maintenance’ approach in PD‑L1‑positive patients exhibits potential for long‑term disease control, providing a novel treatment model for advanced‑stage ITAC.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Comprehensive treatment for intracranial invasive sinonasal intestinal‑type adenocarcinoma with a focus on radiotherapy dosage and immunological combination therapy: A case report

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Abstract

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